Clinical trials: Colonic Motility
Irritable Bowel Syndrome, Gastro-oesophageal Reflux Disease
The Influence of Concomitant Irritable Bowel Syndrome on Gastro-Oesophageal Reflux Disease Symptoms and Severity.
This research aims to investigate whether there is a link between irritable bowel syndrome (IBS) and acid reflux, particularly whether there is a difference in acid reflux symptoms between people with and without IBS.
- Trial name
- NCT06615856
- Testing
- Questionnaire
- Volunteers
- 124 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Gastrointestinal Dysfunction
Use of High Resolution Colonic Manometry in Studying Motility
An injury to the spinal cord (SCI) results in numerous medical complications, including gastrointestinal (GI) function. Individuals with SCI may experience severe constipation (prolonged stool retention), incontinence…
- Trial name
- NCT02574611
- Testing
- Neostigmine, Glycopyrrolate, High Resolution Colonic Manometry
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Ulcerative Colitis
Gastrointestinal Motility in Severe Ulcerative Colitis Obtained by Motilis-3D-transit
The purpose of this study is to describe gastrointestinal (GI) motility in patients suffering from severe Ulcerative Colitis (UC) and to compare these results with similar results obtained in remission.
- Trial name
- NCT01745029
- Testing
- Motilis-3D-transit
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- University of Aarhus
Irritable Bowel Syndrome
Effect of Cannabinoid Agonist on Gastrointestinal and Colonic Motor Functions in Patients With Irritable Bowel Syndrome (IBS)
Irritable bowel syndrome (IBS) affects about 15% of the U.S. population. There are still no effective and safe medications approved for the treatment of abdominal pain associated with bowel symptoms in IBS.
- Trial name
- NCT01253408
- Testing
- Dronabinol
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Mayo Clinic
Gastrointestinal Disease, Gastrointestinal Disorders
Telehealth-Delivered Gut-Directed Hypnotherapy for Managing GI Health
This study aims to evaluate the specific and non-specific effects of hypnotherapy and to evaluate the efficacy of group-format gut-directed hypnotherapy (GDH) delivered via telehealth for managing gastrointestinal health.
- Conditions
- Gastrointestinal Disease, Gastrointestinal Disorders, Nervous System
- Trial name
- NCT06890663
- Testing
- Nonspecific Hypnotherapy for Relaxation, Gut-Directed Hypnotherapy (GDH), 3-month Follow-Up
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Central Florida
Colorectal Neoplasms, Ileus Postoperative
The ACURE Trial: Acupuncture for Colorectal Recovery
Purpose: The goal of this clinical trial is to evaluate whether electroacupuncture (EA) can accelerate the recovery of bowel function in patients undergoing minimally invasive surgery for colorectal cancer.
- Conditions
- Colorectal Neoplasms, Ileus Postoperative, Postoperative Complication, Gastrointestinal Motility
- Trial name
- ACURE (NCT07496528)
- Testing
- Electroacupuncture (EA), Enhanced Recovery After Surgery (ERAS) Protocol
- Volunteers
- 240 people
- Sponsor
- Chang Gung Memorial Hospital
Chronic Constipation
Effect of PEG, Bisacodyl and Prucalopride on Colonic Motility in Healthy Subjects
This study aim was to evaluate the effect of pharmacological treatments normally used to treat functional constipation and in particular PEG, bisacodyl and prucalopride on colonic motility as assessed by high-resolution manometry.
- Trial name
- NCT03279341
- Testing
- polyethylene glycol, Bisacodyl, Prucalopride
- Where
- Belgium
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gasthuisberg
Colon Resection
The Effect of Gum Chewing on Bowel Motility in Post-operative Colon Resection Patients
The purpose of this study is to determine if chewing mint-flavored sugarless gum after colon resection surgery decrease the time to first flatus, bowel movement and length of stay in the hospital.
- Trial name
- NCT01613274
- Testing
- gum chewing, no gum chewing
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Allina Health System
Colorectal Cancer, Bowel Ileus
Efficacy of Mosapride on Recovery of Intestinal Motility After Elective Colorectal Cancer Surgery
Postoperative ileus (POI) is one of the most common causes of prolonged hospital stays after abdominal surgery. The pathophysiology of POI is multifactorial and complex.It is known to be associated with sympathetic neural…
- Trial name
- NCT04905147
- Testing
- Mosapride
- Where
- Thailand
- Volunteers
- 44 people
- Sponsor
- Mahidol University
Irritable Bowel Syndrome (IBS)
Diet and Motility in IBS
The goal of this observational study is to identify factors that influence symptoms in children with irritable bowel syndrome (IBS), to find ways to make diet treatments work better and possibly create personalized plans to help…
- Trial name
- IBS (NCT07283341)
- Testing
- Wireless Patch System
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Spinal Cord Injury, Neurogenic Bowel
Transdermal Administration of a Prokinetic Agent for Bowel Evacuation in Persons With SCI
Bowel care (BC) is a time-consuming and cumbersome activity of daily living for most individuals with SCI. Previous studies have reported that the average time to complete a BC routine is 45 minutes; 10-20% of SCI individuals…
- Trial name
- NCT02370862
- Testing
- Neostigmine and Glycopyrrolate
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Gastrointestinal Motility Disorders in Children, Hirschsprung Disease
Improvement of Understanding of Pediatric Sacral Neuromodulation: Therapeutic Strategies and Outcome Variables
The goal of this study is to learn about the effects of sacral neuromodulation in pediatric patients with gastrointestinal motility disorders.
- Conditions
- Gastrointestinal Motility Disorders in Children, Hirschsprung Disease, Constipation - Functional
- Trial name
- SMART-GUT (NCT07519915)
- Testing
- SNM/MRI/EMG
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- Friedrich-Alexander-Universität Erlangen-Nürnberg
Healthy
Lubiprostone, Colonic Motility and Sensation
This study is being done to evaluate the effects of lubiprostone, a drug approved and used for constipation, on pattern of contractions of the colon and the colon's sensitivity to distension.
- Trial name
- NCT00953043
- Testing
- lubiprostone, Bowel preparation
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Irritable Bowel Syndrome
Effect of a Cannabinoid Agonist on Colonic Sensory Functions in Patients With Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) affects about 15% of the U.S. population. There are still no effective and safe medications approved for the treatment of abdominal pain associated with bowel symptoms in IBS.
- Trial name
- NCT01786109
- Testing
- Dronabinol
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Michael Camilleri
Eosinophilic Esophagitis, Gastroesophageal Reflux Disease (GERD)
Indiana University Gastrointestinal Motility Diagnosis Registry
Develop a registry (list of patients) with accurate clinical motility diagnosis. This registry will help the doctors to identify the patients with specific disease conditions.
- Conditions
- Eosinophilic Esophagitis, Gastroesophageal Reflux Disease (GERD), Gastroparesis, Functional Vomiting
- Trial name
- NCT04506593
- Testing
- no intervention
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Indiana University
Irritable Bowel Syndrome
Intracolonic FODMAP Infusion in Healthy Volunteers
Irritable bowel syndrome (IBS) is one of the most common chronic diseases of the gut-brain axis. The underlying pathophysiology is multifactorial, poorly understood and differs between the subtypes: constipation-dominant IBS…
- Trial name
- ICOF (NCT06488534)
- Testing
- Fermentable Oligo-, Di- Monosaccharides And Polyols (FODMAPs)
- Where
- Belgium
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Irritable Bowel Syndrome, Diarrhea
Assessment of Gastric Emptying Speed in Patients Who Experience Diarrhea Following a Trigger Meal
The rapid diarrhea that patients experience who have diarrhea occurring after eating specific foods may be causing a "physiologic gastric dumping syndrome".
- Trial name
- NCT01114113
- Testing
- SmartPill capsule
- Sponsor
- Money, Mary E., M.D.
Bowel Dysfunction, Dysmotility
Comparison of a New Non-invasive Device With the Invasive Gold-standard Investigation to Assess Function of the Large Bowel in Children
The goal of this clinical trial is to learn if the new non-invasive device (Body Surface Colonic Mapping) works to accurately assess colonic movement and function in children.The main questions it aims to answer are: Are Body…
- Conditions
- Bowel Dysfunction, Dysmotility, Hirschsprung Disease, Anorectal Malformations
- Trial name
- NCT07789782
- Testing
- Body Surface Colonic Mapping
- Where
- Australia
- Volunteers
- 50 people
- Sponsor
- Murdoch Childrens Research Institute
Chronic Constipation
Effect to Linaclotide on Colonic Motility
This study aim was to evaluate the effect of Linaclotide, a pharmacological treatment normally used to treat functional constipation or irritable bowel syndrome with predominant constipation, on colonic motility as assessed by…
- Trial name
- NCT06989268
- Testing
- Linaclotide 290 micrograms
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven