Clinical trials: Coma, Traumatic
Traumatic Coma
Brain Network Disruptions Related to Traumatic Coma
To provide a fine-grained description of the brain network dysfunctions induced by severe traumatic brain injury (TBI) or anoxic encephalopathy, that are responsible for the acute state of unarousable unawareness, named coma…
- Trial name
- Coma3D (NCT03482115)
- Testing
- PET examination with radiopharmaceutical drug [18F] DPA-714, MRI examination, Blood samples
- Where
- France
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
TBI (Traumatic Brain Injury)
Asia Coma Electrical Stimulation (the ACES Trial)
This study is a prospective multicenter randomized controlled trial from Asian countries to compare the effect and safety of right median nerve stimulation versus traditional treatment for comatose patients at the early stage…
- Trial name
- ACES (NCT02645578)
- Testing
- Right median nerve stimulation
- Volunteers
- 360 people
- Sponsor
- RenJi Hospital
Brain Injury, Coma, Cardiac Arrest (CA)
Prediction for Coma Recovery With Comaweb
The general objective of the comaScore project is to provide an external validation of the accuracy of the comaScore, a score derived from magnetic resonance imaging (MRI), to predict 1 year outcome of patients unresponsive to…
- Conditions
- Brain Injury, Coma, Cardiac Arrest (CA), Traumatic Brain Injury (TBI), Aneurysmal Subarachnoid Hemorrhages (aSAH)
- Trial name
- COMASCORE (NCT03874208)
- Testing
- MRI sequence, MRI
- Where
- France
- Volunteers
- 611 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Head Trauma, Traumatic Coma
The Effect of Auditory and Tactile Stimuli in Traumatic Coma
This study focused on examining the effects of auditory and tactile stimuli to reduce sensory deprivation on consciousness, oxygen saturation and mean arterial pressure in traumatic coma patients.
- Conditions
- Head Trauma, Traumatic Coma, Nursing Caries
- Trial name
- NCT05195606
- Testing
- Auditory stimulus, Tactile stimulus
- Volunteers
- 90 people
- Sponsor
- Akdeniz University
Disorder of Consciousness, Vegetative State
The Use of LIFUP in Chronic Disorders of Consciousness
When patients survive a severe brain injury but fail to fully recover, they often enter a Disorder of Consciousness (DoC) --that is, a set of related conditions of decreased awareness and arousal including the Vegetative State…
- Conditions
- Disorder of Consciousness, Vegetative State, Minimally Conscious State, Minimally Conscious State Plus
- Trial name
- NCT04921683
- Testing
- BX Pulsar 1002 (LIFUP) Low intensity Focused Ultrasound Pulsation
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Acute Brain Injury Coma, Neurocritical Care
Development and Validation of a Prognostic Model for Neurocritical Patients Using Multimodal Brain Monitoring
This study aims to develop and validate a prognostic model for neurocritical patients using multimodal brain monitoring data. By combining data from various monitoring techniques such as EEG, TCD, and NIRS, this model will help…
- Conditions
- Acute Brain Injury Coma, Neurocritical Care, Cerebral Infarction, Intracranial Hemorrhages
- Trial name
- NCT07115459
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xiangya Hospital of Central South University
Stroke, Traumatic Brain Injury
Validation of the FOUR Coma Scale in Russia.
The purpose of this study is to examine the validity of the Russian version of the FOUR Full Outline of UnResponsiveness (hereafter FOUR) scale in adult ICU patients with an acute cerebral insufficiency clinic (hereinafter…
- Conditions
- Stroke, Traumatic Brain Injury, Subarachnoid Hemorrhage
- Trial name
- FOUR-RUS (NCT04018989)
- Where
- 3 sites in Russia
- Volunteers
- 260 people
- Sponsor
- Russian Federation of Anesthesiologists and Reanimatologists
Traumatic Brain Injury
A Pilot Study of NSICU Assessment of Seizure Prophylaxis With Lacosamide
Trial to determine if seizure prophylaxis with IV LCM in NSICU patients experiencing mental status changes due to severe traumatic brain injury (sTBI) will result in improved short- and long-term outcomes and better immediate…
- Trial name
- NCT01110187
- Testing
- lacosamide, Fosphenytoin
- Where
- 3 sites in United States
- Volunteers
- 11 people
- Sponsor
- University of Alabama at Birmingham
Coma, Traumatic
Dopaminergic Disruption Induced by Traumatic Coma: Dopaminergic Pathways Abnormalities and Biomarkers of Recovery Using MRI and 18F-LBT-999 PET
The neural correlates of consciousness have been studied at the macroscopic level. However, the neurochemical basis of these processes remains poorly understood.
- Trial name
- ComaDopa (NCT06930261)
- Testing
- LBT-999
- Where
- France
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Traumatic Brain Injury, Intracerebral Haemorrhage
The EBC Recovery Study
The purpose of this research study to find out if clinically unconscious acute brain injury patients that show brain activation to music and language on electroencephalogram (EEG) (bedside test) have better outcomes and wake up…
- Conditions
- Traumatic Brain Injury, Intracerebral Haemorrhage, Subarachnoid Haemorrhagic Stroke
- Trial name
- NCT04712591
- Testing
- Auditory stimuli
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Miami
Impaired Consciousness
Outcome Predictors of Non Traumatic Coma in Children
To catch the high risk comatosed child to improve service and direct the limited resources to those children in countries with limited resources .
- Trial name
- NCT03618745
- Testing
- CT brain
- Volunteers
- 50 people
- Sponsor
- Assiut University
Brain Injuries, Acute, Brain Injuries, Traumatic
Antiseizure Medication in Seizure Networks at Early Acute Brain Injury
The goal of this clinical trial is to explore the effect of FDA-approved antiseizure drugs in the brain connectivity patterns of severe and moderate acute brain injury patients with suppression of consciousness.
- Conditions
- Brain Injuries, Acute, Brain Injuries, Traumatic, Brain Ischemia, Brain Hypoxia
- Trial name
- NCT06081283
- Testing
- Phenobarbital Sodium Injection, Levetiracetam, Lacosamide Injectable Product
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of North Carolina, Chapel Hill
Consciousness Disorders, Disorders of Consciousness Due to Severe Brain Injury
Promoting Recovery After Brain Injury Using Focused Ultrasound
The overall aim of this study is to develop an intervention that can help recovery in patients surviving severe brain injury but failing to fully recover.
- Trial name
- ReBOUND (NCT07277309)
- Testing
- Low-intensity focused ultrasound
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Massachusetts General Hospital
Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness
fNIRS for Disorders of Consciousness
The goal of this observational study is to learn whether functional near-infrared spectroscopy (fNIRS) can measure brain activity in healthy adults and in people with disorders of consciousness (DoC) in the neuro-intensive care…
- Conditions
- Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness, Coma, Minimally Conscious State
- Trial name
- NCT07485361
- Testing
- Functional Near-Infrared Spectroscopy Monitoring
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Traumatic Brain Injury, Cerebral Anoxia
Intrathecal Baclofen Therapy and Paroxysmal Dysautonomia in Severe Brain-Injured Patients
Within the framework of a prospective double-blind and randomized study evaluating the efficacy of continuous intrathecal baclofen therapy (CIBT) on paroxysmal dysautonomia (main objective) and hypertonia, recovery and tolerance…
- Conditions
- Traumatic Brain Injury, Cerebral Anoxia, Coma, Hypertonia
- Trial name
- NCT00221689
- Testing
- baclofen (drug)
- Where
- France
- Volunteers
- 4 people
- Sponsor
- University Hospital, Bordeaux
Postcomatose Unawareness State, Minimally Conscious State
Eye Tracking Technology in the Diagnosis of Neurological Patients
Demonstrating that diagnostics of the state of consciousness and cognitive functions of patients with consciousness disorders performed using C-Eye X (based on eye-tracking technology) allows a more objective assessment of state…
- Conditions
- Postcomatose Unawareness State, Minimally Conscious State, Vegetative State, Disorder of Consciousness
- Trial name
- NCT05536921
- Where
- 5 sites in Poland
- Volunteers
- 90 people
- Sponsor
- AssisTech Sp. z o.o.
Traumatic Brain Injury, Severe Traumatic Brain Injury
Vagus Nerve Stimulation in Patients in Comatose State
Some patients with severe traumatic brain injury cannot respond at the bedside, yet about 1 in 4 may be aware but unable to show it - a hidden state called cognitive motor dissociation.
- Conditions
- Traumatic Brain Injury, Severe Traumatic Brain Injury, Disorders of Consciousness Due to Severe Brain Injury, Coma, Traumatic
- Trial name
- NCT07719595
- Testing
- Dual-Site Transcutaneous Auricular Nerve Stimulation (taVNS + taTNS)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Sima Mofakham
Disorder of Consciousness, Traumatic Brain Injury
Sub-study of the NEURODOC Project : Neurophysiological Evaluation of a Routine Care Open Label tDCS Session
Limited treatments are available to improve consciousness in severely brain injured patients. Transcranial Direct Current stimulation (tDCS) is one of the few therapeutics that showed evidence of efficacy to increase level of…
- Conditions
- Disorder of Consciousness, Traumatic Brain Injury, Anoxic Brain Injury, Stroke
- Trial name
- Neurodoc (NCT04035655)
- Testing
- Coma Recovery Scale - revised, Electrophysiological recordings
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Brain Injuries
Computed Tomography Perfusion in Patients With Severe Head Injury
Traumatic brain injury (TBI) is a leading cause of post-injury hospitalization, disability, and death worldwide. In Nova Scotia, approximately 50% of major trauma reported is head trauma.
- Trial name
- NCT02756585
- Testing
- ct perfusion
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- Nova Scotia Health Authority
Cerebral Hematoma, Traumatic, Intracerebral Hemorrhage, Traumatic
Interest of Real Time Measurement of Autonomous Nervous System for the Detection of Brain Death
Context: A major lack of organ donors is a serious public health problem. It determines a prolonged delay before a transplant can be performed and thus a significant number of deaths of patients waiting for transplantation.
- Conditions
- Cerebral Hematoma, Traumatic, Intracerebral Hemorrhage, Traumatic, Traumatic Brain Hemorrhage, Traumatic Brain Injury
- Trial name
- MEANS (NCT00918970)
- Where
- 3 sites in France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne