Clinical trials: Colorectal Tumor
Rectal Cancer, Low Anterior Resection Syndrome
Percutaneous Tibial Nerve Stimulation in the Treatment of Anterior Resection Syndrome After Rectal Cancer Surgery
The study aims to evaluate the efficacy of percutaneous tibial nerve stimulation (PTNS) associated with conservative therapy (arm A) for the treatment of low anterior resection syndrome (LARS) compared with only conservative…
- Trial name
- NCT02177084
- Testing
- PTNS
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Cancer, Prostate Cancer
Physicians' Health Study II
The use of vitamin E, vitamin C, beta carotene, and/or multivitamins may keep cancer, cardiovascular disease, eye diseases, or cognitive decline from occurring.
- Conditions
- Cancer, Prostate Cancer, Colorectal Cancer, Cardiovascular Disease
- Trial name
- PHS II (NCT00270647)
- Testing
- Vitamin E, Vitamin C, Multivitamin
- Volunteers
- 14,641 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Solid Tumor, Colorectal Cancer
A Study of TRK-950 in Combinations With Anti-Cancer Treatment Regimens in Patients With Advanced Solid Tumors
The main purpose of this study is to establish the safety and the recommended dose of TRK-950 in combination with FOLFIRI, Gemcitabine / Cisplatin, Gemcitabine / Carboplatin, Ramucirumab / Paclitaxel, PD1 inhibitors (Nivolumab or…
- Conditions
- Solid Tumor, Colorectal Cancer, Cholangiocarcinoma, Bladder Cancer
- Trial name
- NCT03872947
- Testing
- TRK-950, Irinotecan, Leucovorin
- Where
- 14 sites in United States, France
- Volunteers
- 138 people
- Sponsor
- Toray Industries, Inc
Colorectal Cancer, Liver Metastasis
Sintilimab Combined With Regorafenib and HAIC in Patients With Colorectal Liver Metastasis
To evaluate the safety and efficacy of sintilimab combined with regorafenib and HAIC in patients with colorectal liver metastasis who failed second-line therapy
- Trial name
- NCT05524155
- Testing
- HAIC, Sintilimab, Regorafenib
- Volunteers
- 30 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Colorectal Cancer Metastatic
Evaluation of the Safety and the Tolerability of Durvalumab Plus Tremelimumab Combined With FOLFOX in mCRC
Colo-rectal cancer is still one of the leading causes of cancer death worldwide. In France, approximately 40 500 new cases are diagnosed each year.
- Trial name
- MEDITREME (NCT03202758)
- Testing
- Durvalumab, Tremelimumab and ,FOLFOX
- Where
- 5 sites in France
- Volunteers
- 57 people
- Sponsor
- Centre Georges Francois Leclerc
Colorectal Cancer Stage II
First-line Irinotecan, Lederfolin and 5FU (FOLFIRI) and Bevacizumab in Patients With Advanced Colorectal Cancer
Bevacizumab in combination with chemotherapy represents a standard of care for first-line treatment in patients with advanced colorectal cancer.
- Trial name
- CENTRAL (NCT01853813)
- Testing
- Bevacizumab and FOLFIRI
- Where
- 13 sites in Italy
- Volunteers
- 85 people
- Sponsor
- Gruppo Italiano per lo studio dei Carcinomi dell'Apparato Digerente
Colorectal Cancer
Single Incision Plus One Port Laparoscopic Surgery Assistant Enhanced Recovery After Surgery on Colorectal Cancer
Conventional laparoscopic surgery (CLS) for colorectal cancer has been demonstrated to be safe and feasible and present minimally invasive benefits including faster recovery, reduced postoperative pain and shorter hospital stay…
- Trial name
- NCT04268290
- Testing
- Single incision plus one port laparoscopic surgery
- Volunteers
- 120 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Rectal Cancer, Recurrence
Re-irradiation for Pelvic Recurrences in Rectal Cancer Patients
This study investigates the potential benefit of re-irradiation of patients with locally advanced rectal recurrences, by a prospective phase II clinical, imaging and translational research study.
- Conditions
- Rectal Cancer, Recurrence, Radiation Toxicity
- Trial name
- Re-RAD-I (NCT05816980)
- Testing
- Hyperfractionated external beam radiation
- Where
- 2 sites in Denmark, Norway
- Volunteers
- 16 people
- Sponsor
- Aarhus University Hospital
Cancer Colon
The Efficacy Of Complete Mesocolic Excision With Central Vessel Ligation Technique On Lymph Nodes And Safety Margins Compared With Conventional Surgery For Colon Cancer Treatment
Cancer Colon is one of the major public health problems worldwide. Complete eradication of the tumor with no recurrence or residual masses is a challenge which faces all the surgeons and medical staff all over the world.
- Trial name
- NCT04079946
- Testing
- Total Mesocolic Excision with Central Vessel Ligation, conventional surgery of cancer colon
- Volunteers
- 40 people
- Sponsor
- Assiut University
pMMR/MSS Advanced Colorectal Cancer
Clinical Study of MSH2-/- Tumor Cell Vaccines for Advanced pMMR Colorectal Cancer Patients
The goal of this clinical trial is to evaluate the safety and tolerability of an MSH2-/- tumor cell vaccine and to explore its preliminary antitumor activity and immunogenicity in adults with advanced proficient mismatch repair…
- Trial name
- NCT07510308
- Testing
- Low Dose MSH2-/- tumor cell vaccine, Medium Dose MSH2-/- tumor cell vaccine, High dose MSH2-/- tumor cell vaccine
- Where
- 2 sites in China
- Volunteers
- 9 people
- Sponsor
- West China Hospital
Colorectal Cancer
Core Stability Program in Colorectal Cancer Survivors
The purpose of this study is to determine the effects of physical training program to improve deep stabilizer muscle in colorectal cancer survivors
- Trial name
- NCT02052050
- Testing
- core stability
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Universidad de Granada
Organ Preservation, Rectal Cancer
Organ Preservation in Rectal Cancer: Contact X-ray Brachytherapy vs Extending the Waiting Interval and Local Excision
The goal of this prospective phase II feasibility study is to evaluate two additional local treatment options in rectal cancer patients with a good clinical response after neoadjuvant (chemo)radiation: contact x-ray brachytherapy…
- Conditions
- Organ Preservation, Rectal Cancer, Quality of Life, Locally Advanced Rectal Carcinoma
- Trial name
- OPAXX (NCT05772923)
- Testing
- Contact x-ray brachytherapy, Local excision
- Where
- 7 sites in Netherlands
- Volunteers
- 168 people
- Sponsor
- The Netherlands Cancer Institute
Rectum Cancer
Oncological Differences Between Transanal and Laparoscopic Total Mesorectal Excision for Rectal Cancer.
The primary purpose of this study is to compare the differences of oncological in rectal cancer patients undergoing laparoscopic or transanal endoscopy radical resection.
- Trial name
- NCT05201885
- Where
- China
- Volunteers
- 192 people
- Sponsor
- Yanhong Deng
CRC (Colorectal Cancer)
Study of Ruxolitinib in Colorectal Cancer Patients
The purpose of this study was to determine if ruxolitinib, in combination with regorafenib, is safe and effective in the treatment of metastatic colorectal cancer.
- Trial name
- NCT02119676
- Testing
- Ruxolitinib, Regorafenib
- Where
- 86 sites in United States, Australia and 6 more
- Volunteers
- 396 people
- Sponsor
- Incyte Corporation
Colorectal Cancer, Diverticulitis Colon
Seal-G MIST (Minimally Invasive Sealant/Spray Technology) System Safety Study [SEALAR Study]
The purpose of this study is to evaluate safety of Seal-G MIST System in reinforcing colorectal anastomosis, in subjects undergoing colorectal surgery.
- Trial name
- SEALAR (NCT03448874)
- Testing
- Seal-G MIST System
- Sponsor
- Sealantis Ltd.
Colorectal (Colon or Rectal) Cancer, Leak, Anastomotic
Predictive Model For Anastomotic Leakage After Colorectal Cancer Surgery
This pilot study aimed to develop a simplified early postoperative model for AL risk stratification using readily available clinical and laboratory variables.
- Conditions
- Colorectal (Colon or Rectal) Cancer, Leak, Anastomotic, Surgery Complications
- Trial name
- Doesn't exist (NCT07709923)
- Where
- Italy
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University of Foggia
Colorectal Cancer Metastatic
Regorafenib and Sintilimab in Combination with Electroacupuncture in MSS CRC
The aim of this clinical trial is to find out whether Regorafenib and Sintilimab in combination with electroacupuncture works in treating participants with microsatellite stable (MSS) advanced colorectal cancer who have failed…
- Trial name
- NCT06456515
- Testing
- Regorafenib and Sintilimab in combination with electroacupuncture
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The First People's Hospital of Changzhou
Complication, Quality of Life
Open D3 Right Hemicolectomy Compared to Laparoscopic CME for Right Sided Colon Cancer
The primary focus in this study is to investigate and improve the surgical technique. In addition the collection of clinical data during diagnostic and follow up and the collection of tumor and blood gives us the opportunity to…
- Conditions
- Complication, Quality of Life, Surgical Procedure, Unspecified, Lymph Node Metastases
- Trial name
- D3/CME (NCT03776591)
- Testing
- Open surgery, Right colectomy, Laparoscopic surgery
- Where
- Norway
- Volunteers
- 128 people
- Sponsor
- Haraldsplass Deaconess Hospital
Metastatic Colorectal Cancer
Study of Circulating Markers in Serum of Patients Treated for Metastatic Colorectal Cancer
The primary purpose of the study is to confirm the results of previous study about the usefulness of the serum Carcinoembryonic antigen (CEA) kinetic for chemotherapy monitoring in patients with unresectable metastasis of…
- Trial name
- Coca-Colon (NCT01212510)
- Testing
- Blood sampling
- Where
- 4 sites in France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Rouen
Colonic Neoplasms Malignant, Cecal Neoplasms
Local Cecal Cancer - Optimization of Surgical Treatment
The purpose of this study is to determine the clinical efficacy, safety, and oncologic outcomes of ileocecal resection (ICR) with D3 lymphadenectomy compared to standard right hemicolectomy(RHC) for cecal cancer.
- Trial name
- LoCCOSTe (NCT06121089)
- Testing
- ileocecal resection with extended D3 lymphadenectomy., Right hemicolectomy with D3 lymphadenectomy.
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Moscow Clinical Scientific Center
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