Clinical trials: Cognitive-Behavior Treatment
Major Depressive Disorder
Mechanisms of Emotion Regulation Underlying Successful CBT in Depression
This research aims to elucidate mechanisms through which change occurs during cognitive behavior therapy (CBT) for depression. Assessing meta-cognitive processes of self-knowledge (top-down), electrophysiological and behavioral…
- Trial name
- NCT04328103
- Testing
- Cognitive Behavior Therapy (CBT), Nonspecific Supportive Therapy (PBO)
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- New York State Psychiatric Institute
Obsessive-Compulsive Disorder
ITreatOCD: Predicting the Efficacy of Internet-based Cognitive Behavioral Therapy in Obsessive-compulsive Disorder
In the current study, the investigators will characterize obsessive-compulsive disorder (OCD) patients and healthy controls with a comprehensive clinical and neuroimaging assessment, focusing on the basic psychological processes…
- Trial name
- iTREATOCD (NCT05906069)
- Testing
- ICBT
- Where
- Portugal
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Pedro Morgado
Seasonal Affective Disorder (SAD), Winter Depression
Cognitive-behavioral Therapy vs. Light Therapy for Preventing SAD Recurrence
Major depression is a highly prevalent, chronic, and debilitating mental health problem with significant social cost that poses a tremendous economic burden.
- Conditions
- Seasonal Affective Disorder (SAD), Winter Depression, Major Depressive Disorder, Recurrent, With Seasonal Pattern
- Trial name
- NCT01714050
- Testing
- Cognitive-Behavioral Therapy (CBT), Light Therapy (LT)
- Where
- United States
- Volunteers
- 177 people
- Sponsor
- University of Vermont
Gastroparesis
Central and Peripheral Effects of Cognitive Behavioral Therapy on Brain-Gut Axis Signaling in Gastroparetic Patients
This is a single-center pilot study to be conducted at Massachusetts General Hospital. The purpose of this study is to examine the non-pharmacological impact of Cognitive Behavioral Therapy (CBT) on gastroparesis symptoms and…
- Trial name
- NCT03531450
- Testing
- Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Massachusetts General Hospital
Chronic Pain, Pain
Literacy-Adapted Psychosocial Treatments for Chronic Pain --- "Learning About Mastering/My Pain"
Chronic pain is a significant public health problem that affects over 116 million Americans, costs $600 billion annually, and is unequally borne by people in low-income brackets, especially ethnic minorities.
- Conditions
- Chronic Pain, Pain, Widespread Chronic Pain, Chronic Pain Syndrome
- Trial name
- LAMP (NCT01967342)
- Testing
- Pain Ed, CBT for Pain, Usual Care
- Where
- 3 sites in United States
- Volunteers
- 290 people
- Sponsor
- University of Alabama, Tuscaloosa
Multiple Sclerosis
Effects of a Multiple Sclerosis Relapse Therapy on Offspring Neurocognitive Development and Behaviour
Introduction: Fetal exposure to glucocorticoids (GCs) used to induce fetal lung maturation in women threatened by premature labour is known to induce aberrations in brain development and stress sensitivity, cognitive dysfunction…
- Trial name
- MS-Children (NCT04832269)
- Testing
- Exposure to methylprednisolone during pregnancy
- Where
- 2 sites in Germany
- Volunteers
- 80 people
- Sponsor
- Jena University Hospital
Cervical Cancer
An Intervention Study To Improve Human PapillomaVirus ( HPV) Immunization in Haitian and African American Girls
In the United States, Black women are more likely to die of cervical cancer than White women. In developing countries and globally, Haitian immigrant women are more likely to die of cervical cancer than any other women in the…
- Trial name
- HPV (NCT01254669)
- Testing
- BNI-brief Negotiated Interview
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Postpartum Depression
Public Health Nurse-Delivered 1-Day CBT Workshops for PPD
Public Health Nurses (PHN) received training to deliver a day-long Cognitive Behavioural Therapy (CBT)-based workshop for treating postpartum depression (PPD).
- Trial name
- NCT05622305
- Testing
- 1-Day Cognitive Behavioural Therapy-Based Workshop
- Where
- Canada
- Volunteers
- 451 people
- Sponsor
- McMaster University
IBS - Irritable Bowel Syndrome
Zemedy Application for Irritable Bowel Syndrome
The purpose of the study is investigate the effectiveness of Zemedy, a mobile application that enables the digital delivery of a CBT program to people with IBS.
- Trial name
- NCT04723056
- Testing
- Use of Zemedy Application
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Stanford University
Exercise, Ultra-endurance Running
Effect of Exogenous Ketosis During Ultra-endurance Exercise
The aim of this study is to investigate the effect of oral ketone administration during and immediately after an ultramarathon. Potential changes in cognitive function (reaction time, number of errors), running performance, jump…
- Conditions
- Exercise, Ultra-endurance Running, Ketosis, Skeletal Muscle
- Trial name
- NCT05407753
- Testing
- Ketone ester
- Where
- Belgium
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Insomnia
Efficacy of Digital Cognitive Behavioral Therapy for Insomnia (CBT-I)
Insomnia is a common sleep problem, which affects 9.4-38.2% of youths worldwide. Youth insomnia is linked to mental health problems, leading to substantial health and economic burden.
- Trial name
- NCT06593262
- Testing
- app-based digital cognitive behavioral therapy for insomnia with AI chatbot, app-based digital cognitive behavioral therapy for insomnia without AI chatbot
- Where
- Hong Kong
- Volunteers
- 168 people
- Sponsor
- Chinese University of Hong Kong
Autism, Asperger's Syndrome
Cognitive Behavioral Therapy for Anxiety Disorders in Adolescents With Autism
Due to the considerable prevalence of anxiety in youth with autism spectrum disorders, this study seeks to establish the efficacy of a modified cognitive behavioral therapy protocol in 50 adolescents versus other available…
- Conditions
- Autism, Asperger's Syndrome, Pervasive Developmental Disorder Not Otherwise Specified, Generalized Anxiety Disorder
- Trial name
- NCT01563003
- Testing
- Cognitive Behavioral Therapy, Treatment as usual
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Depression Symptoms, Anxiety Symptoms
Internet-based Cognitive Behavioral Therapy: a Factorial Randomized Controlled Trial About Treatment Content and Support
The purpose of this study is to investigate the differences in treatment outcomes between individually tailored and transdiagnostic internet-based cognitive behavioral therapy (ICBT), as well as the differences between weekly…
- Trial name
- NCT06209541
- Testing
- Internet-based cognitive behavioral therapy (ICBT)
- Where
- 2 sites in Sweden
- Volunteers
- 176 people
- Sponsor
- Linkoeping University
Asthma
Cognitive Behavior Therapy for Anxiety-related Asthma in Adults.
This is a study to develop a protocol on Cognitive behavior therapy (CBT) for asthma-related anxiety that in a consecutive study can be translated to internet-delivered CBT.
- Trial name
- NCT03158194
- Testing
- CBT for anxiety-related asthma
- Where
- Sweden
- Volunteers
- 6 people
- Sponsor
- Karolinska Institutet
Advanced Breast Cancer, Advanced Prostate Cancer
Engage Psychosocial Intervention for Cancer Symptoms
The goal of this clinical trial is to test the efficacy a new psychosocial symptom management intervention called ENGAGE for patients with Stage IV breast, prostate, lung, or colorectal cancer.
- Conditions
- Advanced Breast Cancer, Advanced Prostate Cancer, Advanced Lung Cancer, Advanced Colorectal Carcinoma
- Trial name
- Engage (NCT06555588)
- Testing
- ENGAGE, Supportive Care
- Where
- United States
- Volunteers
- 190 people
- Sponsor
- Duke University
Anxiety, Depression
Cognitive Behavioral Therapy for Anxiety and Depression in COPD
The purpose of this study was to examine the efficacy of manualized, short-term group cognitive behavioral therapy for COPD patients suffering from clinically significant symptoms of anxiety and/or depression.
- Conditions
- Anxiety, Depression, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT00545922
- Testing
- Cognitive behavioral therapy, Minimal Telephone Contact
- Where
- Norway
- Volunteers
- 51 people
- Sponsor
- University of Bergen
Depression, Major Depressive Disorder
Novel Neural Circuit Biomarkers of Major Depression Response to CCBT
The purpose of the study is to learn more about computer-assisted cognitive behavioral therapy or "CCBT" and to examine connections in the brains of patients with depression.
- Conditions
- Depression, Major Depressive Disorder, Depressive Disorder, Depression, Unipolar
- Trial name
- NCT03096886
- Testing
- Computer-Augmented Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Depression, Anxiety
Enhancing the Effectiveness of Cognitive Behavioral Therapy Using Non-invasive Brain Stimulation
The purpose of the proposed study is to examine if a repeated treatment of High Definition Transcranial Direct Current Stimulation (HD-tDCS) can increase the functional connectivity between the left ventrolateral prefrontal…
- Conditions
- Depression, Anxiety, Stress Disorders, Post-Traumatic
- Trial name
- NCT05555056
- Testing
- MxN-9 HD-tES Stimulator (Soterix Inc.)
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Insomnia
Study of Trazodone & Cognitive Behavioral Therapy to Treat Insomnia
The purpose of this study is to evaluate the effect of a 3 month medication trial of Trazodone versus 3 months of Cognitive Behavioral Therapy (CBT) in patients with chronic insomnia.
- Trial name
- NCT01348542
- Testing
- Trazodone, Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Milton S. Hershey Medical Center
Endometriosis, Quality of Life
Cognitive Behavioral Therapy in Endometriosis
Endometriosis affects 10% of reproductive aged women and causes severe pain and impaired quality of life (QoL). Surgery for endometriosis results in long term symptom relief in only 40% of women.
- Conditions
- Endometriosis, Quality of Life, Pain
- Trial name
- NCT04448366
- Testing
- Cognitive behavioral therapy
- Where
- 5 sites in Netherlands
- Volunteers
- 100 people
- Sponsor
- Rijnstate Hospital
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