Clinical trials: Collagen Diseases
Progressive Keratoconus
Safety and Efficacy of Corneal Cross-linking in Subjects With Keratoconus
Clinical Trial to Evaluate the Safety and Efficacy of Corneal Cross-linking in Subjects with Keratoconus.
- Trial name
- NCT05314738
- Testing
- NXL Energy 1, NXL Energy 2, NXL Energy 3
- Where
- 3 sites in United States
- Volunteers
- 150 people
- Sponsor
- Glaukos Corporation
Keratoconus
Cyanocobalamin as Photosensitizing Agent
is cyanocobalamin active as Photosensitizing Agent instead of riboflavin ? using cyanocobalamin with mix of external collagen to make crosslinking with cornea collagen to make rigid of cornea
- Trial name
- NCT05395650
- Volunteers
- 1 people
- Sponsor
- EL Romany Ophthalmics Factory
Scar, Keloid
"A Clinical Study Investigating the Effectiveness of OTC Scar-management Modalities"
A Phase II prospective, randomized, double-blind, placebo controlled and comparative clinical study evaluating hydrogel scar-management modalities for effective management of hyperproliferative scars and keloids.
- Conditions
- Scar, Keloid, Hypertrophic Scar, Cicatrix
- Trial name
- NCT04169490
- Testing
- FS2 Emulsion Moisturizer, Active Comparator Onion Skin Extract Gel (Mederma), Active Comparator Silicone Gel (Kelo-Cote)
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- The Center for Clinical and Cosmetic Research
Diffuse Cutaneous Systemic Sclerosis, Rheumatoid Arthritis (RA)
Controlling Hyperactive Immunity With Long-lived Lymphocytes
This study is a Phase 1/2, open-label clinical trial to test an experimental treatment called QEL-005 in adults with two autoimmune conditions: diffuse cutaneous systemic sclerosis (dcSSc) and difficult-to-treat rheumatoid…
- Conditions
- Diffuse Cutaneous Systemic Sclerosis, Rheumatoid Arthritis (RA), Systemic Sclerosis (SSc), Autoimmune Rheumatologic Disease
- Trial name
- CHILL (NCT07473154)
- Testing
- QEL-005
- Where
- 10 sites in Germany, Spain and 1 more
- Volunteers
- 16 people
- Sponsor
- Quell Therapeutics Limited
Keratoconus, Collagen
Effect of Epi-Off Technique Corneal CXL On Endothelial Count by Specular Microscopy in Keratoconus Patients
Determine safety of EPi-off CXL on corneal endothelium by using specular specular microscopy to assess endothelial count.
- Trial name
- NCT05717673
- Testing
- Specular microscopy
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Heba Allah Nashaat Mohamed
Rheumatic Diseases, Gout
Medication Adherence Patterns in Rheumatic Diseases: A Behavioral Trial
Non-adherence to evidence-based prescription medications results in preventable morbidity and mortality for middle-aged and older adults.
- Conditions
- Rheumatic Diseases, Gout, Adherence, Medication, Lupus Erythematosus, Systemic
- Trial name
- NCT04776161
- Testing
- Cue-Reward Intervention, Cue-Reward Intervention with possible intensification
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Brigham and Women's Hospital
Ehlers-Danlos Syndrome, Classic
IGF-I Stimulation of Collagen Synthesis in Ehlers-Danlos Patients
The investigators want to inject insulin-like growth factor-I (IGF-I) into the patella tendon of Ehlers-Danlos patients and healthy controls to evaluate the response in collagen synthesis.
- Trial name
- NCT01446783
- Testing
- mecasermin, Saline
- Where
- Denmark
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Keratoconus
Treatment of Keratoconus Using Collagen Cross-Linking
The purpose of this study is to determine the effectiveness of collagen cross-linking in the cornea in halting the progression and possibly partially reversing the effects of keratoconus.
- Trial name
- NCT00841386
- Testing
- Riboflavin-5-phosphate
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University at Buffalo
Inflammatory Rheumatism
HIIT for Inflammatory Rheumatic Disease: Man vs Machine
The purpose of this study is to compare two modes of delivering high-intensity interval training (HIIT) in a population with inflammatory rheumatic disease over 10 weeks.
- Trial name
- NCT04649528
- Testing
- Effective endurance 4x4 training - Supervised, Effective endurance 4x4 training - APP
- Where
- Norway
- Volunteers
- 49 people
- Sponsor
- Molde University College
Osteogenesis Imperfecta
BBD Longitudinal Study of Osteogenesis Imperfecta
Osteogenesis Imperfecta (OI) is a rare disorder of increased bone fragility characterized by fractures with minimal or absent trauma, dentinogenesis imperfecta (DI), and, in adult years, hearing loss.
