Clinical trials: Colon Resection, active
Endoscopic Mucosal Resection, Endoscopic Submucosal Dissection
Endoscopic Resection of Gastrointestinal Neoplasms
The study aims to retrospectively investigate the endoscopic resection procedures of cancerous and precancerous lesions of the upper and lower digestive tract in order to evaluate the efficacy and safety outcomes and to compare…
- Conditions
- Endoscopic Mucosal Resection, Endoscopic Submucosal Dissection, Gastric Neoplasm, Colonic Neoplasms
- Trial name
- NCT04780256
- Testing
- Endoscopic resection
- Where
- Italy
- Volunteers
- 2,000 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Benign Colon Tumors
Comparison of Methods for Removing Large Benign Broad-based Epithelial Neoplasms of the Colon: ESD and EMR.
Benign epithelial neoplasms of the colon are a significant problem of colorectal surgery and health care not only because of their malignant potential, but also because of their prevalence among the working-age population.
- Trial name
- ESDEMR (NCT07041229)
- Testing
- EMR, ESD
- Where
- Russia
- Volunteers
- 110 people
- Sponsor
- Pirogov Russian National Research Medical University
Colorectal Cancer Stage II, Colorectal Cancer Stage III
A Phase II Clinical Trial Comparing the Efficacy of RO7198457 Versus Watchful Waiting in Patients With ctDNA-positive, Resected Stage II (High Risk) and Stage III Colorectal Cancer
This is a multi-site, open-label, Phase II, randomized, trial to compare the efficacy of RO7198457 versus watchful waiting in patients with circulating tumor DNA (ctDNA) positive, surgically resected Stage II/III rectal cancer…
- Trial name
- NCT04486378
- Testing
- RO7198457 intravenous (IV), Observational group (no intervention)
- Where
- 85 sites in United States, Belgium and 5 more
- Volunteers
- 327 people
- Sponsor
- BioNTech SE
Colorectal Neoplasms Malignant, Lymph Node Excision
Chemoradiotherapy Sequenced Radical Surgery for Colorectal Cancer With PALNM
In left-sided colon and rectal cancer, the occurrence of synchronous para-aortic lymph node metastasis is rare, with the incidence of being approximate 1-2%.
- Conditions
- Colorectal Neoplasms Malignant, Lymph Node Excision, Chemoradiotherapy
- Trial name
- NCT05129774
- Testing
- Radical surgery with PALND, Radical surgery without PALND
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Qilu Hospital of Shandong University
Rectal Disorders, Low Anterior Resection Syndrome
Impact of Early Postoperative Treatment With Posterior Tibial Nerve Stimulation on the Incidence and Duration of Low Anterior Rectal Resection Syndrome
The treatment of rectal cancer is currently based on surgical resection of the rectum with total excision of the mesorectum, associated with neoadjuvant radiochemotherapy.
- Conditions
- Rectal Disorders, Low Anterior Resection Syndrome, Low Anterior Resection
- Trial name
- LARS (NCT05368168)
- Testing
- Posterior tibial nerve stimulation (PTNS)
- Where
- Spain
- Volunteers
- 114 people
- Sponsor
- Innovacion en Cirugía Vigo
Colorectal Cancer, Colorectal Neoplasms
Clinical Outcomes After EMR or ESD of Colorectal Neoplasms - A Multicenter Registry
This study aims to establish a multicenter registry platform to capture clinical data from subjects undergoing colorectal EMR and ESD.
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Adenoma
- Trial name
- NCT05653960
- Testing
- EMR or ESD
- Where
- Hong Kong
- Volunteers
- 2,500 people
- Sponsor
- Chinese University of Hong Kong
Low Anterior Resection Syndrome, Rectal Cancer
Comparison of Transanal Irrigation and Glycerol Suppositories in Treatment of Low Anterior Resection Syndrome
The study is a multicentre randomized controlled trial with the objective to compare the effect of transanal irrigation with glycerol suppositories in patients suffering from major Low Anterior Resection Syndrome (LARS).
- Trial name
- NCT04087421
- Testing
- Qufora Irrisedo Cone System, Glycerol "OBA"
- Where
- Denmark
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Low Anterior Resection Syndrome
Transanal Irrigation for Low Anterior Resection Syndrome.
The aim of this study is to investigate whether the high-volume transanal irrigation (TAI) performed by the Peristeen Plus® system is superior to the low-volume TAI performed by standard 250ml water enema for the treatment of Low…
- Trial name
- HiLoV_TAI (NCT05245331)
- Testing
- Peristeen® Transanal irrigation system with the conic catheter, Standard reusable enema
- Where
- 2 sites in Spain
- Volunteers
- 20 people
- Sponsor
- Hospital Universitari de Bellvitge
Colon Cancer
Laparoscopic Versus Open Right Colectomy for Right Colon Cancer
The purpose of this research protocol is to compare open versus laparoscopic right colectomy (according to the CME technique of complete mesocolic excision) for right colon cancer.
- Trial name
- NCT05713903
- Testing
- Laparoscopic right colectomy, Open right colectomy
- Where
- Greece
- Volunteers
- 114 people
- Sponsor
- Larissa University Hospital
Ulcerative Colitis in Remission
Safety and Efficacy of a STOPping Strategy Versus Classical Maintenance Dose of JAK Inhibitors in Deep Remission Patients With Ulcerative Colitis
This phase IV, multicenter, open-label randomized controlled trial will evaluate whether a JAK inhibitor discontinuation strategy is superior to standard maintenance therapy in adult patients with ulcerative colitis who are in…
- Trial name
- STOP (NCT07718529)
- Testing
- treatment withdrawal
- Where
- 22 sites in France
- Volunteers
- 224 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Rectal Cancer, LARS - Low Anterior Resection Syndrome
Personalized Care Pathways for Bowel Symptoms in Rectal Cancer Patients_contributing Factors (Treatable)
Colorectal cancer is the 2nd and 3rd most common cancer in respectively women and men, of which about 40% is located in the rectum.
- Conditions
- Rectal Cancer, LARS - Low Anterior Resection Syndrome, Active Surveillance
- Trial name
- Treatable (NCT06914245)
- Testing
- Electronic bowel diary, Faecal Incontinence Quality of Life questionnaire (FIQL), EuroQoL 5 dimensions, 5 levels (EQ-5D-5L)
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- KU Leuven
Patients With Resected Stage II Colon Cancer
CIRCULATING TUMOR DNA BASED DECISION FOR ADJUVANT TREATMENT IN COLON CANCER STAGE II
The objective of CIRCULATE trial is to improve care of patients after colon tumor surgery, based on an innovative marker: circulating tumor DNA.
- Trial name
- CIRCULATE (NCT04120701)
- Testing
- mFOLFOX6
- Where
- France
- Volunteers
- 1,980 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
LARS - Low Anterior Resection Syndrome, Rectal Cancer Surgery
Improving Functional Outcomes and Quality of Life in Patients With Rectal Cancer After Surgery With Intensified Follow-up & Surveillance
The goal of this clinical study is to gain further insights into the treatment of patients with Low Anterior Resection Syndrome (LARS) symptoms after rectal resection.
- Conditions
- LARS - Low Anterior Resection Syndrome, Rectal Cancer Surgery, Rectal Cancer, Quality of Life (QOL)
- Trial name
- iRECOVER (NCT06936774)
- Testing
- Intensified follow-up program
- Where
- 5 sites in Switzerland
- Volunteers
- 140 people
- Sponsor
- University Hospital, Basel, Switzerland
Polyp Colorectal, Rectal Adenoma
GelPOINT® Path-Assisted Endoscopic Removal of Colon and Rectal Polyps: A Feasibility and Safety Study
This prospective, single-center, observational feasibility and safety study will evaluate the use of the GelPOINT® Path transanal access platform during endoscopic submucosal dissection (ESD) for the removal of colorectal polyps.
- Conditions
- Polyp Colorectal, Rectal Adenoma, Adenoma Colon Polyp
- Trial name
- NCT07723937
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Baylor College of Medicine
Low Anterior Resection Syndrome, Rectal Cancer
Antegrade Intestinal Fluid Reinfusion for Prevention of Low Anterior Resection Syndrome After Low Anterior Resection: a Single-Center, Prospective Randomized Controlled Trial.
The goal of this clinical trial is to learn if antegrade intestinal fluid reinfusion works to prevent low anterior resection syndrome (LARS) in patients with prophylactic ileal stoma. The main questions it aims to answer are: 1.
- Trial name
- NCT07537998
- Testing
- intestinal fluid infusion, potable water
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Pei-Rong Ding
Natural Orifice Specimen Extraction Surgery, Robotic Surgery
A Prospective Single-center Randomized Controlled Trial of Robotic Surgery With Transrectal Resection Specimens (NOSES-IV) and Traditional Assisted Robotic Surgery for the Treatment of High Rectal and Sigmoid Colon Cancer
This study aimed to compare the short-term efficacy of robotic radical resection of high rectal cancer and sigmoid colon cancer (NOSES-IV) with transrectal resection specimens and traditional robotic surgery in the treatment of…
- Conditions
- Natural Orifice Specimen Extraction Surgery, Robotic Surgery, Short-term Outcomes
- Trial name
- NCT06906952
- Testing
- robotic natural orifice specimen extraction surgery, robotic transabdominal specimen extraction surgery
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Nanchang University
Colorectal Polyp, Colon Adenoma
Cold Snare Endoscopic Mucosal Resection (EMR) vs Cold EMR With Margin Snare Tip Soft Coagulation (STSC)
Randomised controlled trial comparing cold snare endoscopic mucosal resection (EMR) with cold snare EMR and adjuvant margin STSC in the complete resection of 15-40mm lateral-spreading adenomas
- Conditions
- Colorectal Polyp, Colon Adenoma, Colon Cancer
- Trial name
- NCT05041478
- Testing
- Cold Snare Endoscopic mucosal resection with adjuvant snare tip soft coagulation, Cold Snare Endoscopic Mucosal Resection
- Where
- Australia
- Volunteers
- 300 people
- Sponsor
- Western Sydney Local Health District
Colorectal Cancer
EOCRCPred: an AI Model to Predict Survival in EOCRC Patients After Surgery
The goal of this observational study is to develop a predictive model for overall survival in patients under the age of 50 who have undergone surgery for early-onset colorectal cancer (EOCRC).
- Trial name
- NCT06690606
- Where
- 2 sites in China
- Volunteers
- 250 people
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Anastomosis, Perfusion
PPG vs. ICG in Gastrointestinal Resections
This randomized controlled trial compares a novel optical technique against the standard of care for assessing tissue perfusion in gastrointestinal surgery.
- Conditions
- Anastomosis, Perfusion, Postoperative Complications, Gastrointestinal Neoplasms
- Trial name
- NCT06222645
- Testing
- ICG fluorescence imaging technology, Imaging Photoplethysmography System
- Where
- 3 sites in China, Russia
- Volunteers
- 200 people
- Sponsor
- Saint Petersburg State University, Russia
Rectal Cancer, Total Neoadjuvant Treatment
Total Neoadjuvant Therapy and Organ Preservation Versus Surgery for Rectal Cancer.
This study hypothesizes that approximately 50% of rectal cancer patients can preserve their rectum using a watch-and-wait strategy if they achieve a complete or near-complete clinical response to total neoadjuvant therapy (TNT).
- Conditions
- Rectal Cancer, Total Neoadjuvant Treatment, Neoadjuvant Therapy, Radiotherapy
- Trial name
- NCT06758830
- Testing
- Radiation Therapy, Chemoradiotherapy, Consolidation Chemotherapy
- Where
- Lithuania
- Volunteers
- 400 people
- Sponsor
- National Cancer Center Affiliate of Vilnius University Hospital Santaros Klinikos