Clinical trials: Colon Polyps, open to volunteers
Colon Polyp
PULSed Field ablAtion of coloRectal Polyps
The goal of this observational study is to learn about the role of electroporation (the use of small electric pulses applied to tissue) in the treatment (ablation) of colorectal polyps.
- Trial name
- PULSAR (NCT06317727)
- Testing
- Irreversible Electroporation using EndoVE(Endoscopic Vacuum Electrode) and electrical pulses generated using ePORE(electroporation device)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- King's College Hospital NHS Trust
Colorectal Polyps
Metatranscriptomic Markers of Colonic Neoplasia
This study is a collaboration between Viome Life Sciences and Scripps Research Institute to develop and validate a noninvasive molecular diagnostic test for the detection of colorectal polyps.
- Trial name
- NCT07786818
- Testing
- This is an observational study that has no interventions
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Viome
Polyp of Colon, Endoscopic Mucosal Resection
Randomized Trial of Cold EMR Compared to Hybrid Cold EMR.
The goal of this randomized clinical trial is to learn if a combination of hot and cold EMR technique is associated with a lower risk of polyp recurrence without increasing the risk of complication when removing large polyps.
- Trial name
- NCT06937671
- Testing
- Cold EMR, Hybrid EMR
- Where
- 2 sites in United States
- Volunteers
- 194 people
- Sponsor
- The Cleveland Clinic
Polyp of Colon, Artificial Intelligence (AI)
Video/Image Library of Endoscopy Procedures for the Development of AI-empowered Endoscopy Quality Reporting and Educational Modules
The goal of this observational study is to establish a video/image library dataset of complete endoscopy or partial colonoscopy procedures for patients with rectal cancer or inflammatory bowel disease (IBD).
- Trial name
- Videotheque (NCT06822816)
- Where
- Canada
- Volunteers
- 10,000 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Colorectal Carcinoma
Improving Colonoscopy Surveillance for Patients With High Risk Colon Polyps
This clinical trial tests a multilevel intervention at the clinic, provider and patient levels, to improve colonoscopy surveillance in patients with high risk colon polyps.
- Trial name
- NCT06376565
- Testing
- Best Practice, Communication Intervention, Interview
- Where
- United States
- Volunteers
- 1,680 people, healthy volunteers welcome
- Sponsor
- Jonsson Comprehensive Cancer Center
Colonoscopy, Adenoma Detection Rate
Comparison of Adenoma Detection Rate in 3D vs. 2D Surveillance Colonoscopy
There is substantial evidence confirming that identifying and removing colorectal adenomas during colonoscopy helps prevent the development of colorectal cancer.
- Conditions
- Colonoscopy, Adenoma Detection Rate, Three Dimensional, Colon Polyps and Adenomas
- Trial name
- NCT07076966
- Testing
- 3D device
- Where
- 3 sites in Taiwan
- Volunteers
- 660 people
- Sponsor
- National Taiwan University Hospital
FAP, Familial Adenomatous Polyposis
Investigation of β-hydroxybutyrate Supplementation as Chemoprevention in Familial Adenomatous Polyposis
The aim of this study is to evaluate the potential of BHB supplementation as a novel strategy to impede the development and progression of intestinal adenomas in individuals with FAP, thus potentially reducing the need for…
- Trial name
- BHB-FAP (NCT06578637)
- Testing
- R-1,3-Butanediol (10G-A), R-1,3-Butanediol (20G-A), R-1,3-Butanediol (30G-A)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Polyp Colorectal, Rectal Adenoma
GelPOINT® Path-Assisted Endoscopic Removal of Colon and Rectal Polyps: A Feasibility and Safety Study
This prospective, single-center, observational feasibility and safety study will evaluate the use of the GelPOINT® Path transanal access platform during endoscopic submucosal dissection (ESD) for the removal of colorectal polyps.
- Conditions
- Polyp Colorectal, Rectal Adenoma, Adenoma Colon Polyp
- Trial name
- NCT07723937
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Baylor College of Medicine
Colorectal Cancer, Polyp of Colon
Reducing Neoplasia Recurrence After Endoscopic Resection of Large Colorectal Polyps
Large (≥20mm) colorectal polyps often harbor areas of advanced neoplasia, making them immediate colorectal cancer (CRC) precursors.
- Trial name
- ABLATION (NCT06271941)
- Testing
- Hybrid Argon Plasma Coagulation (h-APC), Snare tip soft coagulation (STSC)
- Where
- Canada
- Volunteers
- 892 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Sessile Colonic Polyp, Serrated Lesion
Computer-Aided Water Exchange Colonoscopy With and Without Linked-Color Imaging for Detection of Clinically Significant Serrated Lesions
The goal of this clinical trial is to compare the detection rate of clinically significant serrated lesions (CSSL) in participants undergoing water exchange (WE) colonoscopy with artificial intelligence (AI)-based computer-aided…
- Conditions
- Sessile Colonic Polyp, Serrated Lesion, Sessile Serrated Lesion, Colon Adenomas
- Trial name
- NCT07127471
- Testing
- Water exchange with AI-assisted detection, Water exchange with AI-assisted detection and LCI
- Where
- 4 sites in Canada, Italy and 2 more
- Volunteers
- 1,090 people, healthy volunteers welcome
- Sponsor
- Evergreen General Hospital, Taiwan
Hypoxia, Gastric Polyp
The Efficacy and Safety of the COMBO Endoscopy Oropharyngeal Airway in Gastrointestinal Endoscopy Procedure
Hypoxia represents the prevailing adverse occurrence during the sedation of patients undergoing gastrointestinal endoscopy with propofol.
- Conditions
- Hypoxia, Gastric Polyp, Colon Cancer, Esophageal Cancer
- Trial name
- NCT06081647
- Testing
- the COMBO Endoscopy Oropharyngeal Airway, Regular Nasal Cannula
- Where
- 10 sites in China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Familial Adenomatous Polyposis
Colorectal Adenoma Canceration in FAP
The current internationally accepted treatment method for familial adenomatous polyposis is prophylactic total colorectal resection combined with endoscopic follow-up.
- Trial name
- NCT04531930
- Testing
- surgery, enhanced colonoscopy, self choosed methods
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Changhai Hospital
Gastric Polyps, Intestinal Polyps
Recurrence After Gastric and Intestinal Polyp Resection
This is a retrospective and prospective cohort study designed to evaluate the recurrence rate and identify risk factors after endoscopic resection of gastric and intestinal polyps.
- Conditions
- Gastric Polyps, Intestinal Polyps, Colon Polyps, Colorectal Polyps
- Trial name
- RAGIP (NCT07314554)
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- LanZhou University
Familial Adenomatous Polyposis
Safety Study for the Use of Rapamycin in Children With Familial Adenomatous Polyposis
The hypothesize of this research is that rapamycin is effective and well-tolerated in teenagers with familial adenomatous polyposis (FAP).
- Trial name
- RAPA-4-PAF (NCT06308445)
- Testing
- Rapamycin
- Where
- 4 sites in France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Toulouse
Zenker Diverticulum, Polyp of Colon
Advanced Endo-therapeutic Procedure : Registry-based Observational Study
Advanced therapeutic endoscopy procedures are of increasing importance to provide minimal invasive treatment for GI diseases. The Centre Hospitalier de l'Université de Montréal as tertiary university center is dedicated to…
- Conditions
- Zenker Diverticulum, Polyp of Colon, Colo-rectal Cancer
- Trial name
- AE Registry (NCT04117100)
- Testing
- Polypectomy or myotomy
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Ulcerative Colitis, Inflammatory Bowel Disease (IBD)
Cohort of Patients With Ulcerative Colitis or Polyps Followed in CHU de Bordeaux Associated With a Biocollection - COLIBRI
Ulcerative colitis (UC) is a chronic disease characterized by acute episodes of bloody diarrhea with varying degrees of severity. The most feared event, acute severe UC, can lead to life-threatening and systemic complications.
- Conditions
- Ulcerative Colitis, Inflammatory Bowel Disease (IBD), Acute Severe Ulcerative Colitis
- Trial name
- COLIBRI (NCT07082231)
- Testing
- Blood sample, biopsy
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Bordeaux
Colon Adenomas, Colon Adenomatous Polyp
STSC-HybridAPC Trial
Margin thermal ablation after piecemeal EMR significantly reduces recurrence of large colorectal polyps. As recurrence rates are now low, the key implementation question relates to efficiency and reproducibility of different…
- Trial name
- NCT07682805
- Testing
- Snare Tip Soft Coagulation (STSC), Hybrid APC (ERBE)
- Where
- Australia
- Volunteers
- 140 people
- Sponsor
- Western Sydney Local Health District