- Trial name
- NCT02432625
- Where
- 12 sites in United States, Canada
- Volunteers
- 1,000 people
- Sponsor
- Baylor College of Medicine
Recessive Dystrophic Epidermolysis Bullosa
Gentamicin Therapy for Recessive Dystrophic Epidermolysis Bullosa (RDEB) Nonsense Mutation Patients
Recessive dystrophic epidermolysis bullosa (RDEB) is an incurable, devastating, inherited skin disease for which there is only supportive care.
- Trial name
- NCT02698735
- Testing
- Gentamicin
- Volunteers
- 5 people
- Sponsor
- University of Southern California
Dental Crowding, Gingival Recession
Evaluating the Clinical Efficacy of Collagen Scaffold (Ossix VOLUMAX) With Piezo-Surgical Decortication in Enhancing Orthodontic Treatment Outcomes: A Randomized Controlled Trial
Recent advances in orthodontic treatment have explored various materials to enhance treatment efficacy, particularly focusing on collagen scaffolds.
- Conditions
- Dental Crowding, Gingival Recession, Thin Phenotype
- Trial name
- NCT07097714
- Testing
- Piezocision with ribose cross-linked collagen matrix (Ossix® Volumax), control
- Where
- Russia
- Volunteers
- 70 people
- Sponsor
- NMSI DENTMASTER
Rheumatoid Arthritis, Psoriatic Arthritis
A Study of SPY072 in Rheumatic Disease
This is a multi-center, double-blind, placebo-controlled, Phase 2, proof-of-concept basket study with the goal of assessing the efficacy and safety of SPY072 compared to placebo in adults (aged ≥18 years) with rheumatic disease…
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Axial Spondyloarthritis, Rheumatic Diseases
- Trial name
- SKYWAY-RD (NCT07148414)
- Testing
- SPY002-072
- Where
- 64 sites in United States, Bulgaria and 6 more
- Volunteers
- 285 people
- Sponsor
- Spyre Therapeutics, Inc.
Keloid
Examining the Therapeutic Potential of Botulinum Toxin Type A in the Treatment of Keloids
Keloids are a common form of hypertrophic scars that by definition last beyond 6 months and grow beyond the site of initial injury.
- Trial name
- NCT05330078
- Testing
- Botulinum toxin type A, Vehicle
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Cutaneous Sarcoidosis, Granuloma Annulare
Open-label Trial of Tofacitinib in Cutaneous Sarcoidosis and Granuloma Annulare
To investigate the ability of tofacitinib, a Janus kinase (JAK) inhibitor, to treat patients with cutaneous sarcoidosis and granuloma annulare during 6 months of therapy.
- Trial name
- NCT03910543
- Testing
- Tofacitinib 5 mg twice daily
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Yale University
Periodontal Bone Loss, Periodontal Diseases
Treatment of Intrabony Defects With L-PRF Membrane With or Without Collagen Membranes
For patients having periodontal intrabony lesions, three treatment modalities were executed to evaluate the effect of protecting Leukocyte rich -Platelet Rich Fibrin harvests (applied in the bony defects) with resorbable collagen…
- Trial name
- NCT05496608
- Testing
- L-PRF, OFD, CM
- Where
- Egypt
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Keratoconus
Collagen Crosslinking for Keratoconus - a Randomized Controlled Clinical Trial
The purpose of this study is to determine whether corneal collagen crosslinking is effective in the treatment of progressive keratoconus.
- Trial name
- CXL-RCT (NCT01604135)
- Testing
- Corneal Collagen Crosslinking
- Where
- Sweden
- Volunteers
- 36 people
- Sponsor
- Sahlgrenska University Hospital
Gingival Recession
Comparison of Root Coverage of Gingival Recessions
The purpose of this study is to analyze the percentage of root coverage in Miller class I and II gingival recessions using connective tissue graft and collagen matrix with a two years follow-up.
- Trial name
- NCT02980055
- Testing
- collagen matrix, connective tissue graft
- Volunteers
- 46 people
- Sponsor
- Universidade Federal do Rio Grande do Norte
Spina Bifida, Urothelial Neoplasm
Urothelium Tissue Engineering Using Biopsies From Transurethral Resection of Prostate
Different clinical conditions can require urinary bladder augmentation or replacement. Tissue engineered bladder has been clinically evaluated but is not recommended due to diverse side effects.
- Conditions
- Spina Bifida, Urothelial Neoplasm, Bladder, Neurogenic, Bladder Exstrophy
- Trial name
- IMOPU (NCT03698721)
- Testing
- Transurethral Resection of Prostate
- Volunteers
- 365 people
- Sponsor
- Central Hospital, Nancy, France
Sarcoidosis, Granuloma Annulare
Tyrosine Kinase 2 (TYK2) for GA and CS
To investigate the role of an oral TYK2 inhibitor for the treatment of patients with moderate to severe sarcoidosis with cutaneous involvement (CSAMI score of 10 or greater) and GA (defined as a BSA involvement of at least 5%)…
- Trial name
- NCT06725264
- Testing
- Deucravacitinib
- Where
- United States
- Sponsor
- Yale University
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