Clinical trials: Collagen Diseases
Cicatrix, Post-Surgical Complication
Class I Medical Device on Post-surgical Scars
To compare the effect of a class I pullulan based medical device containing Allium cepa \& HA versus a class I medical device silicone gel on new post-surgical wounds
- Conditions
- Cicatrix, Post-Surgical Complication, Scar Itching, Keloid
- Trial name
- NCT05412745
- Testing
- Kaloidon Plus, silicone gel
- Where
- 2 sites in Italy
- Volunteers
- 64 people
- Sponsor
- University of Rome Tor Vergata
Osteogenesis Imperfecta, Osteogenesis Imperfecta Type III
Mesenchymal Cell Therapy in Osteogenesis Imperfecta (OI)
This is a Phase 1/2 study to determine the safety and efficacy of allogeneic (third party), bone-marrow derived mesenchymal stromal cells (MSCs) for the treatment of Osteogenesis Imperfecta (OI) Type 3.
- Trial name
- NCT05559801
- Testing
- Bone marrow-derived mesenchymal stromal cells (MSCs)
- Volunteers
- 12 people
- Sponsor
- Emory University
Keloid Scar
Pilot Study to Evaluate Clinical Outcomes With the Use of Biovance Following Keloid Scar Revision Surgery
The main purpose of this study is to see if there is clinical benefit of using Biovance in reduction of the recurrence of keloids when used to revise them. It will also assess the postoperative complications.
- Trial name
- NCT02521402
- Testing
- Biovance
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Golla Center for Plastic Surgery
Epidermolysis Bullosa Dystrophica, Squamous Cell Carcinoma
Rigosertib for RDEB-SCC
Epidermolysis bullosa (EB) is a heritable skin disease characterized by marked fragility of epithelialized tissue with blistering in skin and mucous membranes following the slightest mechanical trauma.
- Trial name
- NCT03786237
- Testing
- Rigosertib Oral Capsules / Rigosertib Intravenous
- Where
- Austria
- Volunteers
- 2 people
- Sponsor
- Prof. Johann Bauer
Rare Diseases, Marfan Syndrome
Analysis of Muscular Properties in Patients With MFS and EDS
The goal of this observational study is to learn and assess muscle morphological and electromechanical properties in patients affected with Marfan syndrome (MFS) and Ehlers Danlos syndrome (EDS).
- Conditions
- Rare Diseases, Marfan Syndrome, Ehlers-Danlos Syndrome
- Trial name
- MUSCLE (NCT05720923)
- Testing
- Analysis with Ergometer
- Where
- Italy
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Keratoconus
Adapted Fluence Settings for Corneal Collagen Cross-linking in Mild to Moderate Progressive Keratoconus
the purpose of this study is to compare the efficacy and safety of a new method of corneal cross-linking that uses UV-A irradiation intensity of 9mW/cm2 for 7 minutes to well-known Accelerated corneal cross-linking (9 mW/cm2 UV-A…
- Trial name
- NCT02507362
- Testing
- adjusted corneal collagen cross-linking, accelerated corneal collagen cross-linking, riboflavin 0.1% combined with dextran 20 %
- Where
- Iran
- Volunteers
- 40 people
- Sponsor
- Tehran University of Medical Sciences
Osteogenesis Imperfecta, Osteoporosis
REMS25: Study on the Use of REMS Technology in Diseases Commonly Associated With Reduced Bone Mineral Density (BMD)
This study evaluates bone mineral density (BMD) in pediatric patients aged 5-18 years with conditions negatively affecting bone health, using REMS (Radiofrequency Echographic Multi Spectrometry), a non-invasive and radiation-free…
- Conditions
- Osteogenesis Imperfecta, Osteoporosis, Hypogonadisms, Neoplasia
- Trial name
- NCT07412782
- Testing
- REMS
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Meyer Children's Hospital IRCCS
Keratoconus
Treatment of Keratoconus Using Collagen Cross-Linking
The purpose of this study is to determine the effectiveness of collagen cross-linking in the cornea in halting the progression and possibly partially reversing the effects of keratoconus.
- Trial name
- NCT00841386
- Testing
- Riboflavin-5-phosphate
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University at Buffalo
Osteogenesis Imperfecta
An Efficacy and Safety Trial of Intravenous Zoledronic Acid in Infants Less Than One Year of Age, With Severe Osteogenesis Imperfecta
The investigators have currently finished conducting an international multi-center trial that compares the efficacy and safety of pamidronate and zoledronate in the treatment of moderate to severe forms of Osteogenesis Imperfecta…
- Trial name
- INFOI (NCT00982124)
- Testing
- Zoledronic Acid
- Where
- Canada
- Volunteers
- 14 people
- Sponsor
- Shriners Hospitals for Children
Systemic Lupus Erythematosus
Telehealth CBT for Adolescents and Young Adults With Childhood-onset Systemic Lupus Erythematosus
This study aims to investigate the feasibility and effectiveness of a remotely delivered psychological intervention for youth with cSLE.
- Trial name
- cSLE (NCT04335643)
- Testing
- TEACH
- Where
- 2 sites in United States, Canada
- Volunteers
- 65 people
- Sponsor
- Michigan State University
Degenerative Disc Disease
A Pivotal Study of rhBMP-2/ACS/LT-CAGE® Device for Anterior Lumbar Interbody Fusion in Patients With Degenerative Disc Disease
This study is designed to assess the safety and effectiveness of the rhBMP-2/ACS/LT-CAGE® Device using laparoscopic surgical technique as compared to an historical control group treated with Autogenous Bone/LT-CAGE® Device using…
- Trial name
- NCT01491425
- Testing
- rhBMP-2/ACS//LT-CAGE® Device, Autogenous Bone//LT-CAGE® Device
- Volunteers
- 134 people
- Sponsor
- Medtronic Spinal and Biologics
Anal Fistula
Long-term Follow-up of Anal Fistula Plug
Aim of the study is to evaluate long-term success rate of Biodesign® anal fistula plug for treatment of complex trans-sphincteric anal fistulas.
- Trial name
- NCT03961984
- Testing
- Biodesign® anal fistula plug
- Where
- Sweden
- Volunteers
- 95 people
- Sponsor
- Region Skane
Keloid Scar Following Surgery
Initial Assessment of a Topical Cadexomer Iodine Gel Efficacy on Keloid Scar Revision
This is a 6 month, single site, interventional, open label prospective clinical study to evaluate the effects of a cadexomer iodine gel on the prevention of recurrent keloid formation in patients undergoing keloid scar revision.
- Trial name
- NCT03876548
- Testing
- Cadexomer Iodine Gel
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Next Science TM
Colorectal Cancer
The CSTME Associates With the Prognosis of Stage II and III Colorectal Cancer
Colorectal cancer (CRC) is the second most commonly occurring cancer worldwide. Thirty-five percent of CRC patients are diagnosed at stage II/III, and their outcome differs even if they are in the same stage.
- Trial name
- CRC23_CSTME (NCT05420415)
- Testing
- CSTME
- Where
- China
- Volunteers
- 570 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Infertility, Intrauterine Adhesions
Treatment of Infertility by Collagen Scaffold Loaded With Umbilical Cord Derived Mesenchyma Stem Cells
Study of the treatment of infertility caused by recurrent intrauterine adhesions (IUA) by collagen scaffold loaded with umbilical cord derived mesenchymal stem cells (UC-MSCs) to provide clinical evidence of safety and…
- Trial name
- NCT02313415
- Testing
- UC-MSCs therapy
- Where
- China
- Volunteers
- 26 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Osteogenesis Imperfecta
BBD Longitudinal Study of Osteogenesis Imperfecta
Osteogenesis Imperfecta (OI) is a rare disorder of increased bone fragility characterized by fractures with minimal or absent trauma, dentinogenesis imperfecta (DI), and, in adult years, hearing loss.
- Trial name
- NCT02432625
- Where
- 12 sites in United States, Canada
- Volunteers
- 1,000 people
- Sponsor
- Baylor College of Medicine
Cicatrix, Hypertrophic, Keloid
Influence of a Silicone Gel (Dermatix®) on Thoracic Scar Formation After Harvesting of Autologous Rib Cartilage
So far the evaluation of scar treatment was based on subjective criteria. The patient groups were divided into treated versus non-treated. In this study we use patients undergoing ear reconstruction with autologous rib cartilage.
- Trial name
- NCT00565552
- Testing
- Silicone gel (Dermatix®)
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Schleswig-Holstein
Dermis Density, Wrinkles
The Effect of 16-week Dietary Intake of Food Supplements Containing Collagen and MSM on Skin
The aim of the study is to compare the effects of multiple-dose 16 weeks daily dietary supplementation with 5 g or 3 g of collagen in combination with 1 g or 1.5 g of MSM and 80 mg vitamin C (see 1.2.
- Conditions
- Dermis Density, Wrinkles, Dermis Thickness, Skin Texture
- Trial name
- TO-COSKIN3 (NCT06755892)
- Testing
- ColMSM-HL, ColMSM-LH, ColMSM-LL
- Where
- Slovenia
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- VIST - Faculty of Applied Sciences
Keloid
A Randomized Clinical Study Comparing Two Closure Techniques of Excised Keloids
This investigator initiated study, single-blinded, parallel, randomized study will be conducted in subjects with 2 or more keloids similar in size and duration on a similar area of the body.
- Trial name
- NCT00519493
- Testing
- Suture, Clozex
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Miami
Multiple Myeloma
Study of 4 Bone Turnover Markers in Patients With Multiple Myeloma Treated With Intravenous Bisphosphonate in Routine Care
The aim of this study is looking at the Kinetics of bone turnover markers (C-terminal telopeptides of type I collagene (CTX), amino-terminal telopeptide of type 1 collagen (NTX), Dickkopf-1 (DKK-1) and Sclerostin (SOST)) in serum…
- Trial name
- AMBROBiMM (NCT04111809)
- Testing
- Blood and urine collection
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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