Clinical trials: Colon Rectal Cancer
Colorectal Cancer
A Comparison of Methods to Detect Polyps During Colonoscopy
Colorectal cancer (CRC) is the third most common cancer and second leading cause of cancer deaths in western countries. Colonoscopy is a preferred colorectal screening modality since it has both diagnostic and therapeutic…
- Trial name
- NCT01025960
- Testing
- Standard Inspection Colonoscopy, Dual Inspection Colonoscopy
- Where
- United States
- Volunteers
- 768 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Metastatic Solid Tumors, Advanced Non-squamous Non-small-cell Lung Cancer
A First-in-human Study of BGB-53038, a Pan-KRAS Inhibitor, Alone or in Combinations in Participants With Advanced or Metastatic Solid Tumors With KRAS Mutations or Amplification
This is a first-in-human (FIH), open-label, multicenter, dose escalation and dose expansion study to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and preliminary antitumor activity of BGB-53038 as…
- Conditions
- Metastatic Solid Tumors, Advanced Non-squamous Non-small-cell Lung Cancer, Advanced Colorectal Cancer, Advanced Pancreatic Ductal Adenocarcinoma
- Trial name
- NCT06585488
- Testing
- BGB-53038, Tislelizumab, Cetuximab
- Where
- 17 sites in United States, Australia and 3 more
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- BeOne Medicines
Colorectal Cancer
Interventions to Improve Colon Cancer Screening in Poor Rural Iowa Counties
The goal of the study is to conduct a randomized clinical trial to test several office-based strategies for improving colon cancer screening among individuals who are regular patients at 16 family practice physician offices in…
- Trial name
- NCT01477814
- Testing
- Physician chart reminder, chart reminder, educational mat'ls, FIT, CR,ed mat'ls, FIT, phone call
- Where
- United States
- Volunteers
- 743 people, healthy volunteers welcome
- Sponsor
- Barcey T. Levy
Colorectal Cancer, Colorectal Neoplasms
Early Onset Colorectal Cancer Detection
Colorectal cancer (CRC) once predominantly affected older individuals, but in recent years has witnessed a progressive increase in incidence among young adults.
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Adenocarcinoma, Colorectal Cancer Stage I
- Trial name
- ENCODE (NCT06342401)
- Testing
- ENCODE
- Where
- 13 sites in United States, Italy and 2 more
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Colorectal Neoplasms
Comprehensibility of Colorectal Cancer Screening Educational Materials: Effects on Patient Knowledge and Motivation
The purpose of this study is to determine whether a newly developed patient education document concerning colorectal cancer screening will be better understood and have greater effects on patient knowledge of and motivation for…
- Trial name
- NCT00965965
- Testing
- New colorectal cancer screening patient education document, Traditional colorectal cancer screening education document
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Colo-rectal Cancer
The dıagnostıc Value of Serum autotaxın Level ın Colorectal Cancer
Colorectal cancer is one of the most common causes of cancer-related death. Early diagnosis is extremely important in terms of treatment and mortality.
- Trial name
- NCT06091592
- Testing
- Serum autotaxın levels
- Where
- Turkey (Türkiye)
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Colorectal Cancer, Lung Cancer
Technology-Based Cancer Screening Intervention
The primary purpose of this research study is to contribute to generalized knowledge on how to increase screening for patients at risk of missing their recommended cancer preventive care by using a newly developed predictive…
- Conditions
- Colorectal Cancer, Lung Cancer, Breast Cancer
- Trial name
- NCT04535492
- Testing
- Decision Making Support Tool
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Colorectal Cancer Screening
Improving Colorectal Cancer Screening for Diverse Hispanics in Urban Primary Care
The proposed study seeks to investigate the impact of a culturally targeted print educational intervention on rates of colorectal cancer (CRC) screening via colonoscopy among Hispanics.
- Trial name
- NCT01569620
- Testing
- Best clinical practices plus culturally targeted print materials, Best clinical practices plus standard print materials, Best clinical practices alone
- Where
- United States
- Volunteers
- 386 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Colorectal Cancer
Colonoscopy Versus Fecal Immunochemical Test in Reducing Mortality From Colorectal Cancer (CONFIRM)
Colorectal cancer (CRC) is currently the second most common cause of cancer death in the United States, and one of the most preventable cancers.
- Trial name
- CONFIRM (NCT01239082)
- Testing
- Colonoscopy, Fecal immunochemical test (FIT)
- Where
- 46 sites in United States, Puerto Rico
- Volunteers
- 50,126 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Breast Carcinoma, Colorectal Carcinoma
Survivorship Care Plans and Telehealth Education for the Improvement of Access to Cancer Survivorship, the IMPACT Study
This trial studies how well self-generated survivorship care plans and telehealth education works in improving knowledge and self-efficacy in cancer survivors living in rural areas.
- Conditions
- Breast Carcinoma, Colorectal Carcinoma, Lung Carcinoma, Lymphoma
- Trial name
- NCT04081779
- Testing
- Survivorship Care Plan, Educational Intervention, Questionnaire Administration
- Where
- United States
- Volunteers
- 261 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Colorectal Cancer, Cardiovascular Diseases
Effects of Replacing Red Meat With Legumes on Biomarkers of Chronic Diseases in Healthy Men (Leg4Life)
The aim of this study is to investigate the effects of partial replacement of red meat with legume-based foods on gut metabolism and markers for colorectal cancer as well as markers for cardiovascular diseases and type 2 diabetes…
- Conditions
- Colorectal Cancer, Cardiovascular Diseases, Type2 Diabetes
- Trial name
- NCT04599920
- Testing
- Partial replacement of red meat with legume-based foods
- Where
- Finland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Colonoscopy
Impact of Digital Tools on the Quality of Bowel Preparation for Colonoscopy
This is a single blinded randomized controlled study. The main question of this study is whether better preparation by making full use of digital tools can increase patient compliance with the preparation methods for colonoscopy…
- Trial name
- NCT05734079
- Testing
- Standard of care, Standard of care + Video call, Standard of care + Video call + Educational video film
- Volunteers
- 825 people, healthy volunteers welcome
- Sponsor
- Ziv Hospital
Colorectal Cancer
Collection of Samples From the United States Population for Optimization and Evaluation of Colorectal Cancer (CRC) Plasma Circulating Free-DNA (cfDNA) Marker Panel Performance
This study is designed to prospectively collect blood samples and clinical data from patients that have been newly diagnosed with colorectal cancer and scheduled for resection surgery but are pre cancer treatment, subjects who…
- Trial name
- PROVE (NCT07310446)
- Where
- United States
- Volunteers
- 6,500 people, healthy volunteers welcome
- Sponsor
- Universal Diagnostics
Cancer of Colon, Cancer of Rectum
Colorectal Health Research Champions
The purpose of the Colorectal Health Research Champions program is to provide accurate and reliable colorectal health cancer information that they can share within their communities to encourage cancer prevention, screening, and…
- Trial name
- NCT04812743
- Testing
- Colorectal Health Research Champions
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Colorectal Cancer, Screening
ColoAssist vs. MEI
Colonoscopy aims to investigate the entire colon by advancing the colonoscope tip from the rectum to the cecum, a process called cecal intubation.
- Trial name
- NCT01895504
- Testing
- ColoAssist, MEI
- Where
- 2 sites in Norway
- Volunteers
- 475 people, healthy volunteers welcome
- Sponsor
- Sorlandet Hospital HF
Colo-rectal Cancer, Polyp of Colon
Evaluation of EverLift in the Performance of Polypectomy for Polyps 4-9mm
The focus of the study is to evaluate impact of submucosal injection of EverLift in achieving complete resection during polypectomy of polyps 4-9mm during colonoscopy.
- Conditions
- Colo-rectal Cancer, Polyp of Colon, Adenomatous Polyp of Colon
- Trial name
- NCT04551014
- Testing
- Use of EverLift, Without use of EverLift
- Where
- United States
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Stanford University
Natural Killer Cell Cytokine Production
Measurement of NK Cell Activity in Whole Blood in Subjects Being Screened for Colorectal Cancer Using Colonoscopy
This study will look at measuring the activity of natural killer (NK) cells using the in vitro diagnostic device NK Vue in subjects being screened for colorectal cancer using colonoscopy.
- Trial name
- NCT02291198
- Testing
- NK Vue: NK cell activity in stimulated whole blood
- Where
- Canada
- Volunteers
- 1,081 people, healthy volunteers welcome
- Sponsor
- ATGen Canada Inc
CRC, Precancerous Condition
Noninvasive Early Diagnosis of Colorectal Cancer Using Odor-Targeted Capture, Point-of-Care Testing, and Intelligent Analysis
The goal of this observational study is to see whether a new, noninvasive test that analyzes smells (odor) from breath and intestinal gas can help detect colorectal cancer and precancerous growths at an early stage.
- Conditions
- CRC, Precancerous Condition, Healthy
- Trial name
- NCT07620743
- Where
- China
- Volunteers
- 453 people, healthy volunteers welcome
- Sponsor
- Beijing University of Chinese Medicine
Cancer of Colon
Choice Architecture and Colorectal Cancer Screening Outreach
This pilot study is a 3-arm randomized control trial assessing the effectiveness of sequential or active choice in CRC (colorectal cancer) screening outreach vs.
- Trial name
- NCT03246438
- Testing
- Colonoscopy only, Colonoscopy outreach + mailed FIT follow-up, Colonoscopy + Mailed FIT outreach and follow-up
- Where
- United States
- Volunteers
- 423 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Colon Adenocarcinoma, Colorectal Adenocarcinoma
Family Communications After Genetic Testing
This clinical trial compares patient (proband)-mediated communication to provider-mediated communication for improving genetic testing in first-degree relatives of patients with newly diagnosed colorectal cancer.
- Conditions
- Colon Adenocarcinoma, Colorectal Adenocarcinoma, Rectal Adenocarcinoma, Stage I Colon Cancer AJCC v8
- Trial name
- NCT07143487
- Testing
- Biospecimen Collection, Genetic Testing, Communication Intervention
- Where
- 365 sites in United States, Puerto Rico
- Volunteers
- 4,186 people, healthy volunteers welcome
- Sponsor
- Alliance for Clinical Trials in Oncology