Clinical trials: Colorectal Cancer Recurrent
Lynch Syndrome
Effect of Chemoprevention by Low-dose Aspirin of New or Recurrent Colorectal Adenomas in Patients With Lynch Syndrome
The proposed trial will evaluate the effect of aspirin 300 mg/d and 100 mg/d during 4 years vs placebo, in a 4 groups randomised parallel design in Lynch syndrome patients: patients with proven carriers of pathological mutations…
- Trial name
- AAS-Lynch (NCT02813824)
- Testing
- Acetylsalicylic acid lysinate 300 mg, Acetylsalicylic acid lysinate 100 mg
- Where
- France
- Volunteers
- 852 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Colorectal Cancer
Manipulation of the Gut Microbiome by a Standardized Preoperative Diet to Prevent Colorectal Cancer Recurrence and Metastasis Following Surgery
A single arm, prospective, single center Phase1/2 Dietary intervention trial for subjects diagnosed with colorectal cancer and scheduled for tumor resection more than 21 days from informed consent.
- Trial name
- DIET (NCT06349590)
- Testing
- High-fiber/low-fat meals
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Chicago
Cancer
Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain
This is a phase III, randomized, double-blind, placebo-controlled, multicenter study of the clinical response to fentanyl sublingual spray as a treatment for breakthrough cancer pain.
- Trial name
- NCT00538850
- Testing
- Fentanyl sublingual spray
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- INSYS Therapeutics Inc
Colorectal Neoplasm
Oxaliplatin and S-1 (OS) Versus Oxaliplatin and Capecitabine (XELOX) for Advanced Colorectal Cancer
The aim of this study is to compare the activity and safety of Oxaliplatin and S-1 (OS) and Oxaliplatin and Capecitabine (XELOX) in patients with advance or recurrent colorectal cancer.
- Trial name
- NCT00677144
- Testing
- OS (oxalipaltin+S-1), XELOX (oxalipaltin+capecitabine)
- Where
- South Korea
- Volunteers
- 88 people
- Sponsor
- Hallym University Medical Center
Colorectal Cancer, Polyp of Colon
Hybrid-APC Margin Ablation to Prevent Post EMR Adenoma Recurrence
Endoscopic Mucosal Resection (EMR) is the current standard for effective endoscopic resection of such colon adenomas. If resection is possible in one piece (so-called "en bloc" resection) then recurrence rates are low.
- Trial name
- h-APC_EMR (NCT04015765)
- Testing
- Hybrid Argon Plasma Coagulation and EMR procedure
- Where
- Canada
- Volunteers
- 376 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Rectal Cancer, Rectal Cancer Recurrent
A Trial of Regorafenib Plus Lorigerlimab in Patients With Locally Recurrent or Regrowing pMMR/MSS Localized Rectal Cancer
This is a prospective single-center, single-arm, open-label, phase II study evaluating the safety, activity, and efficacy of regorafenib in combination with lorigerlimab for the treatment of patients with regrowing or locally…
- Trial name
- NCT07223567
- Testing
- Regorafenib, Lorigerlimab
- Sponsor
- M.D. Anderson Cancer Center
Colorectal Cancer
Cetuximab With or Without Brivanib in Treating Patients With K-Ras Wild Type Tumours and Metastatic Colorectal Cancer
RATIONALE: Brivanib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.
- Trial name
- NCT00640471
- Testing
- cetuximab, brivanib alaninate
- Where
- 37 sites in Canada
- Volunteers
- 750 people
- Sponsor
- NCIC Clinical Trials Group
Colorectal Cancer, Recurrence, Local Neoplasm
Follow-up Protocol of Colorectal Endoscopic Mucosal Resection Scars
Nowadays endoscopic mucosal resection (EMR) is the gold standard for the removal of large laterally spreading and sessile colorectal lesions ≥ 20 mm.
- Trial name
- NCT04239365
- Testing
- WLE followed by NBI or NBI followed by WLE (crossover design)
- Where
- Portugal
- Volunteers
- 210 people
- Sponsor
- Portuguese Oncology Institute, Coimbra
Carcinoma of the Appendix, Colorectal Cancer
Intraperitoneal Hyperthermic Perfusion With Oxaliplatin in Treating Patients With Stage IV Peritoneal Cancer Due to Appendix Cancer or Colorectal Cancer
RATIONALE: Drugs used in chemotherapy, such as oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Carcinoma of the Appendix, Colorectal Cancer, Primary Peritoneal Cavity Cancer
- Trial name
- NCT00458809
- Testing
- oxaliplatin
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Wake Forest University Health Sciences
Advanced or Recurrent Colorectal Cancer
Panitumumab for Intravenous Infusion 100 mg and 400 mg Special Drug Use Surveillance "Survey on Unresectable, Advanced or Recurrent Colorectal Cancer With Wild-type KRAS Gene" (All-patient Surveillance)
The efficacy and safety of panitumumab (Vectibix) in the routine clinical setting will be studied. Specifically, information will be collected on the following as events of interest: skin disorders, interstitial lung disease…
- Trial name
- NCT02089737
- Testing
- Panitumumab
- Volunteers
- 3,091 people
- Sponsor
- Takeda
Rectal Cancer Stage II, Rectal Cancer Stage III
Optimal Surgery and MRI Based Radiochemotherapy in Rectal Carcinoma
The objective of the study is to provide proof that a MRI based preoperative radiochemotherapy in patients with locally advanced rectal carcinoma allows limiting RCT to high risk patients without increase of locoregional…
- Trial name
- OCUM (NCT01325649)
- Testing
- total mesorectal excision / long course radiochemotherapy, long course 5-FU bases radiochemotherapy
- Where
- Germany
- Volunteers
- 1,051 people
- Sponsor
- Johannes Gutenberg University Mainz
Colorectal Cancer
Nitrous Oxide and Risk of Cancer Recurrence After Colorectal Surgery: A Randomized, Blinded Study
This study was developed to test the hypothesis that the risk of colorectal cancer recurrence was similar in patients who were randomly assigned to 65% nitrous oxide or nitrogen during colorectal surgery.
