Clinical trials: Colon Disease
Colo-rectal Cancer
Early-Onset Colorectal Cancer: An Observational Retrospective and Prospective Multicenter Study
Observational, retrospective and prospective multicentric Italian study of patients diagnosed with colorectal cancer between age 18-40, aiming at underpinning the biology of vEO-CRC, including colibactin as well as a broader…
- Trial name
- HEBE (NCT06965335)
- Testing
- BIOLOGICAL STUDY aiming at describing clinicophatological features of EO-CRC vs SO-CRC
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Niguarda Hospital
Colorectal Cancer
Azacitidine and CAPOX in Metastatic Colorectal Cancer
The goal of the Phase I portion of this study is to find the highest tolerable dose of azacitidine combined with capecitabine and oxaliplatin (CAPOX) that can be given to patients with metastatic colorectal cancer.
- Trial name
- NCT01193517
- Testing
- Azacitidine, Capecitabine, Oxaliplatin
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- M.D. Anderson Cancer Center
Colon Cancer, Physical Activity
Physical Activity and Its Impact on Colon Cancer Surgery
This is a prospective clinical study that studies how the physical activity level before operation of colon cancer affects the outcome of complication and histology.
- Trial name
- PACOS (NCT03947840)
- Testing
- Physical activity
- Where
- Sweden
- Volunteers
- 85 people
- Sponsor
- Umeå University
Fear of Cancer Recurrence, Colorectal Cancer
Reducing Fear of Cancer Recurrence in Danish Colorectal Cancer Survivors
Cognitive therapy has been shown to reduce fear of cancer recurrence (FCR), mainly in breast cancer survivors. The accessibility of cognitive behavioural interventions could be further improved by Internet delivery, but…
- Conditions
- Fear of Cancer Recurrence, Colorectal Cancer, Anxiety, Health Anxiety
- Trial name
- NCT04287218
- Testing
- TG-iConquerFear, aTAU
- Where
- Denmark
- Volunteers
- 95 people
- Sponsor
- Vejle Hospital
Colorectal Cancer
Safety and Efficacy of Folfox4 + Weekly Cetuximab vs Folfox 4+Biweekly Cetuximab by Metastatic Colorectal Cancer
To assess the efficacy of FOLFOX4 in combination with cetuximab, weekly and FOLFOX4 in combination with cetuximab, biweekly.
- Trial name
- CORE 2 (NCT00479752)
- Testing
- FOLFOX4 (Oxaliplatin), Cetuximab
- Where
- 24 sites in Austria, Bosnia and Herzegovina and 11 more
- Volunteers
- 151 people
- Sponsor
- Central European Cooperative Oncology Group
Colorectal Cancer
Immunotherapy Combined With Y-90 and SBRT for Colorectal Liver Metastases
This study is evaluating the combination of Y-90 radioembolization followed by SBRT with the immunotherapy drugs, durvalumab and tremelimumab, to improve disease control of liver metastases for patients with microsatellite stable…
- Trial name
- NCT03802747
- Testing
- Durvalumab, Durvalumab and Tremelimumab, Y-90 Selective Internal Radiation Therapy (SIRT)
- Sponsor
- University of Colorado, Denver
Adrenocortical Carcinoma, Breast Cancer
Combination Chemotherapy With Suramin Plus Doxorubicin in Treating Patients With Advanced Solid Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Conditions
- Adrenocortical Carcinoma, Breast Cancer, Colorectal Cancer, Prostate Cancer
- Trial name
- NCT00003038
- Testing
- doxorubicin hydrochloride, suramin
- Where
- United States
- Sponsor
- Mayo Clinic
Primary Stage IV Hepatobiliary, Esophageal
Improving Goals of Care Discussion in Advanced Cancer Patients
The goal of this study is to increase and improve Goals of Care discussions for advanced cancer patients by training medical oncologists to conduct these discussions.
- Conditions
- Primary Stage IV Hepatobiliary, Esophageal, Colorectal Cancer, Glioblastoma
- Trial name
- NCT02374255
- Testing
- GoC intervention
- Where
- 4 sites in United States
- Volunteers
- 265 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
IBS - Irritable Bowel Syndrome
Innovative Tools to Produce Legume-based Foods for Increased Consumer Acceptance
The aim of this study is to investigate the effects of enzymatic treatment to reduce GOS (galactooligosaccharides) in legume-based crackers in IBS (irritable bowel syndrome) persons.
- Trial name
- LeguComf (NCT05118243)
- Testing
- Control cracker, Enzyme-treated cracker
- Where
- Finland
- Volunteers
- 20 people
- Sponsor
- University of Helsinki
Colorectal Cancer
Cetuximab Plus Capecitabine as Maintenance Treatment in RAS and BRAF wt Metastatic Colorectal Cancer
This is an open-label, multicenter, randomized study to be conducted in Chinese patients with RAS and BRAF wild-type mCRC. Patients who have already completed 9 cycles of standard first-line induction treatment, without…
- Trial name
- C-CLASSIC (NCT04262635)
- Testing
- Cetuximab, Capecitabine, Cetuximab
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Sun Yat-sen University
Advanced Colon Adenocarcinoma, Advanced Colorectal Adenocarcinoma
Botensilimab, Balstilimab and Regorafenib or Botensilimab and Balstilimab for the Treatment of Advanced or Metastatic Microsatellite Stable Colorectal Cancer
This phase II trial studies how well the combination of botensilimab, balstilimab and regorafenib works compared to botensilimab and balstilimab in treating patients with microsatellite stable colorectal cancer that may have…
- Conditions
- Advanced Colon Adenocarcinoma, Advanced Colorectal Adenocarcinoma, Advanced Rectal Adenocarcinoma, Metastatic Colon Adenocarcinoma
- Trial name
- NCT06575725
- Testing
- Balstilimab, Biopsy, Biospecimen Collection
- Sponsor
- City of Hope Medical Center
Irritable Bowel Syndrome
Serum Levels of Apelin, Chemerin and Adiponectin Adipokines in Irritable Bowel Syndrome and Healthy Subjects
In this observational case-control study investigators aimed to assess the serum levels of adipokines such as Apelin, Chemerin and adiponectin in patients with irritable bowel syndrome (IBS), and compare it with healthy controls.
