Clinical trials: Colon Polyps
Bleeding
Effect of Prophylactic Clip Application for the Prevention of Postpolypectomy Bleeding in Pedunculated Colonic Polyps
Although endoscopic colonic polypectomy has been an established procedure for two decades, the risk of bleeding is still higher after resecting of pedunculated polyps, because of the presence of a large artery in the stalk.
- Trial name
- NCT02156193
- Testing
- Prophylactic clip, No prophylactic management
- Where
- South Korea
- Volunteers
- 238 people
- Sponsor
- The Catholic University of Korea
Adenoma, Colon Polyps
Cap Assisted Colonoscopy for the Detection of Colon Polyps
This simple technique of attaching a transparent cap to the tip of the colonoscope has been evaluated in Japan for improving the detection of polyps and cecal intubation but has not been formally evaluated in the US and other…
- Conditions
- Adenoma, Colon Polyps, Colon Cancer
- Trial name
- NCT01211132
- Testing
- Cap - Transparent retractable extension device., Standard
- Where
- United States
- Volunteers
- 462 people
- Sponsor
- American Society for Gastrointestinal Endoscopy
Colorectal Cancer, Precancerous Condition
S0000D: Effect of Vitamin E and/or Selenium on Colorectal Polyps in Men Enrolled on SELECT Trial SWOG-S0000
RATIONALE: Studying tissue samples in the laboratory from participants receiving treatment on the Selenium and Vitamin E Cancer Prevention Trial (SELECT) SWOG-S0000 may help doctors predict a participant's response to treatment…
- Trial name
- ACP (NCT00706121)
- Testing
- Vitamin E, Selenium
- Where
- United States
- Volunteers
- 8,094 people, healthy volunteers welcome
- Sponsor
- SWOG Cancer Research Network
Polyps
Evaluation of an Endoscopic Suturing System for Tissue Apposition in Colonic Polypectomy
The purpose of this study is to show that the surgical site in the bowel wall can be sewn closed in the colon or intestine, with a new sewing device after removal of a benign polyp according to standard of care.
- Trial name
- NCT00553436
- Testing
- Tissue Apposition System (TAS) Device
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Ethicon Endo-Surgery
Familial Adenomatous Polyposis
Trial of Eflornithine Plus Sulindac in Patients With Familial Adenomatous Polyposis (FAP)
The purpose of this randomized, double-blind, Phase III trial is to determine if the combination of eflornithine plus sulindac is superior to sulindac or eflornithine as single agents in delaying time to the first occurrence of…
- Trial name
- NCT01483144
- Testing
- Eflornithine, Sulindac 150 MG
- Where
- 17 sites in United States, Belgium and 5 more
- Volunteers
- 171 people
- Sponsor
- Cancer Prevention Pharmaceuticals, Inc.
Familial Adenomatous Polyposis (FAP)
Efficacy of Vitamin B1 in Familial Adenomatous Polyposis Patients.
This study aimed to investigate the efficacy of vitamin B1 in patients with familial adenomatous polyposis, and to determine the inhibitory effect of vitamin B1 on the size and number of colorectal adenomas by administering oral…
- Trial name
- VitB1; FAP (NCT06649825)
- Testing
- Vitamin B1
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Shanghai Zhongshan Hospital
Benign Polyps of Large Intestine
Resect and Discard Approach to Diminutive Colonic Polyps
Resect and discard (RD) is a new paradigm for management of diminutive colorectal polyps wherein histology is determined by real-time endoscopic imaging; polyps are then resected and discarded rather than sent for…
- Trial name
- RD (NCT01877525)
- Testing
- Colonoscopy
- Where
- United States
- Volunteers
- 618 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Familial Adenomatous Polyposis
The CHAMP-study: The CHemopreventive Effect of Lithium in Familial AdenoMatous Polyposis
Rationale: Familial adenomatous polyposis (FAP) syndrome is characterized by the development of numerous colorectal polyps. If left untreated, these patients have a chance of nearly 100% of developing colorectal cancer (CRC) at a…
- Trial name
- Lithium in FAP (NCT05402891)
- Testing
- Lithium Carbonate
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Colonic Polyps
Biopsy Forceps Versus Cold Snare for the Resection of Small Colonic Polyps
The purpose of this study is to evaluate and compare the incomplete resection rates for small colon polyps less than or equal to 6 mm in size using two conventional polypectomy tools, jumbo cold biopsy forceps and cold snare.
- Trial name
- NCT02239549
- Testing
- Jumbo cold forceps polypectomy, Cold snare polypectomy
- Where
- United States
- Volunteers
- 419 people, healthy volunteers welcome
- Sponsor
- San Diego Veterans Healthcare System
Colonic Polyps
Cold Polypectomy Site Study
Removal of polyps at colonoscopy reduces colon cancer. Snare polypectomy is the conventional method for removal however the snared area after removal can occasionally appear uneven raising the possibility that complete removal…
- Trial name
- NCT02205125
- Where
- Australia
- Volunteers
- 88 people
- Sponsor
- Professor Michael Bourke
Colonic Polyp
Endoscopic Submucosal Dissection (ESD) Versus Endoscopic Mucosal Resection (EMR) for Large Non Pedunculated Colonic Adenomas: a Randomized Comparative Trial
Initially developed in Japan for the treatment of endemic superficial gastric cancers, endoscopic submucosal dissection (ESD) allows resection of pre-neoplastic and neoplastic lesions of the digestive tract into a single…
- Trial name
- RESECT COLON (NCT03962868)
- Testing
- Experimental procedure : ESD, Comparison procedure: WF-piece meal EMR
- Where
- 6 sites in France
- Volunteers
- 360 people
- Sponsor
- University Hospital, Limoges
Colon Adenomas, Colon Polyps
Impact of Computer-aided Detection System on the Right Colon Adenoma Miss Rate
This is a prospective, multicenter randomized controlled trial designed to determine whether the use of computer-aided detection system could reduce the miss rates of adenomas, SSLs, and polyps in the proximal colon during tandem…
- Conditions
- Colon Adenomas, Colon Polyps, Sessile Serrated Lesion
- Trial name
- NCT07308743
- Testing
- Computer-aided detection-assisted colonoscopy, Conventional white-light colonoscopy
- Where
- China
- Volunteers
- 686 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Colorectal Cancer Control and Prevention
Clinical and Endoscopic Characterization of Patients With Multiple Colorectal Adenomas: A Multicenter Study in Spain (ESPAPOLYP Study)
The aim is to clinically, endoscopically, and molecularly characterize patients with multiple colorectal adenomas, establish the indication for genetic testing to rule out hereditary syndromes and identify the genes to be…
- Trial name
- ESPAPOLYP (NCT06625788)
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Asociación Española de Gastroenterología
Colorectal Cancer
Point of Care Test to Diagnosed Colorectal Cancer and Polyps in Low Middle Income Countries
This is a-two phase study. Phase 1 will adapt a 3-metabolite biosensor that identifies patients with colorectal cancer (CRC) and precancerous polyps to Nigerian patients.
- Trial name
- NCT03173729
- Testing
- Biosensor Point of Care Device
- Where
- 5 sites in Nigeria
- Volunteers
- 926 people, healthy volunteers welcome
- Sponsor
- Obafemi Awolowo University Teaching Hospital
Colonic Polyps, Adenoma
Comparative Study of Colon Capsule and Virtual Colonoscopy (VICOCA)
Summary Colorectal cancer (CRC) represents the second leading cause of cancer deaths in Spain (11,000 deaths per year). Screening of the population over 50 years of age with no significant history (intermediate risk) is…
- Trial name
- VICOCA (NCT02081742)
- Where
- Spain
- Volunteers
- 349 people
- Sponsor
- Begoña González Suárez
Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum
Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps
This trial examines colorectal cancer incidence in participants with 1 to 2 non-advanced adenomas randomized to surveillance colonoscopy at 10 years compared to participants randomized to surveillance colonoscopy at 5 and 10…
- Trial name
- FORTE (NCT05080673)
- Testing
- 5-year and 10 Year Surveillance Colonoscopy after Qualifying Colonoscopy
- Where
- 493 sites in United States, Puerto Rico
- Volunteers
- 9,500 people
- Sponsor
- NRG Oncology
Colon Adenoma, Diverticulosis
Impact of Diverticular Disease on the Detection of Colon Adenomas
Benign adenomas of the colon have the potential to degenerate and become malignant. Therefore adenomatous polyps should be detected and resected during colonoscopy.
- Trial name
- DECADE (NCT02057562)
- Where
- 2 sites in Germany
- Volunteers
- 1,000 people
- Sponsor
- Technical University of Munich
Colorectal Cancer, Colon Polyp
Volatile Organic Compounds (VOCs) Profile in Colorectal Cancer Patients and Healthy Controls.
Volatile organic compounds (VOCs) are low molecular weight (<1 kDa) compounds which represent the final products of cell metabolism.
- Trial name
- NCT04217083
- Testing
- Breath sampling
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Societa Italiana di Chirurgia ColoRettale
Polyp, Adenoma
EndoCuff-assisted Versus Standard Colonoscopy for Adenoma Detection
The EndoCuff is novel flexible cuff that can be attached to the distal tip of the colonoscope and helps to flatten large mucosal folds during withdrawal.
- Conditions
- Polyp, Adenoma, Cancer
- Trial name
- NCT02034929
- Testing
- EndoCuff-assisted colonoscopy, Standard colonoscopy
- Where
- 4 sites in Germany
- Volunteers
- 500 people
- Sponsor
- Helios Albert-Schweitzer-Klinik Northeim
Duodenum Cancer, Familial Adenomatous Polyposis
Duodenal Polyposis Classification in FAP
Duodenal cancer is the leading cause of cancer-related mortality in patients with familial adenomatous polyposis (FAP), yet the current Spigelman staging system provides limited predictive accuracy for advanced neoplasia.
- Conditions
- Duodenum Cancer, Familial Adenomatous Polyposis, Duodenal Polyposis, Ampulla of Vater Adenoma
- Trial name
- DRACO (NCT07199127)
- Testing
- DRACO
- Where
- 2 sites in Italy
- Volunteers
- 300 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano