Clinical trials: Cohort
Depressive Disorder, Depression
Prediction and Validation of Unipolar Depression With Psychosocial-somatic Markers in a Naturalistic Cohort Recruited in an Outpatient Setting
The POKAL-PSY project is a study that monitors participants for five years. The goal of the study is to identify distinguishable subtypes of depression on the basis of biomarkers and to gain insight into their prognostic…
- Conditions
- Depressive Disorder, Depression, Depressive Symptoms, Depressive Episode
- Trial name
- POKAL-PSY (NCT05547711)
- Testing
- drawing blood
- Where
- Germany
- Volunteers
- 950 people, healthy volunteers welcome
- Sponsor
- Julia Eder
Chronic Obstructive Pulmonary Disease, Bronchiectasis
Prediction of Pulmonary Rehabilitation Outcomes in Patients With Chronic Respiratory Disease Based on Metabolomics: a Prospective Cohort Study
To comprehensively evaluate the pulmonary rehabilitation (PR) outcomes of patients with chronic respiratory disease (CRD), and to screen biomarkers for predicting different PR outcomes of patients with CRD using metabolomics…
- Trial name
- NCT05681364
- Testing
- metabonomics
- Volunteers
- 300 people
- Sponsor
- Peking University Third Hospital
Alternating Hemiplegia of Childhood
Sodium Oxybate in Patients With Alternating Hemiplegia of Childhood (AHC-SO)
WHO: The investigators are recruiting children and young adults to participate in a research study who: 1. Have been diagnosed with Alternating Hemiplegia of Childhood (AHC) 2. Are between the ages of 6 months - 25 years old 3.
- Trial name
- AHC-SO (NCT00931164)
- Testing
- Sodium Oxybate
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Utah
HIV Infections
Protocol RV 583 Multinational Observational Cohort of HIV and Other Infections
Multinational Observational Cohort of HIV and other Infections (MOCHI). This observational study is to gain information regarding the number of new HIV infections among people who engage in behaviors that make them vulnerable to…
- Trial name
- MOCHI (NCT05147519)
- Testing
- Novel interventions to achieve HIV remission
- Where
- 4 sites in Kenya, Nigeria and 2 more
- Volunteers
- 2,500 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Cardiovascular Diseases, Heart Failure
The Safety and Efficacy of Pulsed Field Ablation for Patients With Persistent Atrial Fibrillation Comorbid With HFpEF.
The goal of this clinical trial is to evaluate the the mid- and long-term clinical efficacy and safety of pulsed field catheter ablation for patients with persistent atrial fibrillation and HFpEF.
- Conditions
- Cardiovascular Diseases, Heart Failure, Atrial Fibrillation (AF), HFpEF - Heart Failure With Preserved Ejection Fraction
- Trial name
- NCT07077811
- Testing
- pulsed field ablation, antiarrhythmic drug
- Where
- China
- Volunteers
- 158 people
- Sponsor
- Affiliated Hospital of Nantong University
Gastric Cancer, Dysplasia Stomach
Endoscopic Surveillance on a High-risk Population for Gastric Cancer in Latin America: The ECHOS Cohort Study.
The goal of this observational study is to evaluate the risk factors associated with incident HGD/GA in patients with CAG with or without IM who are enrolled in endoscopic surveillance, as well as to compare GA incidence…
- Conditions
- Gastric Cancer, Dysplasia Stomach, Atrophic Gastritis, Helicobacter Pylori Infection
- Trial name
- ECHOS (NCT05969444)
- Where
- 2 sites in Chile
- Volunteers
- 685 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Choledochal Cyst
Clinical Features and Prognosis of Asymptomatic Biliary Dilatation
This study is a multicenter, ambidirectional cohort study aiming to consecutively recruit asymptomatic biliary dilation patients incidentally discovered by imaging from 25 medical centers across China.
