Clinical trials: Colonic Neoplasm
B-cell Malignancies, Colorectal Cancer (CRC)
A Study of the Safety, Tolerability, and Efficacy of Epacadostat Administered in Combination With Nivolumab in Select Advanced Cancers (ECHO-204)
This is a Phase 1/2, open label study. Phase 1 consists of 2 parts. Part 1 is a dose-escalation assessment of the safety and tolerability of epacadostat administered with nivolumab in subjects with select advanced solid tumors…
- Conditions
- B-cell Malignancies, Colorectal Cancer (CRC), Head and Neck Cancer, Lung Cancer
- Trial name
- NCT02327078
- Testing
- Nivolumab, Epacadostat, Chemotherapy
- Where
- 24 sites in United States, United Kingdom
- Volunteers
- 307 people
- Sponsor
- Incyte Corporation
Colorectal Cancer, Lymph Node Metastases
Use of Plasma ctDNA Methylation Haplotypes in Detecting Local Residual or Lymph Node Metastasis
This is a prospective, clinical study. This study is to evaluate the sensitivity of plasma ctDNA methylation haplotypes in detecting local residual or lymph node metastasis.
- Trial name
- NCT03868215
- Testing
- Next-generation sequencing (NGS)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Fudan University
Colorectal Cancer, Gastrointestinal Dysfunction
Electroacupuncture (EA) Promotes Gastrointestinal Functional Recovery After Radical Colorectal Cancer Surgery
The goal of this clinical trial is to verify the efficacy of electroacupuncture in accelerating the recovery of gastrointestinal function after colorectal cancer surgery.
- Trial name
- NCT06128785
- Testing
- Electroacupuncture group, Conventional Treatment group
- Where
- China
- Volunteers
- 305 people
- Sponsor
- Shanghai Yueyang Integrated Medicine Hospital
Recurrent or Metastatic Colorectal Cancer
Combination of Nelmastobart and Capecitabine Therapy in Metastatic Colorectal Cancer
This is an open-label clinical trial aimed at evaluating the safety and efficacy of the combination treatment of nelmastobart with capecitabine in patients diagnosed with metastatic or recurrent colorectal cancer.
- Trial name
- NCT05990543
- Testing
- Nelmastobart and Capecitabine
- Where
- South Korea
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Korea University Anam Hospital
Anastomotic Leakage, Colorectal Cancer
Predictive Factors for Anastomotic Leakage After Colorectal Surgery
Rationale: Colorectal cancer is the fourth most common cause of cancer death worldwide, estimated to be responsible for almost 610,000 deaths in 2008.
- Conditions
- Anastomotic Leakage, Colorectal Cancer, Anastomotic Leak, Colorectal Neoplasms
- Trial name
- REVEAL (NCT02347735)
- Testing
- No interventions, only data collection
- Where
- 4 sites in Netherlands
- Volunteers
- 774 people
- Sponsor
- Maastricht University Medical Center
Blastocystis Infection, Cryptosporidium Infection
Blastocystis and Cryptosporidium Infection in Colorectal Cancer Patients
1. Detect the prevelance of Blastocystis spp. and Cryptosporidium spp. among patients with colorectal cancer attending South Egypt Cancer Institute-Assiut University. 2.
- Conditions
- Blastocystis Infection, Cryptosporidium Infection, Colorectal Cancer
- Trial name
- NCT06379035
- Testing
- ELISA / PCR
- Volunteers
- 54 people
- Sponsor
- Assiut University
Colon Cancer, Benign Disease
Laparoscopic Versus Open Left Colonic Resection
The main goal of this study is to clarify if laparoscopy (LPS) could become the standard approach in patients undergoing left colonic resection.
- Trial name
- NCT00894725
- Testing
- laparoscopic left colonic resection, open left colonic resection
- Where
- Italy
- Volunteers
- 268 people
- Sponsor
- Università Vita-Salute San Raffaele
Mucinous Adenocarcinoma of the Colon, Signet Ring Adenocarcinoma of the Colon
Edrecolomab in Treating Patients With Stage II Colon Cancer
Randomized phase III trial to compare the effectiveness of surgery with or without monoclonal antibody therapy in treating patients who have stage II colon cancer.
- Conditions
- Mucinous Adenocarcinoma of the Colon, Signet Ring Adenocarcinoma of the Colon, Stage IIA Colon Cancer, Stage IIB Colon Cancer
- Trial name
- NCT00002968
- Testing
- edrecolomab, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 2,100 people
- Sponsor
- National Cancer Institute (NCI)
Colorectal Neoplasms
Safety and Efficacy Study of Intravenous Lidocaine After Colorectal Surgery: LIDOREHAB
The purpose of this study is to check if lidocaine intravenous administration during surgery and 24 hours after surgery, associated with standardised management of the patient, helps to accelerate recovery and to improve the…
- Trial name
- NCT00236249
- Testing
- Lidocaine
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Colorectal Cancer
Radiation Therapy and Capecitabine With or Without Oxaliplatin in Treating Patients Who Are Undergoing Surgery for Stage II or Stage III Rectal Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as capecitabine and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or…
- Trial name
- NCT00227747
- Testing
- capecitabine, oxaliplatin, conventional surgery
- Where
- 69 sites in France
- Volunteers
- 598 people
- Sponsor
- UNICANCER
Cancer
Natural History Study of Fungal Infections of the Blood in Patients With Cancer or in Patients Who Have Undergone a Stem Cell Transplant
RATIONALE: Gathering information about how often fungal infections of the blood occur in patients with cancer or in patients who have undergone stem cell transplant may help doctors learn more about the disease.
