Clinical trials: Colonic Diseases, Functional
Fibromyalgia, Irritable Bowel Syndrome
Patient-reported Outcome Measures (PROMs) in Patients With Bodily Stress Syndrome: Protocol for a Prospective Cohort Study
This cohort study implements patient reported outcome measures (PROMs) for patients with bodily stress syndrome in a clinic for functional disorders.
- Conditions
- Fibromyalgia, Irritable Bowel Syndrome, Somatic Symptom, Chronic Fatigue Syndrome
- Trial name
- SYMPA (NCT04667611)
- Testing
- Psychosocial interventions
- Where
- Finland
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Inflammation, Colon, Irritable
The Role of Intestinal Inflammation in Irritable Bowel Syndrome (IBS)
The research project addresses the following hypotheses (A) the normal balance of beneficial and detrimental commensal intestinal bacteria is deranged in IBS, with selective alterations in clinically defined patient subsets i.e.…
- Conditions
- Inflammation, Colon, Irritable, Colonic Diseases, Functional, Irritable Bowel Syndrome
- Trial name
- K23 (NCT01072903)
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Irritable Bowel Syndrome
Curcumin (Tumeric) in the Treatment of Irritable Bowel Syndrome: A Randomized-Controlled Trial
Evidence exists to support low-grade inflammation as the inciting factor leading to visceral hypersensitivity and alteration in motility in irritable bowel syndrome.In the medical literature,there is ample in vitro and in vivo…
- Trial name
- CuTIBS (NCT00779493)
- Testing
- curcumin
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Irritable Bowel Syndrome (IBS), Anxiety
Anxiety and Depression in IBS: A Brain-Gut Axis Study
This study aims to understand how the gut and the brain communicate in people with Irritable Bowel Syndrome (IBS) who also experience anxiety and depression.
- Conditions
- Irritable Bowel Syndrome (IBS), Anxiety, Depression
- Trial name
- NCT07646834
- Testing
- Observational Study (No Intervention)
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Irritable Bowel Syndrome
The FAIS-Trial: Faecal Microbiota Transplantation (FMT) in Adolescents With Refractory Irritable Bowel Syndrome (IBS)
A Double-blind randomised placebo-controlled pilot study as well as a reversed translational part To investigate whether two faecal transplantations from either allogeneic (healthy) or autologous (own) donor, administered through…
- Trial name
- FAIS (NCT03074227)
- Testing
- Allogeneic faecal transplantation, Autologous faecal transplantation
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
IBS - Irritable Bowel Syndrome, Anxiety
Study to Evaluate the Efficacy of Arrae's Bloat & Calm Alchemy Capsules to Reduce Bloating, Heartburn and Gas, and Alleviate the Intensity of IBS Symptoms
This is an open-label observational crossover trial to study the efficacy of a commercial dietary supplement and its effect on common symptoms of IBS (such as bloating, gas, heartburn, and other symptoms).
- Trial name
- NCT05197413
- Testing
- Arrae bloat supplement
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Arrae
Irritable Bowel Syndrome
Management of Irritable Bowel Syndrome in Primary Care (MIBS Trial)
Aims: 1. To pilot an randomized, controlled trial (RCT) to assess the effectiveness of the commonly prescribed medications in UK general practice for IBS: mebeverine (anti-spasmodic) and methylcellulose (bulking-agent) and of the…
- Trial name
- MIBS (NCT00934973)
- Testing
- mebeverine, methylcellulose, CBT website with support
- Where
- United Kingdom
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Hazel Everitt
IBS - Irritable Bowel Syndrome, Healthy
Capsule Microbiota Sampling in IBS/Functional Gastrointestinal Disease
We will sample intestinal microbiota using a microbiome sampling capsule in Healthy, Irritable Bowel Syndrome (IBS), and Functional Gastrointestinal Disease.
- Conditions
- IBS - Irritable Bowel Syndrome, Healthy, Functional Bloating, Functional Gastrointestinal Disorders
- Trial name
- NCT06215222
- Testing
- Microbiota Sampling
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Stanford University
Irritable Bowel Syndrome, Ulcerative Colitis
Phenotyping IBS: Perceptions and Modulations of Visceral Sensations
The purpose of this research study is to improve the understanding of irritable bowel syndrome (IBS) and its underlying cause. The investigators will use magnetic resonance imaging (MRI) to observe differences in the brain…
- Conditions
- Irritable Bowel Syndrome, Ulcerative Colitis, Inflammatory Bowel Disease
- Trial name
- PMVS-P (NCT02693730)
- Where
- United States
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Colorectal Cancer
A Longitudinal Investigation of Cognitive Function in Colorectal Cancer Patients
This is a prospective, longitudinal, controlled study of cognitive function and fatigue in patients with apparently localized CRC treated with adjuvant or neoadjuvant chemotherapy.
- Trial name
- NCT01457287
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Irritable Bowel Syndrome, Crohn Disease
Evaluation of the SIMBA Capsule for Small Intestinal Dysbiosis
The SIMBA Capsule is a small, single-use, ingestible capsule that allows for the non-invasive sampling of small bowel contents using purely mechanical means.
- Conditions
- Irritable Bowel Syndrome, Crohn Disease, Celiac Disease, Ulcerative Colitis
- Trial name
- NCT05633706
- Testing
- fluid biopsy capsule
- Where
- Canada
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Nimble Science Ltd.
Irritable Bowel Syndrome
Brain and Gut Responses to Intragastric Administration of FODMAPs in Healthy Subjects and Patients With Irritable Bowel Syndrome
Low fermentable oligo-, di- and monosaccharides and polyols (FODMAPs) diet is taken as a possible strategy to improve symptoms in IBS patients.
- Trial name
- FODMAPs (NCT04283487)
- Testing
- Fructans, Glucose, Saline
- Where
- Belgium
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Abdominal Pain
Objective Integrated Multimodal Electrophysiological Index for the Quantification of Visceral Pain
The objectives of the study are to 1) Conduct telemetric biosignals (EDA, ECG, and EMG) recording in healthy controls and IBS participants experiencing cutaneous and visceral pain; and 2) Validate the OIME index as a biomarker…
- Trial name
- OIME (NCT06381921)
- Testing
- IBS-PPSM intervention
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Hepatocellular Cancer, Non-small Cell Lung Cancer
Profile of Soluble and Cellular Biomarkers and of Functional Imaging During Antiangiogenic Therapies in Cancer Patients
Tumour angiogenesis has been identified to play a critical role in tumour growth and this knowledge has led to the identification of new targets for cancer therapy.
- Conditions
- Hepatocellular Cancer, Non-small Cell Lung Cancer, Renal Cell Cancer, Colorectal Cancer
- Trial name
- NCT01507740
- Testing
- Avastin, Suntent, Nexavar
- Where
- Austria
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Irritable Bowel Syndrome
Effect of Chronic Feeding of Inulin And Methylcellulose on Colonic Fermentation
To determine the effect on tolerance and gas production from chronic feeding of fermentable fibre (inulin) incorporated into a gel forming fibre (methylcellulose) compared with placebo (maltodextrin)
- Trial name
- CINNAMON (NCT06551961)
- Testing
- methylcellulose, inulin, maltodextrin
- Where
- 2 sites in United Kingdom
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Irritable Bowel Syndrome
SBI in Children With d-IBS
IBS is the most common diagnosis in new patients in our pediatric gastroenterology clinic, accounting for 36 % of all new patients.
- Trial name
- NCT02609529
- Testing
- Medical Food
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Irritable Bowel Syndrome
Ileocecal Sphincter Reflex by Cecal Distension During Colonoscopy
The aim of the current study is to test the hypothesis that patients with IBS may have a defective ICV pressures and may have small bowel bacterial overgrowth.
- Trial name
- NCT01413945
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Irritable Bowel Syndrome With Constipation
An Evaluation of Cultured Milk Drink on Immune Status of Patients With Irritable Bowel Syndrome: Constipation Predominant
Our previous work on the use of probiotics improved the clinical symptoms in irritable bowel syndrome with constipation-predominant.
- Trial name
- NCT04647045
- Testing
- Cultured milk drink
- Where
- Malaysia
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Irritable Bowel Syndrome, Abdominal Pain
Comparing a 182mg Colon-targeted-delivery Peppermint Oil Capsule (Tempocol-ColoPulse®) and a 182mg Enteric-coated Peppermint Oil Capsule (Tempocol®), a Pharmacokinetic Study
This is a pilot study to compare the relative bioavailability between two peppermint oil formulations, namely a ileocolonic release peppermint oil and an small intestinal release peppermint oil (Tempocol®).
- Conditions
- Irritable Bowel Syndrome, Abdominal Pain, Colonic Diseases, Visceral Pain
- Trial name
- NCT02291445
- Testing
- Menthae piperitae aetheroleum/peppermint oil (enteric coated capsule), Menthae piperitae aetheroleum/peppermint oil (colon-targeted-delivery capsule)
- Where
- Netherlands
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
IBS - Irritable Bowel Syndrome
Irritable Bowel Syndrome and Control Volunteers: Diet Challenge
The purpose of this study is to study the relationship between the bile acids, short chain fatty acids and bacteria within the intestines.
- Trial name
- NCT03983434
- Testing
- Inulin
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Indiana University