Clinical trials: Cognitive and Executive Dysfunction
Mild Cognitive Impairment (MCI)
Creative Dance-Supported CO-OP Approach in Older Adults With Mild Cognitive Impairment
The goal of this clinical trial is to evaluate if the CO-OP (Cognitive Orientation to daily Occupational Performance) approach, supported by creative dance, can improve cognitive functions in older adults with mild cognitive…
- Trial name
- COOP-DANCE (NCT06644690)
- Testing
- CO-OP with Creative Dance, CO-OP Only
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Çankırı Karatekin University
Cognitive Orientation, Executive Dysfunction
THE EFFECT OF THE COGNITIVE ORIENTATION TO DAILY OCCUPATIONAL PERFORMANCE (CO-OP) APPROACH IN CHILDREN WITH ATTENTION DEFICIT AND HYPERACTIVITY DISORDER ON MOTOR PERFORMANCE AND EXECUTIVE FUNCTIONS
Attention deficit and hyperactivity disorder (ADHD) is a behavioural and neurodevelopmental disorder that can affect behavioural, emotional, academic, social, and cognitive functions and is not age-appropriate.
- Conditions
- Cognitive Orientation, Executive Dysfunction, Motor Activity
- Trial name
- NCT05125120
- Testing
- COGNİTİVE ORİENTATİTON DAİLY OCCUPATİONAL PERFORMANCE APPROACH
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Mild Cognitive Impairment
DIetary Supplements, Executive funcTions and Vitamin D (DIET-D)
The purpose of this study is to compare the effect after 12 weeks of the oral intake of Lecitone®Se + 200UI/day of D3 vitamin with the effect of a placebo on changes in cognitive performance in Trial Making Test score part B…
- Trial name
- DIET-D (NCT01708005)
- Testing
- Lecitone®Se-Vitamin D3
- Where
- France
- Volunteers
- 160 people
- Sponsor
- University Hospital, Angers
Epilepsy, Quality of Life
Idiopathic Generalized Epilepsy Cognitive and Emotional Profile
The primary goal of the study is to explore the neurocognitive, emotional-behavioral functioning, and quality of life of adolescents with IGE, identifying key factors that affect their overall well-being.
- Conditions
- Epilepsy, Quality of Life, Neuropathology, Emotional Problem
- Trial name
- NCT06782074
- Testing
- emotional and neuropsychological assessment
- Where
- Italy
- Volunteers
- 96 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Cognitive Impairment, Autoimmune Encephalitis
To Explore Cognitive Neural Mechanism of Autoimmune Encephalitis by Using Neuropsychological Tests and Multi-modal MRI
Most of patients with autoimmune encephalitis are left with permanent cognitive deficits of varying severity. The patients' life and career would be affected definitely by cognitive deficits.
- Trial name
- NCT03530462
- Testing
- rituximab, cyclophosphamide, Steroids
- Where
- China
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Traumatic Brain Injury, Executive Dysfunction
Online Emotion Regulation Group Intervention
This study will examine the efficacy of an emotion regulation intervention delivered online to individuals with traumatic brain injury (TBI) with deficits in emotion regulation.
- Conditions
- Traumatic Brain Injury, Executive Dysfunction, Emotion Dysfunction, Emotion Dysregulation
- Trial name
- NCT03479606
- Testing
- Online Emotion Regulation Skills-training
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cognitive Impairment, Stroke
Strategy Training on Improving Executive Functions in Persons Following Acquired Brain Injury
About two-third individuals with acquired brain injury (ABI) experience cognitive impairments. Deficits in executive functions is one of the most prevalent cognitive impairments following ABI which result in decline of recovery…
- Conditions
- Cognitive Impairment, Stroke, Acquired Brain Injury
- Trial name
- NCT04033952
- Testing
- Strategy Training
- Where
- 3 sites in Taiwan
- Volunteers
- 180 people
- Sponsor
- Taipei Medical University
Wellness, Anxiety
WILD 5 Wellness: A 30-Day Intervention
The purpose of this study is to explore the efficacy and feasibility of an integrated, prescriptive, and trackable wellness intervention combining five wellness elements including exercise, mindfulness, sleep, social…
- Conditions
- Wellness, Anxiety, Depression, Cognitive and Executive Dysfunction
- Trial name
- NCT03272555
- Testing
- WILD 5 Wellness Interventions
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Beloit College
Mild Cognitive Impairment (MCI)
Multi-session Transcranial Alternating Current Stimulation to Improve Dual-task Standing and Brain Activity in Older Adults With Mild Cognitive Impairment
Older adults with Mild Cognitive Impairment (MCI) often show less brain activity in a specific range (8-13 Hz, known as alpha power) compared to healthy older adults.
- Trial name
- NCT07097051
- Testing
- real tACS
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- High Point University
Major Depressive Disorder, Cognitive Dysfunction
Musical Attention Control and Executive Function Training for Adults With MDD
The investigators have developed music-based cognitive training sessions derived from Neurologic Music Therapy (NMT) techniques.
