Clinical trials: Colorectal Adenoma
Polyp Colorectal, Endoscopic Mucosal Resection
Structured TXI-RDI Integration for Endoscopic Resection
The goal of this clinical research study is to learn whether two advanced imaging tools, called Texture and Color Enhancement Imaging (TXI) and Red Dichromatic Imaging (RDI), can make the removal of large colon polyps safer…
- Trial name
- STRIkER (NCT07474844)
- Testing
- Texture and Color Enhancement Imaging (TXI) and Red Dichromatic Imaging (RDI), High Definition White Light Endosocopy
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Colonic Adenoma, Colonic Polyp
Evaluation of Endorings-2-assisted Colonoscopy: a New Accessory for Improvement of Adenoma Detection Rate?
Screening colonoscopy for colorectal cancer is essential to diagnose and remove adenomas, precancerous stages of colorectal cancer. Unfortunately approximately 25 % of all adenomas are missed during the examination.
- Conditions
- Colonic Adenoma, Colonic Polyp, Colonic Neoplasms, Colonoscopy
- Trial name
- Endorings-2 (NCT03385434)
- Testing
- Endorings-2
- Where
- Germany
- Volunteers
- 292 people, healthy volunteers welcome
- Sponsor
- University Hospital Muenster
Colorectal Polyp
BLI Based Adenoma Surveillance Strategy
Bowel cancer is the third most common cancer in the UK. It develops through smaller growths in the bowel called polyps. Early recognition and removal of these polyps result in prevention of developing bowel cancer in an…
- Trial name
- BLAST (NCT04111601)
- Testing
- Blue light imaging
- Where
- United Kingdom
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- Portsmouth Hospitals NHS Trust
Colorectal Cancer, Colorectal Neoplasms
Diagnostic Accuracy of a Panel of Bacterial Gene Markers (M3) for Colorectal Advanced Neoplasia
The investigators aim to evaluate and compare the diagnostic accuracy of FIT and the novel panel of bacterial gene markers (Fn, m3, Ch and Bc) collectively named as M3, in detecting colorectal advanced neoplasia.
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Adenoma
- Trial name
- M3-PRO (NCT05405673)
- Testing
- Fecal immunochemical test (FIT)
- Where
- Hong Kong
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Colorectal Cancer, Advanced Adenocarcinoma
Colorectal Cancer and Pre-Cancerous Adenoma Non-Invasive Detection Test Study
This study was a prospective analysis conducted by Geneoscopy Inc. to evaluate the ColoSense test, which is a multi-target stool RNA test for colorectal cancer screening.
- Conditions
- Colorectal Cancer, Advanced Adenocarcinoma, Serrated Polyp
- Trial name
- CRC-PREVENT (NCT04739722)
- Testing
- ColoSense
- Where
- 2 sites in United States
- Volunteers
- 14,263 people, healthy volunteers welcome
- Sponsor
- Geneoscopy, Inc.
Colorectal Adenoma, Colorectal Polyp
Validation of the Global Polypectomy Assessment Tool (GPAT)
Colorectal polypectomy is offten incompletely performed with high variability between endoscopists, resulting in interval cancer or repeated procedures.
- Conditions
- Colorectal Adenoma, Colorectal Polyp, Colo-rectal Cancer
- Trial name
- GPAT (NCT05877456)
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Colorectal Cancer, Colorectal Neoplasms
Early Detection of Advanced Adenomas and Colorectal Cancer
This study aims to develop a highly sensitive, specific, and cost-effective blood assay for early detection of colorectal adenomas and cancer, using advanced machine learning and state-of-the-art biological analyses.
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Polyp, Colorectal Adenocarcinoma
- Trial name
- AACRC (NCT06342440)
- Testing
- DENEB
- Where
- 6 sites in United States, China and 3 more
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Colorectal Cancer, Adenoma Colon
Characterization of Brazilian Colorectal Cancer Screening Population
Colorectal cancer (CRC) is the third most common type of cancer among men and the second among women in Brazil. Despite the high incidence and significance of CRC in Brazil, very little is known about its prevalence among the…
- Trial name
- NCT03355391
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Barretos Cancer Hospital
Colorectal Cancer, Colorectal Adenoma
Protocol to Validate the Performance of the LifeKit® Prevent Colorectal Neoplasia Test for CRC Screening
The purpose of this study is to determine the sensitivity and specificity for LifeKit Prevent Colorectal Neoplasia Test for colorectal cancer (CRC) and for adenoma, including advanced adenoma.
- Trial name
- PREVENT (NCT04693546)
- Testing
- LifeKit Prevent Colorectal Neoplasia Test, FIT Test
- Where
- United States
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Metabiomics Corp
Colonic Polyps, Colonic Neoplasms
Development of Quality Indicators and Quality Improvement Plan of Colonoscopy in Experienced Endoscopist
The purpose of this study is to determine clinical factors affecting quality indicators of colonoscopy including adenoma detection rate, and whether quality of colonoscopy could be elevated by improving related factors.
- Trial name
- NCT02385552
- Testing
- Feedback
- Where
- 2 sites in South Korea
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Colorectal Cancer, Adenoma
The Implication of Plasma ctDNA Methylation Haplotypes in Detecting Colorectal Cancer and Adenomas
This is a multicenter, clinical study. This study is to evaluate the sensitivity of plasma ctDNA methylation haplotypes in detecting colorectal cancer, adenoma and the specificity in healthy individuals.
- Trial name
- NCT03737591
- Testing
- Next-generation sequencing (NGS)
- Where
- China
- Volunteers
- 1,138 people, healthy volunteers welcome
- Sponsor
- Fudan University
Colorectal Polyp, Colorectal Adenoma
Artificial-intelligence-based QUAntification of Size measuremeNts of Adenoma in Routine Endoscopy
Polyp size and count determines the follow-up intervals after colonoscopy. However, relying on the endoscopist's optical diagnosis for size estimation has shown considerable variability, leading to erroneous surveillance…
- Trial name
- AQUASNARE (NCT06040710)
- Testing
- POSEIDON size estimation software with the EndoMind polyp detection system
- Where
- Germany
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Wuerzburg University Hospital
Colorectal Cancer
Prevention and Early Detection Biomarkers of Adenomas and CRC Lesions During CRC Screening
The investigators designed a prospective study to evaluate the predictive ability of detection of mutations in genes involved in carcinogenesis of the colon (eg hMLH1, K-Ras, B-Raf, ccfDNA) in a sample of Greek population…
- Trial name
- NCT02596113
- Where
- Greece
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Evangelismos Hospital
CRC (Colorectal Cancer), Adenoma Colon
An Exploratory Study on Gene Methylation Detection of Colorectal Cancer
The goal of this exploration study is to evaluate the performance of a colorectal cancer (CRC) early screening model based on the DNA methylation technology platform.
- Trial name
- NCT07033156
- Testing
- This study does not require intervention trials
- Where
- China
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Zhejiang Provincial People's Hospital
Colorectal Neoplasms
Comparative Efficacy of Water & Indigo Carmine vs. Water or Air Method on Adenoma Detection Rate (ADR) - a Randomized Controlled Trial (RCT)
Adenoma detection rate (ADR) is a quality indicator of colonoscopy performed for colorectal cancer screening. Population studies have shown that traditional air colonoscopy fails to eliminate post screening colonoscopy cancers or…
- Trial name
- NCT01607255
- Testing
- Indigo carmine, water (exchange) method, water (exchange) plus dye method
- Where
- United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Artificial Intelligence, Colonic Adenoma
Artificial Intelligence-Assisted Colonoscopy in Colorectal Cancer Screening in a General Hospital
Cancer can develop in the colon, or large bowel. Examination of the colon with a tube fitted with a camera is called a colonoscopy. Colonoscopy allows detection of small growths in the colon, called "polyps".
- Conditions
- Artificial Intelligence, Colonic Adenoma, Colonic Neoplasms, Colonic Polyp
- Trial name
- Delta-AI (NCT06792292)
- Testing
- conventional colonoscopy procedure, artificial intelligence-assisted colonoscopy procedure
- Where
- Belgium
- Volunteers
- 765 people, healthy volunteers welcome
- Sponsor
- Chirec
Colorectal Adenoma, Colorectal Neoplasms
Adenoma Detection Rate in Colonoscopy Performed With EndoRings
The study is designed to examine whether colonoscopy using an EndoRings cap has a higher adenoma detection rate than conventional colonoscopy.
- Trial name
- NCT03219918
- Testing
- EndoRings II Distal Attachment
- Where
- Denmark
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Zealand University Hospital
Colonic Adenoma, Colonic Cancer
R vs L Lateral Decubitus Positioning in Colonoscopy
Colonoscopy continues to be the gold standard in detecting precancerous lesions in the colon. It relies on adequate visualization of the bowel wall to see and remove such lesions.
- Trial name
- NCT03355495
- Testing
- Colonoscopy - Position Change
- Where
- Canada
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Memorial University of Newfoundland
Colonic Neoplasm
Narrow Band Imaging for Diagnosis of Proximal Serrated Polyps
Although colonoscopy is considered the gold standard for diagnosis of colonic polyps, the missed rate for colonic adenoma ranged from 15-32%.
- Trial name
- NCT01725321
- Testing
- Narrow band imaging
- Where
- China
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Pancreatic Cancer, Thyroid Cancer
Integrated Cancer Repository for Cancer Research
The iCaRe2 is a multi-institutional resource created and maintained by the Fred \& Pamela Buffett Cancer Center to collect and manage standardized, multi-dimensional, longitudinal data and biospecimens on consented adult cancer…
- Conditions
- Pancreatic Cancer, Thyroid Cancer, Lung Cancer, Esophageal Cancer
- Trial name
- iCaRe2 (NCT02012699)
- Where
- 42 sites in United States
- Volunteers
- 999,999 people, healthy volunteers welcome
- Sponsor
- University of Nebraska