Clinical trials: Colorectal Cancer (CRC) Screening
Colorectal Cancer, Colorectal Neoplasms
Longitudinal Performance of Epi proColon
This study will evaluate longitudinal performance of Epi proColon with respect to test positivity, longitudinal adherence to Epi proColon screening, adherence to follow-up colonoscopy and diagnostic yield, as well as assay…
- Trial name
- PERT (NCT03218423)
- Testing
- Epi proColon
- Where
- 6 sites in United States
- Volunteers
- 4,500 people, healthy volunteers welcome
- Sponsor
- Epigenomics, Inc
High Risk (Above Average) Subjects, Non Compliant Patients for Colo Rectal Cancer [CRC] Screening
Evaluation of C-Scan System in Providing Structural Information and Detection of Polypoid Lesions in High Risk Subjects
The purpose of this study is to establish the efficacy of Check-Cap's C-Scan System in providing structural information on colonic polypoid lesions and masses, as an adjacent tool to Feacal Immunochemical Test [FIT] in high risk…
- Conditions
- High Risk (Above Average) Subjects, Non Compliant Patients for Colo Rectal Cancer [CRC] Screening, Counterindicated Patients for Colonoscopy
- Trial name
- NCT03356002
- Testing
- C-Scan System
- Where
- 7 sites in Israel
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Check-Cap Ltd.
Colon Cancer Screening
Patient Reminders Optimizing Mail-in Prevention Testing for Colorectal Cancer
Screening is an important tool for early colorectal cancer detection, and the most recent evidence suggests that early detection significantly improves survival rates.
- Trial name
- PROMPT-CRC (NCT06710509)
- Testing
- Three Messaging Nudges
- Where
- United States
- Volunteers
- 2,106 people
- Sponsor
- Laura Feemster
Colorectal Cancer
CB-17-08 Augmented Endoscopy System for Mucosal Lesion Detection During Colonoscopy for Colon Rectal Cancer.
The aim of this study is to assess the performance of the CB-17-08 to help endoscopists find potential mucosal polyps during the colonoscopy procedure, without significant noise disturbing the endoscopist attention, nor negative…
- Trial name
- NCT03954548
- Testing
- CB-17-08 CADe
- Where
- 10 sites in United States, Italy and 1 more
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Cosmo Artificial Intelligence-AI Ltd
Colorectal Cancer, Colorectal Neoplasms
Clinical Performance of the Mainz Biomed Colorectal Cancer Screening Test for Colorectal Cancer and Advanced Adenoma
This study is to determine how the Mainz Biomed Colorectal Cancer Screening Test works when used in people aged ≥45 years of age and at an average risk of developing colorectal cancer.
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Polyp, Colorectal Adenoma
- Trial name
- reconAAsense (NCT05636085)
- Testing
- Mainz Biomed Colorectal Cancer Screening Test
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Mainz Biomed
Colo-rectal Cancer, Cancer Colon
AI-EMERGE: Development and Validation of a Multi-analyte, Blood-based Colorectal Cancer Screening Test
Freenome is using a type of artificial intelligence, called machine learning, to identify patterns of cell-free biomarkers in blood to detect cancer early.
- Conditions
- Colo-rectal Cancer, Cancer Colon, Cancer, Rectum, Neoplasms,Colorectal
- Trial name
- NCT03688906
- Where
- 30 sites in United States, Canada
- Volunteers
- 3,275 people, healthy volunteers welcome
- Sponsor
- Freenome Holdings Inc.
Colorectal Neoplasms, Digestive System Diseases
Exact CRC Screening Test: Stool Sample Collection Study to Support Assay Validation Testing
The objective of this study is to confirm the sensitivity and specificity of a stool DNA test for detection of colorectal cancer and pre-cancer.
- Conditions
- Colorectal Neoplasms, Digestive System Diseases, Colonic Diseases, Colorectal Cancer
- Trial name
- NCT01600209
- Where
- 13 sites in United States
- Volunteers
- 674 people, healthy volunteers welcome
- Sponsor
- Exact Sciences Corporation
Non Small Cell Lung Cancer, Colorectal Cancer
A Study of Personalized Neoantigen Cancer Vaccines
The purpose of this study is 1) to evaluate the feasibility of manufacturing a patient-specific neoantigen cancer vaccine, which involves predicting the patient's neoantigens and generating a vaccine that encodes the predicted…
- Conditions
- Non Small Cell Lung Cancer, Colorectal Cancer, Gastroesophageal Adenocarcinoma, Urothelial Carcinoma
- Trial name
- NCT03794128
- Testing
- Blood collection for research (next-generation sequencing [NGS]), Blood collection for research (HLA typing)
- Where
- 5 sites in United States
- Volunteers
- 93 people
- Sponsor
- Gritstone bio, Inc.
Colorectal Cancer Screening
Optimization of the Bowel Preparation Regimen for the PillCam® COLON 2 Capsule Endoscopy Procedure
This study is designed to determine the optimal bowel preparation regimen for PillCam® COLON 2 Capsule Endoscopy System (CCE) procedures in average risk patients.
- Trial name
- NCT02481219
- Testing
- PillCam® COLON 2 procedure-CONTROL, Senna tablets, PEG
- Where
- 6 sites in United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Medtronic - MITG
Colo-rectal Cancer
Motility of the Check-cap's MD1 Colon Capsule in Subjects Following Colon Rectal Cancer Screening by Colonoscopy
To monitor the Whole Gut Transit Time and repeatability of the motility of MD1 capsules in the colon of subjects with known polyps and in healthy subjects. Multi-Center, Open, Home Monitoring, Prospective Study.