- Conditions
- Major Depressive Disorder, Cognitive Dysfunction, Suicide
- Trial name
- NCT05694156
- Testing
- Music-based cognitive training
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- Unity Health Toronto
Mild Cognitive Impairment (MCI), Depression
Brain Aging and Treatment Response in Geriatric Depression
The proposed project will evaluate the role of neuroimaging biomarkers of brain aging (i.e., neurodegenerative and vascular brain changes) and mild cognitive impairment in the patterns of treatment response to memantine combined…
- Trial name
- NCT01902004
- Testing
- Escitalopram, Memantine
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- University of California, Los Angeles
Dementia, Neurocognitive Disorders
Effect of Individual Cognitive Stimulation on Memory and Executive Function in Older Adults With Alzheimer's Disease
This multicentre study, with a randomised controlled repeated measures experimental design, will be conducted in several Portuguese institutions, which provide care and supportive services for older adults diagnosed with mild or…
- Conditions
- Dementia, Neurocognitive Disorders, Cognitive Impairment, Cognitive Dysfunction
- Trial name
- NCT05433493
- Testing
- Cognitive stimulation
- Where
- 14 sites in Portugal
- Volunteers
- 142 people
- Sponsor
- Rsocialform - Geriatria, Lda
Schizophrenia; Psychosis, Cognitive Impairment
Efficacy of Computer-assisted Cognitive Remediation in Patients With Schizophrenia
Objective: To determine the efficacy of computer-assisted cognitive remediation (CACR) in patients with chronic schizophrenia in the community settings.
- Conditions
- Schizophrenia; Psychosis, Cognitive Impairment, Executive Function, Randomized Controlled Trial
- Trial name
- NCT04773171
- Testing
- Computer-assisted Cognitive Remediation, Conventional training programmes
- Where
- Hong Kong
- Volunteers
- 72 people
- Sponsor
- The Hong Kong Polytechnic University
Brain Injuries
Cognitive Rehabilitation of Executive Dysfunction - Goal Management Training in Patients With Acquired Brain Injury
The main objective of this study is to examine the effect of Goal Management Training for patients with executive difficulties after acquired brain injury in a randomized controlled trial.
- Trial name
- NCT02692352
- Testing
- Goal Management Training, Brain Health Workshop
- Volunteers
- 70 people
- Sponsor
- Sunnaas Rehabilitation Hospital
Activities of Daily Living, Accidental Fall
Bingocize: A Novel Mobile Application for Older Adult Health
This study tests the effectiveness of using a new mobile application (Bingocize®) to improve older adults' (a) adherence to an engaging exercise program, and (b) aspects of functional performance, health knowledge, dietary…
- Conditions
- Activities of Daily Living, Accidental Fall, Sarcopenia, Arteriosclerosis
- Trial name
- Bingocize (NCT03629912)
- Testing
- Socially-Based Exercise Intervention for Older Adults
- Where
- 4 sites in United States
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Western Kentucky University
Aging, Cognitive Decline
Evaluation of the Online Memory & Aging Program and Online Goal Management Training
The current study is designed to test the effectiveness of online programs for memory and executive functions in healthy aging. The investigators are testing online adaptations of two cognitive interventions that have been…
- Trial name
- NCT03602768
- Testing
- Goal Management Training, Memory & Aging Program, Cambridge Brain Sciences
- Where
- Canada
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Baycrest
Dementia, Mild, Mild Cognitive Impairment
CAPABLE Family Pilot - Adapting CAPABLE for Older Adults With Mild Cognitive Impairment (MCI)/Early Stage Dementia and Their Care Partners
The purpose of this study is to test the adapted protocol, CAPABLE Family which builds upon the evidenced based CAPABLE program to address older adults with co-occurring physical disability and mild cognitive impairment or early…
- Conditions
- Dementia, Mild, Mild Cognitive Impairment, Disability Physical, Impairment, Cognitive
- Trial name
- NCT05187117
- Testing
- CAPABLE Family - Open Label Pilot, CAPABLE Family - Randomized Control Trial
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Mild Cognitive Impairment, Lack of Physical Activity
Change in Executive Function and IADL Using a Virtual Supermarket Environment Among People With MCI
The aim of the study is to investigate the feasibility of using a virtual supermarket as an intervention tool for overcoming deficits in executive function as well as enhancing IADL performance among persons with Mild Cognitive…
- Trial name
- EF-VAPS (NCT01103453)
- Testing
- Virtual Action Planning Supermarket (VAP-S) Software
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Carmel Medical Center
Parkinson Disease, Executive Dysfunction
Effect of Computer-based Cognitive Training on Attention and Executive Functions in Patients With Parkinson's Disease
The current study adresses the effect of two different computer-based cognitive trianing programmes on attention and executive functions in patients with Parkinson's disease.
- Trial name
- NCT03285347
- Testing
- Computer-based cognitive training
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Bispebjerg Hospital
Mild Cognitive Impairment (MCI), Parkinsons Disease (PD)
Study to Investigate Vagus Nerve Stimulation to Augment Executive Function in Healthy and Cognitively Impaired Populations
This study plans to learn more about how stimulating the vagus nerve through gentle electrical stimulation applied to the ear can affect decision-making, problem-solving, and other thinking abilities.
- Conditions
- Mild Cognitive Impairment (MCI), Parkinsons Disease (PD), Healthy Adult
- Trial name
- NCT07424365
- Testing
- transcutaneous auricular vagus nerve stimulation
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver