Clinical trials: Colonic Neoplasm
Mesothelin-Expressing Tumors, Epithelial Ovarian Cancer
CT-95 in Advanced Cancers Associated With Mesothelin Expression
This is a Phase 1a/1b, first-in-human (FIH), open-label, multi-center dose escalation and expansion study of the safety, pharmacokinetics (PK), pharmacodynamics, and antitumor activity of single-agent CT-95 in subjects with…
- Conditions
- Mesothelin-Expressing Tumors, Epithelial Ovarian Cancer, Malignant Pleural Mesothelioma, Advanced, Malignant Peritoneal Mesothelioma, Advanced
- Trial name
- NCT06756035
- Testing
- CT-95
- Where
- 9 sites in United States
- Volunteers
- 70 people
- Sponsor
- Context Therapeutics Inc.
Colorectal Neoplasms, Diarrhea
Safety Study of the Chemotherapy Modulator PHY906 in Patients With Advanced Colorectal Cancer
The triple combination chemotherapy of irinotecan, 5-fluorouracil and leucovorin (CPT-11/5-FU/LV or Saltz regimen) is the treatment of choice for patients with advanced colorectal cancer.
- Trial name
- NCT00036517
- Testing
- PHY906
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- PhytoCeutica
Colorectal Cancer, Colorectal Neoplasms
Resistance vs Aerobic Prehabilitation Before Colorectal Cancer Surgery
The goal of this clinical trial is to learn which type of exercise before surgery best reduces complications after colorectal surgery in adults with colorectal cancer or precancerous lesions.
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Postoperative Complications
- Trial name
- NCT07896174
- Testing
- Resistance Training Prehabilitation, Aerobic Training Prehabilitation, Standard Trimodal Care
- Where
- Hungary
- Volunteers
- 480 people
- Sponsor
- Semmelweis University
Colonic Neoplasms
Laparoscopic Versus Open Surgery for Colon Cancer With Visceral Obesity
This study aims to elucidate whether there is a difference in long-term prognosis between laparoscopic surgery and open surgery in colon cancer patients with visceral obesity.
- Trial name
- LOVO (NCT07314996)
- Testing
- Laparoscopic surgery, Open surgery
- Where
- China
- Volunteers
- 664 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Circulating Tumor DNA, Recurrence
Circulating Tumor DNA Based Adjuvant Chemotherapy in Stage II Colon Cancer Patients: the MEDOCC-CrEATE Trial
Patients in the Prospective Dutch ColoRectal Cancer cohort (PLCRC) with non-metastatic colon cancer that gave consent for additional blood withdrawals are enrolled in the observational PLCRC-MEDOCC substudy.
- Conditions
- Circulating Tumor DNA, Recurrence, Colon Cancer Stage II
- Trial name
- CrEATE (NCT06434896)
- Testing
- ctDNA analysis after surgery
- Where
- 29 sites in Netherlands
- Volunteers
- 1,320 people
- Sponsor
- UMC Utrecht
Colorectal Cancer
Veteran Primers for CRC Screening
This is a prospective, randomized controlled trial that will evaluate the effectiveness of primer postcards sent two weeks prior to the mailing of a FIT kit in improving adherence to annual CRC screening.
- Trial name
- NCT04923646
- Testing
- Primer
- Where
- United States
- Volunteers
- 2,404 people, healthy volunteers welcome
- Sponsor
- VA Puget Sound Health Care System
Colorectal Cancer
A Study of Avastin (Bevacizumab) and Xeloda (Capecitabine) as Maintenance Treatment in Patients With Metastatic Colorectal Cancer
This 2 arm study assessed the efficacy and safety of maintenance treatment with Avastin (bevacizumab) + Xeloda (capecitabine), after initial treatment with Xeloda + oxaliplatin + Avastin, in patients with metastatic colorectal…
- Trial name
- NCT00623805
- Testing
- Bevacizumab, Capecitabine, Oxaliplatin
- Where
- 10 sites in Turkey (Türkiye)
- Volunteers
- 123 people
- Sponsor
- Hoffmann-La Roche
Colorectal Cancer (CRC), Gastric Cancer (GC)
A Prospective Real-World Observational Study of Intratumoral Oncolytic Virus Injection Combined With Immune Checkpoint Inhibitors for Metastatic Tumors (Colorectal Cancer, Gastric Cancer, and Hepatocellular Carcinoma)
The goal of this single-arm, open-label, prospective clinical trial is to evaluate the safety, feasibility, and preliminary antitumor activity of intratumoral oncolytic virus (H101, recombinant human type 5 adenovirus) combined…
- Conditions
- Colorectal Cancer (CRC), Gastric Cancer (GC), Hepatocellular Carcinoma (HCC)
- Trial name
- NCT07850882
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Jie Yuan，MD
NSCLC, SCLC
Milaberon in Advanced Solid Tumors: an Open, Multicenter Clinical Study
This study is an exploratory study, and all the drugs involved are listed drugs. The dosage of mirabetron is selected according to the basis of previous research.
- Conditions
- NSCLC, SCLC, Colorectal Cancer, Pancreas Cancer
- Trial name
- NCT06534762
- Testing
- Mirabegron
- Where
- China
- Volunteers
- 260 people
- Sponsor
- Zhejiang Provincial People's Hospital
Tumor, Colorectal, Organoids
Testing a Functional Precision Medicine Approach to Select Chemotherapy for Metastatic Colorectal Cancer (COSENSE-1)
COSENSE-1 is an unblinded, phase II, single-armed, single center feasibility study for using a functional precision medicine platform to select oxaliplatin-based versus irinotecan-based chemotherapy regimens, for male and female…
- Conditions
- Tumor, Colorectal, Organoids, Tumoroid, Metastatic Colorectal Cancer
- Trial name
- COSENSE-1 (NCT06907342)
- Testing
- FOLFOX or FOLFIRI
- Where
- Norway
- Volunteers
- 148 people
- Sponsor
- St. Olavs Hospital
Breast Cancer, Prostate Cancer
Integration of Cancer Health Activities Into African American Churches
The proposed project will compare two ways to apply a known-effective cancer educational strategy through African American churches: 1) a standard method vs.
- Conditions
- Breast Cancer, Prostate Cancer, Colorectal Cancer
- Trial name
- NCT03178383
- Testing
- Project HEAL, Project HEAL 2.0
- Where
- United States
- Volunteers
- 446 people, healthy volunteers welcome
- Sponsor
- University of Maryland, College Park
Colorectal Cancer
PD-1 Antibody Combined With COX Inhibitor in MSI-H/dMMR or High TMB Colorectal Cancer
PD-1(programmed death protein 1)antibody has been to approved in patients with MSI-H/dMMR advanced cancer and has achieved significant efficacy.
- Trial name
- PCOX (NCT03638297)
- Testing
- PD-1 antibody + cox inhibitor
- Where
- 2 sites in China
- Volunteers
- 29 people
- Sponsor
- Sun Yat-sen University
Colon Cancer, Breast Cancer, Cancer of the Head and Neck
Safety, Immunogenicity and Pharmacokinetics of SYN004 in Patients With Solid Tumors
A first-in-human evaluation of SYN004, a monoclonal antibody that binds to the EGF receptor on cancer cells. Cetuximab, a marketed antibody, has been shown to be effective by inhibiting the growth of cancer cells thereby…
- Trial name
- SYN004_Ph_1 (NCT02391727)
- Testing
- SYN004
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Synermore Biologics Co., Ltd.
Neuropathy, Painful, Chemotherapy-induced Peripheral Neuropathy
Lidocaine for Oxaliplatin-induced Neuropathy
Oxaliplatin-induced neuropathy is a major dose-limiting side effect in patients with colorectal cancer treated with the FOLFOX chemotherapy regimen.
- Conditions
- Neuropathy, Painful, Chemotherapy-induced Peripheral Neuropathy, Colorectal Cancer
- Trial name
- NCT03254394
- Testing
- Lidocaine Hydrochloride, FOLFOX regimen
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Washington University School of Medicine
Solid Tumor, Advanced Solid Tumor
A Study on the Prevalence of Clinically Useful Mutations in Solid Tumor Characterized by Next Generation Sequencing Methods on Liquid Biopsy Analysis (POPCORN)
The implementation of liquid biopsy in clinical practice has been favored by the rapid development of genome sequencing techniques designed to analyze mutations in ctDNA.
- Conditions
- Solid Tumor, Advanced Solid Tumor, Locally Advanced Solid Tumor, Colon Rectal Cancer
- Trial name
- POPCORN (NCT06028724)
- Where
- Italy
- Volunteers
- 782 people
- Sponsor
- Centro di Riferimento Oncologico - Aviano
Colorectal Neoplasms
TAS-OX for Refractory Metastatic Colon Cancer
This study will examine the safety and effectiveness of oxaliplatin in combination with TAS-102 (TAS-OX) for treatment of patients with metastatic colorectal cancer whose cancer has progressed or recurred after FOLFOX…
- Trial name
- NCT02848079
- Testing
- combined TAS-102 and TAS-OX
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Yale University
Breast Cancer, Colon Cancer
Feasibility of an Evidence-based Walking Program in Cancer Pts 60+ During Chemotherapy
The study will look at conducting a medium-intense walking program called Walk With Ease with cancer patients age 60 and above who are starting chemotherapy treatment.
- Conditions
- Breast Cancer, Colon Cancer, Lung Cancer
- Trial name
- WWE (NCT01789983)
- Testing
- Walk With Ease Program, Collect Blood, GA and Other Survey Tools
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Colorectal Neoplasm
Ultra-sensitivity Quantitative Fecal Immunochemical Test in Detecting Colorectal Advanced Adenoma and Colorectal Cancer
Early detecting and removing of colorectal advanced adenomas can reduce the incidence of colorectal cancer. Because of the less bleeding of advanced adenomas, sensitivities of the common used quantitative fecal immunochemical…
- Trial name
- NCT04856423
- Testing
- The us-qFIT and colonoscopy with pathological examination
- Where
- 6 sites in China
- Volunteers
- 6,000 people
- Sponsor
- Shandong University
Colon Cancer, Laparoscopic Colon Surgery
Analysis of Surgical and Oncologic Outcomes After Complete Mesocolic Excision or Non-complete Mesocolic Excision for Right-Sided Colon Cancer
The goal of this observational study is to investigate the efficacy and safety of a modified D3 lymphadenectomy approach compared to Complete Mesocolic Excision (CME) in patients with right-sided colon cancer.
- Conditions
- Colon Cancer, Laparoscopic Colon Surgery, Lymph Node Dissection, Robotic Surgical Procedures
- Trial name
- NCT06684223
- Where
- South Korea
- Volunteers
- 3,787 people
- Sponsor
- Asan Medical Center
Colorectal Cancer
Efficacy and Safety Study of Imprime PGG With Cetuximab in Subjects With Stage IV KRAS-Mutated Colorectal Cancer
Study BT-CL-PGG-CRC0821 is a Phase 2, open-label, multicenter, efficacy and safety study. It will be conducted using a two-stage design with the intention of determining the initial efficacy of Imprime PGG in combination with a…
- Trial name
- NCT00912327
- Testing
- Imprime PGG
- Where
- 3 sites in United States
- Volunteers
- 18 people
- Sponsor
- HiberCell, Inc.
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