Clinical trials: Colonic Diseases, Functional
Functional Gastrointestinal Disorders, Overlap Syndromes
Overlap FGIDs and Genetic Polymorphism
1. To analyze the prevalence of overlap syndromes among NERD or RH, FD, and IBS patients, and to identify and to compare the differences in their characteristics and symptoms, and to determine their risk factors. 2.
- Trial name
- NCT04712617
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Clostridium Difficile Infection, Multi Drug Resistant Organisms
Establishment of the Human Intestinal and Salivary Microbiota Biobank - Gastrointestinal Diseases
This is a prospective, clinical, multicentre study aimed to collect biological samples and study microbiota from subjects with Clostridium Difficile (CDI), subjects affected by Multi Drug Resistant Organisms (MDRO) infection…
- Conditions
- Clostridium Difficile Infection, Multi Drug Resistant Organisms, Chronic Inflammatory Bowel Disease, Irritable Bowel Syndrome
- Trial name
- BIOMIS-Gastr (NCT04698148)
- Testing
- Biological sample collection, Questionnaire, Medical examination
- Where
- 3 sites in Italy
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Lactose Intolerance, Irritable Bowel Syndrome
The Effects of Lactose Intolerance on Gastrointestinal Function and Symptoms in a Chinese Population
Lactose is a carbohydrate found in milk,and Lactase Deficiency (LD) is a condition in which the small intestine cannot digest this carbohydrate due to absent or insufficient amounts of lactase.Individuals with LD may be…
- Trial name
- NCT01286597
- Testing
- dietary restriction
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Sir Run Run Shaw Hospital
Irritable Bowel Syndrome, Diarrhea- Irritable Bowel Syndrome
To Study the Effect of Short-chain Fructooligosaccharides in Women With Irritable Bowel Syndrome
To evaluate whether there is clinical improvement through the scales (Bristol, IBS severity score, and IBS quality of life) in women with irritable bowel syndrome after administration of SC-FOS (short-chain…
- Conditions
- Irritable Bowel Syndrome, Diarrhea- Irritable Bowel Syndrome, Constipation-predominant Irritable Bowel Syndrome
- Trial name
- NCT05941650
- Testing
- Short Chain Fructooligosaccharides, Corn Starch
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Chihuahua
Irritable Bowel Syndrome
A Clinical Study to Determine the Safety and Efficacy of An Oral Probiotic Supplementation in the Management of Irritable Bowel Syndrome With Protein Digestion.
This is an open-label, two-arm, prospective, interventional, in-use safety and efficacy study of an oral probiotic supplementation in adult subjects having irritable bowel syndrome.
- Trial name
- NCT06687720
- Testing
- MetBroma
- Where
- India
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- NovoBliss Research Pvt Ltd
Irritable Bowel Syndrome
Brain-derived Neurotrophic Factor Participates in Visceral Hyperalgesia in Irritable Bowel Syndrome (IBS) Patients
Brain-derived neurotrophic factor (BDNF), originally known to be a member of the nerve growth factor family, has aroused attention as a modulator in visceral hyperalgesia recently.
- Trial name
- NCT00925223
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Shandong University
Irritable Bowel Syndrome
Clinical Effectiveness of Enteric Coated(E.C.) Anise-oil on Irritable Bowel Syndrome
Colpermin ® (Peppermint oil) is used in the treatment of Irritable Bowel Syndrome but Peppermint (Mentha x piperita) isn't native in Iran.
- Trial name
- IBS-Anise (NCT02364830)
- Testing
- Anise-oil EC Capsule, Colpermin®
- Where
- 2 sites in Iran
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Shiraz University of Medical Sciences
IBS - Irritable Bowel Syndrome
Gluten Free Diet in IBS Patients Stratified According to Their Antigliadin Status
Gluten-free diet has been shown to improve gut symptoms in patients with celiac disease and also in adult patients with diagnosis of Irritable Bowel Syndrome (Rome III criteria).
- Trial name
- GFD_IBS (NCT03492333)
- Testing
- Gluten free diet
- Where
- Canada
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- McMaster University
Irritable Bowel Syndrome, Abdominal Pain
Impact of a Yoga Intervention on Pain and Multiomics in Participants With IBS
The purpose of this research study is to see if a six-week yoga program delivered online/virtually via Zoom, reduces abdominal pain in people with irritable bowel syndrome (IBS).
- Trial name
- NCT04315714
- Testing
- Yoga Program
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Allergic Rhinitis, Asthma
Integrating Targeted MedlinePlus Health Prescriptions Into Clinic Practice Workflow
The specific aim of this proposed project is to implement a standard process for integrating MedlinePlus health information prescriptions into the clinic workflow.
- Conditions
- Allergic Rhinitis, Asthma, Back Pain, Benign Prostatic Hypertrophy
- Trial name
- NCT00634608
- Testing
- Health Information Prescription
- Where
- United States
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Irritable Bowel Syndrome
A Phase 1, First Time in Human (FTIH) Study to Evaluate GSK3352589, a REarranged During Transfection (RET) Growth Factor Receptor Tyrosine Kinase Inhibitor, in Healthy Volunteers
This FTIH study is designed to assess the safety, tolerability and pharmacokinetic (PK) of escalating single and repeat oral doses of GSK3352589 in normal healthy volunteers.
- Trial name
- NCT03154086
- Testing
- GSK3352589
- Where
- Australia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Irritable Bowel Syndrome
Multicenter Withdrawal Clinical Trials of N-acetyl Glucosamine Capsule for IBS-D Treatment
This study is a withdrawal randomized clinical trail to evaluate the clinical efficacy and safety of 1.1 chemical drugs N-acetyl glucosamine on Chinese IBS-D patients coming from four centers in chongqing.
- Trial name
- NCT01893606
- Testing
- N-acetyl-D-glucosamine
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Third Military Medical University
Stress, Irritable Bowel Syndrome
Evaluating and Treating Potential Research Participants With Digestive Disorders
Background: Some research studies focus on digestive disorders, such as nutritional, gastrointestinal, and liver disorders. Researchers want to examine and treat people with digestive disorders in order to learn more about these…
- Conditions
- Stress, Irritable Bowel Syndrome, Obesity, Abdominal Pain
- Trial name
- NCT01736280
- Testing
- Standard of Care
- Where
- United States
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- National Institute of Nursing Research (NINR)
Irritable Bowel Syndrome
Phase I Clinical Trial of DA-6886 in Healthy Male Subjects
DA-6886_IBS_I is a phase I, dose block-randomized, double-blind, placebo-controlled, single/multiple dosing, dose escalation clinical trial with open-labelled food effect study of single dose to investigate the safety…
- Trial name
- NCT01633723
- Testing
- DA-6886
- Where
- South Korea
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Dong-A ST Co., Ltd.
Inflammatory Bowel Diseases, Irritable Bowel Syndrome
Precision Diagnostics of Functional and Organic Intestinal Pathology Based on Cellular and Molecular Profiling
Differential diagnosis of functional and organic intestinal pathology is carried out in line with approved clinical guidelines and includes a significant list of interventions.
- Conditions
- Inflammatory Bowel Diseases, Irritable Bowel Syndrome, Healthy Volunteers
- Trial name
- NCT05277662
- Testing
- cell and molecular diagnostics in accordance with functional test results
- Where
- 2 sites in Russia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Moscow State University of Medicine and Dentistry
Irritable Bowel Syndrome
Effect of Modified Cellulose on Colonic Fermentation of Inulin
A 3-way randomised cross-over study to test the hypothesis that combining either psyllium or methylcellulose to form a gel incorporating inulin will reduce gas production as compared to inulin given with a placebo, maltodextrin.
- Trial name
- COCOA2 (NCT05911347)
- Testing
- Psyllium, Methylcellulose, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Intestinal Diseases, Irritable Bowel Syndrome
Biomarkers for Intestinal Permeability in Patients With Constipation
Our overall objective with this study is firstly to provide a comprehensive assessment of intestinal permeability, mucosal barrier function using existing biomarkers and secondly to explore novel biomarkers for measuring…
- Conditions
- Intestinal Diseases, Irritable Bowel Syndrome, Constipation
- Trial name
- NCT02246647
- Testing
- Permeability measurement, Esophagogastroduodenoscopy, Flexible sigmoidoscopy
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Irritable Bowel Syndrome, Gallstone Disease
Pharmacokinetics, Bioequivalence, and Safety Study of Trimedat® 76,95 mg Orally Disintegrating Tablets and Trimedat® 100 mg Tablets in Healthy Volunteers.
This study aims to evaluate pharmacokinetic profile, safety and establish bioequivalence of the investigational drug Trimedat® 76,95 mg orally disintegrating tablets compared to the reference drug Trimedat® 100 mg tablets in…
- Conditions
- Irritable Bowel Syndrome, Gallstone Disease, GERD, Biliary Dyskinesia
- Trial name
- NCT07421011
- Testing
- Trimedat®
- Where
- Russia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Valenta Pharm JSC
Colorectal Cancer (CRC) Screening
A Novel Multi-functional Artificial Intelligence System on Treatment Efficacy and Implementation in Colonoscopy
To overcome non-neoplastic polyp (NNP) resections, computer-aided diagnosis (CADx) systems have been developed. In a meta-analysis, the performance of CADx systems was superior to endoscopists.
- Trial name
- mAInstream (NCT07844252)
- Testing
- CADe/CADx
- Volunteers
- 2,818 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Irritable Bowel Syndrome, Microbial Colonization
Microbiota Profiling in IBS
This study investigates differences in microbiota profiles and metabolite levels between mild and severe IBS patients, compared to matched healthy controls. Two fecal samples, with one month in between, will be analyzed.
- Conditions
- Irritable Bowel Syndrome, Microbial Colonization, Dietary Habits
- Trial name
- IBSQUtrition (NCT03720314)
- Testing
- NA observational study
- Where
- Netherlands
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Wageningen University