- Trial name
- NCT00781352
- Testing
- nitrous oxide, nitrogen
- Where
- Austria
- Volunteers
- 408 people
- Sponsor
- The Cleveland Clinic
Rectal Cancer Recurrent
Surgery Plus Chemo Versus Chemoradiotherapy Followed by Surgery Plus Chemo for Locally Recurrent Rectal Cancer
JCOG1801 is a randomized phase III trial which was initiated in Japan in August 2019 to confirm the superiority of preoperative chemoradiotherapy followed by surgery plus adjuvant chemotherapy for local relapse-free survival over…
- Trial name
- JCOG1801 (NCT04288999)
- Testing
- Chemotherapy, Preoperative radiotherapy, Procedure
- Where
- 45 sites in Japan
- Volunteers
- 110 people
- Sponsor
- National Cancer Center Hospital East
Colorectal Cancer
ZD 1839 Plus Combination Chemotherapy in Treating Patients With Locally Advanced, Locally Recurrent, or Metastatic Colorectal Cancer
Phase I trial to study the effectiveness of ZD 1839 combined with irinotecan, leucovorin, and fluorouracil in treating patients who have locally advanced, locally recurrent, or metastatic colorectal cancer.
- Trial name
- NCT00026364
- Testing
- fluorouracil, gefitinib, irinotecan hydrochloride
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- National Cancer Institute (NCI)
Colorectal Neoplasms
Envafolimab Combined With Endostatin in Recurrent or Metastatic MSS-type Colorectal Cancer
The objective is to investigate the efficacy and safety of envafolimab combined with recombinant human endostatin (endostatin) in the treatment of MSS-type colorectal cancer patients with recurrence or metastasis after failure of…
- Trial name
- NCT05551247
- Testing
- Envafolimab, recombinant human endostatin (endostatin)
- Volunteers
- 30 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Recurrent or Metastatic Colorectal Cancer
A Phase I Trial of HDFL48 in Recurrent or Metastatic Colorectal Cancers
To determine the maximum tolerated dose and dose limiting toxicity of 5-FU and leucovorin with novel 48-hour infusion schedule, and to collect toxicity profile at different dose level of 5-FU/LV 48-hour infusion.
- Trial name
- NCT00155558
- Testing
- 5-Fluorouracil, Leucovorin
- Where
- Taiwan
- Volunteers
- 16 people
- Sponsor
- National Taiwan University Hospital
Colorectal Cancer
Radiation Therapy Plus Irinotecan in Treating Patients With Colon Cancer
RATIONALE: Radiation therapy uses high energy x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00003344
- Testing
- irinotecan hydrochloride, radiation therapy
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Medical University of South Carolina
Colorectal Neoplasms
Follow-up After Oncological Resection by Endoscopic Colorectal ESD (Endoscopic Submucosal Dissection)
Colorectal cancer is a common and leading cause of death. Pre-cancerous lesions, as well as some so-called superficial cancers, can be resected via endoscopy.
- Trial name
- FORCE (NCT07871227)
- Testing
- Surgery, Radiochimiotherapy
- Where
- 14 sites in France
- Volunteers
- 1,200 people
- Sponsor
- University Hospital, Bordeaux
Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum
Fluorouracil With or Without Eniluracil in Treating Patients With Advanced Colorectal Cancer
Randomized phase III trial to compare the effectiveness of fluorouracil given by infusion with that of fluorouracil plus eniluracil given by mouth in treating patients who have metastatic, recurrent, or residual advanced…
- Conditions
- Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum, Recurrent Colon Cancer, Recurrent Rectal Cancer
- Trial name
- NCT00003873
- Testing
- fluorouracil, eniluracil
- Where
- United States
- Volunteers
- 950 people
- Sponsor
- National Cancer Institute (NCI)
Colo-rectal Cancer, Anastomosis, Leaking
The Factors Influencing the Success of Redo Surgery and Anal Function for Anastomosis Failure or Local Tumor Recurrence
To analyze the influencing factors of the success of redo surgery due to anastomotic fistula or anastomotic recurrence after rectal cancer surgery and to evaluate the anal function of patients
- Trial name
- NCT07440888
- Testing
- redo surgery
- Volunteers
- 143 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences