Clinical trials: Colonic Polyp, active
Colorectal Carcinoma, Polyp
New bioMarkers tO straTIfy cOlorectal caNcer Referrals
The goal of this observational study is to evaluate if a blood test for circulating progastrin (hPG80) and transposable elements (TEs) can accurately predict colorectal cancer (CRC) or polyps in adult patients referred to the…
- Conditions
- Colorectal Carcinoma, Polyp, Colorectal Adenoma
- Trial name
- MOTION (NCT07035691)
- Where
- United Kingdom
- Volunteers
- 582 people
- Sponsor
- Queen Mary University of London
Shared Decision Making, Colonic Polyp
The Impact of a Patient Decision Aid on Treatment Choices for Patients With an Unexpected Malignant Colorectal Polyp
Management of unexpected malignant colorectal polyps removed endoscopically can be challenging due to the risk of residual tumor and lymphatic spread.
- Conditions
- Shared Decision Making, Colonic Polyp, Decision Aids, Rectal Polyp
- Trial name
- NCT05776381
- Testing
- Shared Decision Making using a Patient Decision Aid.
- Volunteers
- 110 people
- Sponsor
- Vejle Hospital
Colorectal Cancer Screening, Colonic Polyps/Colonoscopy/Colorectal Neoplasms
The Impact of Image-Assisted Colonoscope on Patient Experience, Physician Workload, and Examination Quality
Colonoscopy is the cornerstone for colorectal cancer screening, diagnosis, and post-treatment surveillance. Procedural quality is influenced by patient anatomy, particularly variations in colonic configuration such as sigmoid…
- Conditions
- Colorectal Cancer Screening, Colonic Polyps/Colonoscopy/Colorectal Neoplasms, Difficult Colonoscopy, Colonoscopy-Related Discomfort
- Trial name
- LOOP-p1 (NCT07541924)
- Testing
- CT-Based Image-Assisted Colonoscope Insertion
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- DONG WU
Colorectal Cancer, Colorectal Adenoma
The Implementation of Genetic Risk for Colorectal Cancer Screening
The goal of this study is to investigate genetic risk for colorectal cancer utilizing polygenic risk scores (PRS) for adults over 45 who have not received their first colonoscopy. The main questions it hopes to address are: 1.
- Conditions
- Colorectal Cancer, Colorectal Adenoma, Colorectal Polyp
- Trial name
- PRO-GENE-COLON (NCT07621757)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Colorectal Cancer, Endometrial Cancer
Discovering New Targets for Colorectal and Endometrial Cancer Risk Reduction
The primary aim of this study is to collect and store data, tissue, and personal and family histories from patients being screened for colorectal cancer and/or endometrial cancer at NYPH and WCM for routine clinical care and to…
- Conditions
- Colorectal Cancer, Endometrial Cancer, Hereditary Cancer Syndromes
- Trial name
- NCT06096688
- Where
- United States
- Volunteers
- 1,120 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Colon Polyp
Artificial Intelligence in the Detection of Right Sided Colonic Polyp in Different Operator Experience
Colonoscopy is the gold standard modality for the detection of colonic polyp. However, miss polyp occurs especially in right sided colon.
- Trial name
- NCT05990218
- Testing
- Artificial intellegence. CADe syste,, control
- Where
- Thailand
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Colonic Polyp, Colon Lesion
Comparative Analysis of AI Software for Enhanced Polyp Detection and Diagnosis
Purpose \& Research Questions The purpose of this study is to evaluate whether artificial intelligence (AI) improves the detection of polyps and whether the system can classify the type and severity of detected changes.
- Trial name
- NCT06077435
- Testing
- AI
- Where
- Sweden
- Volunteers
- 915 people
- Sponsor
- Sahlgrenska University Hospital
Familial Adenomatous Polyposis (FAP)
Phase 3 Trial of eRapa in Patients With Familial Adenomatous Polyposis
The main goal of this clinical trial is to learn if the drug eRapa works to slow down the progression of disease in patients diagnosed with Familial Adenomatous Polyposis (FAP). Researchers will compare eRapa to Placebo.
- Trial name
- SERENTA (NCT06950385)
- Testing
- eRapa (encapsulated rapamycin)
- Where
- 29 sites in United States, Denmark and 5 more
- Volunteers
- 168 people
- Sponsor
- Rapamycin Holdings Inc.
Colorectal Cancer, Adenomatous Polyps
Multi-omics Study for Early Detection of Colorectal Cancer (MOED-CRC)
The primary objective of the study is to screen multi-omics markers in blood samples and construct a prediction model for CRC based on liquid biopsy, and we will further optimize the prediction model by validating its clinical…
- Conditions
- Colorectal Cancer, Adenomatous Polyps, Adenoma, Advanced Adenoma
- Trial name
- NCT06220617
- Where
- 6 sites in China
- Volunteers
- 3,600 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Colorectal Cancer, Polyps
The Correlation of Postoperative Polyp Recurrence and Colorectal Cancer
Postoperative endoscopic polyp recurrence correlation of colorectal cancer: a retrospective cohort open-label study
- Trial name
- NCT07708415
- Testing
- Endoscopic polypectomy
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Gansu Provincial Hospital
Colorectal Cancer, Colorectal Neoplasms
Early Detection of Advanced Adenomas and Colorectal Cancer
This study aims to develop a highly sensitive, specific, and cost-effective blood assay for early detection of colorectal adenomas and cancer, using advanced machine learning and state-of-the-art biological analyses.
