Clinical trials: Colonic Motility
Colo-rectal Cancer
Motility of the Check-cap's MD1 Colon Capsule in Subjects Following Colon Rectal Cancer Screening by Colonoscopy
To monitor the Whole Gut Transit Time and repeatability of the motility of MD1 capsules in the colon of subjects with known polyps and in healthy subjects. Multi-Center, Open, Home Monitoring, Prospective Study.
- Trial name
- NCT03785665
- Testing
- MDI
- Where
- Israel
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Check-Cap Ltd.
IBS - Irritable Bowel Syndrome, Gastrointestinal Motility Disorder
Effects of Epetôme on Gastrointestinal Function, Inflammation and Wellbeing in Adults With IBS-like Symptoms (EPEGUT)
Irritable bowel syndrome (IBS) is a common functional gastrointestinal condition characterised by symptoms including abdominal pain or discomfort, bloating, altered bowel habits and changes in digestive comfort.
- Trial name
- EPEGUT (NCT07916948)
- Testing
- EPEGUT
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Roehampton
Effects of 2 Mu-opiates on Gastrointestinal Transit
Comparison of the Effects of Tapentadol and Oxycodone on Gastrointestinal and Colonic Transit in Humans
Tapentadol is FDA approved for the treatment of moderate to severe acute pain. Due to the dual mechanism of action as an opioid agonist and norepinephrine reuptake inhibitor, there is potential for off label use in chronic pain.
- Trial name
- tap-oxy (NCT01500317)
- Testing
- Tapentadol, Oxycodone
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Irritable Bowel Syndrome
Comparing of the Gastrointestinal Motility in Irritable Bowel Syndrome (IBS) Patients With Healthy Volunteers
The hypothesis of the study is that the motility of the small intestine and the colon will alter according to the subtype of the irritable bowel syndrome (IBS) patient.
- Trial name
- NCT00957398
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- University of Aarhus
Allergic Rhinitis, Asthma
Integrating Targeted MedlinePlus Health Prescriptions Into Clinic Practice Workflow
The specific aim of this proposed project is to implement a standard process for integrating MedlinePlus health information prescriptions into the clinic workflow.
- Conditions
- Allergic Rhinitis, Asthma, Back Pain, Benign Prostatic Hypertrophy
- Trial name
- NCT00634608
- Testing
- Health Information Prescription
- Where
- United States
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Irritable Bowel Syndrome, Healthy Subjects
Application of Diaphragmatic Breathing in Patients With Disorders of Gut-brain Interaction
Patients with disorders of gut-brain interaction (DGBI) often present gastrointestinal symptoms that do not show noticeable irregularities in standard examinations.
- Conditions
- Irritable Bowel Syndrome, Healthy Subjects, Functional Gastrointestinal Disorders, Laryngopharyngeal Reflux
- Trial name
- NCT06205446
- Testing
- Healthy subjects : abdominal breathing, Laryngopharyngeal reflux disease subjects : abdominal breathing, Dyspepsia subjects : abdominal breathing
- Where
- Taiwan
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Buddhist Tzu Chi General Hospital
Healthy, Colonic Motility
High Resolution Colonic Manometry in Relation to 3D-Transit Times in Healthy Controls.
Background: Within recent years, new methods for detailed assessment of gastrointestinal (GI) motility have been developed. Hence, the electromagnetic 3D-Transit system is a safe, non-invasive method for detailed description of…
- Trial name
- NCT04231721
- Testing
- High Resolution Colonic Manometry and 3D-Transit system
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Janne Ladefoged Fassov
Colon Resection, _large Interstinal Surgery
Study to Assess the Effect on Recovery of GI Motility and Safety and to Determine the Optimal Dose of LD02GIFRO
This clinical trial is conducted to determine the optimal dose of LD02GIFRO in improvement of gastrointestinal motility between each dose group by comparing the effectiveness and safety in patients undergoing colon resection.
- Trial name
- NCT01624571
- Testing
- LD02GIFRO
- Where
- South Korea
- Volunteers
- 147 people
- Sponsor
- LG Life Sciences
Neurogenic Bowel Dysfunction
Stimulation for Colonic Motility
The investigators are testing the effect of electrical stimulation of the rectum on colonic motility. Most individuals with spinal cord injury develop neurogenic bowel dysfunction, which includes slowed colonic motility, which…
- Trial name
- NCT02641483
- Testing
- Electrical Rectal Stimulation
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- VA Office of Research and Development
Irritable Bowel Syndrome, Constipation
Effects of Lubiprostone on Gastrointestinal Transit & pH in Irritable Bowel Syndrome (IBS) With Constipation
Irritable bowel syndrome (IBS) is a common disorder which presents with abdominal pain or discomfort in association with altered bowel habit.
- Trial name
- NCT01162863
- Testing
- Lubiprostone, Smartpill wireless motility capsule
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Michigan
Functional Gastrointestinal Disorders, Overlap Syndromes
Overlap FGIDs and Genetic Polymorphism
1. To analyze the prevalence of overlap syndromes among NERD or RH, FD, and IBS patients, and to identify and to compare the differences in their characteristics and symptoms, and to determine their risk factors. 2.
- Trial name
- NCT04712617
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Ulcerative Colitis, Crohn Disease
Systems Biology of Gastrointestinal and Related Diseases
This is a longitudinal observational study on patients with gastrointestinal and related disease. The study will be conducted for at least 10 years, following each participant over time, as they either go through relapses and…
- Conditions
- Ulcerative Colitis, Crohn Disease, Obesity, Colon Polyp
- Trial name
- NCT05579444
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Viome
Spinal Cord Injury
Effects of Acute SCI on Colonic Motility & Tone
This study will compare individuals with acute SCI to control patients in order to: 1. Determine if there are changes in colonic tone and sensation after SCI by comparing the fasting responses to the postprandial responses; 2.
- Trial name
- NCT00013312
- Testing
- Determine colonic tone
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- US Department of Veterans Affairs
Food Allergy in Infants, Proctocolitis
Suspicion of Non IgE-mediated Cow's Milk Protein Allergy: Prevalence and Evolution
Cow's milk protein allergy (CMPA) is often evoked in infants, in particular in front of delayed symptoms such as rectal bleeding, atopic dermatitis, excessive crying, reflux, failure to thrive...
- Conditions
- Food Allergy in Infants, Proctocolitis, Atopic Dermatitis, Reflux, Gastroesophageal
- Trial name
- NCT04651829
- Testing
- oral food challenge 1, oral food challenge 2
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hôpital Armand Trousseau
Irritable Bowel Syndrome
Effect of Bifidobacterium on Irritable Bowel Syndrome
There has been no data on effect of Bifidobacterium breve on symptoms of patients with irritable bowel syndrome (IBS). We hypothesized that Bifidobacterium breve is effective on symptoms of IBS patients.
- Trial name
- PBIBS (NCT00737841)
- Testing
- Bifidobacterium breve
- Where
- Japan
- Volunteers
- 50 people
- Sponsor
- Tohoku University
Irritable Bowel Syndrome
Caecal pH as a Biomarker for Irritable Bowel Syndrome
Irritable bowel syndrome is common. Currently, it is a diagnosis of exclusion. There is increasing evidence of the importance of the microbiota in the pathophysiology of this disorder.
- Trial name
- NCT02360384
- Testing
- Linaclotide, FODMAP diet
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- Wingate Institute of Neurogastroenterology
Hypertension, Depression
Patient-Centred Innovations for Persons With Multimorbidity - Quebec
The aim of Patient-Centred Innovations for Persons With Multimorbidity (PACE in MM) study is to reorient the health care system from a single disease focus to a multimorbidity focus; centre on not only disease but also the…
- Conditions
- Hypertension, Depression, Anxiety, Musculoskeletal Pain
- Trial name
- PACEinMM-QC (NCT02789800)
- Testing
- DIMAC02
- Where
- 2 sites in Canada
- Volunteers
- 284 people
- Sponsor
- Université de Sherbrooke
Ageing, Constipation
Colonic Motility in Constipation and Ageing
The reason chronic constipation (CC) becomes commoner with age is not fully understood. New studies suggest that bowel contraction patterns, dietary fibre and gut bacteria are important and may differ in older people.
- Trial name
- NCT02575742
- Testing
- 3D-Transit system
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Hypertension, Depression
Patient-Centred Innovations for Persons With Multimorbidity - Ontario
The aim of Patient-Centred Innovations for Persons With Multimorbidity (PACE in MM) study is to reorient the health care system from a single disease focus to a multimorbidity focus; centre on not only disease but also the…
- Conditions
- Hypertension, Depression, Anxiety, Musculoskeletal Pain
- Trial name
- PACEinMM-ON (NCT02742597)
- Testing
- TIP / IMPACT Plus Care Coordination
- Where
- 9 sites in Canada
- Volunteers
- 175 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Colorectal Cancer (CRC)
Trial of Gum Chewing to Enhance the Restoration of Intestinal Motility in Colorectal Cancer Surgery
Surgery is one of the most frequent treatments of colorectal cancer. However, delayed restoration of intestinal motility is a common phenomenon in patients who undergo colorectal surgery, and may reduce comfort, prevent the early…
- Trial name
- NCT06860685
- Testing
- gum chewing
- Where
- China
- Volunteers
- 292 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute