Clinical trials: Colonic Adenomatous Polyps
Colonic Dysplasia, Adenomatous Polyps
Study of Performance of Confocal Endomicroscope With Fluorescein Imaging Agent in the Colon
The overall aim of this research project is to evaluate the imaging performance of a confocal endomicroscope. Fluorescein, an FDA-approved topical fluorescent dye, will be used to provide topical mucosal contrast.
- Conditions
- Colonic Dysplasia, Adenomatous Polyps, Irritable Bowel Disease
- Trial name
- NCT03220711
- Testing
- confocal endomicroscope, Fluorescein
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Michigan
Cancer
Incidental Cancer in Familial Adenomatous Polyposis
Colectomy is life-saving in patients with familial adenomatous polyposis (FAP) because cancer development is inevitable in individuals with this disease.
- Trial name
- NCT05171426
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Dr. Ersin Arslan Education and Training Hospital
Familial Adenomatous Polyposis
Azithromycin Treatment for Readthrough of APC Gene Stop Codon Mutations in Familial Adenomatous Polyposis
Colorectal cancer (CRC) is a leading cause for cancer related mortality in the western world with a lifetime risk of 6%. Etiology is complex, while genetic background significantly affects the risk.
- Trial name
- FAP (NCT04454151)
- Testing
- Azithromycin Tablets
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Colorectal Neoplasm, Colorectal Cancer
Colorectal Cancer Screening Using Stool DNA-based SDC2 and SFRP2 Methylation Test in China
The primary objective is to determine sensitivity, specificity, positive predictive value and negative predictive value of a bi-target stool DNA testing (the methylation status of SDC2 and SFRP2) for colorectal cancer and…
- Conditions
- Colorectal Neoplasm, Colorectal Cancer, Adenomatous Polyps, Adenoma
- Trial name
- NCT04515082
- Testing
- Stool-based SDC2 and SFRP2 DNA methylation test, FIT
- Volunteers
- 4,800 people
- Sponsor
- Changhai Hospital
Familial Adenomatous Polyposis (FAP)
Observational Familial Adenomatous Polyposis Registry Study In Patients Receiving Celecoxib Compared to Control Patients
This is a registry-based observational study assessing clinical outcomes in FAP patients receiving celecoxib compared with historical/concurrent registry patients who have not received celecoxib.
- Trial name
- NCT00151476
- Testing
- Celecoxib, Routine Medical Care
- Where
- 4 sites in United States, Canada and 2 more
- Volunteers
- 68 people
- Sponsor
- Pfizer
Colonic Adenomatous Polyps
Effectiveness and Safety of the Endoscopic Removal of Large and Flat Colonic Polyps With LumenR RetractorTM
Colorectal cancer accounted for 142,570 new cancer cases and 51,370 cancer deaths in USA in 2010 and worldwide has become the third most common cancer and second leading cause of cancer related deaths.
- Trial name
- NCT02051465
- Testing
- LumenR Retractor, Removal without overtube
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Mercy Medical Center
Familial Adenomatous Polyposis (FAP)
Expanded Access to 0.5 mg eRapa for Familial Adenomatous Polyposis
This expanded access program provides 0.5 mg eRapa (encapsulated rapamycin) to patients with familial adenomatous polyposis (FAP) who have no satisfactory alternative treatment options and are not eligible to participate in a…
- Trial name
- eRapa-FAP (NCT07689942)
- Testing
- eRapa (encapsulated rapamycin)
- Sponsor
- Biodexa Pharmaceuticals