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Polyp, Colorectal Adenocarcinoma
- Trial name
- AACRC (NCT06342440)
- Testing
- DENEB
- Where
- 6 sites in United States, China and 3 more
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Colon Cancer Prevention, Polyp Colorectal
Delayed Surveillance Colonoscopy Following Piecemeal EMR
This multicenter, prospective, randomized non inferiority trial, conducted at four Israeli hospitals, will evaluate whether a relaxed surveillance strategy after piecemeal endoscopic mucosal resection (pEMR) of large non…
- Trial name
- NCT07328308
- Testing
- Colonoscopy after bowel cleansing
- Where
- Israel
- Volunteers
- 760 people
- Sponsor
- Rambam Health Care Campus
Colonic Polyp
Computer Aided Diagnosis (CADx) for Colorectal Polyps Resect-and-Discard Strategy
Colonoscopic removal of adenomatous polyps reduce both the incidence and mortality of colorectal cancer (CRC). The common clinical management of colorectal polyp detected during colonoscopy is to remove them and send for…
- Trial name
- CADx (NCT06062095)
- Testing
- AI-powered computer-aided diagnosis (CADx)
- Where
- Hong Kong
- Volunteers
- 1,764 people
- Sponsor
- Chinese University of Hong Kong
Familial Adenomatous Polyposis (FAP)
Efficacy of Vitamin B1 in Familial Adenomatous Polyposis Patients.
This study aimed to investigate the efficacy of vitamin B1 in patients with familial adenomatous polyposis, and to determine the inhibitory effect of vitamin B1 on the size and number of colorectal adenomas by administering oral…
- Trial name
- VitB1; FAP (NCT06649825)
- Testing
- Vitamin B1
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Shanghai Zhongshan Hospital
Colon Polyp, Colon Neoplasia
Prospective Study of Using Novel Bipolar Scissors in Colorectal Endoscopic Submucosal Dissection
This study is an interventional, prospective, single-center study to evaluate the safety and effectiveness of a novel radiofrequency and microwave ablation flexible bipolar (SpydrBlade Flex, CREO Medical, UK) for colorectal ESD…
- Trial name
- NCT06715332
- Testing
- Colorectal ESD with SpydrBlade Flex
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- Chinese University of Hong Kong
Colonic Polyp, Sedation Complication
A Comparison of Remimazolam Besylate and Propofol Sedation in Patients Undergoing Colonoscopic Polypectomy
The goal of this prospective, randomized, controlled study is to compare remimazolam besilat/sufentanyl and propofol/sufentanyl in patients during colonoscopic polypectomies procedures.
- Trial name
- Bypro (NCT07456111)
- Testing
- Remimazolam besylate, Propofol
- Where
- Croatia
- Volunteers
- 90 people
- Sponsor
- Clinical Hospital Centre Zagreb
Gastric Polyps, Intestinal Polyps
Recurrence After Gastric and Intestinal Polyp Resection
This is a retrospective and prospective cohort study designed to evaluate the recurrence rate and identify risk factors after endoscopic resection of gastric and intestinal polyps.
- Conditions
- Gastric Polyps, Intestinal Polyps, Colon Polyps, Colorectal Polyps
- Trial name
- RAGIP (NCT07314554)
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- LanZhou University
Colon Polyps, Colonoscopy
Imaging the Colon Using a Colonoscope Compatible Imaging Probe
The goal of this study is to use a colonoscope compatible device capable of taking images of the lower gastrointestinal tract. The main question it aims to answer is: Is the colonoscope compatible optical coherence tomography…
- Trial name
- NCT07365436
- Testing
- Feasibility of using a CC-OCT probe to image the GI tract
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Massachusetts General Hospital
Malignant Colorectal Polyp, Colorectal Cancer
Malignant Polyp Registry
The purpose of this study is to learn more about malignant colorectal polyps (early colorectal cancers removed during colonoscopy) and the risk that cancer remains, comes back, or spreads after the polyp is removed.
- Conditions
- Malignant Colorectal Polyp, Colorectal Cancer, T1 Colorectal Cancer
- Trial name
- NCT07619079
- Testing
- Questionnaires
- Where
- 7 sites in United States
- Volunteers
- 500 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Colorectal Cancer
Development of a New Simplified Tool to Predict LNPCPs Histology and Assess the Risk of Submucosal Invasive Cancer. The Colorectal Regular-Irregular Score
Colorectal cancer (CRC) is the third most common malignancy worldwide and the second leading cause of cancer related death. It can be prevented by endoscopic detection and complete resection of colorectal polyps.
- Trial name
- CRIS (NCT07584486)
- Testing
- Learning tool (CRIS/JNET), Learning tool (JNET/CRIS)
- Where
- Belgium
- Volunteers
- 764 people
- Sponsor
- University Hospital, Ghent