Clinical trials: Cohort
Fractures, Bone
Comparing Efficacy of Bone Marrow Aspirate Concentrate (BMAC) Combined With Allograft in Treatment of Calcaneus Fractures
The purpose of this study is to evaluate the efficacy of BMAC when used in conjunction with viable allograft bone for treating displaced intra-articular calcaneal fractures, in terms of rate of allograft incorporation into the…
- Trial name
- BMAC (NCT05017961)
- Testing
- Autograft, Allograft only, Allograft combined with BMAC
- Sponsor
- University of Alabama at Birmingham
Fulminant Myocarditis
Clinical Assessment of New Treatment Regimen for Adult Fulminant Myocarditis
This is a retrospective cohort study to assess the clinical outcome of patients with fulminant myocarditis using "Life-support Based Comprehensive Treatment Regimen" and conventional therapy.
- Trial name
- NCT03268642
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Tongji Hospital
Diabetic Autonomic Neuropathy Type 2, Perioperative Complication
Effect of Diabetes Mellitus on Cardiac Autonomic Function in Surgical Patients Undergoing General Anesthesia
Because autonomic neuropathy affects the constriction of thermoregulatory blood vessels, it is more difficult for diabetic patients to maintain their own body temperature in cold environments than normal people, and therefore it…
- Conditions
- Diabetic Autonomic Neuropathy Type 2, Perioperative Complication, Temperature Change, Body
- Trial name
- NCT06432270
- Volunteers
- 388 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
PTEN Gene Mutation
Cancer Risk Assessment in Patients With a Constitutional Alteration of the PTEN Gene
This is a multicentric, observational, retrospective and prospective study, aiming to estimate the risk of cancer occurrence in subjects carrying a PTEN mutation, based on the constitution of a national cohort.
- Trial name
- COCO (NCT05630105)
- Where
- 45 sites in France
- Volunteers
- 430 people
- Sponsor
- Institut Bergonié
Colonic Polyp, Colonoscopy
Endoscopic Resection of Large Colorectal Polyps: An Observational Cohort Study
This protocol describes a prospective cohort study. It addresses an important challenge in the prevention of colorectal cancer and duodenal cancer: how to safely and effectively remove large polyps.
- Conditions
- Colonic Polyp, Colonoscopy, Complication, Recurrence
- Trial name
- NCT04220905
- Where
- United States
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- White River Junction Veterans Affairs Medical Center
Capsular Contracture of Breast Implant
Prospective Longitudinal Cohort Study of Implant Age, Pocket Plane, Incision, Surface Texture, and Volume as Predictors of Clinically Significant Capsular Contracture
This prospective breast implant surveillance cohort will evaluate whether implant age, pocket plane, incision route, surface texture, and volume predict clinically significant capsular contracture.
- Trial name
- NCT07810231
- Testing
- Breast Implant Exposure, Standardized Capsular Contracture Assessment
- Where
- Colombia
- Volunteers
- 3,000 people
- Sponsor
- Research Inc
Respiratory Infection, COVID-19 Respiratory Infection
COVID-Like Illness Respiratory Pathogens. A Prospective Cohort on the COVID-19 Post-acute Condition
Identifying multiorgan sequalae and complications through high quality, prospective matched controlled studies throughout the course of COVID-19 is important for the acute and long-term management of patients and for health…
- Conditions
- Respiratory Infection, COVID-19 Respiratory Infection, Sequelae of; Infection
- Trial name
- CLEAR (NCT05047666)
- Volunteers
- 1,232 people
- Sponsor
- Bernhard Nocht Institute for Tropical Medicine
Cerebrovascular Circulation, Magnetic Resonance Imaging
Brain Blood Flow Responses During Exercise: Younger Cohort
Brain blood flow will be measured during exercise using magnetic resonance imaging.
- Trial name
- NCT06446622
- Testing
- MRI
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Childhood Fibrolamellar Carcinoma, Recurrent Childhood Fibrolamellar Carcinoma
Testing the Addition of an Anti-cancer Drug, DT2216, to the Usual Chemotherapy Treatment for Relapsed or Refractory Solid Tumors and Fibrolamellar Carcinoma
This phase I/II trial tests the safety, side effects and best dose of DT2216 in combination with irinotecan and how well it works in treating children, adolescents and young adults with solid tumors and fibrolamellar cancer that…
- Conditions
- Childhood Fibrolamellar Carcinoma, Recurrent Childhood Fibrolamellar Carcinoma, Recurrent Childhood Malignant Solid Neoplasm, Recurrent Fibrolamellar Carcinoma
- Trial name
- NCT06620302
- Testing
- Bcl-XL Proteolysis Targeting Chimera DT2216, Biospecimen Collection, Irinotecan
- Where
- 21 sites in United States
- Volunteers
- 81 people
- Sponsor
- Children's Oncology Group
Chronic Disease, Cancer
The Dampness Syndrome of Chinese Medicine Cohort Study
The researchers plain to build a large-scale, longitudinal, prospective cohort characterized by TCM dampness syndrome. With the biobank of this cohort the investigators want to find the causality between TCM dampness syndrome and…
- Conditions
- Chronic Disease, Cancer, Dementia Alzheimers, Metabolic Disease
- Trial name
- DACOS (NCT05315895)
- Testing
- natural aging process
- Where
- China
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Guangzhou University of Traditional Chinese Medicine
Hepatocellular Carcinoma, COVID-19
COVID-19 Infection in Patients With Hepatocellular Carcinoma
Since December 2019, a new disease named COVID-19 linked to a new coronavirus, SARS-CoV2 has emerged in China in the city of Wuhan, Hubei province, spreading very quickly to all 5 continents, and responsible for a pandemic.
- Trial name
- COVID19-CHIEF (NCT04367805)
- Testing
- nasopharyngeal Covid 19 RT-PCR
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Resectable Hepatocellular Carcinoma (HCC)
Integration of Imaging, Molecular, Pathological, and Clinical Outcome Data in Hepatocellular Carcinoma.
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death globally. Surgical resection is the mainstay of curative-intent treatment, but the 5-year postoperative recurrence rate can be as high as 70%.
- Trial name
- IMPACT (NCT07912853)
- Testing
- Resection
- Where
- China
- Volunteers
- 380 people
- Sponsor
- West China Hospital
Cancer, Radiation Therapy
Improving Outcomes for Older Adults Undergoing Radiation Therapy
The purpose of this study is to improve healthcare received by people ≥ 65 years who are receiving radiation therapy (RT). The study will primarily examine patients ability to complete RT, changes in a patients' daily function…
- Trial name
- NCT05721053
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Myocardial Infarction
AIDAVA G1 LDL-C Substudy Protocol
This retrospective substudy describes low-density lipoprotein cholesterol (LDL-C) changes and treatment-target attainment among patients with previous myocardial infarction who participated in the AIDAVA first-generation (G1)…
- Trial name
- NCT07839845
- Where
- Estonia
- Volunteers
- 37 people
- Sponsor
- North Estonia Medical Centre
Schizophrenia
Observational Study of Long Acting Injectable Medications (LAIs) in Schizophrenia (OASIS)
The objectives of this study are to describe characteristics, treatment patterns, and outcomes of patients with schizophrenia newly initiated on 1 of 4 FDA-approved atypical Long Acting Injectable (LAI) antipsychotics (ABILIFY…
- Trial name
- NCT03919994
- Where
- 57 sites in United States
- Volunteers
- 338 people
- Sponsor
- Alkermes, Inc.
Gallbladder Cancer and Extrahepatic Cholangiocarcinoma
Camrelizumab and Chemotherapy With or Without Anlotinib as First-line Treatment for Advanced Gallbladder Cancer and Extrahepatic Cholangiocarcinoma
To evaluate the efficacy and safety of camrelizumab and chemotherapy with or without anlotinib as first-line treatment for advanced gallbladder cancer and extrahepatic cholangiocarcinoma
- Trial name
- NCT06901622
- Testing
- Camrelizumab, anlotinib, nab-paclitaxel, S-1, Camrelizumab, nab-paclitaxel, S-1
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Left Ventricular Diastoic Dysfunction Cohort Study
Epidemic Profile of Left Ventricular Diastoic Dysfunction in the Community Elderly and Establishing Prediction Model: the Northern Shanghai Study
This study is one of the largest ongoing prospective population studies to evaluate target organ damages (TODs) and Left Ventricular Diastoic Dysfunction in the community-dwelling elderly Chinese, which is authorised and funded…
- Trial name
- ELITISM (NCT03735251)
- Testing
- Diuretic，Betaloc，antiplatelet drugs
- Volunteers
- 1,920 people, healthy volunteers welcome
- Sponsor
- Ya-Wei Xu
Acute-on-chronic Hepatitis B Liver Failure
Characteristics and Risk Factors for Invasive Fungal Infection With Acute-on-chronic Hepatitis B Liver Failure
This is a single-center retrospective study. The clinical data of patients with Acute-on-chronic Hepatitis B liver failure who were hospitalized in the Department of Hepatology, Qilu Hospital of Shandong University from January…
- Trial name
- NCT06190002
- Volunteers
- 500 people
- Sponsor
- Qilu Hospital of Shandong University
Malnutrition, Sarcopenia
Malnutrition and Sarcopenia in Adults With Chronic Kidney Disease in Tunisia
The TUN-CKDN study is a national, multicenter, prospective cohort study conducted in nephrology centers in Tunisia. It aims to describe how often malnutrition and sarcopenia (loss of muscle strength and muscle mass) occur in…
- Conditions
- Malnutrition, Sarcopenia, Renal Insufficiency, Chronic
- Trial name
- TUN-CKDN (NCT07906405)
- Testing
- Standardized nutritional and muscle assessment
- Where
- Tunisia
- Volunteers
- 4,000 people
- Sponsor
- Dacima Consulting
Respiratory Insufficiency, Ventilator Weaning
Extubation Guided by Bedside Ultrasound
The aging of the global population has led to an increased number of surgical procedures being performed on elderly patients. However, with aging, the main structure and function of the lungs undergo progressive changes involving…
- Conditions
- Respiratory Insufficiency, Ventilator Weaning, Postoperative Complications
- Trial name
- NCT05674812
- Testing
- Multimodal pre-extubation risk assessment in elderly surgical patients
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Lili Jia
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