Clinical trials: Cold Exposure
Behavior, Stress
Cold Water and Decision-Making
The behavioral within-subject cross-over design study "CoVa" aims to investigate the effect of a short-term full-body cold-water immersion vs.
- Conditions
- Behavior, Stress, Quality of Life, Psychological Wellbeing
- Trial name
- CoVa (NCT06908447)
- Testing
- Cold-water immersion, Warm-water immersion (Control)
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- German Institute of Human Nutrition
Cognitive Function
Acute Effects of Cold Exposure on Cognitive Function
This is a randomized controlled human exposure crossover study. Investigators aims to assess the acute effects of low-temperature exposure on cognitive function and the underlying mechanisms.
- Trial name
- NCT06654167
- Testing
- Low temperature (15℃) group, Moderate temperature (22℃) group
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fudan University
Calorie Deficiency, Fasting
Effects of Calorie Restriction and Cold Stimuli on Health-related Indicators, Cognitive and Motor Functions
The goal of this clinical trial was to identify if duration of acute calorie restriction (CR)/fasting or combination CR with cold stimuli have any effects on mental and physical health-related markers, and to clarify if different…
- Conditions
- Calorie Deficiency, Fasting, Cold Exposure
- Trial name
- NCT05545943
- Testing
- 2-days of zero calorie restriction and whole-body cold-water immersion, 6-days of calorie restriction, 2-days of zero calorie restriction without whole-body cold-water immersion
- Where
- Lithuania
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Lithuanian Sports University
Healthy
The Effect of Exposure to Aversive Non-verbal Vocalizations on Pain Tolerance
Humans produce non-verbal vocalizations (shouting, growling, screaming), laughter, ...) in various contexts that are likely to perform biological functions. and important social issues.
- Trial name
- CRYPAIN (NCT04423874)
- Testing
- Cold pressor task (CPT), index NOL, Playback Experiments
- Where
- France
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Brown Adipose Tissue, Metabolic Disease
Brown Adipose Tissue as Nutrient Buffer Through Diet Induced Thermogenesis
To test the hypothesis that active BAT improves metabolic health by buffering postprandial metabolites plasma metabolites and energy expenditure will be compared in volunteers with and without active BAT.
- Trial name
- BANDIT (NCT06078345)
- Testing
- Carbohydrate, Fat, Protein
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Lower Respiratory Tract Infection (LRTI)
Procalcitonin Antibiotic Consensus Trial (ProACT)
The ProACT study is a 5 year, multicenter study that will test the effect of implementation of a novel procalcitonin guideline on antibiotic use and adverse outcomes in Emergency Department (ED) patients with Lower Respiratory…
- Trial name
- ProACT (NCT02130986)
- Testing
- Procalcitonin level, Results of procalcitonin (PCT) level to treating clinician, Provide procalcitonin guideline to treating clinician
- Where
- 13 sites in United States
- Volunteers
- 1,664 people
- Sponsor
- University of Pittsburgh
Thermogenesis
Beta 2 Adrenergic Stimulation vs Cold Exposure to Activate Human Brown Adipose Tissue
The purpose of the study is to asses brown adipose tissue activity in humans after intravenous administration of the selective beta-2-adrenergic agonist fenoterol as compared to the natural activator of brown adipose tissue, a…
- Trial name
- ASCENT (NCT05294965)
- Testing
- Fenoterol, Mild cold exposure
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Obesity
Chronic Intermittent Cold Exposure on Weight Loss
1. To test whether chronic intermittent cold exposure is more effective in programmed body weight loss when compared to conventional programmed weight loss. 2. To measure the metabolic responses (e.g.
- Trial name
- CICE (NCT01312090)
- Testing
- Whole body cryotherapy, counseling and behavioral therapy for weight loss
- Volunteers
- 20 people
- Sponsor
- Helsinki University Central Hospital
Dry Eye Disease
A Long-Term Safety Study Evaluating the Safety and Systemic Exposure of AR-15512
The purpose of this study is to evaluate the safety of topical ophthalmic 0.003% AR-15512 compared to its vehicle dosed twice daily (BID) in subjects with dry eye disease (DED) for 12 months.
- Trial name
- COMET-4 (NCT05493111)
- Testing
- 0.003% AR-15512 ophthalmic solution, AR-15512 vehicle ophthalmic solution
- Where
- 10 sites in United States
- Volunteers
- 275 people
- Sponsor
- Aerie Pharmaceuticals
Healthy Volunteers
Food Intake Response to Short-Term Modifications of Metabolism in Humans
One reason people gain weight is eating more calories from food than what they need for energy over 24 hours. Metabolism is the amount of energy a person uses over 24 hours.
- Trial name
- NCT02939404
- Testing
- Cold exposure, Normal temperature, Fixed diet
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Nitrate, Caffeine
The Effects of Nitrate, Caffeine, and Cold Exposure on Cardiovascular Function.
Dietary inorganic nitrate supplementation may have positive implications on cardiovascular function. The aim of this project is to determine if nitrate supplementation can attenuate the effects that caffeine and cold exposure…
- Conditions
- Nitrate, Caffeine, Cold Exposure
- Trial name
- NCT06602921
- Testing
- TruBeet inorganic beetroot juice, Caffeine, Cold pressor test
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Sleep Deprivation, Cold Exposure
Modafinil to Optimize the Performance of Cold-Stressed Sleep-Deprived Personnel
Environmental and workplace stressors are common and often unavoidable in military operations. Two critical stressors are cold stress and sleep loss. They both can substantially degrade operational effectiveness.
- Trial name
- NCT07830056
- Testing
- Modafinil (M), 200 mg Microcrystalline Cellulose
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Eating Habit, Cold Exposure
Assessment of the Effects of a 24-hour Cold and Heat Exposure on the Factors Influencing Food Intake
Military personnel and athletes have a very high energy expenditure which is increased during certain key periods (intense training, competition and mission).
- Conditions
- Eating Habit, Cold Exposure, Heat
- Trial name
- TEMPCA (NCT05584527)
- Testing
- Heat exposure (32°C), Cold exposure (16°C), Thermoneutral exposure (24°C)
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Adipose Tissue, Brown, Brown Adipose Tissue
Winter-Swimming and Brown Adipose Tissue Activity in Middel-aged Obese Subjects (WinterBAT).
This study investigates repetitive cold-water exposure on brown fat activity assessed by PET/CT scanning. Furthermore we will assess glucose control upon winter-swimming.
- Conditions
- Adipose Tissue, Brown, Brown Adipose Tissue, Uncoupling Protein 1, Cold Exposure
- Trial name
- WinterBAT (NCT03541096)
- Testing
- Winter Swimming, Control group
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Kristian Karstoft
Hypertension
Cardiovascular Responses to Cold in Hypertension
Wintertime is associated with increased morbidity and mortality and a majority is related to cardiovascular causes, such as myocardial infarctions, heart failures, and strokes.
- Trial name
- ColdHTN (NCT02007031)
- Where
- 2 sites in Finland
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University of Oulu
Cold Water Immersion, Immune Function
Cold Water Exposure and Immune Function Study
The purpose of this clinical trial is to explore the effects of a 4 week cold-water immersion (CWI) intervention on measures of immune function, sleep quality, mental health and well-being, and muscular strength.
- Conditions
- Cold Water Immersion, Immune Function, Muscular Strength, Mental Health
- Trial name
- NCT06667479
- Testing
- Cold Water Immersion (CWI) - Cold Tub Immersion (CI), Cold Water Immersion (CWI) - Cold Shower (CS), Control Group (CO)
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Northern Colorado
Metabolic Dysfunction-Associated Steatohepatitis (MASH)
A Prospective Study of Cold Exposure in Patients With MASH
This prospective, single-center, single-arm exploratory study aims to evaluate the safety, feasibility, and potential metabolic and hepatic effects of repeated cold exposure in patients with metabolic dysfunction-associated…
- Trial name
- NCT07821749
- Testing
- Water-Perfused Cooling Suit
- Where
- China
- Volunteers
- 11 people
- Sponsor
- Renmin Hospital of Wuhan University
Brown Adipose Tissue
Effect of Glyceroltrinitrate on Human Energy Expenditure and Brown Adipose Tissue Thermogenesis
The aim of this study is to evaluate the efficacy of glyceroltrinitrate (Nitroderm® TTS) to activate and expand human BAT as compared to mild cold exposure.
- Trial name
- NEXT (NCT05711199)
- Testing
- Glyceroltrinitrat
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Cold Exposure
Effects of Winter Swimming on Blood Indicators and Oxidative Stress in Males
Exposure of the human body to cold water triggers numerous beneficial physiological changes. The study aimed to assess the impact of regular winter swimming on blood morphological, rheological, and biochemical indicators and…
- Trial name
- NCT06223087
- Testing
- winter swimming
- Where
- Poland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University School of Physical Education, Krakow, Poland
Influenza, Human, Acute Respiratory Infection
Study of Post-Exposure Ingavirin® Prophylaxis of Influenza and Acute Respiratory Viral Infections
The purpose of the study was to evaluate efficacy of prophylactic Ingavirin intake by people having contact with sick people infected with influenza and other acute respiratory viral infections
- Conditions
- Influenza, Human, Acute Respiratory Infection, Common Cold, Flu
- Trial name
- NCT03189537
- Testing
- Ingavirin (Imidazolyl Ethanamide Pentandioic Acid)
- Where
- 2 sites in Russia
- Volunteers
- 400 people
- Sponsor
- Valenta Pharm JSC