Clinical trials: Colonic Neoplasm
Patients With Metastatic Colorectal Cancer Who Were TP53-mutant and LRPPRC-positive and Had Previously Failed Prior First-line Treatment
Gossypol Acetate + FOLFIRI + Bev in mCRC With TP53-Mutant and LRPPRC Positive
This study is a single-center, single-arm clinical trial involving patients with TP53-mutated and LRPPRC-positive metastatic colorectal cancer.
- Trial name
- NCT07337551
- Testing
- Gossypol acetate Combined with Bevacizumab and FOLFIRI
- Volunteers
- 20 people
- Sponsor
- Guiying Wang
Colo-rectal Cancer
Total Neoadjuvant Treatment Without Surgery For Locally Advanced Rectal Cancer
NO-CUT is a one-stage phase II trial seeking to establish whether an oxaliplatin-based chemotherapy preceding standard neo-adjuvant fluoropyrimidines-based chemo radiotherapy, can safely spare demolitive surgical intervention in…
- Trial name
- NO-CUT (NCT03565029)
- Testing
- XELOX, Radiotherapy
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- Niguarda Hospital
Colorectal Neoplasms, Sedentary Behavior
An Intervention to Reduce Sedentary Behavior and Promote Physical Activity in Colorectal Cancer Chemotherapy
This single-group feasibility study develops and evaluates an intervention designed to reduce sedentary behavior and promote physical activity in patients with colorectal cancer undergoing chemotherapy.
- Trial name
- NCT07845877
- Testing
- Sedentary behavior reduction intervention for patients with colorectal cancer undergoing chemotherapy
- Volunteers
- 40 people
- Sponsor
- Yonsei University
Colorectal Cancer
Dacomitinib Plus PD-0325901 in Advanced KRAS Mutant NSCLC
This is a phase I/II multi-center open-label proof of concept study, consisting of two parts. Part A of this study is designed to identify the recommended phase 2 dose (RP2D) of the combination regimen of dacomitinib plus…
- Trial name
- M13DAP (NCT02039336)
- Testing
- Dacomitinib, PD-0325901, Docetaxel
- Where
- 3 sites in Netherlands
- Volunteers
- 35 people
- Sponsor
- The Netherlands Cancer Institute
Colon Cancer
Chronic Loose Stools Following Right-sided Hemicolectomy for Colon Cancer and the Association With Bile Acid Malabsorption and Small Intestinal Bacterial Overgrowth Using a Novel Sampling Device
The goal of this clinical research study is to learn about gastrointestinal symptoms in participants who have undergone SC or RC and their impact on the quality of life of these participants.
- Trial name
- NCT06927011
- Testing
- Capscan
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- M.D. Anderson Cancer Center
Colorectal Neoplasms
Targeted Forceps Biopsy for Colorectal Tumors
This study evaluates whether targeted forceps biopsy with careful tumor surface evaluation can improve diagnostic accuracy of colorectal tumors larger than 2 cm during colonoscopy.
- Trial name
- NCT03604237
- Testing
- Targeted group
- Where
- South Korea
- Volunteers
- 64 people
- Sponsor
- Kyungpook National University Hospital
Adult Solid Tumor
CANscriptTM Clinical Outcomes in a Real-World Setting (ANCERS)-2
The purpose of this study is to test the CANscript™ sensitivity assay, which is a new and different assay developed to test the sensitivity of different cancer types to physician selected therapies (both drugs and/or drug…
- Trial name
- ANCERS-2 (NCT03253575)
- Testing
- CANscript
- Where
- 30 sites in United States
- Volunteers
- 800 people
- Sponsor
- Mitra RxDx, Inc.
Colorectal Cancer
Inclusion of Elderly Patients With Colorectal Cancer in Clinical Trials
Background: Inadequate representation of elderly cancer patients in randomized clinical trials (RCTs) leading to a lack of external validity thereby an uncertainty regarding benefit-risk balance of cancer treatment in elderly…
- Trial name
- SAGE (NCT01754636)
- Testing
- No intervention
- Where
- France
- Volunteers
- 707 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sarcopenia, Postoperative Complications
Sarcopenia in Colorectal Cancer Patients, Intervention Study
The sarcopenia is a new concept for evaluating the functional status of patients, introduced during the last 20 years. This is defined as the relationship between the deterioration of muscle mass and the decrease in strength, the…
- Conditions
- Sarcopenia, Postoperative Complications, Infection;Post Surg Procedure
- Trial name
- NCT05491434
- Testing
- Protein supplement
- Where
- Spain
- Volunteers
- 370 people
- Sponsor
- Hospital Universitari de Bellvitge
Colorectal Cancer
Irinotecan Hydrochloride, Fluorouracil, and Leucovorin Calcium With or Without Zibotentan in Treating Patients With Metastatic Colorectal Cancer
RATIONALE: Drugs used in chemotherapy, such as irinotecan hydrochloride, fluorouracil, and leucovorin calcium, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from…
- Trial name
- FOLFERA (NCT01205711)
- Testing
- FOLFIRI regimen, fluorouracil, irinotecan hydrochloride
- Where
- 4 sites in United Kingdom
- Volunteers
- 111 people
- Sponsor
- Cardiff University
Arthritis, Rheumatoid, Colitis, Ulcerative
A Study to Learn About the Study Medicine Called Infliximab (Genetical Recombination)[Infliximab Biosimilar 3] in People With Rheumatoid Arthritis, Ulcerative Colitis, Crohn's Disease, or Psoriasis
The purpose of this study is to learn about the safety of the safety of the study medicine called infliximab for the possible treatment of rheumatoid arthritis (RA), ulcerative colitis (UC, Crohn's disease, or psoriasis.
- Conditions
- Arthritis, Rheumatoid, Colitis, Ulcerative, Crohn Disease, Psoriasis
- Trial name
- NCT05796245
- Where
- Japan
- Volunteers
- 2,207 people
- Sponsor
- Pfizer
Low Anterior Resection Syndrome
Transanal Irrigation to Prevent Major Low Anterior Resection Syndrome
Bowel dysfunction after rectal cancer resection comprises a vast array of bowel symptoms and associated quality-of-life impairment, collectively termed as low anterior resection syndrome (LARS).
- Trial name
- TAILARS (NCT04758195)
- Testing
- Transanal irrigation, Best supportive therapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Colonic Polyp, Colorectal Cancer
Computer Aided Diagnosis of Colorectal Polyps
The purpose of this study is to assess whether computer aided technology (CAD) can help in the diagnosis of polyps found the bowel compared with visual inspection alone and therefore whether it is beneficial in helping clinicians…
- Trial name
- EndoBrain (NCT04510545)
- Testing
- Endobrain, Computer Aided Diagnosis (CAD)
- Where
- United Kingdom
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- King's College Hospital NHS Trust
Colonic Neoplasms, Pain, Postoperative
The Effect of Methods of Self-regulation of Mental State on Pain Perception in the Postoperative Period in Colon Cancer Patients
In this study, it will be investigated whether the methods of self-regulation of mental state have an effect on postoperative pain perception in colon cancer patients.
- Conditions
- Colonic Neoplasms, Pain, Postoperative, Hypnotherapy
- Trial name
- NCT05708872
- Testing
- Autohypnosis, Relaxing music
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
Colorectal Cancer
Serum Endocan Levels in Colorectal Cancer
This case-control study aims to measure serum endocan levels in patients with colorectal cancer and healthy controls using ELISA and to compare the levels between the two groups.
- Trial name
- NCT07842692
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Assiut University
Colorectal Neoplasms Malignant
Effects of COVID-19 Pandemic on the Outcomes of Colorectal Cancer
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been identified as the cause of the Coronavirus disease 19 (COVID-19), which was initially reported in December 2019 in China and has since rapidly spread…
- Trial name
- COVID-CRC (NCT04712292)
- Testing
- Surgical procedure for confirmed or suspected colorectal cancer
- Where
- 45 sites in Italy
- Volunteers
- 15,000 people
- Sponsor
- University of Bologna
Advanced Malignant Solid Neoplasm, Advanced Biliary Tract Carcinoma
Olanzapine for the Management of Cancer Associated Appetite Loss in Patients With Advanced Esophagogastric, Hepatopancreaticobiliary, Colorectal or Lung Cancer
This phase II trial tests how well olanzapine works in managing cancer cachexia in patients experiencing esophagogastric, hepatopancreaticobiliary, colorectal, or lung cancer that may have spread from where it first started to…
- Conditions
- Advanced Malignant Solid Neoplasm, Advanced Biliary Tract Carcinoma, Advanced Esophageal Carcinoma, Metastatic Esophageal Carcinoma
- Trial name
- NCT05705492
- Testing
- Olanzapine, Questionnaire Administration
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- OHSU Knight Cancer Institute
Colorectal Cancer, Metastasis
Hepatic Artery Infusion With Oxaliplatin
Hepatic artery infusion (HAI) with oxaliplatin (OX), systemic 5 fluorouracil (5FU), and leucovorin (HAI/OX/FU) will be implemented using an interventional radiology technique to obviate the need for initial major surgery…
- Conditions
- Colorectal Cancer, Metastasis, Liver Cancer
- Trial name
- NCT00244348
- Testing
- Oxaliplatin (via HAI), 5 Fluorouracil (systemic)
- Where
- United States
- Sponsor
- Medical College of Wisconsin
Colorectal Cancer
Anlotinib Combined With Sintilimab as First-line Treatment for Advanced Non-liver Metastatic Colorectal Cancer
Colorectal cancer (CRC) is the third most common malignant tumor worldwide and the second leading cause of cancer-related deaths.
- Trial name
- NCT07398326
- Testing
- anlotinib and sintilimab
- Where
- China
- Volunteers
- 37 people
- Sponsor
- Shanghai Changzheng Hospital
NSCLC, Prostate Cancer
Clinical Trial of TB511 in Advanced Solid Tumors
1. Study population [TB511 Monotherapy Cohort for Phase 1 and Phase 2a Clinical Trial] Patients with advanced solid tumors who are either refractory or intolerant to standard of care (SoC).
- Conditions
- NSCLC, Prostate Cancer, Colorectal Cancer, Hepatocellular Carcinoma
- Trial name
- NCT06400160
- Testing
- TB511, Keytruda
- Volunteers
- 12 people
- Sponsor
- Twinpig Biolab, Inc.
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