Clinical trials: Colonisation
Meningitis, Bacterial
Defining the Immune Response to Nasopharyngeal Colonisation by the Commensal Neisseria Lactamica
Neisseria meningitidis is a 'bad bacteria' which lives harmlessly in the nose and throat of many young adults (a process called colonisation). However, it can occasionally cause serious disease including meningitis.
- Trial name
- Lac-7 (NCT03633474)
- Testing
- N. lactamica, PBS only
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Southampton
Microbial Colonization
Colonisation Efficacy of Oral Probiotic Fast Melt Powder
To evaluate the colonisation efficacy (i.e. ability of the probiotic bacteria to remain in your mouth) of a fast melt powder that quickly dissolves in the mouth.
- Trial name
- NCT05367518
- Testing
- Probiotic Streptococcus salivarius K12 Fast Melt Powder 1 Billion colony forming units /g), Probiotic Streptococcus salivarius K12 Fast Melt Powder 100 Million colony forming units /g)
- Where
- New Zealand
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- BLIS Technologies Limited
Colonization, Asymptomatic, Colonisation
Encapsulated Probiotics & Gut Microbiota
The aim of this study is to determine whether encapsulation of probiotic bacteria using natural plant protein can enhance bacterial colonisation.
- Trial name
- Probiotics (NCT07439978)
- Testing
- probiotic containing L.rhamnosus R0011 strain, 200 ml yogurt drink
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Chronic Obstructive Pulmonary Disease
An Investigation of the Mechanism of Action of Seretide in Chronic Obstructive Pulmonary Disease
This study is investigating the possible mechanisms of action of an inhaled treatment (Seretide), currently used worldwide in millions of patients with COPD (Chronic Obstructive Pulmonary Disease) and how it improves the symptoms…
- Trial name
- IMAS (NCT00974805)
- Testing
- Seretide 500 Accuhaler
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Southampton
Orthodontic Appliance Complication
Microbial Colonisation On Vacuum-Formed Retainers Constructed On Conventional Models And Three Dimensional (3D) Reconstructed Models
Vacuum-formed retainers are clear or transparent retainers, that hold the teeth in the new position after active orthodontic treatment.
- Trial name
- NCT03844425
- Testing
- Conventional VFR, VFR from SLA, VFR from FDM
- Where
- Malaysia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Microbial Colonization
Lactamica 9: Neisseria Lactamica Inoculation in Late Pregnancy
Bacteria living in the nose and throat are generally harmless, but in some circumstances cause infections of the lungs (pneumonia) and brain (meningitis), which are among the commonest causes of death worldwide in young children…
- Trial name
- NCT04784845
- Testing
- N. lactamica Y92-1009
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Southampton
Clostridioides Difficile Infection
Clostridioides Difficile Colonisation
This study will investigate experimental colonisation with non-toxigenic C.difficile (NTCD) in healthy volunteers. Main outcomes will be safety, tolerability, dose needed to obtain colonisation with NTCD to ultimately determine…
- Trial name
- CloDiCo (NCT05693077)
- Testing
- 10E4 NTCD spores, 10E7 NTCD spores, Vancomycin Oral Capsule
- Where
- Netherlands
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Meningitis, Meningococcal
A Study Assessing Colonisation & Immunogenicity After Nasal Inoculation With N. Lactamica and Eradication on Day 4 or 14
This study is part of a project that aims to develop a vaccine with N. lactamica that prevents meningitis. The investigators have previously given nose drops containing N.
- Trial name
- Lac-3 (NCT03549325)
- Testing
- Neisseria lactamica
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Healthy
The Impact of Food on Gut Microbiome Composition - a Clinical Trial Determining the Influence of Diet in Gut Microbiome Colonisation and Host Health
The goal of this clinical trial is to examine the impact of food derived bacteria on gut microbiome composition and host health.
- Trial name
- FIG (NCT05986955)
- Testing
- Diet
- Where
- Australia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Monash University
Neonatal Sepsis
Use of Probiotics to Reduce Infections, Death and ESBL Colonisation
This study examines the effect of oral probiotic treatment to newborns on preventing hospitalizations, death and colonization with Extended-spectrum beta-lactamase-producing Gram negative bacteria.
- Trial name
- ProRIDE (NCT04172012)
- Testing
- Labinic (R) probiotic mixture
- Where
- Tanzania
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Haydom Lutheran Hospital
Asthma
Effects of Macrolides on Asthma Control
Asthma is a common disease in Westernised societies, affecting up to 10% of the population. Corticosteroids are the most effective treatment for asthma but the therapeutic response varies considerably between individuals.
- Trial name
- NCT00852579
- Testing
- Azithromycin
- Where
- 2 sites in United Kingdom
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Euan J Cameron
Microbial Colonization
Colonization of Skin by M. Luteus Q24 Probiotic
The purpose of this study is to evaluate the skin quality improvement and colonization efficacy following the application of probiotic Micrococcus luteus Q24 (BLIS Q24) to the face from a serum format in healthy adults.
- Trial name
- NCT06137209
- Testing
- Active Comparator: Study Group A: Blis Q24 Serum at higher dose, Active Comparator: Study Group B: Blis Q24 Serum at lower dose
- Where
- New Zealand
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- BLIS Technologies Limited
Microbial Colonization
Colonisation Efficacy of a Probiotic Chewing Gum.
To evaluate the colonization efficacy (the ability of a probiotic bacteria to remain in the mouth) delivered in a chewing gum format.
- Trial name
- NCT05624177
- Testing
- Streptococcus salivarius M18 probiotic 1 billion colony forming units chewing gum (chew 5 minutes), Streptococcus salivarius M18 probiotic 1 billion colony forming units chewing gum (chew 10 minutes)
- Where
- New Zealand
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- BLIS Technologies Limited
Streptococcus Pneumonia
PREVENTING PNEUMOcoccal Disease Through Vaccination (Study 2)
To determine the effect of PCV-13 and PPV-23 vaccination versus control on experimental pneumococcal colonisation of 2 clades of serotypes 3 and 6B at 1 month and 6 months post vaccination respectively, using the EHPC model.
- Trial name
- Pneumo 2 (NCT04974294)
- Testing
- PPV23, PCV13, Saline for injection
- Where
- United Kingdom
- Volunteers
- 516 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
Ventilation, Mechanical, Ventilation-Associated Pneumonia
Surveillance of Neonatal Endotracheal Tube Colonisation
Babies in neonatal intensive care units (NICUs) sometimes need help breathing using a breathing tube (endotracheal tube, or ETT) connected to a breathing machine (ventilator).
- Trial name
- NETT (NCT07664449)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Microbial Colonization
Assessment of Colonisation and Skin Quality Parameter Improvement by Probiotic Micrococcus Luteus Q24 Balm in Healthy Adults.
The purpose of this study is to evaluate the skin quality improvement and colonization efficacy following the application of probiotic Micrococcus luteus Q24 (BLIS Q24) to the elbow and back of forearm in a topical balm format in…
- Trial name
- NCT05750381
- Testing
- Micrococcus luteus Blis Q24 balm
- Where
- New Zealand
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- BLIS Technologies Limited
Sepsis, Septic Shock
Central Venous Catheter Colonisation Among Critically Ill Patients in Intensive Care Units
Background: Central Venous catheter insertion technique and indwelling time are major risk factors for CVC colonisation. Colonisation occurs through microbial migration and biofilm formation along the catheter insertion tract.
- Conditions
- Sepsis, Septic Shock, Post-cardiac Surgery, Post-Cardiorespiratory Arrest Coma
- Trial name
- NCT03270774
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Makerere University
Meningitis, Bacterial
A Controlled Study to Assess Safety, Colonisation and Immunogenicity of Reconstituted Lyophilised Neisseria Lactamica
This study is part of a series of projects to develop and test new vaccines for meningitis. Previously researchers have given nose drops containing N.
- Trial name
- Lac5-Nasal (NCT04135053)
- Testing
- Lyophilised Neisseria lactamica
- Where
- United Kingdom
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Southampton
Meningitis, Meningococcal
A Human Controlled Infection Study with Neisseria Lactamica in Malian Adults
This study is part of a series of projects to improve protection against meningitis. Previously, researchers have given nose drops containing N.
- Trial name
- NCT04665791
- Testing
- Intranasal inoculation with Neisseria lactamica
- Where
- Mali
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Center for Vaccine Development - Mali
Pneumococcal Disease, Pneumococcal Carriage
Carriage to Assess Protection of New Pneumococcal Vaccines - PCV15
Streptococcus pneumoniae (pneumococcus) is a bacterium that causes just under four million serious infections every year. It is normal for pneumococcus bacteria to live in the noses of healthy adults and children as part of the…
- Trial name
- RATIONALE-15 (NCT06731374)
- Testing
- PCV15, Streptococcus pneumoniae serotype 3
- Where
- 2 sites in United Kingdom
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of Oxford