Clinical trials: Colonoscopy
Colonoscopy
Virtual Reality Alternative to Pharmacological Sedation During Colonoscopy
Colonoscopy patients will be fitted with a virtual reality head-mounted display, and virtual experiences will be initiated prior to colonoscope insertion. Colonoscopy will be initiated without standard sedatives and narcotics.
- Trial name
- NCT04349150
- Testing
- Virtual reality
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Colonoscopy
A Safety and Efficacy Comparison of BLI4700 Bowel Preparation Versus an FDA-approved Comparator in Adult Subjects Prior to Colonoscopy
The objective of this study is to compare the safety and efficacy of BLI4700 bowel preparation to an FDA-approved bowel preparation as 2-day, split-dose bowel preparations prior to colonoscopy in adult patients.
- Trial name
- NCT03261960
- Testing
- BLI4700, Magnesium bowel preparation
- Where
- 20 sites in United States
- Volunteers
- 389 people
- Sponsor
- Braintree Laboratories
Colonoscopy
A Safety and Efficacy Comparison of BLI4700 Bowel Prep Versus an FDA-approved Comparator in Adults Prior to Colonoscopy
The objective of this study is to compare the safety and efficacy of BLI4700 bowel preparation to an FDA-approved bowel preparation as 2-day, split-dose bowel preparations prior to colonoscopy in adult patients.
- Trial name
- NCT03404401
- Testing
- BLI4700, Polyethylene glycol bowel preparation
- Where
- 23 sites in United States
- Volunteers
- 620 people
- Sponsor
- Braintree Laboratories
Colonoscopy
A Safety and Efficacy Study of a Bowel Cleansing Preparation (BLI800) in Pediatric Subjects Undergoing Colonoscopy
The objective of this study is to compare the safety, tolerance and efficacy of BLI800 to a PEG based preparation prior to colonoscopy in adolescent patients.
- Trial name
- NCT02819323
- Testing
- PEG-ELS, BLI800
- Where
- 27 sites in United States
- Volunteers
- 91 people
- Sponsor
- Braintree Laboratories
Colonoscopy
The Use of Narrow Band Imaging in Screening Colonoscopy
Narrow band imaging (NBI) is an imaging technique that allows a better definition of capillary pattern and improves the contrast between adenomas and the surrounding mucosa.
- Trial name
- NCT00908648
- Testing
- Narrow Band Imaging
- Volunteers
- 206 people
- Sponsor
- Valduce Hospital
Colonoscopy
Efficacy, Safety and Tolerability of a Bowel Cleansing Preparation (BLI800) in Pediatric Subjects Undergoing Colonoscopy
The purpose o this study is to evaluate the safety, tolerance and efficacy of BLI800 as a bowel preparation prior to colonoscopy in pediatric patients.
- Trial name
- NCT02189850
- Testing
- BLI800 - Dose 1, BLI800 - Dose 2
- Where
- 5 sites in United States
- Volunteers
- 29 people
- Sponsor
- Braintree Laboratories
Colon Staining in Preparation for Colonoscopy
Colon Staining Efficacy of Single Oral Doses of Methylene Blue MMX
To describe and evaluate the mucosal staining efficacy of Methylene Blue MMX® tablets after total oral doses of 150 or 200 mg in patients undergoing a full colonoscopy for various reasons.
- Trial name
- CRO-11-108 (NCT03287219)
- Testing
- Methylene Blue MMX 25 mg modified release tablets
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Cosmo Technologies Ltd
Performance and Tolerance of Colonoscopy
Effectiveness of Abdominal Binder Use During Colonoscopy
Colonoscopy is considered the primary screening test for colorectal cancer screening worldwide. For technical difficulties previously experienced during colonoscopy, especially loop of the colonoscopy device in the colon, many…
- Trial name
- NCT04383132
- Testing
- Abdominal Binder
- Where
- Turkey (Türkiye)
- Volunteers
- 346 people
- Sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Colonoscopy
Polyethylene Glycol Versus Low Volume Solutions Prior to Colonoscopy
Study evaluates the efficacy and tolerability of low volume preparations compared with conventional 4L polyethylene glycol prior to colonoscopy
- Trial name
- NCT02956057
- Testing
- Polyethylene Glycols, Natrium picosulfate / Magnesium citrate, Polyethylene glycol / Ascorbic acid
- Where
- Czechia
- Volunteers
- 1,044 people
- Sponsor
- Tomas Bata Hospital, Czech Republic
Colonoscopy
A Phase III Study of the Efficacy and Safety of Remimazolam Compared to Placebo and Midazolam in Colonoscopy Patients
A prospective, double-blind, randomized, placebo and active controlled, multi-center, parallel group study comparing remimazolam to placebo, with an additional open-label arm for midazolam, in patients undergoing a colonoscopy…
- Trial name
- NCT02290873
- Testing
- Remimazolam, Midazolam
- Where
- 13 sites in United States
- Volunteers
- 461 people
- Sponsor
- Paion UK Ltd.
Colonoscopy
Safety and Efficacy of Remimazolam in ASA III and IV Patients Undergoing Colonoscopy
A prospective, double-blind, randomized, placebo and active controlled, multi-center, parallel group study comparing remimazolam to placebo, with an additional open-label arm for midazolam, in American Society of…
- Trial name
- NCT02532647
- Testing
- Remimazolam, Midazolam
- Where
- 3 sites in United States
- Volunteers
- 79 people
- Sponsor
- Paion UK Ltd.
Colonoscopy
The Affect of Low-Volume Bowel Preparation for Hospitalized Patients Colonoscopies
The purpose of this study is to compare the efficacy of a low-volume bowel preparation versus a high-volume bowel preparation for bowel cleansing on hospitalized patients undergoing colonoscopies.
- Trial name
- NCT01978509
- Testing
- Low volume prep (Prepopik), Moderate volume prep (Moviprep), High volume prep (Golytely)
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Colon Cancer Screening, Colon Polyps
Comparison of Colon Adenoma Detection Rate Using Two Distal Colonoscope Attachments
The goal of this study is to compare two FDA approved distal colonoscope attachment devices, in order to identify which device can increase adenoma detection rate the most without increasing procedure time or risk.
- Conditions
- Colon Cancer Screening, Colon Polyps, Colon Adenomas, Water Exchange Colonoscopy
- Trial name
- NCT02665741
- Testing
- Olympus transparent cap, Medivators Endocuff, Control
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- University of California, Davis
Type 2 Diabetes Mellitus, Colonoscopy
Abnormal Blood Sugar Tests in Diabetic Patients During Colonoscopy Preparation
Type 2 diabetes is rapidly increasing globally and has been associated with an increased risk of colorectal cancer. Therefore, the numbers of diabetic patients who will undergo colonoscopic screening are expected to grow…
- Trial name
- NCT03109951
- Testing
- Colonoscopy preparation using polyethylene glycol
- Where
- South Korea
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- Catholic Kwandong University
Colonoscopy, Adjunct Anesthesia Medication
Diphenhydramine as an Adjunctive Sedative in Patients on Chronic Opioids
To access the efficacy of adding diphenhydramine as adjunct to improve sedation and to reduce the amount of standard sedatives used during colonoscopy in patients on chronic opioids.
- Trial name
- NCT01967433
- Testing
- Diphenhydramine
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Oklahoma
Post-polypectomy Bleeding, Polypectomy
Risk of Post-polypectomy Bleeding With Prophylactic Hemoclipping
A randomized trial aimed at determining whether or not hemoclips are effective in preventing post-polypectomy bleeds on polyps that are 10mm in size or greater.
- Conditions
- Post-polypectomy Bleeding, Polypectomy, Elective Colonoscopy
- Trial name
- NCT01647581
- Testing
- Hemoclip Placement, NO hemoclip placement
- Where
- 3 sites in United States
- Volunteers
- 11,182 people
- Sponsor
- VA Office of Research and Development
Colonoscopy
Propofol and Dexmedetomidine Versus a Propofol Only Regimen for Sedation During Colonoscopy
An ideal sedative for colonoscopy should have properties that include: rapid onset and offset of action, provide cardiopulmonary stability, have minimal adverse effects, and allow for smooth recovery, and early discharge.
- Trial name
- NCT03139279
- Testing
- Dexmedetomidine, Propofol
- Where
- United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- State University of New York - Downstate Medical Center
Colonoscopy
Adenoma Detection Rate With a New Pediatric Colonoscope With a Short Turn Radius (Pentax Retroview) Compared With a Standard Pentax Pediatric Colonoscope
The purpose of this study is to determine whether the new colonoscope that provides both a traditional and a retrograde view (bending 180 degrees to look behind itself) of the colon can detect more polyps than a standard…
- Trial name
- NCT03807089
- Testing
- Conventional Pediatric Colonoscope, Short-Turn Radius Colonoscope
- Volunteers
- 283 people
- Sponsor
- Massachusetts General Hospital
Colonoscopy, Oxygenation
Comparison of Oxygenation and Ventilation With a Novel Nasal Mask Versus Standard of Care During Colonoscopy
Nasal continuous positive airway pressure (nCPAP) has been shown to effectively relieve upper airway obstruction in patients with OSA as it creates a pneumatic stent in the hypopharynx that reduces obstruction and allows for…
- Conditions
- Colonoscopy, Oxygenation, Ventilation
- Trial name
- NCT03139448
- Testing
- Oxygen via nasal cannula, Oxygen via SuperNO2VA nasal mask
- Where
- United States
- Volunteers
- 174 people
- Sponsor
- Vanderbilt University Medical Center
Desaturation of Blood, Obesity
High-Flow Nasal Cannula and Desaturation Episodes in the Morbidly Obese Patients
It is standard practice in the United States and many parts of world to perform Gastrointestinal (GI) endoscopy with the patient under deep sedation.
- Conditions
- Desaturation of Blood, Obesity, Colonoscopy, Sleep Apnea
- Trial name
- NCT03148262
- Testing
- The Comfort Flo system, The Salter nasal cannula
- Where
- 2 sites in United States
- Volunteers
- 59 people
- Sponsor
- University of Texas Southwestern Medical Center