Clinical trials: Combination Therapy
Neoplastic Cells, Circulating
The Detection of Circulating Tumor Cells (CTCs) in Patients With Prostatic Cancer Undergoing Cryosurgery Combined With DC-CIK Treatment
Circulating tumor cells (CTCs) have the potential to provide a surrogate for'real-time biopsy' of tumor biological activity. Enumeration and molecular characterization of CTCs in prostatic cancer could play an important role in…
- Trial name
- NCT02450435
- Testing
- Flow cytometry (FCM), RT-PCR
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fuda Cancer Hospital, Guangzhou
Gastric Cancer
Disitamab Vedotin Combined With PD-1 and Neoadjuvant Chemotherapy for Locally Advanced Gastric Cancer（RC48-C018）
This trial is a multi-center, open, single-arm, superior phase II clinical study.
- Trial name
- NCT05113459
- Testing
- Disitamab Vedotin Combined With PD-1 and Neoadjuvant Chemotherapy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Guoxin Li
Pioglitazone
Pioglitazone Versus Metformin as First Treatment in Infertile Women With Polycystic Ovary Syndrome
Participants with PCOS will be divided into two groups then each group will randomly recieve one of the following treatment 1. metformin will be adminstered in adose of 500 mg 3 times daily for 3 months to group B. 2.
- Trial name
- NCT03566225
- Testing
- Pioglitazone, Metformin, Clomiphene Citrate
- Where
- Egypt
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Healthy Volunteers
A Study of Interaction of Zasocitinib (TAK-279) With Other Medicines in Healthy Adults
The main aim of this study is to find out how zasocitinib (TAK-279) interacts with other medicines taken by mouth (orally). This will be examined by how the body processes medicines, which is called pharmacokinetics or PK.
- Trial name
- NCT06793943
- Testing
- Zasocitinib, COC, Metformin
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Takeda
High-level Rugby Athletes, Performance
Photobiomodulation Therapy in a Field Test With High-level Rugby Players
Background/Aim: While growing evidence supports the use of photobiomodulation therapy (PBMT) for performance and recovery enhancement, there have only been laboratory-controlled studies.
- Conditions
- High-level Rugby Athletes, Performance, Recovery
- Trial name
- NCT02588768
- Testing
- Photobiomodulation therapy (Phototherapy)
- Where
- Brazil
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Primary Open Angle Glaucoma, Hypertension Ocular
Effects of Magnetic Therapy and Seawater Combined in Decreasing Intraocular Presion.
Glaucoma is among the leading causes for blindness in the western world. Elevated intraocular pressure (IOP) has been identified as the most important risk factor.
- Trial name
- GME (NCT02300818)
- Testing
- Pulsed Electromagnetic Field Therapy, Seawater eyedrops
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- American Society Of Thermalism And Climatology Inc
Dry Eye
Cyclosporine 0.1% / Loteprednol 0.2% Effect on Anterior Segment Normalization
The CLEAN Study: Cyclosporine 0.1% / Loteprednol 0.2% Effect on Anterior Segment Normalization-A Prospective Cohort Study of Combination Therapy in the Treatment of Dry Eye
- Trial name
- CLEAN (NCT05322148)
- Testing
- Klarity CL, Cylcosporine 0.1%/Loteprednol Etabonate 0.2% Preservative Free
- Where
- 3 sites in United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Research Insight LLC
Burning Mouth Syndrome
Low Level Laser Therapy Plus Topical Clonazepam Treatment to Burning Mouth Symdrome
Burning mouth syndrome (BMS) is a condition that affects the oral mucosa; this is seen mainly in postmenopausal women. The intensity of burning and its clinical manifestations may be variable between patients.
- Trial name
- BurnLasCLo (NCT04313907)
- Testing
- low level laser therapy plus topical clonazepam
- Where
- Mexico
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional Autonoma de Mexico
Nerve Injury, Laser Therapy
Histopathological, Biochemical And Electrophysiological Evaluation Of Single Or Combined Use Of Diode Laser/Steroid Treatment On Facial Nerve Injury
The objective of the study will be to investigate the effect of low-level diode laser therapy (LLLT) and steroid on facial nerve injury.
- Conditions
- Nerve Injury, Laser Therapy, Methylprednisolone, Facial Nerve Injuries
- Trial name
- facial nerve (NCT06185426)
- Testing
- Methyprednisolon and low level laser theraphy
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University
Healthy Volunteers
Phase 1 Study of ALZT-OP1 Combination Therapy in Normal Healthy Volunteers
This is an open-labeled, cross-over design, pharmacokinetic study, to determine the pharmacokinetics of ALZT-OP1 (a combination drug therapy) designated as ALZT-OP1a and ALZT-OP1b, in both plasma and CSF, following…
- Trial name
- NCT02482324
- Testing
- ALZT-OP1a, ALZT-OP1b, Dry Powder Inhaler
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- AZTherapies, Inc.
Trachoma, Lymphatic Filariasis
Safety Study of Combined Azithromycin, Ivermectin and Albendazole for Trachoma and Lymphatic Filariasis
Trachoma and lymphatic filariasis (LF) are two 'Neglected Tropical Diseases' (NTDs), infectious diseases that affect millions of poor people in countries in the developing world.
- Trial name
- AZIVAL2 (NCT01903057)
- Testing
- azithromycin, ivermectin, albendazole
- Where
- Mozambique
- Volunteers
- healthy volunteers welcome
- Sponsor
- Emory University
Ulcerative Colitis
Combined Microbiota and Metabolic Signature in Ulcerative Colitis Predicts Anti-Inflammatory Therapy Success
The primary goal of the study is to develop an early (within 4 weeks) combined microbiota/metabolic signature predicting clinical response upon anti-inflammatory treatment in UC patients.
- Trial name
- COMMIT (NCT05702879)
- Testing
- Ozanimod, TNF Inhibitor, Steroids
- Where
- Switzerland
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Skin Laxity
Retrospective Evaluation of Combination Treatment With the Ulthera System
A retrospective study to evaluate the Ulthera® System for its potential interaction with toxins and fillers. Up to 500 subjects will be enrolled.
- Trial name
- NCT02444169
- Testing
- Ultherapy, Incobotulinumtoxin A, Radiesse
- Where
- 5 sites in United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Ulthera, Inc
Crohn's Disease (CD)
Biologics and Paediatric Enteral Nutrition in Crohn's Disease Study
Crohn's disease (CD) is a chronic, incurable condition associated with gut inflammation. Two important treatments currently used to manage CD are special drug injections (biologics) or a liquid-only diet using specialised…
- Trial name
- BIOPIC-Kids (NCT07522528)
- Testing
- enteral nutrition
- Where
- 6 sites in United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Nonsquamous Nonsmall Cell Neoplasm of Lung
Evaluate the Safety and Efficacy of BLEX 404 Oral Liquid Combined With Pemetrexed + Cisplatin Therapy
Maitake is reported with immunomodulatory functions against tumor growth in terms of its unique molecular structure, β-glucan polysaccharides within 1, 6 main chain having 1, 3 branches and a 1, 3 main chain having 1, 6 branches…
- Trial name
- NCT05764928
- Testing
- BLEX 404
- Where
- Taiwan
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Rgene Corporation
Women Health, Physiotherapy
Pelvic Floor Physiotherapy Combined With Sexual Therapy in Vaginismus Treatment
Studies on pelvic floor physiotherapy in individuals diagnosed with vaginismus are quite limited in the literature. While current studies have focused on certain physiotherapy modalities, the literature is quite limited in terms…
- Conditions
- Women Health, Physiotherapy, Exercise
- Trial name
- NCT06760767
- Testing
- sexual therapy, Pelvic floor physiotherapy combined with sexual therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Medipol University
Sarcopenia
Combined Effects of Resistance Training and Nutritional Supplements in the Treatment of Sarcopenia
Age-related sarcopenia is associated with increased morbidity, mortality, disability and reduced resistance to metabolic stress.
- Trial name
- NCT00748696
- Testing
- Fortimel Extra®, resistance training, combined treatment
- Where
- France
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Hyperpigmentation, Melasma
Evaluation of Efficacy and Tolerabilty of MelaB3 Serum in Combination of 35% Glycolic Acid Peeling Compared to 35% Glycolic Acid Peeling Alone in Various Hyperpigmentation Conditions
Randomized clinical trial to assess the effectiveness and tolerability of Mela B3 serum in combination with 35% glycolic acid peel vs.
- Conditions
- Hyperpigmentation, Melasma, Solar Lentigo, Peeling
- Trial name
- NCT07429786
- Testing
- Glycolic acid peel alone, MelaB3 serum
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cosmetique Active International
Non-small Cell Lung Cancer
FMT+Immunotherapy+Chemotherapy As First-line Treatment for Driver-gene Negative Advanced NSCLC
This study plans to reconstruct intestinal microecology through fecal microbiota transplantation (FMT), and combine with standard first-line therapy to enhance the anti-tumor immune effect at the same time, thereby extending the…
- Trial name
- NCT06403111
- Testing
- Fecal Microbiota Transplantation (FMT)+chemotherapy+immunotherapy
- Where
- China
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Changzhou No.2 People's Hospital