Clinical trials: ColoRectal Cancer and Inflammatory Bowel Disease
Pancreatitis, Acute, Crohn Disease
Cost Effectiveness of an Intervention in Hospitalized Patients With Disease-related Malnutrition
Objectives: To evaluate the effectiveness, and cost-effectiveness, of three hospitalized patient care strategies in relation to disease-related malnutrition (DRM) hospital admissions based on results such as length of stay of the…
- Conditions
- Pancreatitis, Acute, Crohn Disease, Ulcerative Colitis, Inflammatory Bowel Diseases
- Trial name
- NCT04188990
- Testing
- Nutritional dietary intervention, By demand, Usual current care
- Where
- 2 sites in Spain
- Volunteers
- 1,051 people
- Sponsor
- Hospital Galdakao-Usansolo
Colorectal Cancer, Inflammatory Bowel Diseases
Sublingual Microcirculation and Postoperative Ileus
The aim of this pilot study is to establish if a correlation between sub-lingual microcirculation measured by Orthogonal polarization spectral (OPS) imaging and symptoms of postoperative ileus exist in patients undergoing…
- Conditions
- Colorectal Cancer, Inflammatory Bowel Diseases, Gastrointestinal Dysfunction
- Trial name
- NCT01828047
- Testing
- orthogonal polarization spectral (OPS) imaging
- Where
- Canada
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Gabriele Baldini, MD, MSc, Assistant Professor
Renal Cell Carcinoma, Non Small Cell Lung Cancer
Patient Preference for Subcutaneous vs. Intravenous Immune Therapy
The study will evaluate patient and Health Care Professional- reported preference for Subcutaneous (SC) compared with IV nivolumab administration or similarly for SC compared with IV pembrolizumab.
- Conditions
- Renal Cell Carcinoma, Non Small Cell Lung Cancer, Melanoma, Colo-rectal Cancer (dMMR/MSI-H CRC)
- Trial name
- PSI-Immune (NCT07223424)
- Testing
- nivolumab, pembrolizumab
- Where
- United States
- Volunteers
- 880 people
- Sponsor
- Diwakar Davar
Ulcerative Colitis
Effects of Eicosapentaenoic Acid on Subjects at High Risk for Colorectal Cancer
The aim of this study is to test Eicosapentaenoic acid's effects on markers relevant to colorectal carcinogenesis, RNA and DNA profiles, and the possibility that Eicosapentaenoic Acid treatment might be associated with changes of…
- Trial name
- EPAUC (NCT02069561)
- Testing
- Eicosapentaenoic Acid
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Lower Urinary Tract Symptoms, Colorectal Disorders
Lower Urinary Tract and Sexual Function in Women Following Surgery for Colorectal Disorders
This is a prevalence study evaluating lower urinary tract, prolapse, bowel, and sexual symptoms in women with a colorectal disorder who are planning to undergo surgery.
- Trial name
- NCT00667550
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of California, Irvine
Colorectal Disorders, Regional Anesthesia Morbidity
Transversus Abdominis Plane Blocks With and Without Dexamethasone
Dexamethasone will be used as an adjunct to local anesthetics (bupivacaine) to prolong the duration of laparoscopically-placed transversus-abdominis plane blocks in elective colorectal resection.
- Conditions
- Colorectal Disorders, Regional Anesthesia Morbidity, Analgesia, Local Anesthetic Complication
- Trial name
- TAP-DEX (NCT05432934)
- Testing
- Dexamethasone
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Colorectal Cancer
An Evaluation of Probiotic in the Clinical Course of Patients With Colorectal Cancer
Colorectal cancer (CRC) is the most common cancer for men and the second most common for women. Several studies have shown that gut microbiome may play a role in triggering intestinal inflammation that leads to the development of…
- Trial name
- NCT03782428
- Testing
- Probiotic
- Volunteers
- 52 people
- Sponsor
- Dr. Liyana Zaharuddin
Colon Cancer, Breast Cancer
SurgicAl Metabolic Phenotyping Longitudinal Evaluation Study
This work will use a new approach to measure how surgery effects human biochemistry and metabolism. It will create a metabolic signature or 'phenotype' for surgical injury that will help clinicians choose the right surgical…
- Conditions
- Colon Cancer, Breast Cancer, Trauma, Inflammatory Bowel Disease
- Trial name
- SaMPLE (NCT01378013)
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Colon Cancer, Inflammatory Bowel Diseases
Functional Restoration After Abdominal and Pelvic Laparoscopic Surgery: Effect of Perioperative Intravenous Lidocaine
This is a blinded randomized controlled trial in patients undergoing laparoscopic colon surgery. The aim of this study is to assess whether perioperative intravenous lidocaine has an impact on the early post operative physical…
- Conditions
- Colon Cancer, Inflammatory Bowel Diseases, Diverticulitis
- Trial name
- NCT00982618
- Testing
- Lidocaine, Epidural Block, PCA Morphine
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Ulcerative Colitis, Rectal Cancer
Surgical and Oncological Outcomes in Patients With Ulcerative Colitis-associated Rectal Cancer
This is a retrospective observational study to investigate the short-term surgical outcomes, and long-term oncological outcomes of patients diagnosed with Ulcerative colitis and rectal cancer.
