Clinical trials: Colonic Neoplasm
Malignant Neoplasms of Digestive Organs, Colorectal Cancer
Study of Durvalumab (MEDI4736) (Anti-PD-L1) and Trametinib (MEKi) in MSS Metastatic Colon Cancer
The goal of this clinical research study is to learn if durvalumab and trametinib can help to control microsatellite stable (MSS) colorectal cancer. The safety of these drugs will also be studied.
- Conditions
- Malignant Neoplasms of Digestive Organs, Colorectal Cancer, Colon Cancer
- Trial name
- NCT03428126
- Testing
- Durvalumab, Trametinib
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- M.D. Anderson Cancer Center
Hereditary Breast and Ovarian Cancer Syndrome, Lynch Syndrome
Pediatric Reporting of Adult-Onset Genomic Results
The Investigators will conduct a longitudinal, mixed-methods cohort study to assess primary and secondary psychosocial outcomes among MyCode adolescent participants and their parents, and health behaviors of children who received…
- Conditions
- Hereditary Breast and Ovarian Cancer Syndrome, Lynch Syndrome, Familial Hypercholesterolemia
- Trial name
- NCT03832985
- Testing
- Child(ren) receive an adult-onset result, Child(ren) received a pediatric-onset result, Control - Negative Result
- Where
- United States
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Geisinger Clinic
Solid Tumor
Dose-Esc/Exp RMC4630 & Cobi in Relapsed/Refractory Solid Tumors & RMC4630& Osi in EGFR+ Locally Adv/Meta NSCLC
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetic (PK), and pharmacodynamic (PD) profiles of RMC-4630 and cobimetinib in adult participants with relapsed/refractory solid tumors with specific…
- Trial name
- NCT03989115
- Testing
- RMC-4630, Cobimetinib, Drug: Osimertinib
- Where
- 24 sites in United States, South Korea
- Volunteers
- 113 people
- Sponsor
- Revolution Medicines, Inc.
Ibuprofen, Ketorolac
IV Ibuprofen vs Ketorolac in Post Operative Pain in Colorectal Cancer Surgeries in Obese Patient
The aim of this study is to assess the Efficacy of IV Ibuprofen and Ketorolac in the Management of Postoperative Pain in obese patients Following abdominal cancer surgery.
- Conditions
- Ibuprofen, Ketorolac, Colorectal Cancer
- Trial name
- NCT05782608
- Testing
- IV ibuprofen, IV ketorolac
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Colorectal Cancer
A Study of Coformulated Favezelimab/Pembrolizumab (MK-4280A) Versus Standard of Care in Subjects With Previously Treated Metastatic PD-L1 Positive Colorectal Cancer (MK-4280A-007)-China Extension Study
The purpose of this China extension study is to assess the safety and efficacy of coformulated favezelimab/pembrolizumab (MK-4280A) in adult Chinese participants with metastatic colorectal cancer.
- Trial name
- NCT05600309
- Testing
- favezelimab/pembrolizumab, regorafenib, TAS-102
- Where
- 24 sites in China
- Volunteers
- 94 people
- Sponsor
- Merck Sharp & Dohme LLC
Colorectal Cancer
A Psychosocial Intervention for Patients With Colorectal Cancer and Their Family Caregivers
This study aims to develop a smartphone-based psychosocial intervention for patients with colorectal cancer and their family caregivers and to improve patients' confidence in self-care, psychological well-being, social support…
- Trial name
- iCanManage (NCT04159363)
- Testing
- An interactive Colorectal Cancer self-Management enhancement smartphone-based psychosocial intervention programme (iCanManage)
- Volunteers
- 200 people
- Sponsor
- Singapore Cancer Society
Colorectal Polyp, Colorectal Neoplasms
Narrow Band Imaging in Diagnosis of Colorectal Polyps
Optical diagnosis of colorectal polyps is a promising tool to avoid risks of unnecessary polypectomies and to save costs of tissue pathology.
- Trial name
- NCT04831814
- Testing
- Near Focus NBI, Standard Focus NBI
- Where
- Thailand
- Volunteers
- 118 people
- Sponsor
- Prince of Songkla University
Cancer, Cancer (Colon Cancer, Breast Cancer, Lymphoma, Chronic Lymphoma Leukemia, Multiple Myeloma)
EHealth Educational Intervention to Improve Self-Management and Coping Behaviors Among Cancer Patients
Brief Summary This study evaluates the effectiveness of a structured eHealth-based educational and support intervention in improving self-management practices and psychological coping behaviors among adult cancer patients.
- Trial name
- EHCancer (NCT07457112)
- Testing
- Structured eHealth Educational Intervention
- Where
- Egypt
- Volunteers
- 212 people
- Sponsor
- Zagazig University
Liver Cancer
Resveratrol and Human Hepatocyte Function in Cancer
The purpose of this study is to determine if Resveratrol, a nutritional supplement, shows a beneficial effect in the cellular function of normal liver cells and diseased liver cells (cancer cells) in samples of liver tissue taken…
- Trial name
- NCT02261844
- Testing
- Resveratrol
- Where
- United States
- Sponsor
- University of Louisville
Colo-rectal Cancer
NURSE-led Geriatric Assessment in Older Colorectal Cancer Patients
Older colorectal cancer patients frequently present with frailty, comorbidity, and other age-related vulnerabilities that may affect treatment tolerance and outcomes.
- Trial name
- NURSE-GA (NCT07872787)
- Testing
- Nurse-led Geriatric Assessment
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- Helse Stavanger HF
Colorectal Cancer, Metastatic Cancer
Chemotherapy Via an Implantable Pump Compared With a Subcutaneous Port for Unresectable Liver Metastases in Patients With Resected Colorectal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug or giving the drugs in different ways may kill more tumor cells.
- Trial name
- NCT00002793
- Testing
- fluorouracil, leucovorin calcium
- Where
- Germany
- Volunteers
- 336 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Colon Cancer
NIMA-Colon Cancer Study
The goal of this study is to evaluate the effects of nutritional supplementation and physical activity interventions on recovery, muscle strength, nutritional status, inflammation, and metabolic health in adults with colon cancer…
- Trial name
- NIMA (NCT07534852)
- Testing
- Standard hypercaloric-hyperproteic nutritional supplementation, HMB-enriched hypercaloric-hyperproteic nutritional supplementation with vitamin D and calcium, Supervised exercise program
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Colon Adenocarcinoma
Role of Immunoscore® in Stage II-III Colorectal Cancer
The proposed study is a bidirectional analytical study, composed of a retrospective and a prospective cohorts. Patients with stage II - III colorectal cancer undergoing oncological surgery will be analyzed.
- Trial name
- NCT05422547
- Testing
- Immunoscore Colon Test
- Where
- 2 sites in Brazil
- Volunteers
- 100 people
- Sponsor
- D'Or Institute for Research and Education
Colorectal Cancer
Capecitabine and Radiation Therapy With or Without Panitumumab in Treating Patients With Advanced Rectal Cancer
RATIONALE: Drugs used in chemotherapy, such as capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00814619
- Testing
- panitumumab, capecitabine, therapeutic conventional surgery
- Where
- 24 sites in Hungary, Switzerland
- Volunteers
- 68 people
- Sponsor
- Swiss Cancer Institute
Colorectal Cancer
Combination Chemotherapy and Bevacizumab in Treating Patients With Stage IV Colon Cancer That Cannot Be Removed By Surgery
RATIONALE: Drugs used in chemotherapy, such as fluorouracil, leucovorin, and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00321828
- Testing
- bevacizumab, fluorouracil, leucovorin
- Where
- 163 sites in United States
- Volunteers
- 90 people
- Sponsor
- NSABP Foundation Inc
Colorectal Neoplasms
Invasiveness and Chemoresistance of Cancer Stem Cells in Colon Cancer
The main objective of this study is to identify and characterize subpopulations of cells with invasive capacity in colorectal cancer from primary tumor, blood and metastatic samples.
- Trial name
- NCT01577511
- Testing
- Samples and follow up
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Colorectal Cancer
Low Versus Standard Intraabdominal Pressure in Robot-assisted Colorectal Cancer Surgery
The goal of this clinical trial is to investigate the influence of low intraabdominal pressure (compared to standard intraabdominal pressure) during robot-assisted colorectal cancer surgery on patients wellbeing after surgery.
- Trial name
- LIPS (NCT06783244)
- Testing
- Low intraabdominal pressure (8 mmHg)
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Victoria Rosberg
Melanoma, Prostate Cancer
An Expanded Access Program for AM0010 (Pegilodecakin)
This is an Expanded Access Program (EAP) available to patients who have advanced cancers, who have failed or progressed on standard of care systemic therapy and do not qualify for ongoing clinical trials.
- Conditions
- Melanoma, Prostate Cancer, Ovarian Cancer, Renal Cell Carcinoma
- Trial name
- NCT03554434
- Testing
- AM0010
- Sponsor
- Eli Lilly and Company
Colorectal Cancer
The C-SPAN Coalition: Colorectal Cancer Screening and Patient Navigation
Participants will be mailed an invitation to complete CRC screening along with a fecal immunochemical test (FIT) kit, containing a 1-sample "Polymedco Over the Counter (OC) Sensor FIT", simplified English/Spanish instructions on…
- Trial name
- C-SPAN (NCT03181334)
- Testing
- Branch I, Branch II, Branch III
- Where
- 2 sites in United States
- Volunteers
- 7,711 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Colorectal Cancer
Construction and Empirical Research of the Applicable Baduanjin Protocol for Patients With Colorectal Cancer Enterostomy
The goal of this clinical trial is to understand the application effect of the applicable version of Baduanjin protocol in patients with enterostomy and verify the safety and efficacy of this protocol.
- Trial name
- NCT07172087
- Testing
- Baduanjin for patients with enterostomy
- Where
- China
- Volunteers
- 258 people
- Sponsor
- Sichuan Cancer Hospital and Research Institute
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