Clinical trials: Colo-rectal Cancer
Colorectal Neoplasms, Aberrant DNA Methylation
Diagnostic Potential of Hypermethylated DNA in Colorectal Cancer
Colorectal cancer (CRC) is one of the most common forms of cancer and the second leading cause of cancer-related deaths in the western world.
- Trial name
- NCT02928120
- Where
- Denmark
- Volunteers
- 658 people, healthy volunteers welcome
- Sponsor
- Ole Thorlacius-Ussing, MD, DMSc, Professor of Surgery
Colorectal Cancer, Adenomatous Colorectal Polyps
Selenium for Prevention of Adenomatous Colorectal Polyps
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. Selenium may be effective in preventing the recurrence of adenomatous colorectal polyps.
- Conditions
- Colorectal Cancer, Adenomatous Colorectal Polyps, Precancerous Condition
- Trial name
- NCT00078897
- Testing
- Selenium
- Where
- 7 sites in United States
- Volunteers
- 1,621 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Colorectal Cancer
Efficacy of Vitamin D in Colorectal Cancer Chemoprevention
Vitamin D's ability to prevent colorectal cancer (CRC) has been suspected for nearly 30 years, but has never been directly studied in humans.
- Trial name
- NCT01574027
- Testing
- Vitamin D3 (cholecalciferol)
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Colorectal Cancer
Computerized and Mailed Reminders in Increasing the Rate of Colorectal Cancer Screening in Adults With an Average Risk for Colorectal Cancer
RATIONALE: Screening may help doctors find colorectal cancer sooner, when it may be easier to treat. Computerized and mailed reminders may help increase the rate of colorectal cancer screening in adults with an average risk for…
- Trial name
- NCT00355004
- Testing
- counseling intervention, fecal occult blood test, screening colonoscopy
- Where
- 3 sites in United States
- Volunteers
- 21,860 people, healthy volunteers welcome
- Sponsor
- Harvard Medical School (HMS and HSDM)
Colorectal Carcinoma
Improving Colonoscopy Surveillance for Patients With High Risk Colon Polyps
This clinical trial tests a multilevel intervention at the clinic, provider and patient levels, to improve colonoscopy surveillance in patients with high risk colon polyps.
- Trial name
- NCT06376565
- Testing
- Best Practice, Communication Intervention, Interview
- Where
- United States
- Volunteers
- 1,680 people, healthy volunteers welcome
- Sponsor
- Jonsson Comprehensive Cancer Center
Colorectal Cancer, Colorectal Adenoma
Adenoma Detection Rate in Artificial Intelligence-assisted Colonoscopy
The goal of this quasi randomized multicenter controlled clinical trial (RCT) is to investigate whether a combined real time computer-aided polyp detection (CADe) and computer-aided polyp characterization (CADx) system (GI…
- Conditions
- Colorectal Cancer, Colorectal Adenoma, Colorectal Neoplasms
- Trial name
- NCT05740137
- Testing
- AI-assisted colonoscopy
- Where
- 4 sites in Denmark
- Volunteers
- 795 people, healthy volunteers welcome
- Sponsor
- Ismail Gögenur
Colorectal Cancer
A Prospective Cohort Study on Colorectal Cancer Screening in Community Population
This study will validate the real world results of polygene methylation detection in colorectal cancer in a large prospective community cohort.
- Trial name
- NCT05485077
- Where
- China
- Volunteers
- 18,000 people, healthy volunteers welcome
- Sponsor
- Singlera Genomics Inc.
Colorectal Cancer, Precancerous Condition
S0000D: Effect of Vitamin E and/or Selenium on Colorectal Polyps in Men Enrolled on SELECT Trial SWOG-S0000
RATIONALE: Studying tissue samples in the laboratory from participants receiving treatment on the Selenium and Vitamin E Cancer Prevention Trial (SELECT) SWOG-S0000 may help doctors predict a participant's response to treatment…
- Trial name
- ACP (NCT00706121)
- Testing
- Vitamin E, Selenium
- Where
- United States
- Volunteers
- 8,094 people, healthy volunteers welcome
- Sponsor
- SWOG Cancer Research Network
Cardiovascular Diseases, Cardiotoxicity
Cancer Treatment Related Cardiovascular Toxicity: Comprehensive Myocardial and Vascular Phenotyping
Observational prospective cohort study designed to assess the mechanisms of fluoropyrimidine induced cardiovascular toxicity.
- Conditions
- Cardiovascular Diseases, Cardiotoxicity, Fluorouracil Adverse Reaction, Malignancy
- Trial name
- PC-TOX (NCT06048458)
- Testing
- Cardiovascular magnetic resonance with stress perfusion, CT coronary angiography, Retinal OCT angiography
- Where
- United Kingdom
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University College, London
Colorectal Neoplasms
A Multicenter, Clinical Study of FOLFOXIRI With Bevacizumab As First-line Therapy in Patients With mCRC
The purpose of this study to assess efficacy and tolerability of combination therapy FOLFOXIRI with Bevacizumab (BV) as a first-line therapy in patients with metastatic colorectal cancer.
- Trial name
- QUATTRO (NCT02246049)
- Testing
- Bevacizumab, 5-fluorouracil, Irinotecan hydrochloride
- Where
- Japan
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- EPS Corporation
Colorectal Cancer
Clinical Trial of Quantitative Detection Kit for Hsp90α in Colorectal Cancer
Detect plasma Hsp90α concentration of colorectal cancer patients, healthy volunteers, benign colorectal diseases patients.
- Trial name
- NCT02324114
- Testing
- Hsp90
- Where
- China
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Beijing Protgen Biotechnology Development Co., Ltd.
Colorectal Cancer, Advanced Adenoma
Diagnosis of Colorectal Cancer and Advanced Adenoma Using Cancer-specific Methylation Signatures
Colorectal cancer is a common malignant tumor of the digestive tract. It is still a challenging task to detect colorectal cancer at an early stage.
- Trial name
- NCT03828396
- Where
- China
- Volunteers
- 1,300 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
Colorectal Cancer
Precision-Based Magnesium Trial
Colorectal cancer is the fourth most common incident cancer and the second most common cause of cancer death in the United States, with approximately 150,000 new cases and 57,000 deaths per year.
- Trial name
- NCT01105169
- Testing
- Magnesium glycinate
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Colorectal Cancer, Diet Habit
Walnuts and Colon Health (The WellNut Trial)
The purpose of this research study is to examine whether adding walnuts to your diet can have a beneficial effect on the gut bacteria population, inflammatory markers in the blood, and the tissue that lines the inside of the…
- Trial name
- NCT05195970
- Testing
- Walnuts
- Where
- 2 sites in United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- UConn Health
Healthy Subject
Fiber and Fish Oil Supplements for the Prevention of Colorectal Cancer
This trial studies how fiber and fish oil supplements affect the metabolism and activities of colon cells in healthy individuals.
- Trial name
- NCT04211766
- Testing
- Dietary Fiber, Fish Oil, Comparator
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Colorectal Cancer (Diagnosis), Non-cancer Controls
Epigenetic Signature for CRC Early Detection
The epiCED is a noninvasive blood-based assay designed for early detection of colorectal cancer (CRC) using circulating cell-free DNA (cfDNA) 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) epigenetic markers.
- Conditions
- Colorectal Cancer (Diagnosis), Non-cancer Controls, DNA Methylation, Cell Free DNA
- Trial name
- epiCED (NCT07224854)
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Colorectal Polyp, Colorectal Cancer
Assessment of the Blink (First) Impression Regarding the Presence of Cancer Within Colorectal Polyps
Colorectal cancer (CRC) is a leading cause of death in the Western world. It can be effectively prevented by removal of pre-malignant polyps during colonoscopy.
- Conditions
- Colorectal Polyp, Colorectal Cancer, Colono
- Trial name
- NCT05699954
- Testing
- Presence of Blink impression features for cancer in colorectal polyps
- Where
- Belgium
- Volunteers
- 191 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Colorectal Cancer, Adenoma
A Multi-center Trial to Establish a Model for the Early Diagnosis of Colorectal Cancer by the Detection of 5-hydroxymethylcytosine (5-hmC) in Plasma Cell-free DNA
In this study, the investigators establish a model for the early diagnosis of colorectal cancer based on the detection of 5-hydroxymethylcytosine (5-hmC) in training group and validate the effectiveness of the model using a…
- Trial name
- NCT03676075
- Where
- China
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Fudan University
Colorectal Cancer
Cohort Study to Evaluate the Relapse Risk Test in Colorectal Cancer
A Retrospective Cohort Study to Evaluate a Multigene assay to assess the recurrence risk of colorectal cancer.
- Trial name
- NCT05115786
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- HBI Solutions Inc.
Colonic Neoplasms, Colorectal Neoplasms
Evaluating Strategies to Present Colon Cancer Screening Information
This is a study examining the effects of different educational-motivational materials about colorectal cancer screening on perceptions and intentions to get screened.
- Conditions
- Colonic Neoplasms, Colorectal Neoplasms, Colonic Diseases, Gastrointestinal Neoplasms
- Trial name
- NCT02485561
- Testing
- Health communication intervention, Education information
- Where
- United States
- Volunteers
- 486 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine