Clinical trials: Colorectal Anastomosis
Rectum Cancer, Stoma Colostomy
Effects of Modified Precision Functional Sphincter-Preserving Surgery (PPS) on Ultralow Rectal Cancer
RATIONALE: Colorectal cancer is one of the most common cancers. However, approaches to minimize surgical trauma, preserve anal function, avoid abdominal stoma, and improve quality of life for patients with ultralow rectal cancers…
- Conditions
- Rectum Cancer, Stoma Colostomy, Faecal Incontinence, Leakage, Anastomotic
- Trial name
- NCT05245565
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai 10th People's Hospital
Rectal Cancer
LifeSeal™ Pilot Study in Subjects Undergoing Circular Stapled Anastomosis Created Within 10 cm of the Anal Verge
A Pilot Study in Subjects Undergoing circular stapled anastomosis created within 10 cm of the anal verge.
- Trial name
- NCT02046278
- Testing
- LifeSeal™ Kit
- Where
- 8 sites in Belgium, Israel and 1 more
- Volunteers
- 70 people
- Sponsor
- LifeBond Ltd.
Rectal Neoplasms, Low Anterior Resection Syndrome
Comparison of Postoperative Anal Function Between Parks and Bacon Techniques in Low Rectal Cancer
The goal of this study is to compare the postoperative anal function of patients with ultra-low rectal cancer after Parks operation (colon anal anastomosis) and Bacon operation (colon anal pull-out anastomosis), which may provide…
- Conditions
- Rectal Neoplasms, Low Anterior Resection Syndrome, Anastomotic Leak, Quality of Life
- Trial name
- NCT05943444
- Testing
- Parks technique, Bacon technique
- Where
- China
- Volunteers
- 256 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Anastomotic Leaks
Surgical Intuition in Anastomotic Leakage After Colorectal Surgery
The SURGUT study aims to assess how well a computer model predicts bowel leaks after surgery. It will also examine whether adding surgeons' intuition improves these predictions.
- Trial name
- SURGUT (NCT07888478)
- Where
- 2 sites in Switzerland
- Volunteers
- 4,300 people
- Sponsor
- University Hospital, Basel, Switzerland
Anastomotic Leakage, Colorectal Cancer
Predictive Factors for Anastomotic Leakage After Colorectal Surgery
Rationale: Colorectal cancer is the fourth most common cause of cancer death worldwide, estimated to be responsible for almost 610,000 deaths in 2008.
- Conditions
- Anastomotic Leakage, Colorectal Cancer, Anastomotic Leak, Colorectal Neoplasms
- Trial name
- REVEAL (NCT02347735)
- Testing
- No interventions, only data collection
- Where
- 4 sites in Netherlands
- Volunteers
- 774 people
- Sponsor
- Maastricht University Medical Center
Anastomosis, Leaking
Anastomotic Leak in Covid-19
evaluate the incidence of anastomotic leak after colorectal surgery
- Trial name
- NCT06663033
- Testing
- colorectal surgery
- Where
- Egypt
- Volunteers
- 390 people
- Sponsor
- Zagazig University
Colon Cancer
Intracorporeal Versus Extracorporeal Anastomotic After Laparoscopic Right Colectomy
Background: Laparoscopic assisted right hemicolectomy is recommended for right colon cancer. As a more minimally invasive procedure, intracorporeal ileocolic anastomosis has potential advantages: reducing torsion and traction on…
- Trial name
- NCT05493033
- Testing
- Intracorporeal anastomotic after LRC, Extracorporeal anastomotic after LRC
- Volunteers
- 1,158 people
- Sponsor
- Beijing Friendship Hospital
Rectal Neoplasms
Defunctioning Cannula Ileostomy After Lower Anterior Resection of Rectal Cancer
Most surgeons suggest the use of fecal diverting to address the high morbidity and mortality associated with anastomotic leakage (AL) in patients with high risk factors on AL who are undergoing anterior resections.
- Trial name
- NCT01980238
- Testing
- cannula ileostomy, loop ileostomy, LAR
- Where
- China
- Volunteers
- 300 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Anastomotic Leak, Rectal Cancer
Serial Endoscopic Surveillance & Direct Topical Antibiotics to Define the Role of Microbes in Anastomotic Healing
Rationale: The surgical complication of intestinal anastomotic leak remains a clear and present danger to patients despite advances in surgical technique and ever more powerful antibiotics.
- Trial name
- SES-DTA (NCT02682485)
- Testing
- Cipro, metronidazole, neomycin combo, Serial Endoscopic Surveillance, Saline
- Sponsor
- University of Chicago
Albumin; Double
Determination of Albumina as an Early Predictor of Postoperative Infections in Colorectal Surgery
Colorectal surgery has traditionally been associated with significant morbidity and prolonged hospital stay. Overall complication rates have been reported to be 26-35%.
- Trial name
- ALB-CIR (NCT03643523)
- Testing
- Albumine detection
- Volunteers
- 70 people
- Sponsor
- Corporacion Parc Tauli
Colorectal Cancer
Peri-Strips Dry (PSD) Veritas Collagen Matrix Staple Line Reinforcement for Colorectal Surgery
Purpose of the study is to assess the utility of PSD Veritas as a staple line reinforcement to minimize the risk of leakage during or after colo-rectal surgery.
- Trial name
- NCT00559013
- Testing
- Staple line reinforcement
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- Baxter Healthcare Corporation
Anastomotic Leakage
Anastomotic Leakage Following Laparoscopic Resection for Rectal Cancer
Anastomotic leak (AL) is a breakdown of a suture line in a surgical anastomosis with a subsequent leakage of the luminal content.
- Trial name
- NCT02718729
- Testing
- Laparoscopic resection for rectal cancer
- Where
- 2 sites in Egypt, Italy
- Volunteers
- 59 people
- Sponsor
- Mansoura University
Colorectal Cancer, Surgery
Future of Colorectal Cancer Surgery
Colorectal cancer is the third most common cancer in the UK and Ireland, it is the second commonest cancer in both men and women.
- Trial name
- FOCCuS1 (NCT04220242)
- Testing
- Video recordings with analysis thereafter applied, Examination of microsections of tissue excised for the purposes of cancer resection, Cancer organoid development and testing
- Where
- Ireland
- Volunteers
- 250 people
- Sponsor
- Mater Misericordiae University Hospital
Low Rectal Cancer, Rectal Neoplasms
Reinforced Versus Conventional Anastomosis in Laparoscopic Low Rectal Cancer Resection: A Comparative Study
Study Description This prospective, controlled clinical study aims to compare the clinical outcomes of reinforced anastomosis using 8-10 interrupted sutures versus the conventional Dixon procedure in patients undergoing…
- Conditions
- Low Rectal Cancer, Rectal Neoplasms, Colorectal Cancer
- Trial name
- NCT07346534
- Testing
- Reinforced Anastomotic Suturing (8-10 Interrupted Sutures), Conventional Laparoscopic Dixon Procedure
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shanghai 10th People's Hospital
Colorectal Surgery, Colorectal Resection
AUGUR-AI - Indocyanine Green Fluorescence Angiography Representer
Surgery can effectively treat colorectal cancer, but it is a complex procedure with risks and complications. Surgeons often rely on cameras to visually guide their instruments during operations, especially in minimally invasive…
- Conditions
- Colorectal Surgery, Colorectal Resection, Anastomosis, Surgical, Fluorescence Guided Surgery
- Trial name
- AUGUR-AI (NCT06708819)
- Where
- Ireland
- Volunteers
- 300 people
- Sponsor
- Mater Misericordiae University Hospital
Colorectal and Ileorectal Anastomosis, Colocolic and Ileocolic Anastomosis
A Clinical Study Comparing Standard Anastomosis Closure Technique to Standard Closure Techniques Plus Sylys® Surgical Sealant
The Cohera Sylys® Surgical Sealant study is a prospective, randomized, controlled, multicenter clinical study comparing standard anastomosis closure technique (Control) to standard closure technique plus Sylys® Surgical Sealant…
- Conditions
- Colorectal and Ileorectal Anastomosis, Colocolic and Ileocolic Anastomosis, Coloanal and Ileoanal Anastomosis
- Trial name
- NCT02841891
- Testing
- Sylys® Surgical Sealant, Stapled Anastomosis Colectomy Procedure
- Where
- 16 sites in United States
- Volunteers
- 58 people
- Sponsor
- Cohera Medical, Inc.
Rectal Cancer, Colon Cancer
Contribution of Preserving the Superior Left Colic Artery to the Vascularization of the Descending Colon Prior to Colorectal Anastomosis During Left-Sided or Rectal Resections for Colorectal or Ovarian Cancer. (Revascularisation Colique)
Colorectal cancers and ovarian cancers are respectively the 2nd and 5th cause of cancer mortality in France. Surgical resection is a crucial step in the therapeutic management of colorectal cancers.
- Conditions
- Rectal Cancer, Colon Cancer, Ovarian Cancer
- Trial name
- NCT07098182
- Testing
- Clamping and restauration of arterial blood of the inferior mesenteric artery
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Rectum Cancer
End to End Versus Side to End Anastomosis After Anterior Resection of Cancer Rectum
Comparison between end to end and side to end anastomosis after anterior resection of cancer rectum and compare the outcomes of both surgical techniques. The main outcomes were bowel functional outcomes and QoL.
- Trial name
- NCT06311279
- Testing
- Anterior resection of Rectal cancer
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Sohag University
Postoperative Complications, Proteinosis
Preserving Left Colonic Artery During Radical Resection of Rectal Cancer
To evaluate the feasibility and clinical significance of preserving left colonic artery in rectal cancer surgery.The investigators will focus on the effect of preserving left colonic artery during radical resection of rectal…
- Trial name
- NCT03776370
- Testing
- Preserve the left colonic artery, The left colonic artery is not preserved
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- Third Military Medical University
Rectal Cancer, Anastomotic Leak
CRP-guided Transanal Drainage Removal After Rectal Surgery
Transanal drainage tube (TDT) has the benefit of reducing intraluminal pressure after rectal surgery and may provide ideal regional environment for anastomotic healing.
- Trial name
- NCT05502354
- Testing
- removal of transanal drainage tube
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Qilu Hospital of Shandong University