Clinical trials: Colon, Sigmoid
Solid Tumor, Colorectal Cancer
Live Biotherapeutic Product GB104 Phase 1 Study in Colorectal Cancer
Prospective, open label, multi-dose, sequential dose escalation, single-center, Phase 1 trial
- Conditions
- Solid Tumor, Colorectal Cancer, Sigmoid Colon Cancer, Rectosigmoid Junction Cancer
- Trial name
- NCT05943041
- Testing
- GB104(Level 1), GB104(Level 2), GB104(Level 3)
- Where
- South Korea
- Volunteers
- 9 people
- Sponsor
- GILongevity
Constipation
Anti-peristaltic Ileo-sigmoid Anastomosis for the Treatment of Slow-transit Constipation:Therapeutic Evaluation
Purpose: To evaluate the curative effect of Laparoscope Sub-total Colectomy with Anti-peristaltic ileosigmoid anastomosis for the treatment of slow-transit constipation on the patients with STC.
- Trial name
- NCT02147574
- Testing
- Anti-peristaltic ileosigmoid anastomosis
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Anlong Zhu
Colon Polyps
Prospective Study of Colon Serrated Polyps
With this study, the investigators plan to review the clinical, epidemiology, pathology, and endoscopic features of colon serrated lesions as well as outcome of endoscopic resection of these lesions.
- Trial name
- NCT02332785
- Testing
- Data Collection
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- M.D. Anderson Cancer Center
Colonoscope Passage
The Effect of Cap-assisted Water Exchange Colonoscopy on Straight Passage of the Colonoscope Through the Sigmoid Colon, Without Loop Formation
A prospective, single-center, single-blind, randomized controlled study to compare the proportion of straight passage through the sigmoid colon without loop formation between conventional colonoscope passage, left colon water…
- Trial name
- NCT06992856
- Testing
- Conventional colonoscope passage, left colon water exchange colonoscope passage, cap-assisted left colon water exchange colonoscope passage
- Where
- China
- Volunteers
- 531 people
- Sponsor
- Fudan University
Cancer, Colorectal Neoplasms
Improving Radical Treatment Through MRI Evaluation of Pelvic Sigmoid Cancers
Patients with suspected or proven sigmoid colon adenocarcinoma, eligible for curative treatment whose MRI can be reviewed prior to surgery and has no decision regarding radical treatment are eligible.
- Conditions
- Cancer, Colorectal Neoplasms, Colon, Sigmoid, Magnetic Resonance Imaging
- Trial name
- IMPRESS (NCT02222844)
- Testing
- Preoperative MRI scan
- Where
- 16 sites in United Kingdom
- Volunteers
- 244 people
- Sponsor
- Imperial College London
Sigmoid Cancer, Sigmoid Colon Cancer
Sigmoid Colon Organ Motion in Radiotherapy
Radiotherapy is used in cancer treatment to eradicate microscopic cancer cells to lower the risk of recurrence. The radiotherapy plan must account for organ movement inside the body to ascertain adequate dose is delivered to the…
- Trial name
- NCT03259828
- Testing
- Adjuvant image-guided radiotherapy
- Where
- Taiwan
- Volunteers
- 4 people
- Sponsor
- National Cheng-Kung University Hospital
Rectal Carcinoma, Sigmoid Colon Carcinoma
Indocanine Green as Tracer for Lymph Nodes Dissection in Station 253
This is a prospective randomized controlled study. investigators will randomly assign patients to the indocanine green (ICG) group and control (CL)group to compare the differences of lymph nodes dissection in station 253 between…
- Trial name
- NCT04848311
- Testing
- lymph nodes dissection at 253 station assisted by ICG
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Performance and Tolerance of Colonoscopy
Carolina-ColoWrap® in Colonoscopy Performance and Outcomes Study
Colonoscopy is the gold-standard for colorectal cancer screening in the US. However, complete colonoscopy can be a challenging technical procedure, even for expert gastroenterologists due to variations in patient anatomy…
- Trial name
- C3PO (NCT02025504)
- Testing
- ColoWrap
- Where
- 3 sites in United States
- Volunteers
- 350 people
- Sponsor
- ColoWrap, LLC
Food Allergy in Infants, Proctocolitis
Suspicion of Non IgE-mediated Cow's Milk Protein Allergy: Prevalence and Evolution
Cow's milk protein allergy (CMPA) is often evoked in infants, in particular in front of delayed symptoms such as rectal bleeding, atopic dermatitis, excessive crying, reflux, failure to thrive...
- Conditions
- Food Allergy in Infants, Proctocolitis, Atopic Dermatitis, Reflux, Gastroesophageal
- Trial name
- NCT04651829
- Testing
- oral food challenge 1, oral food challenge 2
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hôpital Armand Trousseau
Sigmoid Diverticulitis (Hinchey I and II), Sigmoid Diverticulosis With Two or More Attacks of Diverticulitis
Laparoscopic Transvaginal Hybrid Anterior Resection: a Prospective Data Collection
Transvaginal hybrid procedures are of interest as an available NOTES-Procedure for the clinical routine. Few authors have demonstrated the feasibility and safety of such procedures (e.g.
- Trial name
- NCT01043731
- Testing
- Laparoscopic transvaginal hybrid anterior resection
- Where
- Switzerland
- Volunteers
- 45 people
- Sponsor
- Cantonal Hospital of St. Gallen
Endometriosis, Sigmoid, Endometriosis, Rectum
Three-dimensional (3D) Rectal Water Contrast Transvaginal Ultrasonography Versus Computed Colonography in the Diagnosis of Rectosigmoid Endometriosis
Rectosigmoid involvement by endometriosis causes intestinal symptoms such as constipation, diarrhea, and dyschezia. A non-invasive diagnosis of bowel endometriosis is relevant to provide the patients information on the potential…
- Trial name
- NCT04295343
- Testing
- Three-dimensional (3D) rectal water contrast transvaginal ultrasonography, Computed colonography
- Where
- Italy
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Ospedale Policlinico San Martino
Outcome
Treatment in Right Colon Diverticulitis Patients
The right colon diverticula, unlike those in the left colon, contain all layers of the colon and is called the true diverticulum. Perforation is observed less frequently due to its full thickness.
- Trial name
- NCT04746326
- Testing
- Failure conservative treatment, Surgery, Conservative treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Tepecik Training and Research Hospital
Healthy Volunteer, Rheumatoid Arthritis
Phenomics in Autoimmune and Inflammatory Diseases
The family of inflammatory/autoimmune systemic diseases (IAD) form a continuum from pure inflammatory diseases to pure autoimmune diseases, encompassing a large panel of inflammatory diseases with some autoimmune components, and…
- Conditions
- Healthy Volunteer, Rheumatoid Arthritis, Ankylosing Spondylitis, Systemic Lupus Erythematosus/Antiphospholipid Syndrome
- Trial name
- TRANSIMMUNOM (NCT02466217)
- Testing
- 1: AID groups, 2: Control groups
- Where
- 2 sites in France
- Volunteers
- 537 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Radius Fracture Distal
Effects of Ulnar Styloid and Sigmoid Notch Fractures on Postoperative Wrist Function of Distal Radius Fracture Patients
To study the effects of ulnar styloid and sigmoid notch fractures on postoperative wrist function in patients with distal radius fracture
- Trial name
- NCT03359278
- Testing
- open reduction and internal fixation
- Volunteers
- 139 people
- Sponsor
- Peking University People's Hospital
Diverticulitis
Laparoscopic Versus Open Sigmoid Colectomy for Diverticular Disease
Aim: This is a prospective, randomized comparison of traditional open (OS) and laparoscopic sigmoidectomy (LS) in patients with complicated diverticular disease.
- Trial name
- NCT00453830
- Testing
- laparoscopic sigmoid resection
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University Hospital, Geneva
Diverticular Disease of Left Side of Colon
Quality of Life (QOL) After Elective Sigmoidectomy for Diverticular Diseases (DIVERTI)
Acute diverticulitis of the left colon is among the most common abdominal disorders. To date, both conservative therapy in uncomplicated stages and emergency surgery in perforated disease with peritonitis are consensual.
- Trial name
- DIVERTI-QDV (NCT04730765)
- Testing
- left elective colectomy (Surgical Experimental Group), antibiotic therapy (medical Control Group)
- Volunteers
- 220 people
- Sponsor
- University Hospital, Caen
Endoscopic Surgical Procedure
Percutaneous Sigmoid Fixation For Management Of Recurrent Sigmoid Volvulus
The investigators included all patients who were presented to emergency department with recurrent sigmoid volvulus at Zagazig University hospital between (August 2024 to August 2025).
- Trial name
- NCT07155304
- Testing
- percutaneous sigmoid colon fixation
- Where
- Egypt
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Orthotopic Neobladder
The Supraspinal Control of Lower Urinary Tract Function in Patients With Orthotopic Sigmoid Neobladder.
Orthotopic sigmoid neobladder surgery is one of the ideal urinary diversion methods after radical cystectomy.In recent years, functional imaging studies have revealed brain regions related to urinary system function, but brain…
- Trial name
- NCT05558111
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Natural Orifice Specimen Extraction Surgery, Robotic Surgery
A Prospective Single-center Randomized Controlled Trial of Robotic Surgery With Transrectal Resection Specimens (NOSES-IV) and Traditional Assisted Robotic Surgery for the Treatment of High Rectal and Sigmoid Colon Cancer
This study aimed to compare the short-term efficacy of robotic radical resection of high rectal cancer and sigmoid colon cancer (NOSES-IV) with transrectal resection specimens and traditional robotic surgery in the treatment of…
- Conditions
- Natural Orifice Specimen Extraction Surgery, Robotic Surgery, Short-term Outcomes
- Trial name
- NCT06906952
- Testing
- robotic natural orifice specimen extraction surgery, robotic transabdominal specimen extraction surgery
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Nanchang University
Colorectal Cancer, Sigmoid Cancer
Complete Mesocolon Excision vs Locoregional Lymphadenectomy in Sigmoid Colon Cancer (CMELL)
A randomized, controlled clinical trial comparing lymphadenectomy with extended inferior mesenteric artery ligation (complete mesocolon excision: which includes lymphoma tissue from the origin of the inferior mesenteric vein)…
- Trial name
- CMELL (NCT03083951)
- Testing
- Complete mesocolon excision, Conventional locoregional lymphadenectomy
- Where
- Spain
- Volunteers
- 93 people
- Sponsor
- Pere Planellas Giné