Clinical trials: Cold Exposure, active
Metabolic Dysfunction-Associated Steatohepatitis (MASH)
A Prospective Study of Cold Exposure in Patients With MASH
This prospective, single-center, single-arm exploratory study aims to evaluate the safety, feasibility, and potential metabolic and hepatic effects of repeated cold exposure in patients with metabolic dysfunction-associated…
- Trial name
- NCT07821749
- Testing
- Water-Perfused Cooling Suit
- Where
- China
- Volunteers
- 11 people
- Sponsor
- Renmin Hospital of Wuhan University
Healthy Lifestyle
BATokines as Biomarkers of Brown Fat in Humans
Brown adipose tissue (BAT) burns excess calories to produce heat in response to environmental cold. Rapidly growing evidence from rodent and human studies suggests that the presence and activation of brown fat are far more…
- Trial name
- NCT05050240
- Testing
- Cooling Vest Procedure, Fasting overnight
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Coronary Artery Disease, Percutaneous Coronary Intervention (PCI)
Cold-Region Exposure and Cardiac Remodeling After PCI
This multicenter prospective observational cohort study aims to investigate the association between cumulative cold-region exposure and adverse left ventricular remodeling and cardiovascular outcomes in patients with coronary…
- Conditions
- Coronary Artery Disease, Percutaneous Coronary Intervention (PCI), Left Ventricular Remodeling, Cold Exposure
- Trial name
- COLD-PCI (NCT07773870)
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Chinese PLA General Hospital
Cold Exposure
Omega-3 Fatty Acids as Regulators of Brown Adipose Tissue During Cold Exposure
This clinical trial will assess the whether fish oil supplementation can modulate brown fat activation, shivering, thermal comfort and skin blood flow during cold exposure.
- Trial name
- NCT05822141
- Testing
- Fish Oil
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana University
Sleep Deprivation, Cold Exposure
Modafinil to Optimize the Performance of Cold-Stressed Sleep-Deprived Personnel
Environmental and workplace stressors are common and often unavoidable in military operations. Two critical stressors are cold stress and sleep loss. They both can substantially degrade operational effectiveness.
- Trial name
- NCT07830056
- Testing
- Modafinil (M), 200 mg Microcrystalline Cellulose
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Brown Adipose Tissue, Cold Exposure
Intermittent Cold Exposure and Brown Adipose Tissue Hyperplasia
This clinical trial explores how repeated short-term cold exposure impacts the molecular and physiological function of brown adipose tissue (BAT), a thermogenic organ associated with improved cardiometabolic health.
- Conditions
- Brown Adipose Tissue, Cold Exposure, 18F-FDG PET/CT
- Trial name
- ICEBATH (NCT07048405)
- Testing
- Cooling, Biopsies, Injection of 18F-FDG
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Obesity (Disorder)
JOULE - Metabolic Adaptation to Weight Loss in Response to a Behavioural Lifestyle Program With or Without Semaglutide in Adolescents With Obesity
The Joule MARS study is a single center, randomized, open label clinical trial aiming to explore the metabolic adaptations that occur in response to weight management in adolescents with obesity.
- Trial name
- JOULE-MARS (NCT06852391)
- Testing
- Semaglutide Pen Injector, Behavioural Lifestyle Program (BLP)
- Where
- Canada
- Volunteers
- 74 people
- Sponsor
- McMaster University
Solid Tumors, Solid Malignancies
Controlled Cold Exposure Combined With PD-1/PD-L1 Immunotherapy in Solid Tumors (NIVALIS)
This is a single-center, prospective, single-arm, open-label phase I exploratory study that plans to enroll 24 participants with solid malignancies.
- Conditions
- Solid Tumors, Solid Malignancies, Cold Exposure, Immunotherapy
- Trial name
- NIVALIS (NCT07538479)
- Testing
- Controlled Cold Exposure, Investigator-Selected Standard PD-1/PD-L1 Inhibitor-Based Therapy
- Where
- China
- Volunteers
- 24 people
- Sponsor
- West China Hospital
Cold Exposure
Energy Dense Fueling for Cold-Weather Operations
High daily energy expenditures without compensatory increases in energy intakes results in severe energy deficits during cold-weather military operations.
- Trial name
- NCT07489690
- Testing
- High Fat, High Carbohydrate
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Healthy
The Effect of Exposure to Aversive Non-verbal Vocalizations on Pain Tolerance
Humans produce non-verbal vocalizations (shouting, growling, screaming), laughter, ...) in various contexts that are likely to perform biological functions. and important social issues.
- Trial name
- CRYPAIN (NCT04423874)
- Testing
- Cold pressor task (CPT), index NOL, Playback Experiments
- Where
- France
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Adipose Tissue, Brown, Brown Adipose Tissue
Winter-Swimming and Brown Adipose Tissue Activity in Middel-aged Obese Subjects (WinterBAT).
This study investigates repetitive cold-water exposure on brown fat activity assessed by PET/CT scanning. Furthermore we will assess glucose control upon winter-swimming.
- Conditions
- Adipose Tissue, Brown, Brown Adipose Tissue, Uncoupling Protein 1, Cold Exposure
- Trial name
- WinterBAT (NCT03541096)
- Testing
- Winter Swimming, Control group
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Kristian Karstoft
Cold-water Immersion, High Heat Sauna
Thermodynamic Exposure and Sleep in Military Cadets
This pilot study investigates the effects of cold-water immersion, traditional sauna use, and their combination on sleep architecture and psychological health in military cadets.
- Conditions
- Cold-water Immersion, High Heat Sauna, Combination of Cold-water Immersion and High Heat Sauna
- Trial name
- NCT07201935
- Testing
- Cold Water Immersion, High Heat Sauna
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Cardiovascular System
Acute Effects of Cold Exposure on Cardiovascular System
This is a randomized controlled human exposure crossover study. Investigators aim to assess the acute effects of low temperature exposure on cardiovascular system and the underlying mechanisms.
- Trial name
- NCT06652425
- Testing
- Low temperature (15°C) group, Moderate temperature (22°C) group
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fudan University
Brown Adipose Tissue, Human
A Multi-modal Cohort Study of Brown Adipose Tissue Based on Paired Comparisons at Room Temperature and After Cold Exposure
This study is a single-center, prospective clinical study that plans to prospectively recruit volunteers aged 18-40 years, including metabolically healthy individuals and those with diabetes mellitus and hyperlipidemia.
- Trial name
- BAT-PACT (NCT07908719)
- Testing
- cold exposure
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Jinling Hospital, China
Cognitive Function
Acute Effects of Cold Exposure on Cognitive Function
This is a randomized controlled human exposure crossover study. Investigators aims to assess the acute effects of low-temperature exposure on cognitive function and the underlying mechanisms.
- Trial name
- NCT06654167
- Testing
- Low temperature (15℃) group, Moderate temperature (22℃) group
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fudan University
Appetite
Assessment of the Effects of Acute Exposure to Cold and Heat on Appetite
Military personnel and athletes have a very high energy expenditure, which is increased during certain key periods (intense training, competition and missions).
- Trial name
- TEMPCA2 (NCT06809296)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Pancreas Disease
A COMBINATION OF RECTAL INDOMETHACIN AND COLD WATER EXPOSURE OF THE AMPULLA AFTER ERCP IS SUPERIOR TO RECTAL INDOMETHACIN ALONE IN REDUCING THE INCIDENCE OF POST-ERCP PANCREATITIS -RCT
Endoscopic retrograde cholangiopancreatography (ERCP) has emerged as the primary modality in the management of biliary and pancreatic disease. The complications occurring from ERCP can range from mild to fatal.
- Trial name
- ERCP (NCT07574970)
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Asian Institute of Gastroenterology, India
Behavior, Stress
Cold Water and Decision-Making
The behavioral within-subject cross-over design study "CoVa" aims to investigate the effect of a short-term full-body cold-water immersion vs.
- Conditions
- Behavior, Stress, Quality of Life, Psychological Wellbeing
- Trial name
- CoVa (NCT06908447)
- Testing
- Cold-water immersion, Warm-water immersion (Control)
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- German Institute of Human Nutrition
Obesity, Metabolic Disease
Thermogenic Silencer Regulatory Factors in Humans
A promising approach to correct the metabolic dysfunction associated with obesity is to activate brown fat non-shivering thermogenesis (NST).
- Conditions
- Obesity, Metabolic Disease, Cold Exposure
- Trial name
- NCT06424132
- Testing
- Cold Vest Exposure Period, Rewarming Exposure Period, Fasting
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Healthy Volunteers
Showers and Stress
The study investigates whether repeated exposure to cold showers can improve the ability to cope with and respond to stress. In particular, it examines both the psychophysiological effects of cold showers and the role of…
- Trial name
- S A S (NCT07611422)
- Testing
- Positive expectation about the effects of cold and warm showers, No expectation regarding the exposure to cold water and/or to warm showers
- Where
- Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Catholic University of the Sacred Heart