Clinical trials: Communicable Diseases
HIV Infections
Efficacy of Treatment Intensification With Maraviroc on HIV-1 Viral Latency in Recently Infected Hiv-1 naïve Patients Starting Raltegravir Plus Tenofovir/Emtricitabine
The intensification with maraviroc in recently HIV-1-infected patients of a preferred gold-standard triple therapy composed of raltegravir plus tenofovir/emtricitabine could accelerate the decay of the HIV-1 reservoir in latently…
- Trial name
- NCT00808002
- Testing
- Raltegravir, Maraviroc, Tenofovir/Emtricitabine
- Where
- 2 sites in Spain
- Volunteers
- 30 people
- Sponsor
- Germans Trias i Pujol Hospital
Neonatal Infection
Newborn Infection Control and Care Initiative for Health Facilities to Accelerate Reduction of Newborn Mortality
Newborn mortality continues to be unacceptably high in Cambodia, despite reductions in maternal and under five year old mortality.
- Trial name
- NICCI (NCT02271737)
- Testing
- Training HC/VHSG, Health Education, and Supportive Supervision
- Where
- Cambodia
- Volunteers
- 1,938 people
- Sponsor
- National Institute of Public Health, Cambodia
Sarcoma, Kaposi, HIV Infections
A Study of Doxorubicin in the Treatment of AIDS-Related Kaposi's Sarcoma
To study the natural course of AIDS related Kaposi's sarcoma and to determine the usefulness and safety of weekly administration of small doses of doxorubicin.
- Trial name
- NCT00000996
- Testing
- Doxorubicin hydrochloride
- Where
- 12 sites in United States
- Volunteers
- 48 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Infectious Keratitis
Investigation of the Microbiome of the Cornea in Microbial Keratitis
Design: Prospective observational diagnostic study and methods-comparison. Aims: The overall aim of the project is to better define the pathogenic microorganisms in patients with microbial keratitis (MK) through a better…
- Trial name
- STOICA (NCT04030403)
- Where
- United Kingdom
- Volunteers
- 219 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
End Stage Renal Disease
Analysis of CRBSI Rates in Patients With a NexSite™ HD (Hemodialysis) Catheter
A U.S. multi-centre post approval registry to analyse the CRBSI rate in patients with the NexSite HD Catheter for long term vascular access for hemodialysis.
- Trial name
- NCT02453646
- Testing
- NexSite HD Patients
- Where
- 6 sites in United States
- Volunteers
- 120 people
- Sponsor
- Marvao Medical
Chronic Hepatitis C
A Phase 2 Study to Evaluate the Safety and Efficacy of VX-135 With Ribavirin in Treatment-Naïve Subjects With Chronic Hepatitis C
A Phase 2 study to evaluate the safety and efficacy of two different once daily doses VX-135 in combination with ribavirin in treatment-naïve subjects with chronic hepatitis C
- Trial name
- NCT01726946
- Testing
- VX-135, ribavirin
- Where
- 6 sites in United States
- Volunteers
- 10 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Acute Respiratory Infection
Efficacy and Safety of XC8, Film-coated Tablets, in Children With Acute Respiratory Viral Infections
The study is planned to evaluate the therapeutic efficacy and safety of XC8, film-coated tablets, in the treatment of dry non-productive cough on the background of acute respiratory infections in children from 6 to 17 years…
- Trial name
- NCT06379542
- Testing
- XC8
- Where
- 6 sites in Russia
- Volunteers
- 252 people
- Sponsor
- Valenta Pharm JSC
HIV Infections, Cytopenias
A Double-Blind, Placebo-Controlled Study With Open-Label Follow-Up To Determine the Safety and Efficacy of Subcutaneous Doses of r-HuEPO in AIDS Patients With Anemia Induced by Their Disease and AZT Therapy
To determine the safety and efficacy of erythropoietin administered subcutaneously to AIDS patients with anemia secondary to their disease and/or concomitant zidovudine (AZT) therapy.
- Trial name
- NCT00002073
- Testing
- Epoetin alfa
- Where
- United States
- Sponsor
- Ortho Pharmaceuticals
HIV, HIV Infections
Study to Evaluate the Safety and Efficacy of Stribild Versus Ritonavir-Boosted Atazanavir Plus Truvada in Human Immunodeficiency Virus, Type 1 (HIV-1) Infected, Antiretroviral Treatment-Naive Adults
To evaluate the safety and efficacy of Stribild®, a single tablet regimen (STR) containing fixed doses of elvitegravir (EVG)/cobicistat (COBI [GS-9350])/emtricitabine (FTC)/tenofovir disoproxil fumarate (TDF) versus…
- Trial name
- NCT01106586
- Testing
- Stribild, ATV, Ritonavir
- Where
- 146 sites in United States, Australia and 15 more
- Volunteers
- 708 people
- Sponsor
- Gilead Sciences
Human Immunodeficiency Virus, Hepatitis C, Chronic
HIV Drug Switch Followed by HCV Therapy in HIV-HCV Co-Infection
This is an prospective open label pilot study conducted over 32 weeks. A total of 25 eligible participants who are infected with HCV and HIV will be recruited from 2 Canadian HIV Trials Network (CTN) sites (Ottawa Hospital…
- Trial name
- CTN289 (NCT02660905)
- Testing
- E/C/F/TAF;, Ledipasvir-Sofosbuvir
- Where
- 2 sites in Canada
- Volunteers
- 25 people
- Sponsor
- Ottawa Hospital Research Institute
HIV, HIV Infections
A Study to Examine the Human Papillomavirus Types Exposure in Women From Southern Africa and Brasil
This is a study to determine what Human Papillomavirus HIV seropositive women in Botswana, South Africa and Brasil have been exposed to during their life. The Human Papillomavirus causes cervical cancer.
- Trial name
- NCT00840905
- Where
- 3 sites in Botswana, Brazil and 1 more
- Volunteers
- 487 people
- Sponsor
- Cynthia S Firnhaber
Post-Viral Fatigue Syndrome, Post-Viral Disorder (Disorder)
Study to Evaluate the Benefit of RUCONEST in Improving Neurological Symptoms in Post COVID-19 Infection
Randomized, Double Blind, Placebo Controlled, Proof-of-Concept Study to Evaluate the Benefit of RUCONEST in Improving Neurological Symptoms in Post-SARS-CoV-2 Infection.
- Conditions
- Post-Viral Fatigue Syndrome, Post-Viral Disorder (Disorder), Covid19
- Trial name
- NCT04705831
- Testing
- Ruconest
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- IMMUNOe Research Centers
Microbial Colonization
Impact of Quinoa Milk Fermented With Lactic Acid Bacteria From Foods on Human Oral and Intestinal Flora
The demand for alternatives to dairy products has increased in recent years and a lot of proposals for vegetable milk and yogurt products have taken place in the market.
- Trial name
- NCT04280731
- Testing
- fermented quinoa
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Lund University
Toxoplasmosis, Cerebral, Toxoplasmosis
Analysis of Cerebrospinal Fluid in Patients With Cerebral Toxoplasmosis at CHSD (2004-2024)
This study looks at patients who were treated for cerebral toxoplasmosis at CHSD between 2004 and 2024. It focuses on analyzing their cerebrospinal fluid (CSF) to better understand the biological signs of the disease.
- Conditions
- Toxoplasmosis, Cerebral, Toxoplasmosis, Meningitis, HIV Infections
- Trial name
- NCT07044037
- Where
- France
- Volunteers
- 53 people
- Sponsor
- Centre Hospitalier de Saint-Denis
Early Ventilator Associated Pneumonia
Duration of Antibiotic Treatment for Early VAP (DATE) Trial
Hypothesis: 4 days of antibiotic therapy, as compared to 8 days, is equally effective and results in decreased antibiotic exposure among surgical ICU patients with early VAP.
- Trial name
- DATE (NCT01994980)
- Testing
- Default 4 days antibiotic therapy
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Denver Health and Hospital Authority
HIV Infections
The Safety and Effectiveness of Adefovir Dipivoxil Plus Indinavir Combined With Zidovudine or Lamivudine or Stavudine in HIV-Infected Patients Who Have Not Taken Anti-HIV Drugs
To evaluate the safety and tolerance of adefovir dipivoxil and indinavir administered orally in combination with zidovudine, lamivudine, or stavudine in HIV-infected patients with CD4 cell counts >= 100 cells/mm3 and an HIV-1 RNA…
- Trial name
- NCT00002379
- Testing
- Indinavir sulfate, Levocarnitine, Adefovir dipivoxil
- Where
- 15 sites in United States, Puerto Rico
- Volunteers
- 100 people
- Sponsor
- Gilead Sciences
Human Immunodeficiency Virus
Kaletra in Combination With Antiretroviral Agents
The purpose of this study is to investigate the tolerability of Kaletra (lopinavir/ritonavir) in combination with new substances such as integrase inhibitors (INIs), C-C chemokine receptor type 5 (CCR5) antagonists, and new…
- Trial name
- PROTEKT (NCT01076179)
- Volunteers
- 502 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Human Immunodeficiency Virus Infections, HIV Infections
Safety and Immunogenicity Study of tgAAC09, an HIV Vaccine in an Adeno-associated Virus (AAV) Capsid
This phase 2 study will evaluate the safety, immunogenicity and optimal timing of two injections at three dose levels of the tgAAC09 vaccine in healthy volunteers.
- Trial name
- TGC14F (NCT00888446)
- Testing
- tgAAC09, Formulation buffer
- Where
- 5 sites in South Africa, Uganda and 1 more
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- International AIDS Vaccine Initiative
HIV Infections, Leukemia
Aberrant Myeloid Lineage Differentiation in HIV/AIDS Patients
The investigators included 782 HIV-infected patients from January 2016 to October 2020 Zhongnan Hospital of Wuhan University, whose AIDS diagnosis criteria met the "AIDS Diagnosis and Treatment Guide (2018 edition)" of Chinese…
- Trial name
- NCT05808803
- Volunteers
- 782 people
- Sponsor
- Zhongnan Hospital
Human Immunodeficiency Virus (HIV), Hepatitis C (HCV)
Persuasive Health Communication Intervention for HIV/HCV
A major impediment to emergency department (ED)-based HIV/HCV screening success is that often ED patients at risk for, or later diagnosed with, HIV and HCV decline testing.
- Trial name
- NCT05968573
- Testing
- Video Format with Captions, Video Format without Captions, Health Educator
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of South Florida