- Trial name
- NCT00445952
- Testing
- clinical observation, management of therapy complications
- Where
- 5 sites in Belgium, France and 3 more
- Volunteers
- 304 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Colorectal Cancer, Colo-rectal Cancer
ctDNA-guided Surveillance for Stage III CRC, a Randomized Intervention Trial
IMPROVE-IT2 is a randomized multicenter trial comparing the outcomes of ctDNA guided post-operative surveillance and standard-of-care CT-scan surveillance.
- Conditions
- Colorectal Cancer, Colo-rectal Cancer, ctDNA, Gastro-Intestinal Disorder
- Trial name
- NCT04084249
- Testing
- ctDNA-analysis, Intensified Follow-up Schedule
- Where
- 10 sites in Denmark
- Volunteers
- 359 people
- Sponsor
- Claus Lindbjerg Andersen
Colorectal Carcinoma
Implementation Research to Increase Colorectal Cancer Screening Rates Among Low Income and Ethnic Minority Groups
This clinical trial implements research strategies to increase colorectal cancer (CRC) screening rates among low income and ethnic minority groups.
- Trial name
- NCT06090643
- Testing
- Best Practice, Consultation, Educational Intervention
- Where
- United States
- Volunteers
- 9,745 people, healthy volunteers welcome
- Sponsor
- Jonsson Comprehensive Cancer Center
Ovarian Cancer, Breast Cancer
Study of AZD5305 as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Malignancies
This research is designed to determine if experimental treatment with PARP inhibitor, AZD5305, alone, or in combination with anti-cancer agents is safe, tolerable, and has anti-cancer activity in patients with advanced solid…
- Conditions
- Ovarian Cancer, Breast Cancer, Pancreatic Cancer, Prostate Cancer
- Trial name
- PETRA (NCT04644068)
- Testing
- AZD5305, Paclitaxel, Carboplatin
- Where
- 68 sites in United States, Australia and 12 more
- Volunteers
- 702 people
- Sponsor
- AstraZeneca
Metastatic Colorectal Cancer
Biomarker Directed Treatment in Metastatic Colorectal Cancer
This pilot study is being mounted to assess whether treatment assignment by ERCC-1 gene expression status suggests better clinical results from historical experience in metastatic colorectal cancer (mCRC).
- Trial name
- NCT01703390
- Testing
- FOLFIRI + Cetuximab, modifiedFOLFOX6 + Cetuximab
- Where
- 11 sites in Austria
- Volunteers
- 47 people
- Sponsor
- Arbeitsgemeinschaft medikamentoese Tumortherapie
Biliary Tract Cancer (BTC), Colorectal Cancer (CRC)
A Phase 1/2 Study of INCB001158 in Combination With Chemotherapy in Subjects With Solid Tumors
The purpose of this open-label nonrandomized Phase 1/2 study is to evaluate INCB001158 in combination with chemotherapy in participants with advanced/metastatic solid tumors.
- Conditions
- Biliary Tract Cancer (BTC), Colorectal Cancer (CRC), Endometrial Cancer, Gastroesophageal Cancer (GC)
- Trial name
- NCT03314935
- Testing
- INCB001158, Oxaliplatin, Leucovorin
- Where
- 10 sites in United States, Belgium and 1 more
- Volunteers
- 149 people
- Sponsor
- Incyte Corporation
Colorectal Cancer, Colon Cancer
Molecular Profiling of Colorectal Cancer
In this translational research study, Formalin-Fixed-Paraffin-Embedded (FFPE) tumor tissue blocks from patients with early-stage (II-III) colorectal cancer will be assessed for a comprehensive cancer gene panel from NIPD Genetics…
- Conditions
- Colorectal Cancer, Colon Cancer, Colon Adenocarcinoma
- Trial name
- NCT04863768
- Testing
- Gene panel
- Where
- Greece
- Volunteers
- 300 people
- Sponsor
- Hellenic Cooperative Oncology Group
Colorectal Carcinoma
A Community-Based Educational Intervention to Improve Colorectal Cancer Screening
This study investigates the facilitators and barriers to colorectal cancer screening in underserved populations with a focus on African American, Latinx, and Asian (Chinese) in the Sidney Kimmel Cancer Center catchment area.
- Trial name
- NCT04392050
- Testing
- Interview, Focus Group, Questionnaire Administration
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Colorectal Cancer
Colorectal Cancer Screening Intervention Study
Colorectal cancer (CRC) is one of the leading causes of cancer mortality in the United States, and African Americans (AfAms) still fare worse in CRC incidence and mortality compared to European Americans (EuAms).
- Trial name
- NCT06424197
- Testing
- Racial group-targeted messages, Explicit Commitment
- Where
- United States
- Volunteers
- 799 people, healthy volunteers welcome
- Sponsor
- Oakland University
Colorectal Cancer
Study of Bevacizumab Plus Chemotherapy in Patients With Metastatic Colorectal Cancer
This study evaluates the relationship of biomarker expression and efficacy of bevacizumab plus chemotherapy in patients with unresectable/metastatic colorectal cancer.
- Trial name
- NCT01679327
- Testing
- Oxaliplatin, Xeloda, Calcium folinate (CF)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chinese Academy of Medical Sciences
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