Clinical trials: Collagen Diseases
Recessive Dystrophic Epidermolysis Bullosa
Mesenchymal Stromal Cells in Adults With Recessive Dystrophic Epidermolysis Bullosa
To assess whether intravenously administered third-party bone marrow-derived mesenchymal stromal cells (MSCs) are safe and have an impact on disease severity in RDEB
- Trial name
- ADSTEM (NCT02323789)
- Testing
- Mesenchymal stromal cells
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- King's College London
Coronary Artery Disease
Collagen-thrombin Matrix Efficacy During Cardiac Surgery: a Prospective Randomized Controlled Trial
In this prospective open-label randomized trial, 160 patients with elective off-pump coronary artery bypass (OPCAB) surgery were enrolled.
- Trial name
- NCT04310150
- Testing
- Collastat, Floseal
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Yonsei University
Epidermolysis Bullosa, Recessive Dystrophic Epidermolysis Bullosa
Phase 3, Open-label Clinical Trial of EB-101 for the Treatment of Recessive Dystrophic Epidermolysis Bullosa (RDEB)
The purpose of this trial is to evaluate safety and efficacy of surgical application of EB-101 (autologous, gene-corrected keratinocyte sheets) as a treatment of recessive dystrophic epidermolysis bullosa (RDEB).
- Trial name
- NCT04227106
- Testing
- EB-101
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- Abeona Therapeutics, Inc
Rheumatoid Arthritis, Ankylosing Spondylitis
Impact of Air Pollution on the Course of Inflammatory Rheumatism
The objective of this study is to see if there is a link between air pollution and inflammatory rheumatism (rheumatoid arthritis and ankylosing spondylitis) To do this, the investigators are going to follow a cohort of about…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Psoriatic Arthritis
- Trial name
- NCT05862584
- Testing
- Questionnaires
- Where
- France
- Volunteers
- 86 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Necrobiosis Lipoidica
Ruxolitinib Cream in the Treatment of Cutaneous Necrobiosis Lipoidica
This research study is evaluating the safety and efficacy of a topical drug treatment "Ruxolitinib" in treating Necrobiosis Lipoidica (NL).
- Trial name
- NCT04492618
- Testing
- Ruxolitinib
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Aaron R. Mangold
Epidermolysis Bullosa Dystrophica, Recessive
Ex Vivo Gene Therapy Clinical Trial for RDEB Using Genetically Corrected Autologous Skin Equivalent Grafts
This phase I/II clinical trial aims to treat 3 adult subjects with Recessive Dystrophic Epidermolysis Bullosa, expressing residual C7 levels, by genetically corrected autologous skin equivalent grafts on selected areas (up to 300…
- Trial name
- EBGraft (NCT04186650)
- Testing
- COL7A1-SIN retroviral vector engineered autologous tissue-engineered skin
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Autoimmune Rheumatologic Disease
Safety and Immunogenicity of PCV20 in Pediatric Patients With Autoimmune Rheumatic Diseases
This clinical trial evaluates the immunogenicity (humoral and cellular) and safety of the 20-valent pneumococcal conjugate vaccine (PCV20) in children, adolescents, and young adults aged 2-25 years with autoimmune rheumatic…
- Trial name
- PCV20-PARD (NCT07252791)
- Testing
- Pneumococcal Vaccine
- Where
- Brazil
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Rheumatoid Arthritis - Rheumatism
Application of Warm Water and Warm Salt Water to Patients With Rheumatoid Arthritis
This pretest-posttest randomized controlled study aimed to determine the effect of warm salt water and warm water bath applied to the hands and feet on pain, fatigue, sleep quality, and functional capacity in patients with…
- Trial name
- NCT05888220
- Testing
- warm salt water bath
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Keloid, Surgical Scar
Safety and Efficacy of Infrared Diode Laser on Improvement of Scar and Prevention of Recurrence of Excised Keloid
A pilot study will be conducted on 2 type of subjects, one with plastic surgery scar with a randomization of laser treated portions, and other with keloid excision scar with a complete laser treatment.
- Trial name
- NCT01158196
- Testing
- infra-red diode laser
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Ekkyo
Rare Diseases, Marfan Syndrome
Analysis of Muscular Properties in Patients With MFS and EDS
The goal of this observational study is to learn and assess muscle morphological and electromechanical properties in patients affected with Marfan syndrome (MFS) and Ehlers Danlos syndrome (EDS).
- Conditions
- Rare Diseases, Marfan Syndrome, Ehlers-Danlos Syndrome
- Trial name
- MUSCLE (NCT05720923)
- Testing
- Analysis with Ergometer
- Where
- Italy
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Rheumatoid Arthritis
Phase 1 Trial of Type II Collagen (CII) APL A12 in Rheumatoid Arthritis Patients
This is a Phase I clinical trial to determine whether orally administered APL A12 at one or more doses is superior to placebo in effecting a 25% reduction in interferon (IFN) stimulation index in 1(II)-stimulated culture of…
- Trial name
- NCT01123655
- Testing
- APLA12
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- VA Office of Research and Development
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Scleroderma, Scleroderma, Systemic
Telerehabilitation on Hand-Affected Scleroderma
Telerehabilitation Approach on Individuals with Hand-Affected Scleroderma
- Conditions
- Scleroderma, Scleroderma, Systemic, Scleroderma Associated Digital Ulcer, Hand Rheumatism
- Trial name
- NCT04684225
- Testing
- Hand Therapy via Telerehabilitation, Hand Therapy via home-exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Istanbul University
Keloids, Keloids Scars
A Prospective Observational Clinical Study on Exploring the Value of Surgical Excision Combined With 32P Application in the Treatment of Keloids and the Factors Affecting the Prognosis of Combined Therapy
Keloids are non-cancerous (benign) growths on the skin. They form after an injury, when the skin makes too much connective tissue that thickens and hardens. These keloids cause big problems for people.
- Trial name
- NCT07413497
- Volunteers
- 401 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
DMARD Resistant Rheumatoid Arthritis
Low Dose Rituximab as a First Line Biologic Therapy for the Treatment of DMARD Resistant Patients With Rheumatoid Arthritis
In this project the investigators decide to evaluate the efficacy and safety of half dose mabthera (it means 500 mg infusion two weeks apart) in conventional drug resistant cases of rheumatoid arthritis.
- Trial name
- NCT01593332
- Testing
- Rituximab
- Where
- Iran
- Volunteers
- 44 people
- Sponsor
- Mashhad University of Medical Sciences
Systemic Rheumatic Diseases, Intensive Care Unit
Prognosis of SRD Patients in the ICU
Critically ill systemic rheumatic disease (SRD) patients have benefited from better provision of rheumatic and critical care in recent years.
- Conditions
- Systemic Rheumatic Diseases, Intensive Care Unit, Corticosteroids
- Trial name
- ProSyDICU (NCT04398381)
- Where
- France
- Volunteers
- 525 people
- Sponsor
- University Hospital, Montpellier
Rheumatic Diseases, Rheumatic Disorder
Effects of Aerobic Exercise in Rheumatoid Arthritis
This study aims to evaluate the effects of aerobic exercise therapy on quality of life, functional capacity, mood, and fatigue in patients with rheumatoid arthritis.
- Trial name
- NCT07504887
- Testing
- Standard Medical Care (SMC), Patient Education, Aerobic Exercise Group
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Kutahya Health Sciences University
Gingival Diseases
Connective Tissue Graft Versus Collagen Matrix.
Despite the potential role of soft tissue thickness in maintaining gingival margin stability, the existing literature has mainly focused on investigating the effect of different surgical techniques on recession coverage…
- Trial name
- NCT04678804
- Testing
- Mucogingival surgery for single recession coverage
- Where
- Italy
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Parma
Vascular Ehlers-Danlos Syndrome
Clinical Trial to Compare the Efficacy of Celiprolol to Placebo in Patients With Vascular Ehlers-Danlos Syndrome
This is a prospective, Phase 3, randomized, double-blind, placebo-controlled efficacy study to evaluate celiprolol in patients genetically confirmed as COL3A1-positive vEDS using a decentralized clinical trial design.
- Trial name
- DiSCOVER (NCT05432466)
- Testing
- ACER-002 (celiprolol) 200 mg BID
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Acer Therapeutics Inc.
Breast Cancer
SurgiMend in Two-stage Implant-based Breast Reconstruction in Patients With Pre-Mastectomy Radiotherapy
This is a prospective clinical study comparing two-stage breast reconstruction following mastectomy with and without the use of SurgiMend® PRS fetal bovine collagen matrix in patients with pre-mastectomy radiation therapy.
- Trial name
- NCT01959867
- Testing
- SurgiMend® PRS, No Intervention
- Sponsor
- Integra LifeSciences Corporation
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.