Clinical trials: Cold
Asthma, Asthma Exacerbations
Vitamin D In the Prevention of Viral-induced Asthma in Preschoolers
In this 7-month randomized controlled trial, children aged 1 to less than 6 years, with recurrent asthma attacks triggered mostly by colds, will receive a high dose of vitamin D or a placebo every 3.5 months during their usual…
- Conditions
- Asthma, Asthma Exacerbations, Preschool Child, Vitamin D
- Trial name
- DIVA (NCT03365687)
- Testing
- Vitamin D
- Where
- 9 sites in Canada
- Volunteers
- 323 people
- Sponsor
- Professor Francine Ducharme
Ankle Fractures, Swelling
Effect of Cool Spray and Cold Packs in Reducing Preoperative Edema and Pain in Ankle Fractures in Ubonratchathani
The use of evaporative coolants in the management of acute musculoskeletal injury has received increasing attention recently. However, its efficacy compared with conventional cryotherapy in treating injured human subjects remains…
- Conditions
- Ankle Fractures, Swelling, Cryotherapy Effect
- Trial name
- 3-armRCT (NCT06293209)
- Testing
- 3M cold pack, Perskindol cold spray
- Where
- Thailand
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Thai Traditional Medical Knowledge Fund
Cold Contact Urticaria
Cold Urticaria Treatment With Xolair
Urticaria is a very frequent skin condition characterised by transient wheal and flare type skin reactions associated with severe pruritus.
- Trial name
- CUTEX (NCT01580592)
- Testing
- Omalizumab
- Where
- 3 sites in Germany
- Volunteers
- 31 people
- Sponsor
- Charite University, Berlin, Germany
Raynaud's Disease, Raynaud's Disease Secondary to Scleroderma
Dose Response Study of a Topical Gel for the Treatment of Raynaud's Phenomenon
The Purpose of this study is to determine the response to two different strengths of a topical gel containing nitroglycerin in patients with Raynaud's disease.
- Conditions
- Raynaud's Disease, Raynaud's Disease Secondary to Scleroderma, Raynaud's Disease Secondary to Autoimmune Disease
- Trial name
- NCT00378521
- Testing
- MQX-503
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- MediQuest Therapeutics
Asthma (Diagnosis)
The Effect of a Cold Air Eucapnic Hyperventilation Test on Lower Respiratory Airways in Healthy Volunteers and Patients With Asthma
In this study, we want to evaluate the feasibility and safety of a CAEH test in healthy volunteers and patients with asthma. We want to develop a CAEH test to differentiate patients with different types of asthma and…
- Trial name
- CLARINET (NCT07220928)
- Testing
- Cold air challenge
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Fever
Fever Management in Children With Febrile Neutropenia
The aim of this study is to determine the effect of the cold steam application on body temperature in combination with the treatment algorithm in fever management in children with febrile neutropenia.
- Trial name
- NCT05189236
- Testing
- Control Group (Only Algorithm of Febrile Neutropenia Management), Experimental Group (Algorithm of Febrile Neutropenia Management+Cold Steam)
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Acibadem University
Postoperative Pain
The Effect of Intermittent Cryotherapy Exposure on Patients' Quality of Recovery After Surgery
"Cryotherapy", or cold therapy, can include the use of gel packs, ice bags, ice baths, whole body chambers, and cold aerosol sprays.
- Trial name
- ICE (NCT04564963)
- Testing
- Cryotherapy
- Where
- 3 sites in Canada
- Volunteers
- 196 people
- Sponsor
- Sunnybrook Health Sciences Centre
Coronary Artery Disease
Year-round Health Enhancing Exercise and Coronary Artery Disease
A cold season involves higher cardiovascular morbidity and mortality. Several epidemiologic studies have implicated that persons with a cardiac disease, such as coronary artery disease (CAD) may be at higher risk for these…
- Trial name
- NCT02855905
- Testing
- Exercise/Rest and cold/neutral temperature
- Where
- Finland
- Volunteers
- 21 people
- Sponsor
- University of Oulu
MDRPA
Clinical Study on the Treatment of Lower Respiratory Tract Infection With Pseudomonas Aeruginosa by Ceftazidime and Avibatam
Multidrug-resistant Gram-negative bacteria (MDR-GNB) is emerging globally as a pathogen of concern in healthcare-associated infections (HAIs), and a threat to public health.There has been an alarming rise in the prevalence of…
- Trial name
- NCT06992102
- Where
- China
- Volunteers
- 500 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Influenza, Viral Respiratory Infection
A Study to Evaluate the Safety, Tolerability and Efficacy of XC221 in Patients With Uncomplicated Influenza or Other Acute Viral Upper Respiratory Infections
A multicenter, randomized, double-blind, placebo controlled comparative study to evaluate the safety, tolerability and efficacy of XC221 used at 100 mg daily and at 200 mg daily in patients with uncomplicated influenza or other…
- Conditions
- Influenza, Viral Respiratory Infection, Acute Viral Upper Respiratory Infections
- Trial name
- NCT05030324
- Testing
- XC221 100 mg, XC221 200 mg
- Where
- 9 sites in Russia
- Volunteers
- 255 people
- Sponsor
- Valenta Pharm JSC
Chronic Obstructive Pulmonary Disease (COPD)
A Study to Test a Potential New Treatment for COPD Patients Suffering From the Common Cold or Influenza
The aim of the study is to assess the safety of inhaled SNG001 and the ability of inhaled SNG001 to 'switch on' the cells' anti-viral defences in patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT03570359
- Testing
- Interferon Beta-1A
- Where
- 16 sites in United Kingdom
- Volunteers
- 122 people
- Sponsor
- Synairgen Research Ltd.
