Clinical trials: Colon Surgery
Cholecystitis, Cholecystitis, Chronic
Shortwave Infrared Surgical Imaging Device Study
The goal of this observational study is to perform an in-human assessment of an investigational shortwave infrared (SWIR) imaging device, aimed to enhance the visualization of critical anatomical structures during surgical…
- Conditions
- Cholecystitis, Cholecystitis, Chronic, Chronic Calculous Cholecystitis, Primary Hyperparathyroidism
- Trial name
- NCT07744425
- Testing
- Observational study of SWIR imaging device in surgery
- Where
- 6 sites in United States
- Volunteers
- 50 people
- Sponsor
- Cision Vision, Inc.
Colorectal (Colon or Rectal) Cancer, Leak, Anastomotic
Predictive Model For Anastomotic Leakage After Colorectal Cancer Surgery
This pilot study aimed to develop a simplified early postoperative model for AL risk stratification using readily available clinical and laboratory variables.
- Conditions
- Colorectal (Colon or Rectal) Cancer, Leak, Anastomotic, Surgery Complications
- Trial name
- Doesn't exist (NCT07709923)
- Where
- Italy
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University of Foggia
Surgical Site Infection, Colon Surgery
D-PLEX 312 - Safety and Efficacy of D-PLEX in the Prevention of Post Abdominal Surgery Incisional Infection (SHIELD II)
Phase III, Prospective, Multinational, Multicenter, Randomized, Controlled, Two-arm, Double Blind Study to Assess Efficacy and Safety of D-PLEX Administered Concomitantly with the Standard of Care (SoC), Compared to a SoC Treated…
- Conditions
- Surgical Site Infection, Colon Surgery, Abdominal Surgery, Post-Op Infection
- Trial name
- D-PLEX312 (NCT04411199)
- Testing
- D-PLEX, Standard of Care (SoC)
- Where
- 58 sites in United States, Bosnia and Herzegovina and 11 more
- Volunteers
- 975 people
- Sponsor
- PolyPid Ltd.
Liver Transplant Surgery, Colorectal Cancer Metastatic
Colorectal Metastasis to Liver Extraction With Auxiliary Transplant and Delayed Resection
Liver transplantation (LT) has become an accepted treatment for selected patients with unresectable liver metastases due to colorectal cancer (CRLM).
- Conditions
- Liver Transplant Surgery, Colorectal Cancer Metastatic, Colon Cancer Liver Metastases
- Trial name
- CLEAR (NCT06698146)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Northwestern University
Colorectal Surgery, Benign or Malignant Rectal or Colon Tumors
Laparoscopic Colorectal Surgery Using Low-pressure Combined With Warm and Humidified Carbon Dioxide Insufflation
To improve post-operative recovery, medical device was developed combining low-pressure pneumoperitoneum and heated and humidified Carbon Dioxide (95˚F \& 95% RH) during laparoscopic surgery to reduce the harmful effects of…
- Trial name
- PAROS3 (NCT05934981)
- Testing
- Laparoscopic surgery under low pressure and warm and humidified CO2 Insufflation, Laparoscopic surgery under low pressure and conventional Insufflation
- Where
- 2 sites in France
- Volunteers
- 148 people
- Sponsor
- Bordeaux Colorectal Institute Academy
Minimal Invasive Surgery, Colon Surgery
The Anorectal Function and QoL of Patients Receiving Transrectal NOSE Via Rigid TAMIS Platform in Minimal Invasive Colon Surgery
The primary objective of this study is to prospectively determine and precisely estimate the incidence of Internal Anal Sphincter (IAS) Injury at 12 months following colectomy with Transrectal NOSE.
- Trial name
- NCT07653607
- Testing
- Pre-op and post-op anorectal function and quality of life evaluation
- Volunteers
- 57 people
- Sponsor
- Chang Gung Memorial Hospital
Elective Colon Surgery
Comparing No Mechanical Bowel Preparation With Oral Antibiotics Alone in Patients Undergoing Elective Colon Surgery
The REaCT NSQIP will compare oral antibiotics vs. no antibiotics, which are two standards of care treatments for preoperative preparation of the bowel prior to colorectal surgery
- Trial name
- REaCT-NSQIP (NCT03663504)
- Testing
- No Preparation, Neomycin and Flagyl
- Where
- 6 sites in Canada
- Volunteers
- 630 people
- Sponsor
- Ottawa Hospital Research Institute
Surgical Site Infection, Colon Surgery
D-PLEX 311: Safety and Efficacy of D-PLEX in the Prevention of Post Abdominal Surgery Incisional Infection
Phase III, Prospective, Multinational, Multicenter, Randomized, Controlled, Two-arm, Double Blind Study to assess Efficacy and Safety of D-PLEX Administered Concomitantly with the Standard of Care (SoC), compared to a SoC treated…
- Conditions
- Surgical Site Infection, Colon Surgery, Abdominal Surgery, Post-Op Infection
- Trial name
- NCT04233424
- Testing
- D-PLEX, Standard of Care (SoC)
- Where
- 62 sites in United States, Bulgaria and 8 more
- Volunteers
- 977 people
- Sponsor
- PolyPid Ltd.
Abdominal Surgery, Colon Surgery
D-PLEX 310: Safety and Efficacy of D-PLEX in the Prevention of Post Abdominal Surgery Incisional Infection
Subjects who are planned to undergo an abdominal (colon) surgery and who will meet the study entry criteria will be randomly divided into 2 groups: for half D-PLEX will be administered concomitantly with the standard of care…
- Conditions
- Abdominal Surgery, Colon Surgery, Post-Op Infection
- Trial name
- NCT03633123
- Testing
- D-PLEX, Standard of Care (SoC)
- Where
- 8 sites in Israel
- Volunteers
- 202 people
- Sponsor
- PolyPid Ltd.
Anastomosis; Complications, Anastomosis, Surgical
Role of Indexed Oxygen Delivery in Anastomotic Insufficiencies in Elective Laparoscopic Colorectal Resections for Cancer
Colorectal cancer is a very commonly diagnosed malignancy worldwide, and surgical resection remains the mainstay of treatment. Outcomes depend on preoperative staging, surgical quality, complication rates, and multidisciplinary…
- Conditions
- Anastomosis; Complications, Anastomosis, Surgical, Anastomosis, Leaking, Anastomotic Leaks
- Trial name
- NCT07099820
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Saint Camillus International University of Health Sciences
Laparotomy, Laparotomy Surgery
Saudi Emergency Laparotomy Audit
The Saudi Emergency Laparotomy Audit (SELA) is a national, multicenter observational clinical audit designed to evaluate outcomes and quality of care for patients undergoing emergency laparotomy in Saudi Arabia.
- Conditions
- Laparotomy, Laparotomy Surgery, Emergency Treatment, Abdominal Diseases
- Trial name
- SELA (NCT07429929)
- Testing
- Emergency Laparotomy
- Where
- Saudi Arabia
- Volunteers
- 10,000 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Colorectal Cancer (CRC), Rectal Cancer Surgery
Indocyanine Green Fluorescence Angiography in Laparoscopic Sigmoid and Rectal Cancer Surgery
Anastomotic leakage remains a major complication after colorectal cancer surgery. Indocyanine green fluorescence angiography (ICG-FA) allows real-time intraoperative assessment of bowel perfusion; however, its clinical impact…
- Conditions
- Colorectal Cancer (CRC), Rectal Cancer Surgery, Sigmoid Colon Cancer
- Trial name
- NCT07423130
- Where
- Poland
- Volunteers
- 115 people
- Sponsor
- Jagiellonian University
Rectal Tumors, Tumor of Sigmoid Colon
Effect of Dexmedetomidine on Lung Protection in Elderly Patients Undergoing Laparoscopic Surgery for Colorectal Cancer
The primary change in aging lung tissue among older people is atrophy, leading to a significant decline in ventilatory function.
- Conditions
- Rectal Tumors, Tumor of Sigmoid Colon, Lung Injury, Surgery, Laparoscopic
- Trial name
- Dex (NCT07385898)
- Testing
- Dexmedetomidine, Normal saline
- Where
- China
- Volunteers
- 64 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Cancer of Colon, Surgery
Effect of Music Prehabilitation on Preoperative Anxiety Before Surgery
The goal of this multicenter randomized controlled trial is to investigate the effect of music prehabilitation on preoperative anxiety in patients undergoing elective oncological colorectal resection.
- Conditions
- Cancer of Colon, Surgery, Anxiety
- Trial name
- MU-PRIOR (NCT05982184)
- Testing
- Music
- Where
- 5 sites in Netherlands
- Volunteers
- 116 people
- Sponsor
- Erasmus Medical Center
Anastomotic Leakage in Colon Surgery, Anastomotic Leak Rectum
Anastomotic Leakage in Colorectal Cancer Surgery in Syria
Anastomotic leakage is a serious complication of colorectal cancer surgery, particularly in resource-limited and conflict-affected settings.
- Conditions
- Anastomotic Leakage in Colon Surgery, Anastomotic Leak Rectum, Anastomotic Leak Large Intestine
- Trial name
- NCT07092631
- Where
- Syria
- Volunteers
- 119 people
- Sponsor
- Elie Bitar
Colon Cancer, Colon Adenocarcinoma
Sentinel Node and Organ-sparing Surgery in Stage I Colon Carcinoma
The aim of this study is to reduce the need for colectomy and its' associated morbidity and mortality in patients with pT1-2 colon carcinoma after endoscopic resection and an estimated lymph node metastasis (LNM) risk of >15%, or…
- Conditions
- Colon Cancer, Colon Adenocarcinoma, Sentinel Lymph Node, Sentinel Lymph Node Biopsy
- Trial name
- SENTRY (NCT06652672)
- Testing
- Organ-sparing surgery, Standard of care segmental resection
- Where
- Netherlands
- Volunteers
- 341 people
- Sponsor
- Meander Medical Center
Surgical Site Infection, Colon Surgery
Gut Decolonisation With Neomycin/Metronidazole or Rifaximin Before Colon Surgery
The goal of this clinical trial is to find out if a gut cleaning using Rifaximin works as well as the usual treatment with Neomycin and Metronidazole to prevent infections after colon surgery.
- Conditions
- Surgical Site Infection, Colon Surgery, Surgical Site Infections
- Trial name
- NeoRiDe (NCT07180615)
- Testing
- Rifaximin (Xifaxan), Metronidazole, Neomycin Sulfate
- Where
- 4 sites in Switzerland
- Volunteers
- 458 people
- Sponsor
- Universität Luzern
Colo-rectal Cancer, Colo-rectal Surgery
Post Operative Hospital at Home After Colorectal Surgery
The goal of this feasibility study is to investigate whether a virtual Hospital at Home is safe and possible for patients undergoing planned minimally invasive colorectal surgery.
- Conditions
- Colo-rectal Cancer, Colo-rectal Surgery, Colocolic and Ileocolic Anastomosis, Colon and/or Rectal Resection With Anastomosis for Cancer
- Trial name
- POPHaH (NCT07113717)
- Testing
- virtual Hospital at Home
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Nordsjaellands Hospital
Pain, Postoperative, Pain, Abdominal
Optimal Peripheral Nerve Block After Minimally Invasive Colon Surgery
The purpose of the trial is to identify the "most simple non-inferior of three different methods", placebo, laparoscopic assisted transverse abdominal plane block (L-TAP) and ultrasound guided TAP block (US-TAP), using…
- Conditions
- Pain, Postoperative, Pain, Abdominal, Analgesia, Surgery
- Trial name
- OPMICS (NCT04311099)
- Testing
- Active drug, Injection of Ropivacaine - Ultrasound-guided transverse abdominal plane block, Injection of Ropivacaine - Laparoscopic assisted transverse abdominal plane block
- Where
- 5 sites in Denmark
- Volunteers
- 360 people
- Sponsor
- Claus Anders Bertelsen, PhD, MD
Colorectal Surgery, Benign or Malignant Rectal or Colon Tumors
Low Stable Pressure Pneumoperitoneum in Colorectal Surgery (CROSS STUDY)
The objective of this prospective, international cohort is to incorporate the low stable pressure (using Airseal Insufflator) approach and its associated parameters into the early rehabilitation program after colorectal surgery…
- Trial name
- CROSS (NCT06154785)
- Where
- 18 sites in Belgium, France and 6 more
- Volunteers
- 300 people
- Sponsor
- Bordeaux Colorectal Institute Academy