- Trial name
- NCT07028164
- Where
- China
- Volunteers
- 1,008 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Preterm Labor
Uterocervical Angle in Patients With Preterm Premature Rupture of the Membranes
To evaluate the performance of uterocervical angle (UCA) in the prediction of labor timing in patients with preterm premature rupture of the membranes
- Trial name
- NCT04095507
- Testing
- uterocervical angle
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Nefise Nazlı YENIGUL
EARLY UNDIFFERENTIATED SPONDYLARTHROPATHIES
French Cohort of Undifferentiated Spondyloarthritis
This study is a large national multicenter, longitudinal, prospective follow-up of patients presenting with early inflammatory back pain in order to set up a database to facilitate several investigations on diagnosis, prognosis…
- Trial name
- DESIR (NCT01648907)
- Testing
- Imaging exams
- Where
- France
- Volunteers
- 708 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pseudomonas Infections, Pseudomonas Aeruginosa
Antimicrobial Therapy for Difficult-to-treat Pseudomonas Aeruginosa
The primary objective of the ADDICT study is to assess and compare the clinical efficacy of available options for antimicrobial therapy (new beta-lactam/beta-lactamase inhibitor combination, cefiderocol or older agents such as…
- Conditions
- Pseudomonas Infections, Pseudomonas Aeruginosa, Prognosis, Drug Resistance, Multiple, Bacterial
- Trial name
- ADDICT (NCT06738771)
- Where
- 48 sites in France, Reunion
- Volunteers
- 600 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Pancreatic Cancer
LDE225 With Fluorouracil, Leucovorin, Oxaliplatin, and Irinotecan for Untreated Advanced Pancreatic Cancer
LDE225 is a new medicine that blocks the Hedgehog (Hh) pathway. The Hh pathway is a cascade of molecular events that control cell growth and have been linked with the development of many human cancers, including pancreatic…
- Trial name
- NCT01485744
- Testing
- LDE225; Fluorouracil; Leucovorin; Oxaliplatin; Irinotecan
- Where
- 2 sites in United States
- Volunteers
- 39 people
- Sponsor
- Massachusetts General Hospital
Alzheimer Disease, Dementia
Cognitive Impairment Cohort Study of the Elderly Population in SheMountain
This study is a prospective observational study, which involves a cohort of 2000 all-sex and all-ethnic people aged 60 years and above with permanent residence in Tianma area, SheMountain Town, Songjiang District (suburban area)…
- Conditions
- Alzheimer Disease, Dementia, Neurodegenerative Diseases, Cognitive Impairment
- Trial name
- SheMountain (NCT05667935)
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Osteoporosis
Percutaneous Vertebroplasty Versus Conservative Treatment in GIOPVCF
Based on the case reports and other literature, the investigators hypothesize that using PVP for treating GIOPVCF is associated with increased risk of vertebral refractures and does not provide further benefits compared to…
- Trial name
- NCT03330340
- Testing
- Percutaneous Vertebroplasty
- Volunteers
- 106 people
- Sponsor
- Peking University First Hospital
Lumbar Radiculopathy, Lumbar Disc Herniation
Prediction of TEI Success in Sciatica
Rationale: Treatment with transforaminal epidural injections is part of usual care in patients suffering from lumbar radiculopathy.
- Conditions
- Lumbar Radiculopathy, Lumbar Disc Herniation, Lumbar Spinal Stenosis
- Trial name
- POTEISS (NCT04540068)
- Testing
- Transforaminal Epidural Injection
- Where
- Netherlands
- Volunteers
- 388 people
- Sponsor
- Eduard Verheijen
HIV, Hepatitis C
THISTLE - The HIV-HCV Silibinin Trial
Chronic hepatitis C virus (HCV) is a major cause of morbidity and mortality worldwide with an estimated number of 180 million infected patients.
- Trial name
- THISTLE (NCT01816490)
- Testing
- Intravenous Silibinin (iSIL)
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Zurich
Disability
Prospective Study and Analysis of Biomechanical Parameters of Human Movement Based on Disability Indicators in Older Adults
Mobility loss in older people is caused by a variety of aging impairments in various body systems.The disability, which includes physical impairments and resulting activity limitations or participation restrictions, can arise…
- Trial name
- MOBA-P (NCT05656690)
- Testing
- Exposure to disability
- Where
- Portugal
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Polytechnic Institute of Porto
Pancreatic Ductal Adenocarcinoma
Oncolytic Virotherapy Plus PD-1 Inhibitor and Lenvatinib for Patients With Advanced Pancreatic Cancer
The objective of this study is to evaluate the safety/tolerability efficacy of oncolytic virotherapy combined with Tislelizumab plus lenvatinib for advanced pancreatic cancer patients who were relapsed or refractory to standard…
- Trial name
- NCT05303090
- Testing
- H101, Tislelizumab, lenvatinib
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Fudan University
Cerebral Small Vessel Diseases
Cohort Study of Inpatients and Outpatient Patients With Cerebral Small Vessel Disease
This cohort study involves the dynamic collection of clinical information, including serum parameters , blood pressure variability, imaging data, and neuropsychological scales, in patients with cerebral small vessel disease…
- Trial name
- NCT05985213
- Testing
- data collection and follow-up
- Where
- China
- Volunteers
- 1,078 people, healthy volunteers welcome
- Sponsor
- Shanghai Yueyang Integrated Medicine Hospital
Central Venous Access Complications
Immediate Mechanical Complications After Central Venous Catheterization
The goal of this observational study is to determine the incidence of immediate mechanical complications after central venous catheterization and to explore factors associated with major mechanical complications in adolescent and…
- Trial name
- CATH-RISK (NCT07367620)
- Testing
- Central Venous Catheterization
- Where
- Sweden
- Volunteers
- 29,114 people
- Sponsor
- Thomas Kander
Medication Adherence
Perspectives on Prophylactic Antibiotic Use in Dermatologic Surgery
This is a prospective, multi-center observational survey study to uncover how antibiotic differences can influence utilization decisions.
- Trial name
- NCT04150523
- Testing
- Survey
- Where
- 8 sites in United States
- Volunteers
- 338 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
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