Clinical trials: Cohort
Infertility
Obesity and Intracytoplasmic Sperm Injection Cycle Outcome
Obesity has been associated with menstrual irregularities, chronic an-ovulation, infertility, and poor outcomes in women undergoing in vitro fertilization.
- Trial name
- NCT03778684
- Testing
- Visceral fat thickness, Body mass index
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Assiut University
Coronary Heart Disease, Acute Myocardial Infarction
Twenty-year Follow-up of the Inter99 Cohort
Being born small increases your risk of developing Type 2 diabetes (T2D) with age. Furthermore, data even suggest that some of the diseases ("complications") in the eyes, kidneys, nerves, liver, blood vessels and heart often seen…
- Conditions
- Coronary Heart Disease, Acute Myocardial Infarction, Cardiovascular Diseases, Type 2 Diabetes
- Trial name
- NCT05166447
- Where
- Denmark
- Volunteers
- 4,000 people
- Sponsor
- Bispebjerg Hospital
Total Knee Replacement, Osteoarthritis
Knee Replacement Outcome Predicted by Physiotherapists
The aim is to assess if physiotherapists attending inpatients at elective orthopaedic wards can predict the future course (post hospitalisation) of recovery of patients undergoing KA.
- Trial name
- NCT02982785
- Testing
- Standard post-operative rehabilitation
- Where
- 2 sites in Denmark
- Volunteers
- 364 people
- Sponsor
- Marius Henriksen
Pregnancy, Breast Cancer
Outcome of Pregnancy and Breast Cancer
Investigators are interested to explore the clinical and pathological characteristics of breast cancer with pregnancy, maternal age at the time of diagnosis of breast cancer during pregnancy, median gestational age at diagnosis…
- Trial name
- Pregnancy (NCT02774915)
- Where
- Saudi Arabia
- Volunteers
- 20 people
- Sponsor
- National Guard Health Affairs
PONV
Amisulpride for the Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Surgery
This study aims to focus on patients undergoing gynecological laparoscopic surgery and further evaluate the role of amisulpride in preventing postoperative nausea and vomiting in these patients.
- Trial name
- Amisulpride (NCT07554040)
- Testing
- Tropisetron
- Volunteers
- 526 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cervical Intraepithelial Neoplasia Grade 2 (CIN2)
Biomarkers Predictive for Cervical Intraepithelial Neoplasia Grade 2 (CIN2) Evolvement
Introduction Cervical intraepithelial neoplasia CIN1 (low grade), CIN2 (moderate grade), CIN3 (severe grade) defines cervical precancer lesions derived from the squamous epithelial cell line.
- Trial name
- NCT05049252
- Where
- Denmark
- Volunteers
- 500 people
- Sponsor
- University of Aarhus
Nerve Block, Regional Anesthesia
Training Non-Anesthesia Personnel to Perform Nerve Blocks in Microgravity
Space exploration is rapidly progressing with multiple upcoming missions planned to the moon and International Space Station, and projected missions to Mars in the early 2030s.
- Conditions
- Nerve Block, Regional Anesthesia, Microgravity, Space Analogue
- Trial name
- Block-aid (NCT07849049)
- Testing
- Simulated microgravity, Normal earth gravity
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Nova Scotia Health Authority
Cerebral Amyloid Angiopathy, Small Vessel Cerebrovascular Disease
Prognosis of Cerebral Small Vessel Disease
Prognosis of small vessel disease (SVD) depends on the underlying type of SVD and index manifestation. The aim of this prospective, observational cohort study is to determine the risk of different outcome events among patients…
- Conditions
- Cerebral Amyloid Angiopathy, Small Vessel Cerebrovascular Disease, Cadasil, CAA - Cerebral Amyloid Angiopathy
- Trial name
- PRO-SVD (NCT05734378)
- Where
- Switzerland
- Volunteers
- 900 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Gastric Adenocarcinoma, Malignant Melanoma
This Study is a Phase II Study of AZD6738 in Combination With Durvalumab in Patients With Solid Tumor (Cohort A (N=30): GC Who Have Failed Secondary Chemotherapy Treatments Regimen; Cohort B (B=30): Melanoma Patients Who Have Failed to IO)
This study is a phase II study of AZD6738 in combination with durvalumab in patients with solid tumor (cohort A (N=30): GC who have failed secondary chemotherapy treatments regimen; cohort B (B=30): melanoma patients who have…
- Trial name
- NCT03780608
- Testing
- AZD6738, Durvalumab
- Where
- South Korea
- Volunteers
- 61 people
- Sponsor
- Samsung Medical Center
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia
A Phase 1, Open-Label, Dose-Escalation & Expanded Cohort, Continuous IV Infusion, Multi-center Study of the Safety, Tolerability,PK & PD of EPZ-5676 in Treatment Relapsed/Refractory Patients With Leukemias Involving
The purpose of this study is to determine the safe dose of EPZ-5676, to evaluate the safety of EPZ-5676 in patients with advanced hematologic malignancies, and to conduct a preliminary assessment of the anti-leukemia activity of…
- Conditions
- Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome, Myeloproliferative Disorders
- Trial name
- NCT01684150
- Testing
- EPZ-5676
- Where
- 8 sites in United States, Germany and 1 more
- Volunteers
- 51 people
- Sponsor
- Epizyme, Inc.
Uveitis
Acute and Chronic Inflammatory Disease, Lifestyle and Treatment Response
Acute and chronic inflammatory eye diseases are difficult to diagnose and maintain quiescent with therapy. Proposed study is aimed to find on the one hand, novel factors for recurrence of the disease or remission of inflammation…
- Trial name
- ACID LTR (NCT04193020)
- Testing
- Surveillance card
- Where
- Poland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Ampullary Adenocarcinoma
The ADAPTA Study: ADjuvant chemotherAPy After Curative Intent resecTion of Ampullary Cancer.
Ampullary adenocarcinoma (AAC) is a rare gastrointestinal cancer with varying survival rates, particularly the aggressive pancreatobiliary (PB) subtype.
- Trial name
- ADAPTA (NCT06068023)
- Testing
- Folfirinox, Capox
- Where
- Italy
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Fondazione Poliambulanza Istituto Ospedaliero
Study of Three Doses of AZT-04 for Skin Appearance
Safety Study of AZT-04 for Cosmetic Use
Double Blind, Three Cohort, Placebo-controlled Trial to Assess Safety, Tolerance and Induced Bacterial Colony Counts of Three Ascending Doses of AZT-04 in Healthy Adult Volunteers
- Trial name
- NCT03820076
- Testing
- AZT-04
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Azitra Inc.
Carotid Artery Stenosis Symptomatic, Carotid Endarterectomy (CEA) Surgical Patients
Correlation Between Carotid Stump Pressure and Interhemispheric rSO₂ Asymmetry During Awake Carotid Endarterectomy
This study aims to better understand how well the brain is perfused (supplied with blood and oxygen) during a specific type of surgery called carotid endarterectomy (CEA), which is performed to prevent strokes in people with…
- Conditions
- Carotid Artery Stenosis Symptomatic, Carotid Endarterectomy (CEA) Surgical Patients, Cerebral Hypoperfusion
- Trial name
- NCT07150260
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Izmir Katip Celebi University
SARS-COV-2 Infection
Transplacental Transmission of COVID-19
SARS-CoV-2, the agent responsible for pandemic COVID-19 infection, is transmitted mainly by respiratory droplets. Regarding maternal-fetal transmission, even if the mode of transmission from mother to fetus is not clear, some…
- Trial name
- NCT05124574
- Testing
- Samples concern SARS-COV-2 + pregnant women at the time of childbirth, Samples concern newborns of SARS-COV-2 + mothers at birth
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Monkeypox
Mpox Prospective Observational Cohort Study
The goal of this multicentre prospective observational cohort study is to shed light on the following unknowns: 1. The clinical manifestations of Mpox infection since the 2022 outbreak in Canada. 2.
- Trial name
- MPOCS (NCT06291259)
- Where
- 3 sites in Canada
- Volunteers
- 250 people
- Sponsor
- Unity Health Toronto
Resting Metabolic Rate, Bone Mineral Density, Low, Susceptibility to
The Health of Competitive Fitness Athletes
Fitness athletes emphasize the value of staying lean, muscular and defined, and motivates and inspires followers through social media.
- Conditions
- Resting Metabolic Rate, Bone Mineral Density, Low, Susceptibility to, Body Image, Perfectionism
- Trial name
- NCT03007459
- Testing
- Psychological health, Physiological health
- Where
- Norway
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Norwegian School of Sport Sciences
Colorectal Cancer
Prospective Data Collection Initiative on Colorectal Cancer
Survival after colorectal cancer (CRC) diagnosis strongly depends on local tumor extent, lymph node involvement and the presence of distant metastases.
- Trial name
- PLCRC (NCT02070146)
- Where
- 70 sites in Netherlands
- Volunteers
- 50,000 people
- Sponsor
- Dutch Colorectal Cancer Group
Preterm Labor
Impact of Suspected Preterm Labour on Cardiometabolic Profile and Neurodevelopment
Suspected preterm labour (SPL), define as the presence of regular and painful uterine contractions and cervical shortening, constitute a prenatal insult with potential long-term consequences.
- Trial name
- SKs (NCT05211297)
- Where
- Spain
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Sanitaria Aragón
Perioperative Myocardial Infarction, Disability
TEAMS (Troponin Elevation After Major Surgery) Study
Background to main study question: Cardiac complications are a common cause of morbidity after non-cardiac surgery. Patients with perioperative myocardial injury (both MI, and lower levels of cardiac troponin elevation)…
- Trial name
- TEAMS (NCT02146560)
- Where
- Canada
- Volunteers
- 267 people
- Sponsor
- University Health Network, Toronto
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