Clinical trials: Cohort
Breast Neoplasms
Treatment of Dalpiciclib Combined With Pyrotinib for Trastuzumab-sensitive HER2+ Advanced Breast Cancer(DAP-Her-02)
Based on different HR status, we explored the efficacy and safety of Pyrotinib and Dalpiciclib Isethionate Tablets based combination regimen in the first-line treatment of HER2 + MBC.
- Trial name
- NCT05328440
- Testing
- Pyrotinib Maleate, Dalpiciclib Isethionate Tablets, Inetetamab
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Henan Cancer Hospital
PreDiabetes, Glucose Metabolism Disorders
Development of Continuous Glucose Monitoring System Cohort for Personalized Diabetes Prevention and Management Platform
The purpose of this study is to collect a variety of clinical data and blood glucose changes using a continuous glucose monitoring device for high-risk diabetes patients (prediabetes) in order to develop a personalized diabetes…
- Conditions
- PreDiabetes, Glucose Metabolism Disorders, Diabetes Mellitus
- Trial name
- NCT04369833
- Testing
- continuous glucose monitoring system
- Where
- South Korea
- Volunteers
- 130 people
- Sponsor
- Pusan National University Hospital
Hemodynamics;In-stent Stenosis;Transcranial Doppler;Intracranial Aneurysm;Flow Diverter; Prospective Cohort Study
Hemodynamic Study of In-Stent Stenosis(I) After Flow Diverter(F) Based on 3D-DSA(D) Combined With TCCD(T)
DTFI is a single-center, prospective cohort study aimed at evaluating the hemodynamics of in-stent stenosis after flow diverter implantation, seeking to identify the threshold effect of blood flow in stenosis.
- Trial name
- DTFI (NCT06448949)
- Testing
- Flow Diverter Implantation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Zhujiang Hospital
Radiomics, Hepatocellular Carcinoma (HCC)
Microvascular Invasion for Guiding Treatment of Barcelona Clinic Liver Cancer Stage B Hepatocellular Carcinoma
The goal of this observational study is to explore the role of prediction of microvascular invasion by radiomics based on pre-treatment magnetic resonance imaging for guiding treatment of Barcelona Clinic Liver Cancer stage B…
- Conditions
- Radiomics, Hepatocellular Carcinoma (HCC), Transcatheter Arterial Chemoembolization (TACE), Microvascular Invasion (MVI)
- Trial name
- NCT05889949
- Testing
- Sorafenib, Lenvatinib
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Sun Yat-sen University
Colorectal Cancer, Polyps
The Correlation of Postoperative Polyp Recurrence and Colorectal Cancer
Postoperative endoscopic polyp recurrence correlation of colorectal cancer: a retrospective cohort open-label study
- Trial name
- NCT07708415
- Testing
- Endoscopic polypectomy
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Gansu Provincial Hospital
Cerebral Oxygen Saturation, Postoperative Delirium
Association Between Local Cerebral Oxygenation Monitoring and Postoperative Delirium in Carotid Endarterectomy
Postoperative delirium (POD) is a common perioperative complication, which can lead to adverse outcomes. Patients undergoing carotid endarterectomy (CEA) were elderly, complicated with vascular risk factors, cognitive…
- Conditions
- Cerebral Oxygen Saturation, Postoperative Delirium, Carotid Endarterectomy
- Trial name
- NCT05198635
- Testing
- local cerebral oxygen saturation
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Beijing Tiantan Hospital
COVID-19 Infection
Extension Study in a Cohort of Adult Patients With COVID-19 Infection
The main objective of this study is to evaluate the incidence of post-COVID morbidity and characterize the complications profile in patients who participated in the APLICOV-PC study.
- Trial name
- E-APLICOV-PC (NCT05121740)
- Testing
- Plitidepsin 1.5 mg / day, Plitidepsin 2.0 mg / day, Plitidepsin 2.5 mg / day
- Where
- 10 sites in Spain
- Volunteers
- 34 people
- Sponsor
- PharmaMar
Multiple Sclerosis
Immunisation Status and Safety of Vaccines in Italian MS Patients
Multiple sclerosis (MS) patients are more susceptible to infections than the general population in relation to some specific therapies or increasing disability.
- Trial name
- NCT04300868
- Where
- Italy
- Volunteers
- 3,000 people
- Sponsor
- Monica Ulivelli
COVID-19, Bariatric Surgery Candidate
Bariatric Surgery and COVID-19
The National Bariatric Surgical Registry (NBSR) is a prospectively collected database for all patients undergoing elective bariatric surgery in the UK.
- Trial name
- NCT05532891
- Testing
- COVID-19 pandemic
- Where
- United Kingdom
- Volunteers
- 11,545 people, healthy volunteers welcome
- Sponsor
- Imperial College London
HIV I Infection
A Cohort Study of Use of Doravirine (DOR) Based Regimens in Clinical Practice in Europe DoRavirine Europe Real World/
Following the initiation of Doravirine (DOR) regimen among people living with HIV (PLWH), the study will aim to assess effectiveness, discontinuation, and resistance over the 12-month period.
