Clinical trials: Cold Symptom
Stress, Acute Stress
Neurophysiological and Autonomic Responses to Acute Physical and Emotional Stress: An EEG Study
This study aims to investigate neurophysiological, autonomic, and subjective responses to different acute physical and emotional stress-inducing conditions using a within-subject repeated-measures design.
- Trial name
- NCT07781670
- Testing
- Cold Pressor Test, Negative Autobiographical Memory Recall, Affective Picture-Viewing Task
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pavia
Pain
Pain Thresholds Under High-dose Topical Capsaicin
Aim of the study is to determine heat pain thresholds (HPT in °C) and cold pain thresholds (CPT in °C) during topical capsaicin 8% application, and mechanical pain thresholds (MPT in g) immediately after to find out the exact…
- Trial name
- NCT02570841
- Testing
- Topical High dose Capsaicin
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Coronary Artery Disease
Effect of Cold Application on Pain, Ecchymosis, and Comfort After Transradial Coronary Angiography
This randomized controlled experimental study aimed to examine the effect of cold application after transradial coronary angiography on pain, bruising (ecchymosis), and comfort levels in patients.
- Trial name
- NCT07797179
- Testing
- Standard Post-Procedural TR Band Care, Cold Application
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people
- Sponsor
- Bezmialem Vakif University
Non-allergic Rhinitis
The Prevalence of Local Immunoglobulin E (IgE) Elevation and Its Effect on Intranasal Capsaicin Therapy in the Non-allergic Rhinitis Population
The purpose of this study to determine the therapeutic response of non-allergic rhinitis patients that have been subtyped as non-allergic rhinitis with local IgE elevation or non-allergic rhinopathy to intranasal capsaicin based…
- Trial name
- NCT05093478
- Testing
- Intranasal capsaicin, topical lidocaine
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- The University of Texas Health Science Center, Houston
Hereditary Periodic Fever Syndromes, Cryopyrin-associated Periodic Syndromes (CAPS)
Ilaris NIS in Korea
This is a study to evaluate safety and effectiveness of Ilaris in adult and pediatric patients receiving the drug in a clinical setting for any of the following indications, Hereditary Periodic Fever Syndromes…
- Conditions
- Hereditary Periodic Fever Syndromes, Cryopyrin-associated Periodic Syndromes (CAPS), Colchicine Resistance Familial Mediterranean Fever (crFMF), TNF Receptor Associated Periodic Syndrome (TRAPS)
- Trial name
- REASSURE (NCT06838143)
- Testing
- Ilaris
- Where
- South Korea
- Volunteers
- 25 people
- Sponsor
- Novartis Pharmaceuticals
MS (Multiple Sclerosis), Erythema
A Pilot Study of Warm and Cold Compress to Reduce Injection Site Erythema Due to Peginterferon-beta-1a in MS
Peginterferon-beta-1a (PEG) is an approved treatment for relapsing forms of MS that may cause injection related erythema. This is a randomized controlled cross-over trial of superficial hot and cold modalities to reduce injection…
- Trial name
- PEG-Thermal (NCT02490943)
- Testing
- Warm Compress Before Injection, Cold Compress After Injection
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Brown, Theodore R., M.D., MPH
Nasal Congestion, Common Cold
Post-market Clinical Follow-up Study of an Isotonic Saline Solution for the Relief of Nasal Congestion in Infants and Toddlers
The goal of this observational post-market clinical follow-up study is to evaluate the safety and performance of the CE-marked nasal spray for the relief of nasal congestion in infants and toddlers aged 6 to 48 months at day 5…
- Conditions
- Nasal Congestion, Common Cold, Allergic Rhinitis, Rhinosinusitis
- Trial name
- NASBY (NCT07257224)
- Testing
- Quinton Medical Nasal Health Baby®
- Where
- 2 sites in Spain
- Volunteers
- 83 people
- Sponsor
- Laboratoires Quinton International S.L.
Pain Management, Emergency Unit
The Effectiveness of Local Dry Cold, Hot and Vibration Applications in Peripheral Intravenous Catheterization
Aim: The aim of the present study was to examine the effect on venous dilation, procedure duration and pain severity of local hot, cold and vibration applications performed on the intervention area before peripheral intravenous…
- Conditions
- Pain Management, Emergency Unit, Diarrhea, Nausea
- Trial name
- NCT06378424
- Testing
- Cold Application, Heat Application, Vibration Application
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Uludag University
Immune Response, Upper Respiratory Tract Infection
Walnut and Immunity Study
The main objective of the study is to determine if eating walnuts enhances immune function, in older free-living men and postmenopausal women with overweight.
- Trial name
- walnutimmune (NCT05915390)
- Testing
- walnuts, Habitual diet
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Acute Respiratory Tract Infection, Flu, Human
Effectiveness of a Nasal Spray on Viral Respiratory Infections
There is no cure for cold or flu, most people recover in about within two weeks. Paracetamol may be used to reduce aches or treat fever, headache, or body aches.
- Conditions
- Acute Respiratory Tract Infection, Flu, Human, COVID-19, Common Cold
- Trial name
- NCT06278324
- Testing
- Nasal Spray HSV Treatment
- Where
- France
- Volunteers
- 76 people
- Sponsor
- CEN Biotech
Sleep Disturbance
Sleep Disturbance in Chronic Rhinitis
The aim of this study is to evaluate the characteristic of sleep disturbance in allergic and non-allergic rhinitis in Dr. Cipto Mangunkusumo Hospital, Jakarta.
- Trial name
- NCT05312723
- Where
- Indonesia
- Volunteers
- 22 people
- Sponsor
- Universitas Indonesia
Obese Patients With Bariatric Surgery
The Effect of Cold Application on Nausea and Vomiting After Bariatric Surgery
Obesity is a chronic disease resulting from an excess of body fat mass relative to lean body mass, characterized by a deterioration in the individual's quality of life and health (Kayar and Utku, 2013; Usta and Çavdar, 2013; Tam…
- Trial name
- NCT07825779
- Testing
- ICE
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sakarya University
Obesity, Metabolic Syndrome
Brown Adipose Tissue as a Mechanistic Determinant of Semaglutide Treatment Response in Obesity (BAT-Sema Study)
This study investigates whether the activity of brown adipose tissue (BAT) - a special type of fat that burns energy as heat - can predict how well individuals with obesity respond to semaglutide (Wegovy), a once-weekly…
- Conditions
- Obesity, Metabolic Syndrome, Brown Adipose Tissue
- Trial name
- BAT-Sema (NCT07621640)
- Testing
- Semaglutide (Wegovy®), ¹⁸FDG-PET/CT with cold stimulation, Liver MRI (PDFF + MRE)
- Where
- 2 sites in South Korea
- Volunteers
- 80 people
- Sponsor
- Hallym University
Colorectal Adenoma, Colorectal Neoplasms
Adenoma Detection Rate in Colonoscopy Performed With EndoRings
The study is designed to examine whether colonoscopy using an EndoRings cap has a higher adenoma detection rate than conventional colonoscopy.
- Trial name
- NCT03219918
- Testing
- EndoRings II Distal Attachment
- Where
- Denmark
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Zealand University Hospital
Pain
Mechanism of Human Cold Pain Perception - Involvement of TRPA1, TRPM8, Nav1.7 and Nav1.8
Animal studies suggest that the transient receptor potential ion channels TRPM8 and TRPA1 are cold sensors and that sodium channels Nav1.8 and Nav1.7 are essential for detecting pain induced by cold temperatures.
- Trial name
- NCT05935280
- Testing
- Room temperature, Cold temperature, Lidocain
- Where
- Austria
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Hypothermia Due to Cold Environment
Clinical Evaluation of Effectiveness of the "Therm'Up" Heating Device
Here's a concise summary in English without the numbers: Hypothermia is defined as a core temperature below 35°C and occurs when the body loses more heat than it produces.
- Trial name
- NCT06788925
- Testing
- Patients support with survival coverage, Patients support with active thermic jacket
- Where
- France
- Volunteers
- 100 people
- Sponsor
- ThermoTrauma
Cold Water Immersion, Immune Function
Cold Water Exposure and Immune Function Study
The purpose of this clinical trial is to explore the effects of a 4 week cold-water immersion (CWI) intervention on measures of immune function, sleep quality, mental health and well-being, and muscular strength.
- Conditions
- Cold Water Immersion, Immune Function, Muscular Strength, Mental Health
- Trial name
- NCT06667479
- Testing
- Cold Water Immersion (CWI) - Cold Tub Immersion (CI), Cold Water Immersion (CWI) - Cold Shower (CS), Control Group (CO)
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Northern Colorado
Knee Osteoarthritis
Effect of Foot Massage on Pain and Analgesic Consumption in Total Knee Prosthesis
This randomized controlled trial aims to examine the effects of foot massage combined with cold application on postoperative pain, patient satisfaction, and analgesic consumption in individuals undergoing Total Knee Arthroplasty…
- Trial name
- NCT07126340
- Testing
- Foot Massage and Cold Application, Cold Application
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Alev Keskin
Pedunculated Colorectal Polyps, Haemorrhage
Cold Snare Polypectomy Versus Hot Snare Polypectomy for Resection of Small Pedunculated Polyps
Endoscopic resection of pedunculated polyps mainly focuses on how to prevent bleeding, and also needs to pay attention to the convenience of resection and the integrity of resection, which means that different endoscopic…
- Trial name
- NCT06097650
- Testing
- cold snare polypectomy, hot snare polypectomy
- Where
- China
- Volunteers
- 196 people
- Sponsor
- Ningbo No. 1 Hospital
Antioxidative Stress, Cold
Taxifolin/Ergothioneine and Immune Biomarkers in Healthy Volunteers (TaxEr)
The complexities of the immune system make measuring the impact of dietary interventions upon its function challenging. The immune system is highly responsive to environmental influences, including the diet.
- Conditions
- Antioxidative Stress, Cold, Influenza, Aging
- Trial name
- TaxEr (NCT05190432)
- Testing
- Taxifolin, Ergothioneine, Control
- Where
- United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Southampton