Clinical trials: Combat
Hemorrhage
Tourniquets Type Combat Application Tourniquet: Proximal or Distal Location, Simple or Staggered on Upper and Lower Limb
A tourniquet is used to stop abundant bleeding when simple compression is not effective. The investigators will study the vascular suffering of the tourniquets according to their location on the limb: limb (arm / thigh) or distal…
- Trial name
- GARROTS (NCT03218176)
- Testing
- Proximal single upper limb, Proximal staggered upper limb, Distal single upper limb
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Post Traumatic Stress Disorder
Multi-site Confirmatory Efficacy Treatment Trial of Combat-related PTSD
The purpose of this study is to examine the benefits of combining repetitive Transcranial Magnetic Stimulation (rTMS) coupled with Cognitive Processing Therapy (CPT) in treating combat-related Posttraumatic Stress Disorder (PTSD)…
- Trial name
- NCT03932773
- Testing
- Active rTMS, Cognitive Processing Therapy
- Where
- 3 sites in United States
- Volunteers
- 330 people
- Sponsor
- The University of Texas at Dallas
Melanoma
Combined BRAF-Targeted Therapy & Immunotherapy for Melanoma
This research study is a Phase II clinical trial of an investigational combination of drugs (vemurafenib and aldesleukin) to learn whether the combination works in treating a specific cancer.
- Trial name
- NCT01754376
- Testing
- Aldesleukin, Vemurafenib
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Massachusetts General Hospital
Depression, Depressive Disorder, Treatment-Resistant
Improving Brain Stimulation Through Imaging
There are two protocols, one involving rTMS therapy in people with treatment resistant depression and one involving tDCS in people with stress from the COVID 19 pandemic.
- Conditions
- Depression, Depressive Disorder, Treatment-Resistant, COVID Stress, PTSD - Post Traumatic Stress Disorder
- Trial name
- IBSI (NCT03851380)
- Testing
- Psychological / Functional Assessment, Structural and Functional MRI, Transcranial Magnetic Brain Stimulation and MR Image Guidance
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- VA Office of Research and Development
Military Physical and Sexual Trauma, Combat Trauma
Deployment Health in Regular Military Women
The purpose of this study is to determine potential risk factors for physical and sexual assault in regular military women (as opposed to Reserve and National Guard).
- Conditions
- Military Physical and Sexual Trauma, Combat Trauma, PTSD, TBI
- Trial name
- DHRMS (NCT01692067)
- Where
- 2 sites in United States
- Volunteers
- 871 people, healthy volunteers welcome
- Sponsor
- Iowa City Veterans Affairs Medical Center
PTSD - Post Traumatic Stress Disorder
Virtual Reality and Post Traumatic Stress
Northern Ireland has a legacy of trauma-related mental health problems and a higher estimated prevalence of post-traumatic stress disorder (PTSD) than other comparable post-civil conflict societies.
- Trial name
- NCT06684977
- Testing
- 360 Video, VR Photoscan, Standard TF-CBT
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Queen's University, Belfast
Post Traumatic Stress Disorder
Effects of Antagonistic Actions in Response to Trauma Exposure
The overarching objective of this study is to investigate the use of antagonistic actions as a treatment augmentation strategy for enhancing emotional processing during exposure to trauma-relevant stimuli.
- Trial name
- NCT04617769
- Testing
- Psychoeducation, Exposure
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of Texas at Austin
PTSD - Post Traumatic Stress Disorder, Sepsis
The Effect of Early Intervention on the Incidence of Posttraumatic Stress Disorder After Intensive Care Hospitalization Due to Sepsis
In recent years, the survival rate among intensive care patients has improved due to advancements in diagnosing severe infections and the use of broad-spectrum antibiotics.
- Conditions
- PTSD - Post Traumatic Stress Disorder, Sepsis, ICU
- Trial name
- NCT07707765
- Testing
- Psychiatric interview
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Barzilai Medical Center
Dementia, Agitation
A Music-Based Mobile App for People Living With Alzheimer's Disease and Related Dementias (ADRD)
The purpose of this pilot is to develop a mobile application that detects physiological measures of individuals with Alzheimer's disease and related dementias and triggers auto-play of personalized songs in a wearable device.
- Conditions
- Dementia, Agitation, Depressive Symptoms
- Trial name
- NCT06140342
- Testing
- Feasibility study of music-based mobile app
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Autotune Me LLC
Traumatic Grief, Post Traumatic Stress Disorder PTSD
EMDR Grief Protocol for Traumatic Grief After Earthquake-Related Loss
This pilot randomized controlled study evaluated the effectiveness of the EMDR Grief Protocol in adults who experienced the loss of a loved one in the February 6, 2023 Kahramanmaraş earthquakes.
- Conditions
- Traumatic Grief, Post Traumatic Stress Disorder PTSD, Emotional Processing
- Trial name
- NCT07776769
- Testing
- EMDR Grief Protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Istanbul Bilgi University
Post Traumatic Stress Disorder PTSD
Nurse-Led PTSD Treatment in Primary Care
Purpose of the Study Post-traumatic stress disorder (PTSD) is a common and serious condition, but many people cannot get the help they need because there are not enough mental health specialists (like psychologists or…
- Trial name
- NCT07430657
- Testing
- NurseNET, Referral to PTSD Treatment
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Rush University Medical Center
Post-Traumatic Stress Disorder
Exercise: A Novel Treatment for Combat Post Traumatic Stress Disorder
The primary objective of this pilot intervention study is to examine the efficacy of exercise for reducing the symptoms of posttraumatic stress disorder (PTSD) and other psychiatric and somatic symptoms.
- Trial name
- NCT01626131
- Testing
- exercise training, Stretching training
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- INTRuST, Post-Traumatic Stress Disorder - Traumatic Brain Injury Clinical Consortium
Posttraumatic Stress Disorders, Combat Disorders
A Comparison of Web-Prolonged Exposure (Web-PE) and Present-Centered Therapy (PCT) for PTSD Among Active-Duty Military Personnel
The purpose of this randomized controlled trial is to compare the efficacy and potential biological mechanisms of action of 10 sessions of a web-version of Prolonged Exposure (PE), "Web-PE," delivered over 8-weeks to 10 sessions…
- Trial name
- NCT02556645
- Testing
- Web-PE Therapy, Therapist-Delivered Present-Centered Therapy
- Where
- 4 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Pennsylvania
Stress Disorders, Post Traumatic, Brain Injuries
Mind-Body Skills Groups for the Treatment of War Zone Stress in Military and Veteran Populations
The purpose of this study is to determine whether participation in mind-body skills groups by veterans who have experienced a stressful war-related situation and have symptoms of posttraumatic stress disorder (PTSD), will improve…
- Conditions
- Stress Disorders, Post Traumatic, Brain Injuries, Depressive Disorder, Anxiety Disorders
- Trial name
- NCT01093053
- Testing
- Mind-Body Skills Groups, Standard Treatment
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- The Center for Mind-Body Medicine
Bone Diseases, Developmental
Developing a COMputerised Bone Age Tool
The Greulich and Pyle technique (G\&P) is that most commonly used to assess bone age in children, particularly in the context of suspected skeletal dysplasia.
- Trial name
- COMBAT1 (NCT02617901)
- Testing
- Left hand DXA
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Sheffield Children's NHS Foundation Trust
PTSD - Post Traumatic Stress Disorder
Understanding Non-invasive Vagus Nerve Stimulation Effects in PTSD
The goal of this study is to determine how non-invasive brain stimulation (delivered through the ear called vagus nerve stimulation) affects fear learning processes in people who have experienced psychological trauma.
- Trial name
- SPARK-VNS (NCT06953388)
- Testing
- transcutaneous auricular vagus nerve stimulation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Wayne State University
Post Intensive Care Unit Syndrome, Psychological Trauma
Positive Suggestions Via MP3 Messages
The purpose of this study is to assess the use of an audio recording containing positive suggestion as a means to provide needed psychological support to critically ill patients in a feasible and reliable manner.
- Conditions
- Post Intensive Care Unit Syndrome, Psychological Trauma, Anxiety, Depression
- Trial name
- NCT04437095
- Testing
- Psychological Support Based on Positive Suggestion delivered via pre-recorded MP3 message
- Where
- United States
- Volunteers
- 149 people
- Sponsor
- Mayo Clinic
Psychiatric Disorders, Depression - Major Depressive Disorder
Implementing Action-Based Cognitive Remediation for Transdiagnostic Cognitive Difficulties in a Tertiary Mental Health Hospital
Psychiatric conditions are each defined by different set of symptoms, however, they often share common characteristics such as impairments in cognitive and social functioning.
- Conditions
- Psychiatric Disorders, Depression - Major Depressive Disorder, Schizophrenia and Other Psychotic Disorders, Anxiety and Mood Disorders
- Trial name
- NCT07506070
- Testing
- Action-Based Cognitive Remediation
- Volunteers
- 160 people
- Sponsor
- The Royal Ottawa Mental Health Centre
Military Operational Stress Reaction, Malnutrition (Calorie)
Physiological Response to Protein and Energy-enhanced Food Products During Winter Military Training
Soldiers commonly lose muscle mass during training and combat operations that produce large energy deficits (i.e., calories burned > calories consumed).
- Conditions
- Military Operational Stress Reaction, Malnutrition (Calorie), Weight Loss, Muscle Wasting
- Trial name
- NCT05210205
- Testing
- EAA, Energy Dense, Control
- Where
- Norway
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Chronic Pain, PTSD - Post Traumatic Stress Disorder
Virtual Reality and Cranial Nerve Non-invasive Neuromodulation to Improve Quality of Life for Veterans
Veterans in Canada are twice as likely as the general population to experience chronic pain. This pain is often linked to post-traumatic stress disorder (PTSD), and both have a major impact on their quality of life.
- Conditions
- Chronic Pain, PTSD - Post Traumatic Stress Disorder, Quality of Life (QOL)
- Trial name
- VR & CN-NINM (NCT07137845)
- Testing
- Virtual reality, Cranial nerve non-invasive neuromodulation (CN-NINM)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Université de Sherbrooke