- Trial name
- NCT03366389
- Where
- Iran
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Amir Abbasnezhad
Crohn's Disease (CD), Ulcerative Colitis (UC)
Virtual Group Therapy for IBD Patients With Anxiety and Depression
This study is being done to better understand the complex relationship between mental health and Inflammatory Bowel Disease (IBD), with a particular focus on symptoms of depression and anxiety.
- Conditions
- Crohn's Disease (CD), Ulcerative Colitis (UC), Inflammatory Bowel Diseases (IBD), Anxiety
- Trial name
- NCT07796568
- Testing
- Group Psychotherapy Intervention
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Chicago
Colorectal Cancer, Metastatic Cancer
Combination Chemotherapy in Treating Patients With Colorectal Cancer That Has Spread to the Liver
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving drugs in different ways may kill more tumor cells.
- Trial name
- NCT00006050
- Testing
- FOLFOX regimen, fluorouracil, isolated perfusion
- Where
- 3 sites in France
- Sponsor
- UNICANCER
Colon Cancer
18F-FDG PET/CT and Molecular Tumor Characterisation for Staging and Follow-up of Colon Cancer
The investigators are investigating the usefulness of 18F-Fluordeoxyglucose Positron Emission Tomography/ Computed Tomography (18F-FDG PET/CT) for staging and follow-up of colon cancer.
- Trial name
- COLOPET1 (NCT01636674)
- Testing
- 18F-fluordeoxyglucose positron emission tomography/ computed tomography
- Volunteers
- 66 people
- Sponsor
- Naestved Hospital
Rheumatoid Arthritis, Ankylosing Spondylitis
Assessment of Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, Plaque Psoriasis, Crohn's Disease and Ulcerative Colitis Patients´ Adherence Attitudes to Maintenance Therapy With a Scheduled Adalimumab Treatment in Routine Clinical Practice
The purpose of this non-interventional, multicenter, post-marketing observational study (PMOS) was to assess rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), plaque psoriasis (PS), Crohn's…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Psoriatic Arthritis, Crohn´s Disease
- Trial name
- Adherence (NCT01768858)
- Testing
- Adalimumab
- Volunteers
- 96 people
- Sponsor
- AbbVie
Gastrointestinal Neoplasm
Primary Tumour Response to Induction Chemotherapy in Synchronously Metastasized Colorectal Cancer
We performed a retrospective data analysis of patients with synchronously metastasized colorectal cancer, comparing the histological response on the primary tumour to chemotherapy combined with either vascular endothelial growth…
- Trial name
- NCT05172635
- Where
- Austria
- Volunteers
- 100 people
- Sponsor
- Klinik Favoriten
Colorectal Cancer, Colorectal Adenoma
Adenoma Detection Rate With Endocuff-Assisted Colonoscopy - an Italian Trial
In European countries, colorectal cancer (CRC) represents an important public health problem. It is widely held view that most carcinomas develop from an adenoma-carcinoma progression.
- Conditions
- Colorectal Cancer, Colorectal Adenoma, Colorectal Polyp, Colorectal Neoplasms
- Trial name
- ITAvision (NCT03612674)
- Testing
- Standard colonoscopy, ARC Endocuff Vision
- Where
- 12 sites in Italy
- Volunteers
- 2,100 people
- Sponsor
- Cancer Prevention and Research Institute, Italy
Cholangiocarcinoma, Pancreatic Ductal Adenocarcinoma
Short-term Starvation vs. Normal Diet Before Chemotherapy of Solid Tumors
Recent pre-clinical data provide strong evidence that short-term starvation before the administration of cytostatic drugs for the chemotherapy of solid tumors leads to significantly higher efficacy and lower toxicity levels.
- Conditions
- Cholangiocarcinoma, Pancreatic Ductal Adenocarcinoma, Colorectal Cancer, Gastric Cancer
- Trial name
- NCT02607826
- Testing
- Starvation
- Volunteers
- 298 people
- Sponsor
- University Hospital Tuebingen
Crohn's Enteritis, Crohn Disease
Physical Fitness Levels in Children and Adolescents With Chronic Inflammatory Bowel Disease (CIBD): Crohn's Disease, Ulcerative Colitis, Chronic Unclassified Colitis
Inflammatory bowel diseases (IBDs), including Crohn's disease (CD), ulcerative colitis (UC) and IBD-unclassified (IBD-U), are characterised by chronic inflammation of the gastrointestinal tract.
- Conditions
- Crohn's Enteritis, Crohn Disease, Inflammatory Bowel Diseases, Colitis, Ulcerative
- Trial name
- MICI-FIT (NCT04647578)
- Testing
- GT3X Actigraph accelerometer.
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille