Clinical trials: Colorectal Disorders
Helicobacter Pylori Infection, Colorectal Cancer
European Implementation Study on Simultaneous Screening for Gastric and Colorectal Cancers
The EUGastScreen study is designed as a quality implementation study to explore gastric cancer screening strategies within organised cancer screening frameworks.
- Conditions
- Helicobacter Pylori Infection, Colorectal Cancer, Gastric Cancer
- Trial name
- EUGastScreen (NCT07873580)
- Testing
- Fecal sample acquisition for Helicobacter pylori stool antigen test, Upper endoscopy with biopsies, Colonoscopy with biopsies after bowel cleansing
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- University of Latvia
Colorectal Cancer Screening
Evaluating the Efficacy of the eNav Toolkit to Improve Colorectal Cancer Screening
The purpose of this research study is to evaluate the efficacy of a digital navigation tool, called the eNav to improve colorectal cancer screening uptake among patients treated at federally qualified health centers (FQHC)s.
- Trial name
- NCT06184594
- Testing
- eNav, Standard of Care
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Rectal Cancer
A Pilot Study of Neoadjuvant Chemotherapy Combined With Bevacizumab for Locally Advanced Rectal Cancer
Background: Neoadjuvant chemoradiotherapy (CRT) and total mesorectum excision (TME) has become the standard therapy for the treatment of locally advanced rectal cancer (LARC) to reduce the local recurrence rate, however, no…
- Trial name
- NCT03245203
- Testing
- FOLFIRI+beacizumab, CRT
- Where
- China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Breast Cancer, Colorectal Cancer
KanSurvive: Testing a Model for Improving Cancer Survivorship Care in Rural Practice
Approximately, 20 rural primary care practices to participate in a delayed intervention-controlled trial. Phase I: Formal and structured work flow evaluations to better identify specific gaps in processes of care while assessing…
- Conditions
- Breast Cancer, Colorectal Cancer, Lung Cancer, Prostate Cancer
- Trial name
- KANSURVIVE (NCT04763824)
- Testing
- KanSurvive ECHO and Practice Facilitation
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Colorectal Cancer
Difference of Surgical Site Infection Between Using Sodium Picosulfate Solution(PicosolutionⓇ) and Oral Sulfate Tablet(ORA·FANGⓇ) in Colorectal Cancer Surgery
This is a prospective randomized study to evaluate the difference in the rate of surgical site infection between the patients who used Sodium Picosulfate solution(PicosolutionⓇ) and tablet Oral Sulphate Solution(ORA·FANGⓇ) for…
- Trial name
- NCT04593446
- Testing
- Oral Sulfate Tablet(ORA·FANGⓇ), Sodium Picosulfate Solution(PicosolutionⓇ)
- Where
- South Korea
- Volunteers
- 414 people, healthy volunteers welcome
- Sponsor
- National Cancer Center, Korea
Lynch Syndrome, Contraception
Perception About Benefits and Risks Related to Combined Hormonal Contraceptives Use in Patients With Lynch Syndrome
Combined hormonal contraceptives (CHCs), according to the opinion by The Manchester International Consensus Group, should be considered for women wishing contraception because also positively impact endometrial cancer and ovarian…
- Trial name
- NCT05909410
- Testing
- Survey investigating the CHC use and patients' perception about the relationship between CHC and cancer, diseases and symptoms
- Where
- Italy
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Piazza della Vittoria 14 Studio Medico - Ginecologia e Ostetricia
Colorectal Cancer
Colonoscope Insertion Trial Protocol
This research study is about determining how well a Technically Improved Colonoscope from Olympus works in helping the doctor in guiding the scope through the large bowel or colon.
- Trial name
- NCT01324882
- Testing
- Colonoscopy with Olympus Technically Improved Colonoscope, Control with standard colonoscope Olympus CF-H180
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- UConn Health
Colorectal Cancer
Shared Decision-making and Colorectal Cancer Screening
Conduct a feasibility pilot RCT of a newly developed colorectal cancer screening (CRC) decision aid (DA) including 66 LHL adults 76-85 years recruited from community health centers.
- Trial name
- NCT04748380
- Testing
- CRC decision aid pamphlet, Home Safety Pamphlet
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Abramson Cancer Center at Penn Medicine
GENE EXPRESSION, Colorectal Cancer
Scottish Vitamin D Intervention Study
AIMS To identify the underlying mechanism by which Vitamin D reduces colorectal cancer risk. OBJECTIVES To demonstrate the effects of vitamin D supplementation on serum vitamin D levels.
- Trial name
- (SCoViDS) (NCT04868227)
- Testing
- FULTIUM D3 VITAMIN D3
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Lung Cancer, Colorectal Cancer
PD-L2 Targeting Nanobody Radiotracer for PET Imaging of Solid Tumor
The objective of this study is to construct a noninvasive approach using 68Ga- Mirc415 PET/CT to detect the PD-L2 expression of tumor lesion in patients with colorectal cancer, lung cancer and other solid tumor to identify…
- Trial name
- NCT05803746
- Testing
- 18F-FDG
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Peking University Cancer Hospital & Institute
Colorectal Cancer
Implication of Genetic Variations in Long Intergenic Non-coding RNA 00511 (LINC00511) in Colorectal Cancer
As, there is a lack of information about the association between LINC00511 SNP(s) variants and CRC susceptibility, so this study was undertaken to address whether these SNPs would increase CRC risk or could predict its prognosis.
- Trial name
- NCT06534242
- Where
- Egypt
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Colonic Diseases, Rectal Diseases
Assessing Infectious Risk and Visceral Closure in Natural Orifice Translumenal Endoscopic Surgery (NOTES)
The purpose of this study is to determine: 1. What quantity of bacteria is spilled into the abdomen during a colon resection 2. If there is a correlation between the quantity and post-operative infection 3.
- Trial name
- NOTES (NCT01102725)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Colorectal Cancer, Colorectal Neoplasm
A Stool DNA Test for Detection of Advanced Colorectal Neoplasia in Asymptomatic Chinese Community Population
to determine screening value of stool-based SDC2 DNA methylation test for advanced colorectal neoplasia in the asymptomatic Chinese community population.
- Conditions
- Colorectal Cancer, Colorectal Neoplasm, Advanced Adenoma, Adenoma
- Trial name
- NCT04786704
- Testing
- Stool-based SDC2 DNA methylation test, quantitative Fecal immunochemical test
- Where
- China
- Volunteers
- 12,106 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Colorectal Cancer, Colorectal Adenoma
Protein Signature Based Screening of Colorectal Adenomas and Cancer
Colorectal cancer is a common cancer, that in general develops over a long time period (approximately 10-15 years) from precancerous polyps. The disease is in many cases asymptomatic.
- Trial name
- NCT07881549
- Where
- Sweden
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Region Skane
Rectal Cancer
Detection and Enumeration of Circulating Tumor Cells in Rectal Cancer
Rectal cancer is one of the most common malignant tumors in the world. However, there's also no reliable and sensitive method to monitor diseases and evaluate therapy responses till now.
- Trial name
- NCT01671891
- Testing
- radiation therapy, capecitabine (625mg/m2,bid,d1-5 qw)and oxaliplatin (85mg/m2 d1 qw)
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fudan University
Colorectal Cancer
Personalized Screening Plans to Increase Colorectal Cancer Screening in Healthy Participants
RATIONALE: Developing a personalized screening plan may be more effective than usual care in increasing the number of healthy participants who regularly undergo screening for colorectal cancer.
- Trial name
- NCT00617071
- Testing
- medical chart review, survey administration, fecal occult blood test
- Where
- United States
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Colon Cancer, Chemotherapeutic-Induced Anemia
Intravenous Iron Infusion on Chemotherapy-induced Anemia
FOLFOX, the first-line regimen based on 5-FU and oxaliplatin, is adjuvant chemotherapy for pathologic stage II/III colorectal cancer patients.
- Trial name
- NCT05299411
- Testing
- iron (isomaltoside), Dried Ferrous Sulfate
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Korea University Guro Hospital
Colorectal Cancer
Chemoprevention of Colorectal Cancer: the Role of Non-digestible Carbohydrates
Colorectal cancer is a common disease worldwide. It is now thought that colorectal cancer cells arise from stem cells where the genetic material regulating growth and division of the stem cell has become defective.
- Trial name
- NCT01214681
- Testing
- Maltodextrin and Amioca starch, Hi-maize 260, Polydextrose
- Where
- 2 sites in United Kingdom
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Newcastle University
Non-small Cell Lung Cancer, Esophageal Cancer
Tumor Cell and DNA Detection in the Blood, Urine and Bone Marrow of Patients With Solid Cancers
Patients with resectable solid primary cancers and even limited number of metastases are potentially curable. However, most patients develop recurrences despite surgery.
- Conditions
- Non-small Cell Lung Cancer, Esophageal Cancer, Gastric Cancer, Pancreatic Cancer
- Trial name
- NCT02838836
- Testing
- Study sample collection
- Where
- United States
- Volunteers
- 620 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Colorectal Neoplasms, Colonoscopy
AI-empowered Nudge to Improve Colonoscopy Uptake (AINC)
Colorectal cancer (CRC) ranks third in both incidence and mortality among all malignant tumors in China. Studies have shown that early screening can significantly reduce its incidence and mortality.
- Trial name
- NCT07612436
- Testing
- AI-empowered nudge (AINC) strategy, Usual Care
- Volunteers
- 1,680 people, healthy volunteers welcome
- Sponsor
- Fudan University
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