Clinical trials: Colorectal Adenomas
Colonic Polyps, Adenomatous Polyps
Impact of Indigo Carmine Pump Spraying on the Adenoma Detection Rate
Detection and removal of polyps during colonoscopy is crucial for the prevention of colorectal cancer. Indigo carmine spraying up to the colonic mucosa could probably increase the adenoma detection rate.
- Conditions
- Colonic Polyps, Adenomatous Polyps, Adenoma Detection Rate, Chromoendoscopy
- Trial name
- NCT06596317
- Testing
- Chromoendoscopy, Conventional colonoscopy
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Shandong University
Colorectal Cancer, Colorectal Neoplasms
Serial Gut Microbiome and Bacterial Gene Markers Changes After Endoscopic Resection of Colorectal Advanced Neoplasia
The investigators hypothesize that gut microbiome composition and the four bacterial gene markers (M3) show dynamic changes after endoscopic resection of advanced neoplasia, some key bacteria are associated with restoration of…
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Adenoma
- Trial name
- M3-CAN (NCT05381792)
- Testing
- Bacterial gene markers test
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- Chinese University of Hong Kong
Colon Cancer, Rectal Cancer
Prevention of Colorectal Cancer Through Multiomics Blood Testing
The PREEMPT CRC study is a prospective multi-center observational study to validate a blood-based test for the early detection of colorectal cancer by collecting blood samples from average-risk participants who will undergo a…
- Conditions
- Colon Cancer, Rectal Cancer, Colon Neoplasm, Colon Diseases
- Trial name
- PREEMPT CRC (NCT04369053)
- Testing
- Freenome test
- Where
- 148 sites in United States, Canada
- Volunteers
- 48,995 people, healthy volunteers welcome
- Sponsor
- Freenome Holdings Inc.
Familial Adenomatous Polyposis Coli, FAP
Chemoprevention Trial in Familial Adenomatous Polyposis (FAP) Coli Using EPA
This purpose of this study is to investigate whether the number and size of rectal polyps can be reduced in patients with Familial Adenomatous Polyposis (FAP) by using a highly-purified form of a naturally occurring substance…
- Trial name
- NCT00510692
- Testing
- Eicosapentanoic Acid (EPA), Endoscopy, Biopsies taken
- Where
- United Kingdom
- Volunteers
- 58 people
- Sponsor
- S.L.A. Pharma AG
Colon Polyp, Colon Adenoma
Hybrid APC Assisted EMR for Large Colon Polyps
The purpose of this study to evaluate and examine whether use of Hybrid Argon Plasma Coagulation (APC) as an adjunct to endoscopic mucosal resection (EMR) will reduce the risk of residual or recurrent neoplasia at 6 months.
- Conditions
- Colon Polyp, Colon Adenoma, Colon Cancer
- Trial name
- NCT03390907
- Testing
- Hybrid APC
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Milton S. Hershey Medical Center
Colorectal Adenoma, Colorectal Polyp
Endocuff Vision Colonoscopy vs. AmplifEYE Colonoscopy
The study aims to compare the results between colonoscopies with two different attachments on the distal end of the colonoscope.
- Conditions
- Colorectal Adenoma, Colorectal Polyp, Colorectal Cancer
- Trial name
- NCT03560128
- Testing
- Endocuff Vision device, AmplifEYE device
- Where
- United States
- Volunteers
- 634 people, healthy volunteers welcome
- Sponsor
- Indiana University
Colorectal Cancer Control and Prevention
Clinical and Endoscopic Characterization of Patients With Multiple Colorectal Adenomas: A Multicenter Study in Spain (ESPAPOLYP Study)
The aim is to clinically, endoscopically, and molecularly characterize patients with multiple colorectal adenomas, establish the indication for genetic testing to rule out hereditary syndromes and identify the genes to be…
- Trial name
- ESPAPOLYP (NCT06625788)
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Asociación Española de Gastroenterología
Superficial Colorectal Tumors
Predictive Factors for Failure or Success of Endoscopic Treatment of Superficial Colorectal Tumors
To evaluate the long-term complete remission rate (> 12 months) after endoscopic treatment of early neoplastic colorectal lesions.
- Trial name
- REC (NCT03470883)
- Testing
- Evaluation of the long-term complete remission rate (> 12 months)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Institut Paoli-Calmettes
Colon Polyps, Adenomatous Polyps
Prospective Study for Evaluating Colon Polyp Histology With in Vivo Probe Based Confocal Laser Endomicroscopy
Chromoendoscopy (that involves spraying of dyes over the colonic mucosa) combined with magnification has been utilized for polyp histology identification.
- Conditions
- Colon Polyps, Adenomatous Polyps, Colon Cancer
- Trial name
- NCT01214031
- Testing
- Confocal laser endomicroscopy (CLE)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Midwest Biomedical Research
Polyps, Adenoma Colon
Computer Assisted Selection of Serrated Adenomas and Neoplastic Polyps - a New Clinical DRAft
The aim of the study is to develop a computer program which is able to classify different entities of colorectal polyps on the basis of optical polyp features.
- Conditions
- Polyps, Adenoma Colon, Automatic Judgement, Colonic Neoplasms
- Trial name
- CASSANDRA I (NCT03550625)
- Testing
- Computer program
- Volunteers
- 300 people
- Sponsor
- Technical University of Munich
Adenomatous Polyps
Curcumin for the Chemoprevention of Colorectal Cancer
Specific Aims: To determine if curcuminoids modulate cellular proliferation as measured by proliferating cell nuclear antigen (PCNA) in the colorectal mucosa of subjects with previously resected adenomatous colonic polyps.
- Trial name
- NCT00118989
- Testing
- Curcuminoids
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania