Clinical trials: Colon Surgery, open to volunteers
Colorectal Cancer, Neoadjuvant Radiotherapy
Perioperative Complications After Neoadjuvant Radiotherapy for Colorectal Cancer
Neoadjuvant radiotherapy plays an important role in the treatment of locally advanced colorectal cancer. Although radiation therapy is extremely important in reducing the tumor mass, downstaging, and therefore providing…
- Conditions
- Colorectal Cancer, Neoadjuvant Radiotherapy, Perioperative Complication
- Trial name
- NCT07249333
- Where
- Serbia
- Volunteers
- 80 people
- Sponsor
- Oncology Institute of Vojvodina
Colo-rectal Cancer
Safety & Efficacy of a Novel Asymmetrical Linear Stapler (NALS) for Securing Distal Resection Margin in Laparoscopic Rectal Cancer Surgery: Pilot Study
Through the use of a novel asymmetrical linear stapler (NALS, Meditulip co. Ltd.), we aim to prove that true distal margins greater than 1cm may be harvested more readily and easily compared to the conventional staplers.
- Trial name
- NCT06709170
- Testing
- Novel asymmetrical linear stapler, Signia™
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Colon Cancer, dMMR Colorectal Cancer
Single Arm Study of Neoadjuvant Dostarlimab in Stage II and III Deficient Mismatch Repair Colon Cancers
This is a Phase II, single arm study looking at the rate of major clinical response and non-operative management in Stage II and III colon cancer after 18 weeks (up to 6 cycles) of neoadjuvant dostarlimab.
- Trial name
- NAIO (NCT05239546)
- Testing
- Dostarlimab
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- University of Iowa
Colorectal Carcinoma, Day Surgery
Clinical Research on the Treatment Model of Ambulatory Surgery for Colorectal Cancer
To investigate the postoperative complication incidence and long-term efficacy between ambulatory surgery for colorectal cancer and traditional laparoscopic colorectal surgery in patients with colorectal tumor who are generally…
- Trial name
- NCT06637215
- Testing
- laparoscopic colorectal day surgery, traditional laparoscopic colorectal surgery
- Where
- China
- Volunteers
- 352 people
- Sponsor
- First Hospital of China Medical University
Colo-rectal Cancer, Liver Metastasis
The Role and Safety of Radiofrequency Ablation in Recurrent Liver Metastasis of Colorectal Cancer
The goal of this clinical trial is to learn if radiofrequency ablation works to treat recurrent colorectal cancer liver metastases after surgery in adults. It will also learn about the safety of radiofrequency ablation.
- Trial name
- NCT06609434
- Testing
- Radiofrequency ablation
- Volunteers
- 111 people
- Sponsor
- Peking University Cancer Hospital & Institute
Colorectal Cancer (CRC)
Trial of Gum Chewing to Enhance the Restoration of Intestinal Motility in Colorectal Cancer Surgery
Surgery is one of the most frequent treatments of colorectal cancer. However, delayed restoration of intestinal motility is a common phenomenon in patients who undergo colorectal surgery, and may reduce comfort, prevent the early…
- Trial name
- NCT06860685
- Testing
- gum chewing
- Where
- China
- Volunteers
- 292 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute
Bowel Sounds, Colorectal Cancer
The Value of Bowel Sounds in Evaluating Postoperative Intestinal Function Recovery in Colorectal Cancer Patients
This study enrolls patients scheduled to undergo curative surgery for colorectal cancer. Bowel sounds will be assessed preoperatively and postoperatively.
- Conditions
- Bowel Sounds, Colorectal Cancer, Intestinal Obstruction, Postoperative Ileus
- Trial name
- BRIEF (NCT07705139)
- Testing
- colorectal surgery
- Where
- China
- Volunteers
- 172 people
- Sponsor
- Zhongnan Hospital
Peritoneal Carcinomatosis
Flat Dose vs. Weight-based IP Chemotherapy for CRS/HIPEC
Peritoneal carcinomatosis from advanced gastro-intestinal malignancy has historically been associated with poor overall survival (≤ 12 months) with few treatment options.
- Trial name
- NCT04779554
- Testing
- Mitomycin C, flat dose 40 mg, Mitomycin C, weight-based dose 12.5 mg/m2
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Prakash Pandalai
Colorectal Cancer
Short-term and Long-term Outcomes of Colorectal Cancer Treated With Natural Orifice Specimen Extraction Surgery : a National Registry-based Study
Natural orifice specimen extraction surgery (NOSES) has gained widespread recognition among scholars and has gradually been promoted and popularized around the world.
- Trial name
- NCT06350370
- Testing
- Natural orifice specimen extraction
- Where
- China
- Volunteers
- 8,000 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Colorectal Cancer
T1 Colorectal Cancer After Local Excision: Decision Between Surgery and Active Surveillance (T1LDA Trial)
The goal of this two-arm clinical trial is to compare additional surgery with active surveillance in patients with high-risk pT1 colorectal cancer after local excision.
- Trial name
- T1LDA (NCT07900620)
- Testing
- Additional surgery
- Where
- 14 sites in Finland
- Volunteers
- 500 people
- Sponsor
- Tampere University Hospital
Diverticulitis Colon, Quality of Life
Quality of Life and Surgery in Diverticular Disease
Diverticular disease is one of the most common diseases of the gastrointestinal tract in industrial countries. Prevalence and admission rate due to diverticular disease increases.
- Conditions
- Diverticulitis Colon, Quality of Life, Diverticular Disease of Left Side of Colon
- Trial name
- NCT05393609
- Testing
- Sigmoidectomy, Conservative
- Where
- Denmark
- Volunteers
- 250 people
- Sponsor
- University of Aarhus
Colorectal Cancer
To Explore the Effect of Huaier Granule on the Negative Conversion Rate After the CEA Level Increases Again After Colorectal Cancer Surgery
This study is a prospective, observational and exploratory study to explore the effect of Huaier Granule on the negative conversion rate of patients with increased CEA levels after colorectal cancer surgery.
- Trial name
- NCT06665334
- Testing
- Huaier granule
- Volunteers
- 134 people
- Sponsor
- Fudan University
Quality of Life (QOL), Mismatch Repair Deficient Colorectal Cancer
Research on Effective Strategies After Immunotherapy for Mismatch Repair-deficient Early-stage GI Tumors
This cohort study is divided into two parts: Part A: Registry Cohort All patients with non-metastatic, MMRd/MSI-H colorectal cancers (and other gastrointestinal cancers for exploratory analysis) who have signed the general…
- Conditions
- Quality of Life (QOL), Mismatch Repair Deficient Colorectal Cancer, Microsatellite Instability-High Colorectal Cancer, Stage II Colorectal Cancer
- Trial name
- RESIST (NCT07829081)
- Testing
- Active surveillance after complete response to immunotherapy in MMRd GI cancers, Stand of Care
- Where
- 3 sites in Switzerland
- Volunteers
- 234 people
- Sponsor
- University Hospital, Basel, Switzerland
Colorectal Cancer, Rectal Cancer
A Study of Botensilimab and Balstilimab for Colorectal Cancer With ctDNA+ After Surgery and Chemotherapy
The researchers are doing this study to find out whether the combination of botensilimab and balstilimab (BOT/BAL), followed by balstilimab alone, is an effective treatment for people with microsatellite stable (MSS) colorectal…
- Trial name
- NCT07227636
- Testing
- Botensilimab, Balstilimab
- Where
- 7 sites in United States
- Volunteers
- 284 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Colorectal Cancer, Colorectal Neoplasms
PRIORITY-CONNECT 2 Trial
Objectives: The primary aim of this project is to establish the effectiveness of an individualised stepped, multidisciplinary intervention, including education and peer support group, delivered via a virtual multimodal…
- Trial name
- PC2 (NCT06976710)
- Testing
- Preoperative Exercise, Postoperative Exercise, Preoperative Nutrition
- Where
- 31 sites in Australia
- Volunteers
- 564 people
- Sponsor
- Surgical Outcomes Research Centre (SOuRCe)
Low Anterior Resection Syndrome, Rectal Cancer Surgery
Transanal Irrigation for Low Anterior Resection Syndrome
The preservation surgery of the anal sphincter muscle has become the standard procedure in the treatment of rectal cancer and, thanks to advancements in surgical techniques, can now be performed for tumors located closer to the…
- Conditions
- Low Anterior Resection Syndrome, Rectal Cancer Surgery, Insomnia
- Trial name
- TraLARS (NCT06796296)
- Testing
- Transanal Irrigation (TAI)
- Where
- South Korea
- Volunteers
- 94 people
- Sponsor
- Seoul National University Hospital
Surgery--Complications
Does Prehabilitation Improve Outcome in Coloncancer Surgery?
The study aims to find out if complications after surgery for large bowel (colon) cancer can be reduced or avoided in the most frail and elderly by letting them go through an exercise- and diet regime prior to the surgical…
- Trial name
- PRIO (NCT04199208)
- Testing
- Prehabilitation and Immunonutrition, Standard Care Arm
- Volunteers
- 160 people
- Sponsor
- Region Skane
Right Hemicolectomy
Fluorescence Lymph Node Mapping for Colon Cancer Surgery
Fluorescence-guided surgery using indocyanine green can visualize the complex and diverse lymph node drainage structures for each patient and help determine the extent of dissection of the D3 lymph node tailored to the patient.
- Trial name
- CONSTELLARE (NCT07060443)
- Testing
- Indocyanine green (ICG) injection for intraoperative lymph node imaging, Standard Right Hemicolectomy (Non-ICG)
- Where
- 13 sites in South Korea
- Volunteers
- 186 people
- Sponsor
- Pusan National University Yangsan Hospital
Colorectal Cancer
Prospective Study of Extended Robotic Right Hemicolectomy With Complete Mesocolic Excision for Cancer
A single-center prospective study to elucidate whether extended robot-assisted right colectomy (e-RARC) performs as well as extended open right colectomy (e-ORC) in terms of specimen quality, and in addition, whether less…
- Trial name
- NCT04190589
- Testing
- Robot-assisted laparoscopic extended right colectomy
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Vejle Hospital
Colorectal Cancer, Colorectal Anastomosis
Single-Stapled Technique for Colorectal Anastomosis
The goal of this observational multicenter study is to evaluate the safety and feasibility of a single-stapled technique (SST) for colorectal anastomosis and to explore whether this technique is associated with a reduced rate of…
- Conditions
- Colorectal Cancer, Colorectal Anastomosis, Anastomotic Leakage, Diverticular Disease of Left Side of Colon
- Trial name
- SST (NCT07417358)
- Testing
- Single-stapled colorectal anastomosis, Double-stapled colorectal anastomosis
- Where
- 5 sites in Sweden
- Volunteers
- 500 people
- Sponsor
- Umeå University