- Trial name
- NCT03785665
- Testing
- MDI
- Where
- Israel
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Check-Cap Ltd.
Screening for Colon Cancer, Survey and Questionnaire
Exploring Participant Preference for Screening Methods and Experience Into Colorectal Cancer Screening Programme
The goal of this low-risk interventional study is to analyze participants' assessment of colorectal cancer screening program through screening method preference and experience after FOBT analysis in screaned participant…
- Trial name
- MS-Care (NCT06696534)
- Testing
- Survey using a questionnaire.
- Where
- 2 sites in Portugal, Spain
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- ADVANCED MARKER DISCOVERY S.L.
Colorectal Cancer Screening
Colorectal Cancer Screening Validation Study
The purpose of this study is to evaluate the gene expression patterns from colorectal mucosal cells collected through the use of a standard anoscope and cytology brush.
- Trial name
- CRC screening (NCT00720993)
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- IntelliGeneScan, Inc.
Colo-rectal Cancer
Shield Post-Approval Study Protocol
The Shield post-approval study (PAS) is a prospective, longitudinal study supplemented with Real World Evidence (RWE) to evaluate the longitudinal performance of Shield in an average risk population at a second round of testing…
- Trial name
- SOLAR (NCT06880055)
- Testing
- Shield Blood Test for colo-rectal cancer Screening
- Where
- 69 sites in United States
- Volunteers
- 3,375 people, healthy volunteers welcome
- Sponsor
- Guardant Health, Inc.
Colorectal Cancer
Collection of Samples From the United States Population for Optimization and Evaluation of Colorectal Cancer (CRC) Plasma Circulating Free-DNA (cfDNA) Marker Panel Performance
This study is designed to prospectively collect blood samples and clinical data from patients that have been newly diagnosed with colorectal cancer and scheduled for resection surgery but are pre cancer treatment, subjects who…
- Trial name
- PROVE (NCT07310446)
- Where
- United States
- Volunteers
- 6,500 people, healthy volunteers welcome
- Sponsor
- Universal Diagnostics
Colorectal Cancer Screening, Colorectal Cancer
A Study of Cologuard™ in an Average Risk Population Assessing a Three Year Test Interval
This is a prospective longitudinal study to assess the impact of repeat Cologuard testing at 3 years in average risk patients.
- Trial name
- NCT02419716
- Testing
- Cologuard
- Where
- 40 sites in United States
- Volunteers
- 2,404 people, healthy volunteers welcome
- Sponsor
- Exact Sciences Corporation
Colorectal Cancer Screening, Colorectal Cancer Metastatic
Pilot Study for Colorectal Cancer and Advanced Adenoma Detection With the Mainz Biomed Colorectal Cancer Test
The Mainz Biomed Colorectal Cancer Screening Test is being studied for its performance in the identification of the presence of colorectal cancer (CRC) or advanced adenoma (AA) in the colon in patients at average risk for…
- Conditions
- Colorectal Cancer Screening, Colorectal Cancer Metastatic, Colon Adenocarcinoma
- Trial name
- eAArly DETECT (NCT06864338)
- Where
- United States
- Volunteers
- 2,700 people, healthy volunteers welcome
- Sponsor
- Mainz Biomed
Colorectal Cancer, Adenomatous Polyp of Colon
CRC Screening Using mSEPT9 (Methylated Septin 9) in Chinese Population
The purpose of this study is to evaluate the performance of the SEPT9 gene methylation assay in Colorectal cancer (CRC) high-risk population in Chinese hospitals using the opportunistic screening method.
- Conditions
- Colorectal Cancer, Adenomatous Polyp of Colon, Polyps, Other Disease/Injury
- Trial name
- RESEPT (NCT02540850)
- Where
- 4 sites in China
- Volunteers
- 1,031 people, healthy volunteers welcome
- Sponsor
- BioChain (Beijing) Science and Technology, Inc.
Colorectal Cancer in Patients Under 50 Years of Age, Colorectal Cancer
Colorectal Cancer in Young Adults: Study of Incidence, Survival, and Prognostic Factors in Tarragona, Spain
We conducted an observational, descriptive, longitudinal and retrospective study of 59 patients under 50 years of age diagnosed with CRC in the province of Tarragona, between 2019 and 2024.
- Trial name
- CCR50 (NCT07026955)
- Testing
- colorectal cancer in patients over 50 years of age
- Where
- Spain
- Volunteers
- 59 people
- Sponsor
- HJ23
Colorectal Cancer Screening
Effectiveness of a Cloud-based Digital Health Navigation Program for Colorectal Cancer Screening
mPATH-CRC (mobile Patient Technology for Health) is an automated direct-to-patient digital health program about colorectal cancer screening.
- Trial name
- NCT06821009
- Testing
- mPATH-CRC, Usual Care (Control)
- Where
- 2 sites in United States
- Volunteers
- 6,500 people, healthy volunteers welcome
- Sponsor
- Digital Health Navigation Solutions, Inc
Colorectal Cancer
Multicentre Study for Data Collection, Development, and Evaluation of Novel CRC Screening and Diagnostic Methods
The primary goal is to develop easy accessible diagnostic tools for high risk subjects for colon cancer in different European populations to improve early CRC detection.
- Trial name
- NCT06515821
- Testing
- ONCOSCREEN
- Where
- 8 sites in Bulgaria, France and 4 more
- Volunteers
- 4,100 people
- Sponsor
- Firalis SA