- Trial name
- DrEW (NCT05421806)
- Where
- 19 sites in Belgium, France and 3 more
- Volunteers
- 500 people
- Sponsor
- NEAT ID Foundation
Obstructive Sleep Apnea, Non-small Cell Lung Cancer
Obstructive Sleep Apnea Influences Efficacy of PD-1-Based Immunotherapy Against Non-Small Cell Lung Cancer
This prospective, observational cohort study aims to explore the influence of obstructive sleep apnea(OSA) on the efficacy of PD-1-based immunotherapy in patients with non-small cell lung cancer(NSCLC).
- Trial name
- NCT04743752
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University First Hospital
Humeral Diaphysis Fracture
Conservative Treatment Versus the Surgical Treatment of Diaphyseal Fractures of Humerus
The fracture of the humeral diaphysis is a condition that represents 2% of all fractures. The conservative treatment of diaphyseal fractures of the humerus has long been considered the only option and the surgical treatment was…
- Trial name
- NCT01116349
- Testing
- Plate and screws or nailing, Hanging Support System (HSS) brace
- Where
- 2 sites in Canada
- Volunteers
- 4 people
- Sponsor
- Hopital de l'Enfant-Jesus
Pain Due to Certain Specified Procedures
Single Injection Infromedial Peribulbar Injection in Lacrimal Duct
infromedial injection of 3 ml local anesthetic drugs and assessing the pain during lacrimal duct intubation and probability of false tracking
- Trial name
- NCT04859049
- Testing
- infromedial single injection, medial canthus injection
- Where
- 2 sites in Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Research Institute of Ophthalmology, Egypt
COPD
Chronic Obstructive Pulmonary Disease (COPD) History Assessment In SpaiN (CHAIN)
The research project CHAIN (COPD Assessment History in Spain): "A Multidimensional Study on the Evolution of Chronic Obstructive Pulmonary Disease (COPD)is a multicentre, observational study conducted in several areas of Spain…
- Trial name
- CHAIN (NCT01122758)
- Where
- 2 sites in Spain
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Cimera
COVID-19, Lymphocytopenia
InterLeukin-7 to Improve Clinical Outcomes in Lymphopenic pAtients With COVID-19 Infection ( ILIAD-7-US-I )
Comparison of the effects of CYT107 vs Placebo administered IM at 10μg/kg twice a week for three weeks on immune reconstitution of lymphopenic COVID-19 patients
- Trial name
- ILIAD-7-US-I (NCT04442178)
- Testing
- CYT107
- Where
- 5 sites in United States
- Volunteers
- 26 people
- Sponsor
- Revimmune
HCC, Adjuvant Therapy
Adjuvant Anti-PD-1 Therapy in Resected Hepatocellular Carcinoma
Early hepatocellular carcinoma (HCC) recurrence (driven by residual tumors) and late recurrence (driven by de novo tumors) exhibit distinct biological behaviors, suggesting differential therapeutic vulnerabilities.
- Conditions
- HCC, Adjuvant Therapy, Recurrence, Immune Checkpoint Inhibitor
- Trial name
- NCT07379489
- Testing
- PD-1 Inhibitors
- Volunteers
- 300 people
- Sponsor
- Tongji Hospital
Chronic Pancreatitis
Natural Course and Therapeutic Effect of Chronic Pancreatitis
The goal of this observational study is to establish a prospective cohort of chronic pancreatitis (CP) patients to provide evidence-based guidance for clinical practice and comprehensively optimize diagnostic and treatment…
- Trial name
- NCT06925204
- Testing
- Observation
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Changhai Hospital
Hepatocellular Carcinoma
Pharmacogenetic of Doxorubicin in HCC.
The study included 81 HCC patients, both male and female. Prior to being assessed for eligibility, each recruited patient with HCC received a comprehensive review of their medical history, physical status, and laboratory results.
- Trial name
- NCT06313047
- Testing
- Doxorubicin
- Where
- Saudi Arabia
- Volunteers
- 81 people
- Sponsor
- Rehab Werida
Stroke, Acute Ischemic Stroke
Trial of pRehospital Intervention With trAditional Chinese Medicine for Acute strokE
The main purpose of this trial is to observe whether Xingnaojing, intravenously administered within 24 hours of symptom onset on pre-hospital emergency ambulance, improves the Early neurological deterioration of acute stroke at 3…
- Conditions
- Stroke, Acute Ischemic Stroke, Acute Intracranial Hemorrhage
- Trial name
- TRACE (NCT04275349)
- Testing
- Xingnaojing injection within 24 hours of symptom onset
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Dongzhimen Hospital, Beijing
Adults Aged 50 Years and Older
The Impact of Grandchild Care on Physical Activity and Sedentary Behavior in People Aged 50 Years and Over
Given the widespread provision of grandparental child care, examining its impact on grandparents' energy-expenditure related behaviors in the broader context of health is imperative.
- Trial name
- NCT04307589
- Testing
- Observation
- Where
- Belgium
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
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