Clinical trials: Colorectal Obstruction
Colon Neoplasm, Colorectal Surgery
Study of Intraoperative Colonic Irrigation Versus Stent Placement in Obstructive Left-Sided Colonic Cancer
INTRODUCTION: There are several alternatives for one-stage emergency treatment of obstructive left-sided colonic cancer (OLCC): subtotal colectomy, intraoperative colon lavage (IOCL) with primary anastomosis, and the placement of…
- Conditions
- Colon Neoplasm, Colorectal Surgery, Intestinal Obstruction
- Trial name
- NCT01196494
- Testing
- intraoperative colon lavage with primary anastomosis
- Sponsor
- Corporacion Parc Tauli
Ileus, Post-Operative Adhesions
A Study to Evaluate LB1148 for Return of Gastrointestinal Function and Adhesions in Subjects Undergoing Bowel Resection
The purpose of this study is to establish preliminary evidence of the efficacy, safety, and tolerability of LB1148 for the treatment of post-operative ileus and intra-abdominal adhesions in subjects undergoing elective bowel…
- Trial name
- PROFILE (NCT02836470)
- Testing
- LB1148
- Where
- 28 sites in United States
- Volunteers
- 112 people
- Sponsor
- Palisade Bio
Loop Ileostomy, Colorectal Disorders
Quadratus Lumborum Block : Local Anesthesia Versus Placebo
Opioid analgesics have many side effects. Quadratus lumborum (QL) block is one kind of regional nerve block that can reduce the side effects of opioid analgesics.
- Trial name
- NCT03411096
- Testing
- Quadratus lumborum block using ropivacaine, Quadratus lumborum block with normal saline
- Where
- South Korea
- Volunteers
- 57 people
- Sponsor
- Kyungpook National University Hospital
Rectal Cancer Surgery, Middle and Low Rectal Cancer
Pelvic Floor Peritoneal Closure to Prevent Postoperative Ileus in Mid-Low Rectal Cancer Surgery
The goal of this clinical trial is to determine whether closing the pelvic floor peritoneum during laparoscopic radical resection of mid-low rectal cancer can reduce the incidence of postoperative ileus.
- Conditions
- Rectal Cancer Surgery, Middle and Low Rectal Cancer, Intestinal Obstruction, Ileus
- Trial name
- TOWER-1 (NCT07432542)
- Testing
- Pelvic floor peritoneum reconstruction
- Where
- China
- Volunteers
- 516 people
- Sponsor
- Sun Yat-sen University
Post Operative Pain
Laparoscopic-guided TAP Block vs Epidural Analgesia
The LAPTAP trial will provide evidence on preferred post-operative analgesia method in elective laparoscopic colon surgery.
- Trial name
- NCT05214261
- Testing
- Safety and efficiency of post operative analgesia between laparoscopic-assisted TAP block and epidural analgesia
- Where
- Finland
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Oulu University Hospital
Oncologic Surgery, Cancer
Optimal Perioperative Pain Control in Minimally Invasive Abdominal Cancer Surgery
This is a research study to evaluate the effectiveness of 3 different types of routine pain management regimens used during clinically indicated, minimally invasive oncologic (cancer) surgery.
- Conditions
- Oncologic Surgery, Cancer, Cancer Surgery, Hepatic Cancer
- Trial name
- LapTAP (NCT06731998)
- Testing
- Local Anesthesia, Laparoscopic Transversus Abdominis Plane block
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Anesthesia, Posterior Transversus Abdominis Plane Block
Posterior Transversus Abdominis Plane Block Combined With Sacral Multifidus Plane Block Versus Posterior Transversus Abdominis Plane Block for Laparoscopic Colorectal Surgery
The aim of this study is to compare perioperative analgesic efficacy and safety profile of combined SMPB and posterior TAP block versus posterior TAP block in patients undergoing laparoscopic colorectal cancer surgery.
- Conditions
- Anesthesia, Posterior Transversus Abdominis Plane Block, Sacral Multifidus Plane Block, Laparoscopic Colorectal Surgery
- Trial name
- NCT07280949
- Testing
- sacral multifidus plane block, TAP Block: posterior approach
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Colorectal Disorders, Regional Anesthesia Morbidity
Transversus Abdominis Plane Blocks With and Without Dexamethasone
Dexamethasone will be used as an adjunct to local anesthetics (bupivacaine) to prolong the duration of laparoscopically-placed transversus-abdominis plane blocks in elective colorectal resection.
- Conditions
- Colorectal Disorders, Regional Anesthesia Morbidity, Analgesia, Local Anesthetic Complication
- Trial name
- TAP-DEX (NCT05432934)
- Testing
- Dexamethasone
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Malignant Colorectal Obstruction
Enteral Stents for Colonic Obstruction
The purpose of this study is to verify whether stent positioning for malignant obstruction of the colon and rectum followed by elective surgery allows reduction of postoperative complications and hospital stay without worsening…
- Trial name
- ESCO (NCT00591695)
- Testing
- Stent bridge to surgery + elective surgery, Emergency Surgery
- Where
- 2 sites in Italy, Spain
- Volunteers
- 144 people
- Sponsor
- European Association for Endoscopic Surgery
Colon Neoplasm, Rectum Neoplasm
Ultrasound Guided Transversus Abdominis Plane(TAP) Block in Intensive Care Unit
The Transversus Abdominis Block (TAP) block is known to be an effective means of reducing patient pain after abdominal surgery. In the meantime, the general TAP block has been studied in patients who were in the recovery room and…
- Conditions
- Colon Neoplasm, Rectum Neoplasm, Perforated Colon, Perforated Bowel
- Trial name
- NCT03198338
- Testing
- 0.25% Bupivacaine, 0.5mL/kg, Normal Saline, Ultrasound
- Where
- South Korea
- Volunteers
- 46 people
- Sponsor
- Seoul National University Bundang Hospital
Gastrointestinal Diseases, Ileus Paralytic
Myoelectric Activity Following Colorectal Surgery and Return of Bowel Function
The purpose of the study is to determine if the myoelectrical measurements made by the G-Tech Wireless Patch System correlate with clinical markers of postoperative recovery such as passage of flatus/bowel movement, oral…
- Conditions
- Gastrointestinal Diseases, Ileus Paralytic, Ileus
- Trial name
- NCT05298774
- Testing
- G-tech WPS
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Yale University
Rectal Neoplasms
Palliative Short-Course Radiotherapy in Rectal Cancer
Radiotherapy (RT) is a potentially effective method in the treatment of symptoms of rectal carcinomas. Nevertheless, almost all the evidences about palliative RT in rectal cancer have been published more than two decades ago and…
- Trial name
- NCT02639403
- Testing
- Conformal three-dimensional Radiotherapy
- Volunteers
- 18 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Colorectal Disease
Evaluation of a TAP Block Given During Laparoscopic Colorectal Surgery to Help Control Pain
Patients experience pain after surgery mostly from their abdominal wounds, even when those wounds are small. Decreasing that pain has many benefits.
- Trial name
- TAP Block (NCT01731782)
- Testing
- bupivacaine
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Postoperative Ileus
Effect of Sugared Chewing Gum on Gastrointestinal Recovery After Major Colorectal Surgery
The Purpose of this study is to evaluate the effect of gum chewing on recovery of gastrointestinal function in patient undergoing major colorectal surgery.
- Trial name
- NCT01559662
- Testing
- Sugared Chewing Gum (Juicy Fruit)
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Cedars-Sinai Medical Center
Adhesions, Colectomy
SurgiWrapTM to Reduce Soft Tissue Attachment & Incidence Early Post-Operative Bowel Obstruction in Colorectal Surgery
The purpose of this study is to determine if the use of SurgiWrapTM: (1) prevents/lowers the incidence of Grade 2 or higher soft tissue attachments under the incision made during abdominal surgery, (2) reduces post-operative…
- Trial name
- NCT00531739
- Testing
- Polylactic Acid Sheet
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Cytori Therapeutics
Pain, Postoperative, Crohn Disease
Intraoperative TAP Block With Bupivacaine/Dexamethasone Against Liposomal Bupivacaine (Exparel®)
Traditionally, opioids are heavily utilized in treating postoperative pain but they are associated with numerous side effects. The use of the transversus abdominis plane (TAP) blocks have become standard practice to extend the…
- Conditions
- Pain, Postoperative, Crohn Disease, Inflammatory Bowel Diseases, Colorectal Cancer
- Trial name
- TINGLE (NCT03723447)
- Testing
- Liposomal bupivacaine, Bupivacaine/epinephrine/dexamethasone
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Cedars-Sinai Medical Center
Ileus, Opioid Use
Postoperative Opioid Use and Ileus Occurrence---A Case Control Study
Postoperative ileus (POI) is a significant complication after colorectal surgery, with reported incidence ranging from 10~30%, leading to increased morbidity, hospital length of stay, and thus medical cost.
- Trial name
- NCT05262569
- Testing
- ileus
- Where
- China
- Volunteers
- 596 people
- Sponsor
- Peking University People's Hospital
Laparoscopic Surgical Procedure, Nerve Block
Laparoscopic vs Ultrasound Guided TAP Block in Colorectal Surgery. A Randomised Controlled Study.
A randomized clinical trial aiming to compare two different techniques of performing a nerve blockage of the abdominal wall. When performing surgery on the colon and rectum surgeons often use a minimal invasive technique called…
- Trial name
- LAPTAP (NCT04907461)
- Testing
- LAPTAP
- Where
- Sweden
- Volunteers
- 175 people
- Sponsor
- Danderyd Hospital
Ileostomy - Stoma, Ileus
Efferent Loop Stimulation Previous to Ileostomy Closure. Ileostim Trial.
The loop ileostomy is an effective method used to bypass faecal contents and reduce the sequelae of possible anastomotic leakage.
- Conditions
- Ileostomy - Stoma, Ileus, Rectal Cancer, Surgical Complication
- Trial name
- Ileostim (NCT05302557)
- Testing
- Ileostomy stimulation
- Where
- Spain
- Volunteers
- 68 people
- Sponsor
- Universidad de León
Colorectal Cancer
Analgesia of Erector Spinae Plane Block Versus Quadratus Lumborum Block
Colorectal cancer is the third most common cancer worldwide. These patients usually undergo open surgical resection of cancer under general anaesthesia.
- Trial name
- NCT03803267
- Testing
- Erector spinae plane block, Quadratus lumborum block, Propofol
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Mansoura University