Clinical trials: Colonic Neoplasm
Colorectal Cancer
Enhancing the Anabolic Effect of Perioperative Nutrition With Insulin While Maintaining Normoglycemia
The purpose of this study is to find out whether adding insulin after current colorectal cancer surgery promotes making and keeping proteins in the body, and to find out whether or not this effect can be further increased by…
- Trial name
- NCT02032953
- Testing
- Travasol (amino acid injection), Insulin
- Where
- Canada
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Colorectal Cancer
Informed Choice - Compass
The primary objective of this study is to evaluate the impact of a theoretically grounded video that includes information about CRC screening modality choices on CRC screening rates and time adherent to CRC guidelines.
- Trial name
- NCT05246839
- Testing
- Brief Video, Brief Video Plus
- Where
- 39 sites in United States
- Volunteers
- 1,823 people, healthy volunteers welcome
- Sponsor
- Exact Sciences Corporation
Colorectal Carcinoma
Blood Test (Guardant Shield™) for Screening of Colorectal Cancer in Underserved Patients
This clinical trial evaluates the use of a blood test (Guardant Shield™) for colorectal cancer screening. Colorectal cancer is the third leading cancer and cause of death in the United States.
- Trial name
- NCT05716477
- Testing
- Biospecimen Collection, Survey Administration
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Colorectal Cancer
Does Delaying Curative Surgery for Colorectal Cancer Influence Long-term Disease Free Survival.
This work is an original clinical research article describing the relationship between wait list tome for colorectal cancer patients and long-term survival.
- Trial name
- NCT04430231
- Testing
- Wait list time
- Volunteers
- 602 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Colorectal Carcinoma, Liver Metastases
Microwave Ablation Versus Stereotactic Body Radiotherapy for Colorectal Liver Metastases in Oligometastatic Disease: a Prospective, Randomised, Phase 2 Trial
The LAVA-CRLM trial (Local Ablation Versus Ablative radiotherapy in ColoRectal Liver Metastases) is a prospective, randomised, phase 2 study designed to compare local control and safety of microwave ablation (MWA) versus…
- Trial name
- LAVA-CRLM (NCT03654131)
- Testing
- MWA, SBRT
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Ovarian Cancer, Breast Cancer
Identifying Underserved Individuals inTexas With Hereditary Cancer Risk Using Mobile Mammography Units and Telegenetics.
Identifying women at risk for hereditary cancer potentiates prevention, early detection or personalised treatment against cancer.
- Conditions
- Ovarian Cancer, Breast Cancer, Colorectal Cancer
- Trial name
- NCT05649072
- Testing
- Genetic Testing and Counseling, Screening Form
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- M.D. Anderson Cancer Center
Colorectal Cancer, Circulating Tumor DNA
Dynamic Monitoring of ctDNA Methylation to Predict Relapse in Colorectal Cancer After Radical Resection (POSTCA)
This is a prospective, multicenter, observational, single-blinded controlled study. Dynamic monitoring of patients with resectable colorectal cancer was performed using the previously established colorectal tumor-specific plasma…
- Conditions
- Colorectal Cancer, Circulating Tumor DNA, Surveillance, Methylation
- Trial name
- NCT03737539
- Testing
- Multigene methylation detection
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Fudan University
Colorectal Cancer, Nausea
Delayed Nausea and Vomiting in Patients With Colorectal Cancer Receiving Oxaliplatin
RATIONALE: Learning how often patients experience nausea and vomiting after receiving anti-vomiting medicine and chemotherapy for colorectal cancer may help doctors plan better treatment and improve patients' quality of life.
- Conditions
- Colorectal Cancer, Nausea, Vomiting
- Trial name
- NCT00729677
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Beth Israel Medical Center
Metastatic Colorectal Cancer
Oxaliplatin, 5-FU and Leucovorin in Combination With Oral Capecitabine for Metastatic Colorectal Cancer
The combination of oxaliplatin, 5-FU, leucovorin, and capecitabine is hypothesized to retain and potentially improve upon the activity of the FOLFOX regimens.
- Trial name
- NCT00205322
- Testing
- chemotherapy (capecitabine, oxaliplatin, 5-FU, leucovorin)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Wisconsin, Madison
Colorectal Cancer
Study Using Fluorine-18-Labeled Fluoro-Misonidazole Positron Emission Tomography to Detect Hypoxia in Locally Advanced (T3-T4 and./or N1)Primary Rectal Cancer Patients
When used with a different radioactive tracer called FMISO, a PET scan can find areas of low oxygen in the tumor. We think that having areas of low oxygen is a reason why some tumors are hard to treat with radiation.
- Trial name
- NCT00574353
- Testing
- Fluorine-18-Labeled Fluoro-Misonidazole Positron Emission
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Colorectal Cancer, Enhanced Recovery After Surgery
CHASE : aCcelerated 23-Hour erAS Care for Colorectal Surgery
Rationale: Throughout the years, there has been a rapid change in the perioperative protocols and procedures surrounding colorectal surgery.
- Trial name
- CHASE (NCT04461275)
- Testing
- ERAS 2.0
- Where
- Netherlands
- Volunteers
- 41 people
- Sponsor
- Zuyderland Medisch Centrum
Colorectal Cancer, Colorectal Adenoma
The Implementation of Genetic Risk for Colorectal Cancer Screening
The goal of this study is to investigate genetic risk for colorectal cancer utilizing polygenic risk scores (PRS) for adults over 45 who have not received their first colonoscopy. The main questions it hopes to address are: 1.
- Conditions
- Colorectal Cancer, Colorectal Adenoma, Colorectal Polyp
- Trial name
- PRO-GENE-COLON (NCT07621757)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Colon Cancer
Weekly Topotecan in Patients Treated for Metastatic Colorectal Cancer
This non-randomized phase II study is designed to assess the response rate and toxicity of weekly topotecan as second-line treatment in patients with relapsed or refractory metastatic colorectal cancer.
- Trial name
- NCT00193167
- Testing
- Topotecan
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- SCRI Development Innovations, LLC
Colorectal Cancer
The Feasibility of an Active Lifestyle Programme in Patients Recovering From Colorectal Cancer
Long-term maintenance of physical activity behaviour change post-intervention remains challenging. This study is investigating the feasibility of a behaviour change intervention based on Self-Determination Theory in people…
- Trial name
- MOVE (NCT02751892)
- Testing
- Active lifestyle programme
- Volunteers
- 28 people
- Sponsor
- University of East Anglia
Breast Cancer, Lung Cancer
Patient Reported Outcomes Study Using Electronic Monitoring System for Advanced or Metastatic Solid Cancer
This is a multicenter, open-label, randomized, controlled study to test the hypothesis that ePRO monitoring added to usual care helps prolong OS or maintain and improve HRQoL in patients with unresectable advanced cancers or…
- Conditions
- Breast Cancer, Lung Cancer, Colorectal Cancer, Liver Cancer
- Trial name
- NCT05931445
- Testing
- e-PRO monitoring
- Where
- Japan
- Volunteers
- 500 people
- Sponsor
- Comprehensive Support Project for Oncology Research
Peritoneal Metastasis of Gastric and Colorectal Cancer, LDRT
LDRT Sequential NIPS Immunochemotherapy for Peritoneal Metastasis of Gastric and Colorectal Cancer
There have been initial explorations on the treatment of peritoneal metastasis of gastric and colorectal cancer both at home and abroad.
- Trial name
- TRIUNITE06 (NCT07453875)
- Testing
- LDRT, SOX or CAPOX regimen, Tislelizumab
- Where
- 2 sites in China
- Volunteers
- 9 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Colorectal Neoplasms, Effects of Chemotherapy
Perioperative FOLFIRI VS Adjuvant FOLFIRI in Resectable Advanced CRC Failed to Oxaliplatin
Colorectal cancer (CRC) is one of the most leading causes of cancer death in China. Although multiple treatment modalities including surgery, radiotherapy and chemotherapy have been developed, the prognosis of advanced CRC still…
- Conditions
- Colorectal Neoplasms, Effects of Chemotherapy, Surgery, Metastasis
- Trial name
- NCT02087475
- Testing
- Irinotecan, 5-fluorouracil, Local radiotherapy
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Colorectal Cancer
Panitumumab in Cetuximab Refractory KRAS Wild-Type Colorectal Cancer
The purpose of this research study is to learn whether panitumumab helps treat colorectal cancer in participants who have not responded to treatment with cetuximab. Panitumumab is a human monoclonal antibody.
- Trial name
- NCT00842257
- Testing
- panitumumab
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
HNPCC
Uncertain Genetic Test Results for Lynch Syndrome
Background: Individuals have varying tolerances for receiving ambiguous information. However, not much is known about how ambiguous genetic testing information is received.
- Trial name
- NCT01646112
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Colo-rectal Cancer
Study on the Prediction of Regional Lymph Node Metastasis in Colorectal Cancer by Spectral CT Combined With MSI
Spectral CT was used to prospectively collect medical images and clinical data related to colorectal cancer, evaluate the effect of image quality in the diagnosis of colorectal cancer, and evaluate the application value in the…
- Trial name
- NCT07565831
- Testing
- Investigating the role of spectral CT combined with MSI status in the diagnosis and treatment of colorectal cancer lymph nodes.
- Where
- China
- Volunteers
- 260 people
- Sponsor
- Yunnan Cancer Hospital
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