Clinical trials: Common Mental Disorders
Common Mental Disorders, Severe Mental Disorder
Training Providers to Conduct PRIDES-sSA
Global mental health (MH) and substance use disorders prevention, treatment and research gaps require that efficacious treatments be scaled-up, leveraging existing platforms.
- Trial name
- PRIDE-sSA (NCT03610750)
- Testing
- psychiatric medications and evidence-based psychotherapies
- Where
- Mozambique
- Volunteers
- 901 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Anxiety, Depression
At Work and Coping - Effect Study of Workcoping for Patients With Anxiety and Depression
Mental disorders, mainly various anxiety and depressive disorders, are an increasing reason for sick leave and disability pension.
- Trial name
- AWaC (NCT01146730)
- Testing
- Workcoping and IPS, Ordinary care by GP or NAV
- Where
- Norway
- Volunteers
- 1,202 people, healthy volunteers welcome
- Sponsor
- NORCE Norwegian Research Centre AS
Depression, Anxiety
Single Session Intervention to Prevent Common Mental Disorders and Among College Students
The present study aims to determine the effect of presenting psychoeducation emphasizing "growth-mindset," and information on depression and anxiety symptom severity.
- Trial name
- NCT04267068
- Testing
- Growth Mindset and Modifiable Risk Factor Information, Control
- Where
- United States
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Reno
Intervention Compliance, Usability
CSDM: A Trial to Improve Communication and Shared Decision Making Using a Web-Based Tool
The goal is to develop a pragmatic, scalable intervention to overcome problems with surrogate decision making in ICUs. The aim is to conduct a pilot study among surrogates and clinicians of 50 incapacitated patients at high risk…
- Conditions
- Intervention Compliance, Usability, Acceptability
- Trial name
- CSDM Pilot (NCT02955563)
- Testing
- CSDM Web-Based Tool Intervention
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Alzheimer Disease, Dementia
HEARS-NPS: Addressing Hearing Loss as a Common Unmet Contributor of Neuropsychiatric Symptoms
This randomized controlled trial study aims to evaluate a revised hearing care intervention for older adults with Alzheimer's Disease and Related Dementias (ADRD).
- Conditions
- Alzheimer Disease, Dementia, Hearing Loss, Cognitive Impairment
- Trial name
- HEARS-NPS (NCT06930560)
- Testing
- HEARS-NPS device, HEARS-NPS program
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Bipolar Disorder, Schizophrenia
Emotions in Schizophrenia and Bipolar Disorders: a Common Vulnerability?
The initial aim of the project was to gain an understanding of the comprehension of "language-oriented" emotions among schizophrenic and bipolar patients.
- Trial name
- ELISE (NCT02805088)
- Testing
- Electroencephalographic recordings, neuropsychological evaluation, clinical evaluation of symptoms
- Where
- France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Cancer, Alzheimer Disease
Implement and Test Visual Consent Template and Process
The investigators plan to conduct a stepped wedge randomized control trial to implement and test the consent template and process in three studies. Randomization will occur at the research coordinator/research team level.
- Trial name
- NCT06804837
- Testing
- Visual consent, Standard consent
- Where
- 3 sites in United States
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Obesity, Alzheimer's Disease
Identification of Epigenetic Markers Common to Obesity and Alzheimer's Disease in Women
The purpose of this study is to compare average methylation of epigenetic markers on genomic DNA and some genes (APP, BACE, LRP, SorL1) involved in cerebral amyloid homeostasis: Of obese young adults and healthy young adults Of…
- Trial name
- Oba (NCT02868905)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Polypharmacy, Dementia
Shared Decision Making About Medication Use for People With Multiple Health Problems
The Shared Decision Making about Medication Use for People with Multiple Health Problems study will assess the feasibility and acceptability of a deprescribing educational intervention in primary care for patients with mild…
- Conditions
- Polypharmacy, Dementia, Multiple Chronic Conditions, Deprescribing
- Trial name
- NCT05156073
- Testing
- Educational Materials
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Mental Health
An Evaluation of Innerview™, a Web-based Tool to Support the Integration of Mental Health in the Primary Care Setting
Innerview can address some of the challenges of integrating mental health and primary care by accurately and reliably collecting mental health evidence and activities directly from patients, and then organizing and automating…
- Trial name
- NCT02025647
- Where
- 5 sites in United States
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Pearson/Clinical Assessment
Bibliotherapy
Guided Self-help for Common Mental Disorders
Common mental disorders (CMDs) like depression and anxiety account for a large proportion of disability worldwide. Access to effective treatments like cognitive-behavioral therapy (CBT) is limited and has not reduced the public…
- Trial name
- DWM (NCT04870099)
- Testing
- Doing What Matters in Times of Stress: An Illustrated Guide
- Where
- United States
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Indiana University
Anxiety, Loneliness
Loneliness and Health Outcomes in the High Need Population
The high need population are patients who have three or more chronic diseases and have a functional limitation in their ability to take care for themselves.
- Conditions
- Anxiety, Loneliness, Depression, Alcohol Use Disorder
- Trial name
- NCT05484258
- Testing
- Shared Medical Visit
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Critical Limb Threatening Ischaemia, Depression Disorder
Symptoms of Anxiety and/or Depression and SDM in Older Patients With CLTI
Mental health disorders are common in older people and are often unrecognised. Those living with mental health disorders who are being considered for vascular surgery have worse post operative outcomes, including longer length of…
- Conditions
- Critical Limb Threatening Ischaemia, Depression Disorder, Anxiety
- Trial name
- NCT07529886
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Depression, Anxiety
Growth Mindset Psychoeducation for Modifiable Risk Factors for CMD
The present study aims to determine the effect of presenting psychoeducation emphasizing "growth-mindset," and information on modifiable risk factors (e.g., social contact, physical activity) on engagement with modifiable risk…
- Trial name
- NCT03707522
- Testing
- Growth mindset, Modifiable risk factor (MRF) information, Control
- Where
- United States
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Reno
Depression, Mental Disorder
Digital Training for Non-Specialist Health Workers to Deliver a Brief Psychological Treatment for Depression
The purpose of this 3-arm randomized controlled trial is to compare two forms of digital training (i.e., low-intensity and high-intensity) with traditional face-to-face training of non-specialist health workers to deliver an…
- Conditions
- Depression, Mental Disorder, Psychological
- Trial name
- ESSENCE (NCT04157816)
- Testing
- Face-to-Face Training, Digital Training, Coaching Support
- Where
- India
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Harvard Medical School (HMS and HSDM)
Psychosis
Immune Mechanisms of Antipsychotic Treatment Response
The aim of this study is to investigate the role of the immune system in psychotic symptoms and their response to treatment. The investigators will collect blood and cerebrospinal fluid samples from participants with psychosis…
- Trial name
- IMAT (NCT06687694)
- Where
- United Kingdom
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- King's College London
Anxiety, Depression
Metacognitive Therapy and Work Interventions for Patients on Sick Leave Due to Common Mental Disorders
Common mental health disorders such as anxiety and depression are leading causes of sickness absence and disability in Norway. Despite tremendous costs for individual and society, effective treatment is lacking.
- Trial name
- NCT03301922
- Testing
- Metacognitive therapy and work-focused interventions, Waiting list
- Where
- Norway
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Schizophrenia, Autism Spectrum Disorder
A Computational Neuroscience Perspective on the Shared Social Cognitive Deficits of Autism and Schizophrenia
This retrospective cohort study will examine shared neural mechanisms of social cognitive deficits in adults with autism spectrum disorder and adults with schizophrenia using existing clinical, behavioral, and neuroimaging data…
- Trial name
- NCT07618767
- Where
- Taiwan
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Anxiety
Happy Mother - Healthy Baby: Supplement Study on Biological Processes Underlying Anxiety During Pregnancy
As a supplement to the ongoing randomized evaluation of the Cognitive Behavioral Therapy (CBT) anxiety prevention intervention in Pakistan (R01-MH111859), the investigators propose to explore potential biological mechanisms…
- Trial name
- HMHB-Bio (NCT04566861)
- Testing
- Cognitive Behavioral Therapy (CBT) for anxiety during pregnancy
- Where
- Pakistan
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Type 2 Diabetes Mellitus (T2DM)
GMVs in Primary Care: An RCT of Group-Based Versus Individual Appointments to Reduce HbA1c in Older People
Type 2 diabetes is a major problem of older people; its prevalence is greater than 20% in those aged over 65 years. Treatment such as medication, healthy nutritional choices \& body weight management, as well as physical activity…
- Trial name
- GAP (NCT02002143)
- Testing
- Group Appointments, Individual Appointments (IAs)
- Where
- 2 sites in Canada
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of British Columbia