Colorectal Polyp
Cold Snare Polypectomy of Non-pedunculated Colorectal Adenomas
A prospective randomised controlled trial of cold vs hot snare polypectomy of non-pedunculated colorectal adenomas.
- Trial name
- NCT03859479
- Testing
- Cold snare polypectomy, Hot snare polypectomy
- Where
- Russia
- Volunteers
- 160 people
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
Molar Incisor Hypomineralization
Local Anesthesia in Molar Teeth With Molar Incisor Hypomineralization
To compare responses to electrical pulp test (EPT) and cold test among molar incisor hypomineralization (MIH)-effected and not MIH-effected carious teeth before and after administration of local anesthesia for caries removal.
- Trial name
- NCT04061096
- Testing
- Evaluation of cold test, Evaluation of electrical pulp test, Evaluation of pain during the treatment
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Didem Sakaryali
Cryotherapy Effect, Burn Scar
Observation of the Comfort and Efficacy of CO2 Laser Combined With Cryo 6 for Burn or Linear Scars.
To investigate the effect of 10,600 nm CO2 laser combined with Zimmer Cryo 6 forced cold air device on the comfort and efficacy of patients with burn scars or post-operative linear scars, and to provide a safer, more effective…
- Conditions
- Cryotherapy Effect, Burn Scar, Scar; Previous Cesarean Section
- Trial name
- NCT05555602
- Testing
- Cold-air cooling
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kaiyang Lv, MD-PhD
Healthy Volunteers
A Dose-Block Randomized, Placebo Controlled (Double-blind), Active Controlled(Open-label), Dose-escalation Study
The study design of this trial is a Dose-Block Randomized, Placebo controlled (Double-blind), Active Controlled(Open-label), Dose-escalation.
- Trial name
- NCT02175056
- Testing
- HL2351, Kineret(Anakinra)
- Where
- South Korea
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Handok Inc.
Birth
The Effect of Cold Application to the Sacral Area on Labor Comfort:
Purpose: Cold application is considered as an effective alternative treatment for labor comfort because of its low side effects and easy availability.
- Trial name
- NCT05693623
- Testing
- cold application
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Emine Yıldırım
Common Cold, Pharyngitis
Alleviation of Common Cold Symptoms
Upper respiratory infections (URIs) have long posed a significant burden to the US healthcare system. Well before the coronavirus disease of 2019 (COVID-19) pandemic they have been among the most common acute outpatient…
- Conditions
- Common Cold, Pharyngitis, Fever, Congestion
- Trial name
- NCT06106880
- Testing
- Wintergreen Throat Spray and Aspirin Tablet
- Where
- 6 sites in United States
- Volunteers
- 157 people
- Sponsor
- Applied Biological Laboratories Inc
Common Cold
Efficacy and Safety of Irlanda-1-Association on the Treatment of Common Cold in Children
The purpose of this study is to evaluate the clinical efficacy of the drug associations in the treatment of common cold symptoms.
- Trial name
- NCT02656888
- Testing
- Irlanda-1-Association
- Where
- Brazil
- Sponsor
- EMS
Common Cold
Decongestant Effect, Timing of Effect and Impact on Sleep and General Well-Being of Xylometazoline in Subjects With a Common Cold
The aim of this study is to characterize the time profile of the decongestant properties of xylometazoline and to investigate its effect on sleep, general well-being and smell/taste.
- Trial name
- NCT00452270
- Testing
- Xylometazoline
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Novartis
Upper Respiratory Tract Infections
LiveSpo Navax® Supports the Treatment of Acute Rhinosinusitis and Otitis Media
Acute respiratory tract infections (ARTIs), such as acute rhinosinusitis (ARS) and acute otitis media (AOM), are common worldwide and caused by viruses or bacteria entering the body through the mouth and nose.
- Trial name
- NCT05804123
- Testing
- 0.9% NaCl physiological saline Nasal-spraying, LiveSpo Navax®, Augmentin 500Mg Tablet
- Where
- Vietnam
- Volunteers
- 175 people
- Sponsor
- Anabio R&D