Clinical trials: Colon Resection
Colon Cancer
Colonic Resection or Stoma, or Self-expandable Metallic Stent for obstruCtive Left cOlon Cancer
CROSCO-1 study is a national, multi-center, prospective observational study presenting patients to the emergency departments of the participating centers with obstructive left colon cancer (in the absence of metastases and…
- Trial name
- CROSCO-1 (NCT05801211)
- Testing
- primary tumor resection
- Volunteers
- 434 people
- Sponsor
- Azienda Sanitaria di Firenze
Benign Polyps of Large Intestine
Resect and Discard Approach to Diminutive Colonic Polyps
Resect and discard (RD) is a new paradigm for management of diminutive colorectal polyps wherein histology is determined by real-time endoscopic imaging; polyps are then resected and discarded rather than sent for…
- Trial name
- RD (NCT01877525)
- Testing
- Colonoscopy
- Where
- United States
- Volunteers
- 618 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Colonic Neoplasms
Double Blinded Randomized Clinical Trial of the Effect of Open Versus Laparoscopic Colectomy on Neutrophils in Patients With Colon Cancer
The purpose of this study is: to determine neutrophil activity in patients with colon cancer, to determine levels sFas, sFasL and IL - 17 in serum of healthy volunteers and colon cancer patients and establish its prognostic…
- Trial name
- NCT00860691
- Testing
- Therapeutic conventional colorectal surgery, Therapeutic laparoscopic colorectal surgery, Peripheral blood sampling and performing: ELISA test of sFas, sFasL, IL - 17 and Bursttest
- Where
- Croatia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital Dubrava
Colorectal Neoplasms, Benign
Full-thickness Laparo-endoscopic Excision vs Laparoscopic Colectomy for Colonic Tumors
Adenoma - carcinoma is a classic pathway of carcinogenesis. On this basis, timely removal of colon adenomas is a prophylactic measure to prevent colon cancer.
- Trial name
- FlexLaC (NCT04801355)
- Testing
- full-thickness laparo-endoscopic colon adenomas excision, laparoscopic colon resection
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
Benign Colon Tumors
Comparison of Cold and Hot Loop Resection Techniques for the Removal of Medium-sized Benign Colon Tumors
Widespread introduction of high-resolution videocolonoscopy into clinical practice has led to an increase in the detection of epithelial lesions of the colon, a significant portion of which are small (<10 mm) and miniature (≤5…
- Trial name
- chs (NCT07041255)
- Testing
- Cold endoscopic mucosal resection, Hot endoscopic mucosal resection
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Pirogov Russian National Research Medical University
Colonic Polyps
Biopsy Forceps Versus Cold Snare for the Resection of Small Colonic Polyps
The purpose of this study is to evaluate and compare the incomplete resection rates for small colon polyps less than or equal to 6 mm in size using two conventional polypectomy tools, jumbo cold biopsy forceps and cold snare.
- Trial name
- NCT02239549
- Testing
- Jumbo cold forceps polypectomy, Cold snare polypectomy
- Where
- United States
- Volunteers
- 419 people, healthy volunteers welcome
- Sponsor
- San Diego Veterans Healthcare System
Inflammatory Bowel Diseases, Colon Cancer
Pre-Habilitation Exercise Intervention
The purpose of this study is to see whether exercise can improve the health and well-being of patients scheduled to undergo surgery for a bowel related condition.
- Conditions
- Inflammatory Bowel Diseases, Colon Cancer, Rectal Cancer, Diverticular Disease
- Trial name
- NCT02849717
- Testing
- Exercise for Cancer Patients
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- University of Rochester
Colonic Polyp
Endoscopic Submucosal Dissection (ESD) Versus Endoscopic Mucosal Resection (EMR) for Large Non Pedunculated Colonic Adenomas: a Randomized Comparative Trial
Initially developed in Japan for the treatment of endemic superficial gastric cancers, endoscopic submucosal dissection (ESD) allows resection of pre-neoplastic and neoplastic lesions of the digestive tract into a single…
- Trial name
- RESECT COLON (NCT03962868)
- Testing
- Experimental procedure : ESD, Comparison procedure: WF-piece meal EMR
- Where
- 6 sites in France
- Volunteers
- 360 people
- Sponsor
- University Hospital, Limoges
Colon Resection
Regular Diet Versus Extended Low Residue After Colon Surgery
The goal of this clinical trial is to learn if a 10 day low-residue diet restriction is better for bowel function and quality of life without increasing complications compared to a 6 week low-residue diet restriction after…
- Trial name
- NCT07083076
- Testing
- Short term (10 day) low residue diet restriction, 6 week low residue diet restriction
- Where
- 2 sites in United States
- Volunteers
- 222 people
- Sponsor
- Northwell Health
Colorectal Adenocarcinoma Metastatic to the Liver
Study Comparing HAI Plus Chemotherapy and Chemotherapy Alone in Patients With Unresectable CRLM
To date no prospective trials have been completed that demonstrated whether HAI is an effective adjunct to systemic chemotherapy (target therapy) with respect to advantages in conversional resection rates and survival compared…
- Trial name
- NCT03125161
- Testing
- HAI, chemotherapy ± target therapy
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Fudan University
Colorectal Cancer Stage II, Colorectal Cancer Stage III
Epidemiological Study to Monitor Study Participants With Resected Stage II (High Risk) or Stage III Colorectal Cancer for Circulating Tumor DNA Before, During and After Their Treatment With Adjuvant Chemotherapy
This is a multi-site epidemiological study designed to monitor circulating tumor DNA (ctDNA) status in participants with Stage II (high risk)/III colorectal cancer (CRC) following resection/prior to adjuvant chemotherapy (AdCTx)…
- Trial name
- NCT04813627
- Testing
- Regular blood sample collection for ctDNA assessment
- Where
- 74 sites in United States, Belgium and 2 more
- Volunteers
- 2,079 people
- Sponsor
- BioNTech SE
Colorectal Neoplasms, Neoplasm Metastasis
Intraoperative Intraportal Chemotherapy Combined With Adjuvant Chemotherapy for Stage II and III Colorectal Cancer
In this study, the investigators assessed whether intraoperative Intraportal infusion of 5-FU and oxaliplatin is able to prevent liver metastasis in patients receiving curative colorectal cancer resection.
- Conditions
- Colorectal Neoplasms, Neoplasm Metastasis, Liver Neoplasms
- Trial name
- NCT01972503
- Testing
- 5-FU and oxaliplatin, colorectal cancer resection+ adjuvant chemotherapy (mFOLFOX6)
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Xu jianmin
Colonic Polyps
Detect InSpect ChAracterise Resect and Discard 2
Bowel cancer is a common disorder in the UK. Most cancers happen when a type of polyp, called an adenoma, becomes cancerous. Polyps are growths in the large bowel that can be cancerous, non-cancerous, or pre-cancerous (adenoma).
- Trial name
- DISCARD2 (NCT01603927)
- Testing
- Narrow band imaging for 'optical diagnosis' of colonic polyps (Olympus).
- Where
- 5 sites in United Kingdom
- Volunteers
- 2,500 people
- Sponsor
- South Tyneside and Sunderland NHS Foundation Trust
Colonic Fistula
Endoscopic Management Of Low Output Recurrent Colonic Fistula Or Leak After Anterior Resection For Rectal Cancer
This prospective randomized controlled clinical trial included all patients who developed the manifestations of low output recurrent colonic fistula or leak after colonic anterior resection for rectal cancer at Zagazig University…
- Trial name
- NCT05659446
- Testing
- endoscopy management of low output colonic fistula or leak after anterior resection for rectal cancer
- Where
- Egypt
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Colon Cancer, Resected Stage
A PHASE IB STUDY OF IMMUNOTHERAPY WITH EX VIVO PRE-ACTIVATED AND EXPANDED CB-NK CELLS IN COMBINATION WITH CETUXIMAB, IN COLORECTAL CANCER PATIENTS WITH MINIMAL RESIDUAL DISEASE (MRD)
A study of immunotherapy with expanded CB-NK cells in combination with cetuximab, to evaluate activity against minimal residual disease in patients with colon cancer that have completed adjuvant treatment but are positive for…
- Trial name
- NCT05040568
- Testing
- Cetuximab, Expanded CB-NK cells, Fludarabine phosphate
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- M.D. Anderson Cancer Center
Colon Cancer
Laparoscopic Versus Open Right Colectomy for Right Colon Cancer
The purpose of this research protocol is to compare open versus laparoscopic right colectomy (according to the CME technique of complete mesocolic excision) for right colon cancer.
- Trial name
- NCT05713903
- Testing
- Laparoscopic right colectomy, Open right colectomy
- Where
- Greece
- Volunteers
- 114 people
- Sponsor
- Larissa University Hospital
Colorectal Neoplasms
Colorectal Metastasis Prevention International Trial 2
The short perioperative period (days to weeks around surgery) is characterized by stress-inflammatory responses, including catecholamines (CAs, e.g., adrenaline) and prostaglandins (PGs, e.g., prostaglandin-E2) release, and…
- Trial name
- COMPIT-2 (NCT03919461)
- Testing
- Propranolol and etodolac
- Where
- 6 sites in Israel
- Volunteers
- 200 people
- Sponsor
- Assaf-Harofeh Medical Center
Colon Cancer
CME Versus Standard Right Hemicolectomy for Right Sided Cancers
Our aim of this study is to compare the difference in lymph node yield in CME specimens versus those patients having a standard right hemicolectomy for right sided cancer .The secondary aim of this study was to investigate…
- Trial name
- NCT05230329
- Testing
- right sided hemicolectomy, laparoscopy
- Where
- Denmark
- Volunteers
- 330 people
- Sponsor
- Odense University Hospital
Bowel; Functional Syndrome, Rectal Cancer
Long Term Bowel Function Following Rectal Cancer Surgery
In this longitudinal study, 171 patients were evaluated and compared based on the radiation therapy they received. Bowel function was assessed longitudinally with Memorial Sloan Kettering Cancer Center and Wexner scores every 6…
- Trial name
- NCT05339763
- Testing
- chemoradiotherapy
- Where
- Egypt
- Volunteers
- 171 people
- Sponsor
- Mansoura University
Colorectal Neoplasms, Adenoma Colon
Surveillance Intervals After Piecemeal Resection of Non-pedunculated Colorectal Lesions ≥20mm
Intensive endoscopic surveillance following piecemeal resection of non-pedunculated colorectal lesions (NPCL) ≥20 mm is the current standard of care, given the high recurrence rate of these lesions (15-30%).
- Conditions
- Colorectal Neoplasms, Adenoma Colon, Colonic Polyps, Serrated Adenoma
- Trial name
- NCT06791616
- Testing
- Colonoscopy
- Volunteers
- 746 people
- Sponsor
- Asociación Española de Gastroenterología