- Trial name
- UC-RectalK (NCT04659148)
- Testing
- Total proctocolectomy
- Where
- 2 sites in Italy, United Kingdom
- Volunteers
- 40 people
- Sponsor
- Istituto Clinico Humanitas
Pain, Postoperative, Crohn Disease
Intraoperative TAP Block With Bupivacaine/Dexamethasone Against Liposomal Bupivacaine (Exparel®)
Traditionally, opioids are heavily utilized in treating postoperative pain but they are associated with numerous side effects. The use of the transversus abdominis plane (TAP) blocks have become standard practice to extend the…
- Conditions
- Pain, Postoperative, Crohn Disease, Inflammatory Bowel Diseases, Colorectal Cancer
- Trial name
- TINGLE (NCT03723447)
- Testing
- Liposomal bupivacaine, Bupivacaine/epinephrine/dexamethasone
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Cedars-Sinai Medical Center
Colorectal Cancer, Inflammatory Bowel Diseases
Microbiota-anastomotic Leak Among Colorectal Surgery Patients : Pilot Study
The study is based on the hypothesis that patients with postoperative anastomotic leakage have a different bacterial profile contributing to poor tissue healing, and that patients operated for colon cancer presumably have a…
- Conditions
- Colorectal Cancer, Inflammatory Bowel Diseases, Microbiota, Anastomotic Leak
- Trial name
- NCT03496441
- Testing
- Fecal sample collection for analysis
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Colon Neoplasms, Rectal Neoplasms
The Role of Indocyanine Green (ICG) Fluorescence Imaging on Anastomotic Leak in Robotic Colorectal Surgery
In colorectal surgery, anastomotic leak and its septic consequences still remain as the most concerning complications resulting in substantial morbidity and mortality.
- Conditions
- Colon Neoplasms, Rectal Neoplasms, Inflammatory Bowel Disease, Diverticular Disease
- Trial name
- NCT02598414
- Testing
- Near-infrared ICG fluorescence imaging, Traditional bowel anastomosis, FireFly™
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Acibadem University
Colon Cancer, Inflammatory Bowel Diseases
Bowel Preparation Regimen for Colon Capsule Endoscopy Procedure
The study aims to investigate the effect of the optimized bowel preparation and boost regimens on colon capsule endoscopy procedures, specifically on cleanliness and completion rate.
- Conditions
- Colon Cancer, Inflammatory Bowel Diseases, Gastrointestinal Bleed, Colon Polyp
- Trial name
- NCT05726097
- Testing
- polyethylene glycol, sodium phosphate, polyethylene glycol + ascorbic acid
- Where
- Sweden
- Volunteers
- 147 people
- Sponsor
- Region Skane
Colorectal Cancer, Ulcerative Colitis
FishGastro Study: Fish Consumption and Gastro-Intestinal Health
The purpose of the study is to determine whether increasing the dietary intake of n-3 fatty acids by the consumption of oil-rich fish reduces the risk of developing colorectal cancer.
- Conditions
- Colorectal Cancer, Ulcerative Colitis, Polyps
- Trial name
- NCT00145015
- Testing
- Increased dietary intake of salmon or cod
- Where
- 2 sites in Netherlands, United Kingdom
- Volunteers
- 270 people
- Sponsor
- Quadram Institute Bioscience
Colorectal Cancer, Triple Negative Breast Cancer, NSCLC - Adenocarcinoma
A Study of PDR001 in Combination With CJM112, EGF816, Ilaris® (Canakinumab) or Mekinist® (Trametinib)
The purpose of this study was to combine the PDR001 checkpoint inhibitor with each of four agents with immunomodulatory activity to identify the doses and schedule for combination therapy and to preliminarily assess the safety…
- Trial name
- NCT02900664
- Testing
- PDR001, ACZ885, CJM112
- Where
- 23 sites in United States, Belgium and 7 more
- Volunteers
- 283 people
- Sponsor
- Novartis Pharmaceuticals
Inflammatory Bowel Disease (IBD), Familial Adenomatous Polyposis
Endomicrocancer: Confocal Endomicroscopy in Patients With High Risk of Colorectal Cancer
The principle objective of this study is to validate confocal endomicroscopy (CEM) in a national, multicenter study, in terms of its ability to diagnose neoplastic lesions in vivo, in two groups of patients at high risk of…
- Trial name
- NCT01052376
- Testing
- Confocal endomicroscopy
- Where
- 6 sites in France
- Volunteers
- 73 people
- Sponsor
- Nantes University Hospital
Colorectal Cancer, Diet Habit
Walnuts and Colon Health (The WellNut Trial)
The purpose of this research study is to examine whether adding walnuts to your diet can have a beneficial effect on the gut bacteria population, inflammatory markers in the blood, and the tissue that lines the inside of the…
- Trial name
- NCT05195970
- Testing
- Walnuts
- Where
- 2 sites in United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- UConn Health
Colorectal Cancer
Preoperative Nutritional Status and Postoperative Outcomes in Colorectal Cancer
The aim of this study was to evaluate the effect of preoperative nutritional status, dietary inflammatory index, and systemic inflammatory response on postoperative outcomes.
- Trial name
- NCT06016829
- Testing
- Nutrition Risk Screening 2002 (NRS-2002), Global Leadership Initiative on Malnutrition (GLIM), Measurement of body composition with computed tomography (CT)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 121 people
- Sponsor
- Hacettepe University
Colorectal Neoplasms
Yield and Safety of Colonoscopy in Patients Older Than 80 Years
The aim of the study is to study the risk of colorectal cancer and polyps in people older than 80 years compared to the younger age group.
- Trial name
- NCT00590434
- Where
- United States
- Volunteers
- 169 people
- Sponsor
- Midwest Biomedical Research